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Topic: Diethylcarbamazine

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	Diethylcarbamazine (Filaribits®) - PetPlace.com (Site not responding. Last check: 2007-10-31)
		It is thought that diethylcarbamazine affects the nervous system of the parasite, resulting in paralysis and death of the parasite.
		Diethylcarbamazine should not be used in animals with heartworm infections.
		Diethylcarbamazine is available in 50 mg, 60 mg, 100 mg, 120 mg, 180 mg, 200 mg, 300 mg and 400 mg tablets.
	www.petplace.com /netscape/nsArtShow.asp?artID=1943&conID=19135 (693 words)

	MedlinePlus Drug Information: Diethylcarbamazine (Systemic) (Site not responding. Last check: 2007-10-31)
		Diethylcarbamazine (dye-eth-il-kar-BAM-a-zeen) is used in the treatment of certain worm infections.
		Children—Although there is no specific information comparing use of diethylcarbamazine in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		Diethylcarbamazine may cause loss of vision, night blindness, or tunnel vision with prolonged use.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202192.html (1099 words)

	Wuchereria bancrofti - Wikipedia, the free encyclopedia
		Both diethylcarbamazine and sodium caparsolate are used to kill the worms and their microfilariae.
		Diethylcarbamazine is most commonly used and is administered orally.
		Protection is similar to that of other mosquito spread illnesses; one can use barriers both physical (a mosquito net) and chemical (insect repellent).
	en.wikipedia.org /wiki/Wuchereria_bancrofti (506 words)

	C&EN: COVER STORY - FINE CHEMICALS - POTPOURRI - Shipping, Reorganizing, and Reopening
		Diethylcarbamazine citrate is used to treat lymphatic filariasis.
		The disease is caused by parasitic worms that are transmitted by mosquitos.
		Diethylcarbamazine citrate kills the young worms, which are produced by mating adult parasites at a rate of up to 1,000 per day, says the program's director, Thomas G. Streit.
	pubs.acs.org /cen/coverstory/8029/print/8029finechemicals1a.html (837 words)

	Diethylcarbamazine Citrate Drug Information, Professional
		Diethylcarbamazine should be administered with caution (e.g., gradually increasing doses) to prevent or minimize allergic reactions.
		Diethylcarbamazine is recommended in low initial doses concurrently with systemic corticosteroids to suppress the inflammatory response to the death of microfilariae caused by diethylcarbamazine, especially in moderate to heavy infections with ocular involvement.
		In the suppressive treatment of onchocerciasis, diethylcarbamazine is recommended in low, intermittent doses to preserve eyesight and to relieve pruritus by reducing the microfilarial load.
	www.drugs.com /MMX/Diethylcarbamazine_Citrate.html (1455 words)

	Diethylcarbamazine (Systemic)
		Treatment of pregnant patients with diethylcarbamazine should be delayed until after delivery.
		It is not known whether diethylcarbamazine passes into breast milk.
		Although there is no specific information comparing use of diethylcarbamazine in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
	allnutritionals.com /drugs/d/diethylcarbamazine-systemic.shtml (1088 words)

	NEJM -- Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis
		Diethylcarbamazine caused a significantly more severe systemic reaction than ivermectin (P less than 0.001), whereas the reaction to ivermectin did not differ from the reaction to placebo.
		Diethylcarbamazine markedly increased the number of punctate opacities in the eye (P less than 0.001), as well as the number of dead and living microfilariae in the cornea over the first week of therapy.
		Both ivermectin and diethylcarbamazine promptly reduced skin microfilaria counts, but only in the ivermectin group did counts remain significantly lower (P less than 0.005) than in the placebo group at the end of six months of observation.
	content.nejm.org /cgi/content/short/313/3/133 (425 words)

