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Topic: Dextromethorphan

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	Dextromethorphan (Robitussin-DM®)
		Dextromethorphan is available over the counter but should not be administered unless under the supervision and guidance of a veterinarian.
		Dextromethorphan is used to suppress coughing in cases of tracheal or bronchial irritation.
		Dextromethorphan should not be used in animals with known hypersensitivity or allergy to the drug.
	www.petplace.com /drug-library/dextromethorphan-robitussin-dm/page1.aspx (626 words)

	Drugs and Human Performance FACT SHEETS - Dextromethorphan
		Dextromethorphan is widely distributed, and is rapidly and extensively metabolized by the liver.
		Dextromethorphan is demethylated to dextrorphan, an active metabolite, and to 3-methoxymorphinan and 3-hydroxymorphinan.
		Psychotropic effects of dextromethorphan are altered by the CYP2D6 polymorphism: a pilot study.
	www.nhtsa.dot.gov /people/injury/research/job185drugs/dextromethorphan.htm (1087 words)

	Dextromethorphan - Wikipedia, the free encyclopedia
		Dextromethorphan is a salt of the methyl ether dextrorotatory isomer of levorphanol, a narcotic (opioid) analgesic (and DXM itself is an enantiomeric isomer, that is, a mirror image in the 3D space, of levomethorphan, a substance considered an opioid
		Dextromethorphan is metabolized by various liver enzymes and subsequently undergoes O-demethylation (producing dextrorphan), N-demethylation, and partial conjugation with glucuronic acid and sulfate ions.
		Dextromethorphan was first patented with U.S. Patent 2,676,177, and was approved for over-the-counter purchase as an antitussive in 1958.
	en.wikipedia.org /wiki/DXM (1028 words)

	Dextromethorphan - Wikipedia, the free encyclopedia
		Dextromethorphan (DM or DXM) is an antitussive drug that is found in many over-the-counter cold and cough preparations, usually in the form of dextromethorphan hydrobromide.
		The advantage of dextromethorphan preparations over those containing codeine (now prescription only in the United States) was the lack of physical addiction potential and sedative side-effects, although as with most cough supressants, studies show that its effectiveness is highly debatable.
		Hours after dextromethorphan therapy, (in humans) the metabolites (+)-3-hydroxy-N-methylmorphinan, (+)-3-morphinan, and traces of the unchanged drug are detectable in the urine.
	en.wikipedia.org /wiki/Dextromethorphan (1028 words)

	Dextromethorphan - Encyclopedia, History, Geography and Biography (Site not responding. Last check: )
		Dextromethorphan is a salt of the methyl ether dextrorotatory isomer of levorphanol, a narcotic analgesic.
		Dextromethorphan is metabolized by various liver enzymes and subsequently undergoes O-demethylation, N-demethylation, and partial conjugation with glucuronic acid and sulfate ions.
		Dextromethorphan is predominantly metabolized by the liver, by various hepatic enzymes.
	www.arikah.net /encyclopedia/DXM (745 words)

	The Ultimate Dextromethorphan - American History Information Guide and Reference
		Dextromethorphan is the dextrorotary-enantiomer of the opioid-receptor agonist levomethorphan.
		Dextromethorphan is predominantly metabolized by the liver, by the hepatic cytochrome P450 enzyme known as CYP2D6.
		The advantages of dextromethorphan over codeine are the absence of constipation and physical dependence; it is also less sedative, and has little to no psychological effect in the doses used medically (typically no more than 30 mg, or slightly more, spread over several hours; 10-15 mg is a common dose in cough syrups).
	www.historymania.com /american_history/DXM (3178 words)

	dextromethorphan and promethazine
		Dextromethorphan and promethazine is used to treat coughs; runny nose; sneezing; and congestion associated with allergies or the common cold.
		Dextromethorphan and promethazine is in the FDA pregnancy category C. This means that it is not known whether dextromethorphan and promethazine will harm an unborn baby.
		Dextromethorphan and promethazine is available with a prescription generically and under the brand name Phenergan with dextromethorphan.
	hw.healthdialog.com /kbase/multum/d03360a1.htm (1281 words)

	Dextromethorphan (PIM 179)
		Dextromethorphan is 3 Methoxy-17-methylmorphinan monohydrate, which is the d isomer of levophenol, a codeine analogue and opioid analgesic.
		Dextromethorphan may be associated with histamine release and should not be used in atopic children.
		The antitussive effects of dextromethorphan and the metabolite dextrorphan are secondary to binding in the CNS at non-opioid receptors.
	www.inchem.org /documents/pims/pharm/pim179.htm (4517 words)

