
	Where results make sense

Topic: Dicumarol

In the News (Thu 24 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Treatment of Pancreatic Cancer Cells with Dicumarol Induces Cytotoxicity and Oxidative Stress -- Lewis et al. 10 (13): ...
		A, dicumarol decreases cell viability in a time-dependent and dose-dependent manner as measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.
		A, dicumarol increased the percentage of apoptotic cells in a time-dependent and dose-dependent manner as measured by flow cytometry.
		B, dicumarol increased the percentage of apoptotic cells in a time-dependent and dose-dependent manner as measured by 3,3'-diaminobenzidine staining and flow cytometry.
	clincancerres.aacrjournals.org /cgi/content/full/10/13/4550 (5140 words)

	Sweet Clover Poisoning: Introduction - The Merck Veterinary Manual
		When toxic hay or silage is consumed, hypoprothrombinemia results, presumably because dicumarol combines with the proenzyme required for synthesis of prothrombin (by preventing formation of the active enzyme).
		The time between consumption of toxic sweet clover and appearance of clinical disease varies greatly and depends on the dicumarol content of the particular sweet clover variety being fed, age of the animals, and the amount of feed consumed.
		If the dicumarol content of the ration is low or variable, animals may consume it for months before signs of disease appear.
	www.merckvetmanual.com /mvm/htm/bc/213800.htm (942 words)

	Microencapsulated drug delivery
		The compounds are the anticoagulant dicumarol, plasmid DNA, which is a material used in gene therapy, and insulin, used to treat diabetes.
		For example, the increase in activity of dicumarol could be explained by intestinal uptake of up to 47 percent of the micro-spheres after feeding.
		In the study, the dicumarol also remained in plasma much longer than other forms of the drug orally dispensed to the animals, resulting in improved availability.
	www.brown.edu /Administration/George_Street_Journal/drugnews.html (713 words)

	96-102 (Microsphere Encapsulation)
		After the microspheres were given orally to the rats, the scientists found dicumarol first appeared in the bloodstream within two hours and persisted for three days.
		For example, the increase in activity of dicumarol could be explained by intestinal uptake of up to 47 percent of the microspheres after feeding.
		In the study, the dicumarol also remained in plasma for much longer periods than other forms of the drug orally dispensed to the animals, resulting in improved availability.
	www.brown.edu /Administration/News_Bureau/1996-97/96-102.html (748 words)

	Dicumarol Inhibition of NADPH:Quinone Oxidoreductase Induces Growth Inhibition of Pancreatic Cancer via a ... (Site not responding. Last check: 2007-10-09)
		Dicumarol Inhibition of NADPH:Quinone Oxidoreductase Induces Growth Inhibition of Pancreatic Cancer via a Superoxide-mediated Mechanism -- Cullen et al.
		Dicumarol inhibits the in vitro pancreatic cancer malignant phenotype.
		B, MIA PaCa-2 cells were exposed to DPI and dicumarol at the indicated concentrations, and 4 h later the cytochrome c assay was performed.
	cancerres.aacrjournals.org /cgi/content/full/63/17/5513 (5045 words)

	Dicumarol - Wikipedia, the free encyclopedia
		Dicumarol (or Dicoumarol) is a anticoagulant that functions by as a Vitamin K antagonist (similar to warfarin).
		"Dicumarol is a potent reversible inhibitor of gap junctional intercellular communication.".
		Dicumarol (Dicoumarol), Diphenadione, Ethyl biscoumacetate, Phenprocoumon, Phenindione, Tioclomarol, Warfarin
	en.wikipedia.org /wiki/Dicumarol (248 words)

	Dicumarol
		If you have an allergy to dicumarol or any other part of the medicine.
		If you have any of the following conditions: Severe liver disease, severe kidney disease, open wounds, bleeding that can not be stopped.
		Dicumarol prevents the liver from producing the factors that thicken or clot blood.
	www.umm.edu /altmed/ConsDrugs/Dicumarolcd.html (539 words)

