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Topic: Dichlorvos

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	ATSDR - ToxFAQs™: Dichlorvos
		Dichlorvos is an insecticide which is used to control insects primarily in storage areas and barns.
		Dichlorvos is used for insect control in food storage areas, green houses, and barns, and control of insects on livestock.
		Dichlorvos enters the environment during its manufacture and use, from landfills, and from accidental spills during transport and leaks from storage containers.
	www.atsdr.cdc.gov /tfacts88.html (919 words)

	Dichlorvos
		The oral LD50 for dichlorvos is 61 to 175 mg/kg in mice, 100 to 1090 mg/kg in dogs, 15 mg/kg in chickens, 25 to 80 mg/kg in rats, 157 mg/kg in pigs, and 11 to 12.5 mg/kg in rabbits.
		The dermal LD50 for dichlorvos is 70.4 to 250 mg/kg in rats, 206 mg/kg in mice, and 107 mg/kg in rabbits.
		Dichlorvos is a colorless to amber liquid with a mild chemical odor [13].
	www.the-piedpiper.co.uk /th13(f).htm (679 words)

	Dichlorvos
		Dichlorvos is a colorless to amber oily liquid with a mild aromatic odor.
		Effects on Animals: Dichlorvos is an anticholinesterase agent and may cause excessive salivation, eye tearing, sweating, constricted pupils, respiratory distress, anorexia, vomiting, diarrhea, weakness, twitching, paralysis, a slow and irregular heartbeat, convulsions, coma, and death [Hathaway et al.
		The acute toxicity of dichlorvos for laboratory animals is significantly high; the dermal LD(50) for rabbits is 107 mg/kg and 80 mg/kg in rats; and the acute oral LD(50) in rats is 25 mg/kg [NIOSH 1995; ACGIH 1991; Sax and Lewis 1989].
	www.osha.gov /SLTC/healthguidelines/dichlorvos/recognition.html (4117 words)

	EXTOXNET PIP - DICHLORVOS
		The oral LD50 for dichlorvos is 61 to 175 mg/kg in mice, 100 to 1090 mg/kg in dogs, 15 mg/kg in chickens, 25 to 80 mg/kg in rats, 157 mg/kg in pigs, and 11 to 12.5 mg/kg in rabbits [2,8,13].
		The dermal LD50 for dichlorvos is 70.4 to 250 mg/kg in rats, 206 mg/kg in mice, and 107 mg/kg in rabbits [2,8,13].
		Dichlorvos does not accumulate in body tissues and has not been detected in the milk of cows or rats, even when the animals were given doses high enough to produce symptoms of severe poisoning [2].
	extoxnet.orst.edu /info/extoxnet/pips/dichlorv.htm (2045 words)

	An Evaluation of Dichlorvos
		Dichlorvos was once a very popular insecticide for use in homes and offices and many people may have come in contact with it in the past.
		Dichlorvos has not been found in drinking water in the U.S. Hence, food and water are not expected to be the cause of exposure for people.
		The evidence for the breast cancer risk from dichlorvos is limited to the one study in experimental rats in which it caused an increase in the frequency of benign mammary tumors only.
	envirocancer.cornell.edu /FactSheet/Pesticide/fs20.dichlorvos.cfm (1962 words)

	Pesticides: Results or review of pest...
		Firstly, studies in animals suggested that dichlorvos may have the potential to be a genotoxic carcinogen (that is, it could be capable of causing cancer).
		The ACP were concerned that the difference between the amount of dichlorvos that users may be exposed to, and the amount that may have the potential to cause health effects was not sufficiently large.
		Dichlorvos is one of a number of insecticides that kill insects by interfering with nerve transmission.
	www.hse.gov.uk /pesticides/dichlorvos.htm (2412 words)

	Dichlorvos [factsheet]
		(m g/L) EPA estimates that, if an individual were to drink water containing dichlorvos at 0.1 m g/L* over his or her entire lifetime, that person would theoretically have no more than a one-in-a-million increased chance of developing cancer as a direct result of drinking water containing this chemical.
		* Dichlorvos occurs as an oily colorless to amber liquid that is slightly soluble in water.
		Dichlorvos is used as an anthelmintic (worming agent) for dogs, swine, and horses, as a botacide (agent that kills fly larvae) for horses, and in flea collars for dogs.
	www.lakes-environmental.com /toxic/DICHLORVOS.HTML (1027 words)