	Animal Help: Pharmaceutical Index
		Uses: For the prevention of heartworm disease (Dirofilaria immitis) in dogs, as an aid in the treatment of ascarid infection in dogs (Toxocara canis) and cats (Toxocara canis and Toxascaris leonina) and as an aid in the control of ascarid infections (Toxocara canis) in dogs.
		A repeat dose should be given in 10 to 20 days to remove immature worms which may have entered the intestines from the lungs after the first dose.
		Adult ascarids are unaffected by low level dosing of diethylcarbamazine citrate and must be eliminated by a single, high oral dose.
	www.animalhelp.com /pets/rxdetail.cfm?drug=208 (633 words)

	NEJM -- Diethylcarbamazine prophylaxis for human loiasis. Results of a double-blind study
		To determine whether infection with Loa loa could be prevented in temporary residents of endemic areas, we conducted a randomized, double-blind, placebo-controlled trial of diethylcarbamazine as a chemoprophylactic agent.
		Diethylcarbamazine (300 mg) or placebo was taken orally once a week by Peace Corps volunteers serving in Gabon, Cameroon, and the Central African Republic.
		We conclude that diethylcarbamazine given orally once weekly can be an effective, acceptable chemoprophylactic agent to prevent loiasis in temporary residents of regions of Africa where Loa loa is endemic.
	content.nejm.org /cgi/content/abstract/319/12/752 (345 words)

	Diethylcarbamazine Drug Information
		Pregnancy-Treatment of pregnant patients with diethylcarbamazine should be delayed until after delivery.
		Breast-feeding-It is not known whether diethylcarbamazine passes into breast milk.
		Children-Although there is no specific information comparing use of diethylcarbamazine in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
	www.drugs.com /cons/Diethylcarbamazine.html (1376 words)

	[No title] (Site not responding. Last check: 2007-10-31)
		In vitro effect of diethylcarbamazine, butylated hydroxyanisole and phenobarbitone on the GST of adult female S. cervi was assayed by the addition of these compounds in the maintenance medium.
		Although the intensity of GST activity band was more in extract from diethylcarbamazine or butylated hydroxyanisole treated worms extract, an extra band of activity appeared in those worm extracts compared to control worm extract.
		Purification and quantification of GST from diethylcarbamazine and butylated hydroxyanisole treated worms indicated an increase in enzyme specific activity.
	www.actabp.pl /html/2_2005/493.html (303 words)

	Filaria Journal \| Full text \| Diethylcarbamazine activity against Brugia malayimicrofilariae is dependent on inducible ...
		Diethylcarbamazine activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway
		Bach MK, Brashler JR: Inhibition of the leukotriene synthetase of rat basophil leukemia cells by diethylcarbamazine, and synergism between diethylcarbamazine and piriprost, a 5-lipoxygenase inhibitor.
		Peixoto CA, Rocha A, Aguiar-Santos A: The effects of diethylcarbamazine on the ultrastructure of microfilariae of Wuchereria bancrofti in vivo and in vitro.
	www.filariajournal.com /content/4/1/4 (3732 words)

	Home \| aHealthyme.com
		Either ivermectin, albendazole, or diethylcarbamazine is used to treat a filariasis infection by eliminating the larvae, impairing the adult worms' ability to reproduce, and by actually killing adult worms.
		Diethylcarbamazine, for example, can cause severe allergic reactions and the formation of pus-filled sores (abscesses).
		Rarely, treatment with diethylcarbamazine in someone with very high levels of parasite infection may lead to a fatal inflammation of the brain (encephalitis).
	www.ahealthyme.com /article/gale/100084577 (1446 words)

	Humane Society of Greater Miami Clinic
		The daily preventative called diethylcarbamazine kills larvae the dog is exposed to the day the preventative is given.
		Dogs receiving diethylcarbamazine on a seasonal basis should definitely be tested before the preventative is resumed in the spring or summer.
		Dogs receiving this daily preventative all year round must be tested annually because of the severe reactions that are possible if diethylcarbamazine is given to a dog with adult heartworms.
	www.humanesocietymiami.org /moreonheartworms.htm (836 words)