	Government and academic resources on DICUMAROL
		Genetic control of dicumarol levels in man: The mean half-life of dicumarol in the plasma of seven sets of identical and...
		Dicumarol is a specific inhibitor of quinone oxidoreductase
		Dicumarol: If you have an allergy to dicumarol or any other part of the medicine.
	names.mongabay.com /drugs/ingredients/DICUMAROL.html (431 words)

	Coordinated Action of Glutathione S-Transferases (GSTs) and Multidrug Resistance Protein 1 (MRP1) in Antineoplastic ...
		Dicumarol was chosen as a candidate inhibitor because it has been reported to inhibit a rodent Alpha class GST and was expected
		Inhibition of GST A1-1 by dicumarol, in vitro and in vivo.
		A, kinetic analysis of dicumarol inhibition of GST A1-1 in vitro was accomplished using affinity-purified GST A1-1 and CDNB as the variable substrate (see under "Experimental Procedures").
	www.jbc.org /cgi/content/full/273/32/20114 (5083 words)

	Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-{kappa}B in malignant melanoma ...
		B activation, and cellular proliferation of melanoma cells are reduced by dicumarol, an inhibitor of NQO.
		Dicumarol (250 µM) was added to confluent M1619 cell cultures in complete medium before each experiment.
		A 50 mM concentration of dicumarol was dissolved in water by drop-wise addition of 0.1 N NaOH.
	ajpcell.physiology.org /cgi/content/full/280/3/C659 (7344 words)

	Zyloprim Side Effects, and Drug Interactions - Allopurinol - RxList Monographs (Site not responding. Last check: 2007-10-09)
		Subsequent adjustment of doses of mercaptopurine or azathioprine should be made on the basis of therapeutic response and the appearance of toxic effects (see CLINICAL PHARMACOLOGY).
		Dicumarol: It has been reported that allopurinol prolongs the half-life of the anticoagulant, dicumarol.
		The clinical basis of this drug interaction has not been established but should be noted when allopurinol is given to patients already on dicumarol therapy.
	www.rxlist.com /cgi/generic/allopur_ad.htm (1327 words)

	DICUMAROL Side Effects, DICUMAROL Drug Information, DICUMAROL Dosage
		DICUMAROL is a blood thinner used to keep blood flowing smoothly and prevent the formation of blood clots.
		Before taking DICUMAROL, tell your doctor your medical history, especially of: bleeding problems (ulcers or lengthy or heavy menstrual periods), diabetes, liver or kidney disease, high blood pressure, arthritis, thyroid problems, any infection, recent surgery, any allergies.
		It is important that all doctors and dentists treating you know that you take DICUMAROL so that they can avoid prescribing other drugs that may interfere with its effect.
	www.pharmacyhealth.net /d/dicumarol-3210.htm (616 words)

	How did moldy hay prevent heart attacks? - Plants that Changed History (Site not responding. Last check: 2007-10-09)
		Dicumarol is similar to Vitamin K and interferes with the chemical's ability to activate prothrombin.
		It was only after he became ill and entered a hospital that one of his students returned to manage the lab.
		Dicumarol is probably better known by the name Warfarin for the Wisconsin Alumni Research Foundation.
	www.killerplants.com /plants-that-changed-history/20030506.asp (863 words)

	Pb Side Effects, and Drug Interactions - Phenobarbital - RxList Monographs
		Anticoagulants: Phenobarbital lowers the plasma levels of dicumarol (name previously used: bishydorxycoumarin) and causes a decrease in anticoagulant activity as measured by the prothrombin time.
		Phenobarbital can induce hepatic microsomal enzymes resulting in increased metabolism and decreased anticoagulant response of oral anticoagulants (e.g., warfarin, acenocournarol, dicumarol, and phenprocoumon).
		Patients stabilized on anticoagulant therapy may require dosage adjustments if phenobarbital is added to or withdrawn from their dosage regimen.
	www.rxlist.com /cgi/generic3/phenbarb_ad.htm (991 words)

	DDI: Warfarin and Barbiturates - UK Drug Information Center
		Mechanism: Phenobarbital increases the hepatic microsomal enzymes that metabolize warfarin causing increased clearance of warfarin.
		Summary: Phenobarbital has been shown to increase the dicumarol dose by 33% with a similar effect seen with warfarin.
		Related Drugs: The interaction between barbiturates and anticoagulants has been studied mostly in dicumarol and warfarin, although phenprocoumon is affected similarly.
	www.mc.uky.edu /Pharmacy/dic/DDI/WarfarinBarbituratesDDI.htm (231 words)