	ATSDR - Public Health Statement: Dichlorvos
		Dichlorvos is a synthetic organic chemical used as an insecticide.
		Dichlorvos evaporates easily into the air, which is why it is usually used in enclosed areas.
		Dichlorvos poisoning does not appear to cause permanent damage to the nerves (a condition called "delayed neuropathy").
	www.atsdr.cdc.gov /toxprofiles/phs88.html (2909 words)

	Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment
		Members considered that the positive results obtained in in-vitro mutagenicity tests with dichlorvos in the presence of an exogenous metabolising fraction and in the assay for single strand breakage of DNA also suggested that dichlorvos and/or its metabolites were genotoxic.
		Methylation of purines and nicotinamide in the rat by dichlorvos.
		Hepatotoxicity of trichorfon and dichlorvos in isolated rat hepatocytes.
	www.advisorybodies.doh.gov.uk /Com/dichlorvos.htm (4692 words)

	Dichlorvos (CASRN 62-73-7), IRIS, Environmental Protection Agency
		Dichlorvos could not be detected in any tissue examined from rats that were exposed continuously to either 0.05 or 0.50 mg/cu.m for 14 days.
		Parent dichlorvos was detected in the kidneys of rats exposed to 10 mg/cu.m for 4 hours and in most tissues of rats (although remaining highest in the kidneys) exposed to 90 mg/cu.m for 4 hours.
		Dichlorvos is structurally related to dichloropropene (a probable human carcinogen), which causes forestomach squamous cell tumors in rats and mice, lung tumors in mice and neoplastic nodules in the livers of rats.
	www.epa.gov /iris/subst/0151.htm (8522 words)

	NRDC: OnEarth Magazine, Fall 2006 - Dispatches
		Dichlorvos knocks out insects by inhibiting cholinesterase, an enzyme that activates an essential neurotransmitter in the central nervous system.
		Inhaling dichlorvos vapor can trigger dizziness, sweats, nausea, and vomiting; high doses or prolonged exposure to low levels can cause irregular breathing and heart function and, in extreme cases, death.
		The agency revisited dichlorvos safety again in 2002, when it was required by law to reevaluate the most dangerous pesticides on the market.
	www.nrdc.org /OnEarth/06fal/dispatches.asp (1081 words)

	Dichlorvos (PDS)
		The results gave no indication that dichlorvos vapour is teratogenic in rabbits or rats even at exposure concentrations resulting in maternal deaths in rabbits and causing reduction of plasma, erythrocyte and brain cholinesterase activities in pregnant animals of both species.
		In stationary phase cultures of the yeast treated with dichlorvos, the rate of conversion increased after 5 hours at a concentration of 4 g/l, but no effect was evident with 2 g/l dichlorvos.
		In vitro - Dichlorvos, when added at specific intervals to cultures of human lymphocytes at concentrations ranging from 1 to 40 g/l, was cytotoxic to cells at concentrations of 5-40 g/l; the cytotoxicity was not accompanied by significant cytogenetic changes.
	www.inchem.org /documents/pds/pds/pest2_e.htm (3809 words)

	PANNA: REGISTRANT OF DICHLORVOS REQUESTS CANCELLATION OF CERTAIN USES. U.S. EPA News Release, April 24, 1995.
		Dichlorvos is used to control insects for a wide range of uses in the home, agriculture and commercial establishments.
		Currently, dichlorvos is also undergoing a special review by EPA on grounds that exposure to individuals by this compound from registered uses may pose an unreasonable risk of cancer and an inadequate margin of safety for cholinesterase inhibition (central nervous system effects).
		Affected persons may include the general population from consuming foods with residues of dichlorvos, applicators, agricultural workers entering treated areas, residents/occupants of treated areas, and persons exposed to pets treated with this compound.
	www.panna.org /resources/pestis/PESTIS.1995.85.html (288 words)