	DIMMITROL : Buy Dimmitrol, Side effects of Dimmitrol, Discount Dimmitrol
		Dimmitrol Heartworm Tablets is a tablet containing Diethylcarbamazine given daily for the prevention of heartworm disease in dogs.
		The dosage of Diethylcarbamazine for the prevention of heartworm disease is 3 mg per lb bodyweight.
		Side effects of diethylcarbamazine in dogs at heartworm prevention doses are uncommon although vomiting and diarrhea can occur.
	www.canadavet.com /Dimmitrol.html (477 words)

	Effect of sodium nitroprusside and diethylcarbamazine on hypoxic pulmonary vasoconstriction and regional distribution ...
		Effect of sodium nitroprusside and diethylcarbamazine on hypoxic pulmonary vasoconstriction and regional distribution of pulmonary blood flow in experimental pneumonia -- Light 153 (1): 325 -- American Journal of Respiratory and Critical Care Medicine
		Effect of sodium nitroprusside and diethylcarbamazine on hypoxic pulmonary vasoconstriction and regional distribution of pulmonary blood flow in experimental pneumonia
		nitroprusside or diethylcarbamazine infusion on the efficacy of hypoxic
	ajrccm.atsjournals.org /cgi/content/abstract/153/1/325 (382 words)

	Abstract
		Diethylcarbamazine (DEC) and related compounds such as piperazine, methylpiperazine and DEC-N-oxide have been separated by paper chromatography using pyridine: amyl alcohol: water and butanol: citric acid solvent systems.
		Metabolism of diethylcarbamazine was studied in guinea pigs, rabbits and humans by estimating the amount of diethylcarbamazine and its metabolites excreted in urine after administration of the drug.
		Administration of 50 mg diethylcarbamazine once or three times a day for 3 days activated the demethylating and deethylating enzymes but it did not have any effect on N- oxidizing enzyme of diethylcarbamazine.
	www.jbtdrc.org /Pub/abstract.htm (5741 words)

	Medi-Vet - Filaribits Product Information
		The use of diethylcarbamazine citrate is not recommended in dogs with active D.
		Inadvertent administration to heartworm infested dogs may cause adverse reactions due to pulmonary occlusion.
		of diethylcarbamazine citrate per pound of body weight (one 180 mg.
	www.medi-vet.com /Filaribits.aspx (414 words)

	Medi-Vet - Detail
		Dogs with a history of liver disease or dogs receiving `Filaribits Plus' concurrently with other potentially hepatotoxic drugs should be carefully monitored for clinical or biochemical evidence of hepatic disease.
		The use of diethylcarbamazine citrate is not recommended in dogs with active Dirofilaria immitis infections.
		`Filaribits Plus' are given orally (once a day) at a dosage rate of 3 mg diethylcarbamazine citrate and 2.27 mg oxibendazole per pound of body weight.
	www.medi-vet.com /detail.aspx~ID~2331 (636 words)

	DUPLEX DOPPLER SONOGRAPHIC ASSESSMENT OF THE EFFECTS OF DIETHYLCARBAMAZINE AND ALBENDAZOLE THERAPY ON ADULT FILARIAL ...
		Efficacy of single dose combinations of albendazole, ivermectin, and diethylcarbamazine for the treatment of bancroftian filariasis.
		Long-term efficacy of single-dose combinations of albendazole, ivermectin, and diethylcarbamazine for the treatment of lymphatic filariasis.
		Comparison of single-dose diethylcarbamazine and ivermectin for treatment of bancroftian filariasis in Papua New Guinea.
	www.ajtmh.org /cgi/content/full/71/4/471 (3354 words)

	Follicle.com - Minoxidil sulfate is the active metabolite that stimulates hair follicles
		Diethylcarbamazine proved to be a noncompetitive inhibitor of sulfotransferase and prevented hair growth stimulation by minoxidil but not by minoxidil sulfate.
		Experiments with U-51,607, a potent minoxidil analog that also forms a sulfated metabolite, showed that its activity was inhibited by both chlorate and diethylcarbamazine.
		These studies show that sulfation is a critical step for hair-growth effects of minoxidil and that it is the sulfated metabolite that directly affects hair follicles.
	www.follicle.com /section3/4_4_2.html (472 words)