	TIME.com: Blood and Clover -- Feb. 14, 1944 -- Page 1 (Site not responding. Last check: 2007-10-09)
		If a man takes Dicumarol capsules before or after an operation, dangerous blood clots may not form in his veins.
		He found the guilty chemical in spoiled sweet-clover hay, named it Dicumarol because it is formed from the harmless chemical, coumarin, which gives fresh clover its smell.
		But it is an expensive extract of ox lung and liver, must be given by injection, and is hard to control.
	www.time.com /time/magazine/article/0,9171,885398,00.html (513 words)

	Warfarin Sodium Drug Information, Professional
		In general, because of their higher risk of hemorrhage, indanedione derivatives are used only when an oral anticoagulant is indicated but use of coumarin derivatives is not possible
		Dicumarol is seldom used because of its unpredictable response and high incidence of gastrointestinal side effects
		(hepatic metabolism of the antidiabetic agent may be decreased, especially by dicumarol, leading to increased plasma concentration and half-life, hypoglycemic effect, and risk of toxicity of the antidiabetic agent
	www.drugs.com /MMX/Warfarin_Sodium.html (7216 words)

	Blood Relations
		By disrupting the balance of clotting factors in the bloodstream, large quantities of dicumarol were deemed the culprit in the cattle hemorrhaging.
		This discovery paved the way for the creation of warfarin—brand name Coumadin—a derivative of dicumarol and currently one of the most widely prescribed drugs in the United States.
		For the last 40 years, warfarin has been used safely and effectively to prevent stroke and treat deep vein thrombosis (clots in the legs), pulmonary embolism (clots in the lungs) and other disorders related to abnormal clot formation.
	www.usc.edu /hsc/info/pr/hmm/03spring/bloodrelations.html (944 words)

	April 2003 Medical Update Mayo Clinic in Jacksonville, Fla. (Site not responding. Last check: 2007-10-09)
		Warfarin and dicumarol are vitamin K antagonists that interfere with the gamma-carboxylation of vitamin K-dependent clotting proteins.
		They inhibit synthesis of factors II, VII, IX and X as well as proteins C and S. Dicumarol was introduced in 1942; warfarin in 1953.
		The disadvantages of warfarin are that it requires initial overlap with heparin, has a narrow therapeutic index and requires frequent monitoring for food/drug interactions, the impact of concomitant illnesses such as liver disease and serendipitous changes in the International Normalized Ratio (INR).
	www.mayoclinic.org /medicalupdate/april03.html (1205 words)

	Calcium Is a Key Signaling Molecule in beta -Lapachone-mediated Cell Death -- Tagliarino et al. 276 (22): 19150 -- ...
		NQO1 is inhibited by dicumarol, which competes with NADH or NADPH
		Cells were pretreated with dicumarol for 30 min prior to drug addition, 5 µ
		dicumarol 30 min prior to a 4-h exposure of 5 µ
	www.jbc.org /cgi/content/full/276/22/19150 (6220 words)

	Novel Plastic Beads Enhance Drug Delivery
		"The exciting thing is that with a similar delivery system, we were successful in delivering a small molecule such as dicumarol (an anticoagulant); proteins, such as insulin; and also huge molecules such as DNA," said Dr. Mathiowitz, lead author on the paper.
		In their current study, insulin delivered in microspheres lowered blood sugar levels within two hours, dicumarol remained for in the bloodstream up to three days, and DNA was incorporated into cells and produced a new protein within five days.
		The researchers believe that the success of their work is partially due to the small size of their beads, which ranged from 0.1 to 5 microns in diameter.
	www.eurekalert.org /pub_releases/1997-03/NIoG-NPBE-270397.php (768 words)