	About Dichlorvos: Pesticide used in schools
		EPA estimates that, if an individual were to drink water containing dichlorvos at 0.1 m g/L* over his or her entire lifetime, that person would theoretically have no more than a one-in-a-million increased chance of developing cancer as a direct result of drinking water containing this chemical.
		* Dichlorvos occurs as an oily colorless to amber liquid that is slightly soluble in water.
		Dichlorvos is used as an anthelmintic (worming agent) for dogs, swine, and horses, as a botacide (agent that kills fly larvae) for horses, and in flea collars for dogs.
	www.safe2use.com /poisons-pesticides/pesticides/misc/dichlorvos.htm (860 words)

	Flyspray ban urged as cancer fears rise - [Sunday Herald]
		Ministers were advised last July to recall dozens of household insecticides containing the chemical dichlorvos, because of newÊevidenceÊthatÊitÊcould cause cancer.
		Amvac argued that dichlorvos did not present a risk of cancer to humans, and that this was the position of ÒsophisticatedÓ regulators in other parts of the world.
		FriendsÊofÊtheÊEarthÊfirst argued that dichlorvos was a potential cause of cancer in 1988.
	www.sundayherald.com /21665 (912 words)

	PROPOSED PROVISIONAL ENVIRONMENTAL QUALITY STANDARDS FOR DICHLORVOS IN WATER
		For areas designated to require special protection it is proposed that the dichlorvos concentration should not exceed 1.5 µg/l the 96 hour NOEC for lobster larvae, at any time.
		Using the ADI of 0.004 mg/kg body weight for dichlorvos (WHO/FAO 1977) and allowing that 10% of the ADI may be derived from drinking water, the resulting acceptable concentration in drinking water is 12 µg/l, for an adult drinking 2 l water per day.
		Because of the uncertainties concerning the removal of dichlorvos in water treatment processes and during storage, no PEQS can be proposed for the protection of waters used for the abstraction to potable supply.
	www.fwr.org /environs/dwi0119.htm (689 words)

	Sealice, nuvan and dichlorvos
		Cusack, R. and Johnson, G. A study of dichlorvos (Nuvan; 2,2 dichloroethenyl dimethyl phosphate), a therapeutic agent for the treatment of salmonids infected with sealice (L.salmonis).
		Grave, K., Engelstad, M. and Soli, N. Utilisation of dichlorvos and trichlorfon in salmonid farming in Norway during 1981-1988.
		Toovey, J. and Lyndon, A. Effects of hydrogen peroxide, dichlorvos and cypermethrin on subsequent fecundity of sea lice, Lepeophtheirus salmonis, under fish farm conditions.
	www.ecoserve.ie /projects/sealice/nuvan.html (1169 words)

	DEFRA, UK: 2002 news releases:MINISTERS ACT AGAINST A RANGE OF INSECTICIDES CONTAINING THE CHEMICAL DICHLORVOS (Site not responding. Last check: 2007-11-01)
		This review programme does not cover use of these compounds for other purposes, for example use in human and veterinary medicines (including use as sheep dips, although dichlorvos is not used in sheep dips) as these are authorised and subject to scrutiny under separate legislation.
		The statement and minutes of COM's consideration of dichlorvos are published on the Department of Health website:www.doh.gov.uk/com.htm.
		Luxan Dichlorvos Aerosol 15 is used for the control of western flower thrips on protected cucumbers.
	www.defra.gov.uk /news/2002/020419a.htm (1142 words)

	Media Release - Dichlorvos
		The review is being conducted by the National Registration Authority for Agricultural and Veterinary Chemicals (NRA) as part of its extensive program of analysis of agricultural and veterinary chemicals that have been in use for many years.
		'Dichlorvos is an effective insecticide that is a useful tool for the mushroom, flower, milling, grain handling and other industries.
		Dichlorvos is a volatile organophosphorus insecticide with fumigant action which is used against a variety of insects in agricultural and veterinary situations.
	www.apvma.gov.au /media/mr0009.shtml (836 words)

	Publication of the Advisory Committee on Pesticides' (ACP) minutes giving consideration of dichlorvos.
		Dichlorvos is a pesticide used in a range of household fly killers and also has agricultural uses.
		This review programme does not cover use of these compounds for other purposes, for example use in human and veterinary medicines (including use as sheep dips – but note that dichlorvos is not used in sheep dips) as these are authorised and subject to scrutiny under separate legislation.
		The statement and minutes of COM’s consideration of dichlorvos are expected to be published shortly on the Department of Health website: www.doh.gov.uk/com.htm.
	www.pesticides.gov.uk /acp.asp?id=581 (738 words)