	Dextromethorphan page (Site not responding. Last check: )
		Dextromethorphan is a common ingredient in cough syrups.
		In 1998, an animal study involving chick embryos suggests that early exposure to dextromethorphan is associated with an increased risk for neural tube defects, craniofacial defects, and embryotoxicity.
		In general, it is thought that therapeutic dextromethorphan use during pregnancy does not pose a high risk for malformation.
	www.genetics.missouri.edu /Motis/dextromethorphan.htm (294 words)

	Review of Dextromethorphan Efficacy, Safety, Abuse Potential, and Investigational Uses
		Dextromethorphan is a substrate for a variety of other Cytochrome P450 isoenzymes, such as CYP2B6 (minor), 2C8/9 (minor), 2C19 (minor), 2D6 (major), 2E1 (minor), 3A4 (minor).
		In 1995, it was reported that dextromethorphan and dextrorphan concentrations after ingesting dextromethorphan varied between individuals due to the genetic polymorphisms of the CYP2D6 enzyme.
		Clinical trials confirm that dextromethorphan does not produce physical addiction, lose effectiveness through increased tolerance, or cause withdrawal, even in high experimental doses, but this was over a relatively short period of time.
	www.continuingeducation.com /pharmacy/dextro/abuse.html (651 words)

	Dissociatives: PCP (Angel Dust), Ketamine (Special K) and Dextromethorphan (DXM)
		Dextromethorphan has come into view only recently by drug awareness groups, school counselors and the media.
		Dextromethorphan is the generic name for a common dissociative anesthetic found in almost any over-the-counter cough syrup.
		Recent sales of the powder, dextromethorphan hydrobromide, and the publication of a recipe-like extraction procedure used to separate DXM from cough syrups have become available on the world wide web of the Internet.
	www.recoverythroughsupport.com /factsheets/dextromethorphan-ketamine-pcp.html (1545 words)

	Dextromethorphan
		Dextromethorphan, a semisynthetic narcotic, is an ingredient found in any cold medicine with "DM" or "Tuss" in the title or name.
		At the doses recommended for treating coughs (1/6 to 1/3 ounce of medication, containing 15 mg to 30 mg dextromethorphan), the drug is safe and effective.
		At much higher doses (4 or more ounces), dextromethorphan produces disassociative effects similar to those of PCP and ketamine.
	www.streetdrugs.org /dxm.htm (373 words)

	dextromethorphan - [Medication]
		Do not use dextromethorphan to control a cough that is associated with smoking, asthma, or emphesyma, or a cough that is productive (produces sputum or phlegm).
		Use dextromethorphan only under the supervision of a doctor if you also have nausea, vomiting, a high fever, a rash, or a persistent headache.
		Dextromethorphan is available over the counter generically and under many brand names in lozenge, liquid, and syrup formulations.
	www.peacehealth.org /kbase/multum/d00207a1.htm (1000 words)

	dexchlorpheniramine, dextromethorphan, and pseudoephedrine - Drug Finder - MSN Health & Fitness (Site not responding. Last check: )
		Dexchlorpheniramine, dextromethorphan, and pseudoephedrine is used to treat nasal congestion, sinusitis (inflammation of the sinuses), and coughs associated with allergies, hay fever, and the common cold.
		Symptoms of a dexchlorpheniramine, dextromethorphan, and pseudoephedrine overdose include dry mouth, large pupils, flushing, nausea and vomiting, hyperactivity, or hallucinations.
		Dexchlorpheniramine, dextromethorphan, and pseudoephedrine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants.
	health.msn.com /drugfinder/articlepage.aspx?cp-documentid=100107271 (1528 words)

	dextromethorphan drug information, dextromethorphan side effects
		Dextromethorphan is a salt of the methyl ether dextrorotatory isomer of levorphanol, a narcotic (opioid...
		Dextromethorphan (DXM) DXM is a cough-suppressing ingredient in a variety of over-the...
		Do not use dextromethorphan to control a cough that is associated with smoking, asthma, or emphesyma, or a cough that is...
	www.drugs.com /sch/dextromethorphan (428 words)