	A Comparative Evaluation of Tromexan and Dicumarol in the Treatment of Thromboembolic Conditions--Based on Experience ... (Site not responding. Last check: 2007-10-09)
		A Comparative Evaluation of Tromexan and Dicumarol in the Treatment of Thromboembolic Conditions--Based on Experience with 514 Patients: A Report of the Committee on Anticoagulants of the American Heart Association -- SCARRONE et al.
		A Comparative Evaluation of Tromexan and Dicumarol in the Treatment of Thromboembolic Conditions—Based on Experience with 514 Patients
		Tromexan and dicumarol were found to be quite comparable.
	circ.ahajournals.org /cgi/content/abstract/6/4/489 (177 words)

	Dicumarol not available in Canada at discount prices from Canadian Online Pharmacy
		Do not use Dicumarol (not available in Canada) if you are allergic to this or similar medicines or to any ingredient present in Dicumarol (not available in Canada).
		If you have any questions about the amount and/or frequency of Dicumarol (not available in Canada) you are taking, talk with your health care provider.
		Dicumarol (not available in Canada) is only to be used by the patient for whom it is prescribed.
	www.candrugstore.com /SiteMap/Dicumarol_not_available_in_Canada.htm (684 words)

	An NAD(P)H oxidase regulates growth and transcription in melanoma cells -- Brar et al. 282 (6): C1212 -- AJP - Cell ...
		Pretreatment of cells for 15 min with DPI (50 µmol/l) or dicumarol (250 µmol/l) reduced DCFH oxidation to DCF.
		Treatment with DPI or dicumarol in the absence of DCFH did not result in significant cellular fluorescence within the monitored spectrum (data not shown).
		Mean fluorescence is 754 for untreated, 408 for DPI, and 396 for dicumarol; median fluorescence is 685 for untreated, 355 for DPI, and 359 for dicumarol.
	ajpcell.physiology.org /cgi/content/full/282/6/C1212 (6657 words)

	JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells -- Davison et ...
		dicumarol, significantly increased growth and survival in response
		An immune complex kinase assay was performed to ensure inhibition of JNK1 at this dose of dicumarol.
		dicumarol for 3 days, and viable cells were again counted by
	www.bloodjournal.org /cgi/content/full/103/9/3496 (5329 words)

	Prothrombin time - Wikipedia, the free encyclopedia
		It aided in the identification of the anticoagulants dicumarol and warfarin
		A study of the coagulation defect in hemophilia and in jaundice.
		^ Owren PA, Aas K. The control of dicumarol therapy and the quantitative determination of prothrombin and proconvertin.
	en.wikipedia.org /wiki/Prothrombin_time (1389 words)

	Medical Dictionary: Dicumarol - WrongDiagnosis.com - WrongDiagnosis.com
		Dicumarol: an anticoagulant drug that has now been largely replaced by warfarin
		The following list attempts to classify Dicumarol into categories where each line is subset of the next.
		Duration of treatment with vitamin K antagonists in symptomatic venous thromboembolism (Cochrane Review)
	www.wrongdiagnosis.com /medical/dicumarol_printer.htm (126 words)

	Pulmonary Embolism: What Have We Learned Since Virchow?: Treatment and Prevention -- Dalen 122 (5): 1801 -- Chest
		with dicumarol (and "in many instance" with heparin as well).
		Allen, EV, Hines, EA, Kvale, WF, et al The use of dicumarol as an anticoagulant: experience in 2,307 cases.
		Nichol, ES, Page, SW Dicumarol therapy in acute coronary thrombosis; results in fifty attacks, with review of data on embolic complications and immediate mortality in myocardial infraction.
	www.chestjournal.org /cgi/content/full/122/5/1801 (7606 words)

	Acceleration of Blood Coagulation in Acute Myocardial Infarction as Demonstrated by the Heparin Clotting Time; Effect ... (Site not responding. Last check: 2007-10-09)
		Acceleration of Blood Coagulation in Acute Myocardial Infarction as Demonstrated by the Heparin Clotting Time; Effect of Dicumarol Therapy -- ROSENTHAL et al.
		Acceleration of Blood Coagulation in Acute Myocardial Infarction as Demonstrated by the Heparin Clotting Time; Effect of Dicumarol Therapy
		receiving Dicumarol therapy, revealed that the heparin clotting
	circ.ahajournals.org /cgi/content/abstract/6/2/257 (225 words)

Try your search on: Qwika (all wikis)