	A RANDOMIZED CLINICAL TRIAL COMPARING SINGLE- AND MULTI-DOSE COMBINATION THERAPY WITH DIETHYLCARBAMAZINE AND ...
		Assessment of the effect of diethylcarbamazine on adult Wuchereria bancrofti in vivo.
		Two-year follow-up of the microfilaraemia of asymptomatic brugian filariasis, after treatment with two, annual, single doses of ivermectin, diethylcarbamazine, and albendazole, in various combinations.
		Effect of aggressive prolonged diethylcarbamazine therapy on circulating antigen levels in bancroftian filariasis.
	www.ajtmh.org /cgi/content/full/70/2/191 (3855 words)

	TREATMENT
		Medicines commonly used to treat filariasis include diethylcarbamazine, which reduces microfilariae concentrations and also kills adult worms, albendazole, which kills adult worms, and ivermectin, which kills the microfilariae produced by adult worms.
		,either diethylcarbamazine and albenadazole, or ivermectin and albendazole).
		If a high enough coverage of anti-filariasis drug treatment can be achieved (treating greater than 80% of the people in a community), the disease can be eradicated from an area.
	www.arches.uga.edu /~rose818/symptoms.htm (359 words)

	A controlled trial of ivermectin and diethylcarbamazine in lymphatic filariasis (Site not responding. Last check: 2007-10-31)
		Ivermectin is a new antifilarial drug that can be given in a single oral dose.
		To compare the efficacy and side effects of ivermectin with those of diethylcarbamazine, the standard antifilarial treatment, we conducted a randomized, double-blind trial in 40 South Indian men with lymphatic filariasis caused by Wuchereria bancrofti.
		Eleven patients were initially assigned to receive placebo and after five days were reassigned to one of the three treatment groups.
	www.trc-chennai.org /Publications/pub103.htm (118 words)

	List_Pub
		Effect of diethylcarbamazine on certain serum and cellular enzymes a preliminary study.
		Chromatographic separation and colorimetric estimation of diethylcarbamazine and its metabolites.
		Effect of diethylcarbamazine and diethylcarbamazine-N-oxide on microfilariae in vitro in presence of immune sera and leukocytes.
	www.jbtdrc.org /Pub/list_pub.htm (3461 words)

	[No title]
		Diethylcarbamazine (DEC) kills both microfilariae and adult Loa loa worms.
		Typical loiasis therapy consists of 6mg of DEC per kilogram body of weight per day administered orally for three weeks.
		The photograph of surgical removal of a Loa loa worm is from the
	www.stanford.edu /class/humbio103/ParaSites2001/loiasis/loiasistherapy.html (905 words)

	Anthelmintics, Albendazole, Albenza, Antiminth, Biltricide, Diethylcarbamazine, Hetrazan, Ivermectin, Mebendazole, ...
		Use of our encyclopedia will enable you to make well-informed, responsible decisions for the promotion of your own health and wellness.
		Anthelmintic drugs are used to kill parasites, including roundworms, whipworms, hookworms, pinworms, trichinella (trichinosis), and other less common organisms.
		Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
	www.truestarhealth.com /Notes/1077002.html (240 words)

	FDA > CDRH > CFR Title 21 Database Search
		Each tablet contains either 60, 120, or 180 milligrams of diethylcarbamazine citrate with 45, 91, or 136 milligrams of oxibendazole, respectively.
		Administer orally to dogs at a dosage level of 6.6 milligrams of diethylcarbamazine citrate per kilogram of body weight (3 milligrams per pound of body weight) and 5.0 milligrams of oxibendazole per kilogram of body weight (2.27 milligrams per pound of body weight).
		For prevention of infection with Dirofilaria immitis (heartworm disease) and Ancylostoma caninum (hookworm infection) and for removal and control of Trichuris vulpis (whipworm infection) and mature and immature stages of intestinal Toxocara canis (ascarid infection).
	www.accessdata.fda.gov /scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=520.623 (214 words)

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