	Clinical Trial: Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain
		Dextromethorphan, a commonly used cough suppressant, and topiramate, an anti-seizure medicine, block certain receptors on brain and spinal nerve cells that may cause the cells to produce electrical discharges and pain.
		Thus, the purpose of this study is to evaluate the efficacy and safety of topiramate (TPM) or high-dose dextromethorphan (DM) versus placebo in the treatment of pain in patients with trigeminal neuralgia (TN) and other orofacial neuropathic pain syndromes.
		We propose two 6 month studies respectively evaluating dextromethorphan (60 patients; at least 20 with TN, 20 with definite trigeminal nerve pathology and 20 with likely trigeminal nerve pathology) and topiramate (40 patients; at least 20 with TN, 20 with definite trigeminal nerve pathology).
	clinicaltrials.gov /ct/show/NCT00001725 (1109 words)

	AMA (CSAPH) Report 1 of the Council on Scientific Affairs (I-04)
		Dextromethorphan is a widely used over-the-counter cough suppressant available alone or in combination with other products that are used for symptomatic relief by patients with various upper respiratory ailments.
		Consuming large amounts of dextromethorphan from combination products that include acetaminophen, pseudoephedrine, or antihistamines is more dangerous because of the ancillary toxic effects of these other compounds.
		Repackaging of bulk powdered dextromethorphan for resale as dextromethorphan or as counterfeit PCP or Ecstasy may be a criminal act subject to the jurisdiction of either the FDA (misbranding) or the DEA (counterfeit controlled substance).
	www.ama-assn.org /ama/pub/category/14413.html (451 words)

	DXM - Drug Info - Parents - The Anti-Drug
		Dextromethorphan is a cough-suppressing ingredient in a variety of OTC cold and cough medications.
		Dextromethorphan is a safe and effective cough suppressant when used as indicated on the product label.
		Unfortunately, there are Internet sources that sell dextromethorphan in a bulk powder form or encourage teens to share their experiences with abusing dextromethorphan.
	www.theantidrug.com /drug_info/drug_info_dxm.asp (778 words)

	Dextromethorphan and Cough Medicine Abuse
		Dextromethorphan is a safe and effective active ingredient found in many nonprescription cough syrups, tablets, and gel caps.
		There are well over 100 OTC medicines that contain dextromethorphan, either as the only active ingredient or in combination with other active ingredients.
		You should be aware of what your teen is doing on the Internet, the web sites he or she visits, and the amount of the time he or she is logged on.
	www.drugfree.org /Parent/Resources/Cough_Medicine_Abuse (914 words)

	Dextromethorphan (Systemic) - MayoClinic.com (Site not responding. Last check: )
		Dextromethorphan (dex-troe-meth-OR-fan) is used to relieve coughs due to colds or influenza (flu).
		Dextromethorphan relieves cough by acting directly on the cough center in the brain.
		Although there is no specific information comparing use of dextromethorphan in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
	www.mayoclinic.com /health/drug-information/DR202187 (1408 words)

	DEXTROMETHORPHAN (Street Names: DXM, CCC, Triple C, Skittles, Robo, Poor Man’s PCP)
		Dextromethorphan (DXM) is an over-the-counter (OTC) cough suppressant commonly found in cold medications.
		DXM is often abused in high doses by adolescents to generate euphoria and visual and auditory hallucinations.
		Dextromethorphan (DXM) (d-3-methoxy-N-methyl-morphinan) is the dextro isomer of levomethorphan, a semisynthetic morphine derivative.
	www.deadiversion.usdoj.gov /drugs_concern/dextro_m/dextro_m.htm (696 words)

	acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine, Augusta, Georgia, GA
		Acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine is used to treat nasal congestion, sinusitis (inflammation of the sinuses), runny nose, watery eyes, headache, body aches, and coughs associated with allergies, hay fever, and the common cold.
		Symptoms of an acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine overdose include a dry mouth, large pupils, flushing, sweating, nausea, vomiting, diarrhea, abdominal pain, seizures, confusion, an irregular heartbeat, hyperactivity, or hallucinations.
		Acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants.
	www.universityhealth.org /15754.cfm (1827 words)

	guaifenesin and dextromethorphan, Eastern North Carolina, NC
		Guaifenesin and dextromethorphan is used to treat the symptoms of the common cold and of infections of your sinuses, your lungs, and your throat when they are accompanied by a nonproductive, bothersome cough.
		Guaifenesin and dextromethorphan is in the FDA pregnancy category C. This means that it is not known whether guaifenesin and dextromethorphan will harm an unborn baby.
		Guaifenesin and dextromethorphan is available with a prescription generically and under several brand names.
	www.uhseast.com /115281.cfm (1253 words)

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