	HSE Press Release E076:02 - 19 April 2002
		The ACP was concerned that it could not satisfactorily rule out the possibility that dichlorvos is a genotoxic carcinogen (i.e.
		Members of the public can continue to use up dichlorvos products that they have already bought, and may dispose of used or unused products in household rubbish bins.
		This review programme does not cover use of these compounds for other purposes, for example use in human and veterinary medicines (including use as sheep dips, although dichlorvos is not used in sheep dips) as these are authorised and subject to scrutiny under separate legislation.
	www.hse.gov.uk /press/2002/e02076.htm (1297 words)

	ACEPHATE,ACETAMIPRID,BPMC,CARBENDAZIM,CARBOFURAN,CYPERMETHRIN,DICHLORVOS,FENOXYCARB,GLYPHOSATE--SANONDA ZHENGZHOU ...
		USES:Dichlorvos is strong poisonous to pests with stomach poisoning, contact poisoning and fumigation action.It is mainly used on cotton, fruit trees, vegetable, sugarcane, tobacco, tea, mulberry for controlling pests, it can also be used for public health and grain storage pests controlling.
		1.To avoid phytotoxicity,don't use dichlorvos on Chinese rose and sorghum.it is also sensitive to the emergence of corn and melon.
		The dilution times should be more than 800, it is better to have a test before using.
	www.pesticidechina.com /DICHLORVOS.htm (203 words)

	REVIEW OF DICHLORVOS: JUDICIAL REVIEW OF REGISTRATION PROCEDURES
		The grounds for the challenge were that AMVAC had not been properly informed of the proposed regulatory action or the basis for it and had not been given sufficient time to make representations.
		"Dichlorvos is used in a number of household insecticide products and is important for certain sectors of the horticultural industry.
		The statement and minutes of COM's consideration of dichlorvos are expected to be published shortly on the Department of Health website: www.doh.gov.uk/com.htm.
	www.defra.gov.uk /news/2001/011211b.htm (1089 words)

	Spectrum Laboratories : Chemical Fact Sheet - Cas # 62737
		Dichlorvos is not known to be an eye irritant.
		Dichlorvos may be released to the environment during its production, disposal and use as
		volatilization of dichlorvos from environmental waters and moist soil should generally be slow.
	www.speclab.com /compound/c62737.htm (672 words)

	Pest Control Portal - Dichlorvos Sale Suspended
		Members of the public can continue to use dichlorvos products that they have already bought, and may dispose of used or unused products in household rubbish bins.
		However, no suspended products containing dichlorvos will be allowed into the supply chain until and unless Ministers have the ACP's advice that this is acceptably safe.
		The statement and minuets of COM's consideration of dichlorvos are published on the Department of Health's website: http://wwww.doh.gov.uk/co.htm
	www.pestcontrolportal.com /industry/news/showNewsArticle.asp?id=13 (637 words)

	Documentation for Immediately Dangerous to Life or Health Concentrations (IDLHs) - 62737
		Basis for original (SCP) IDLH: No useful data on acute inhalation toxicity are available on which to base the IDLH for dichlorvos.
		Basis for revised IDLH: The revised IDLH for dichlorvos is 100 mg/m
		Since the toxicity of dichlorvos is about 10 times lower than parathion (based on acute oral toxicity data in animals), the revised IDLH for dichlorvos is 10 times the revised IDLH for parathion (10 mg/m
	www.cdc.gov /niosh/idlh/62737.html (292 words)

	Cyanazine and dichlorvos – a reply (Site not responding. Last check: 2007-11-01)
		EPA also proposed to cancel most uses of the OP dichlorvos because of a risk of cancer from dietary exposure.
		A hormonal mechanism that might have accounted for the tumours in rats was not relevant for humans, and overall the increased levels of tumours were of questionable significance for humans and did not indicate an unacceptable risk.
		The ACP reviewed non-agricultural uses and concluded that dichlorvos was not carcinogenic in the rat and the weight of evidence suggested it did not present a carcinogenic risk to humans or a risk to fertility or reproduction.
	www.pan-uk.org /pestnews/Pn32/pn32p22b.htm (340 words)

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