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Topic: Diffuse intravascular coagulation

In the News (Sat 11 Oct 08)

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	eMedicine - Disseminated Intravascular Coagulation : Article by Mary A Furlong, MD
		DIC is a pathophysiologic term describing a continuum of events that occur in the coagulation pathway in association with a variety of disease states.
		Chronic DIC is characterized by subacute bleeding and diffuse thrombosis.
		Bick RL: Syndromes of disseminated intravascular coagulation in obstetrics, pregnancy, and gynecology.
	www.emedicine.com /EMERG/topic150.htm (3348 words)

	Ebola Virus Haemorrhagic Fever
		In case the activated coagulation factors cannot be rapidly cleared by the liver, a widespread fibrin deposition due to free thrombin activity may follow, and fibrinogen derivatives, as well as fibrin monomers formed due to excessive enzyme-induced proteolysis.
		The first evidence of DIC is the decrease of platelets, of fibrinogen, and of factor V and the presence of fibrine monomers.
		Verstraete : If the intravascular coagulation is induced by gram-negative sepsis or by viruses or by antigenantibody complexes in these specific indications, there is no point whatsoever to inhibit fibrinolysis which is the natural defence line in the body to dispose of these fibrine monomers and fibrine threads.
	www.itg.be /ebola/ebola-41.htm (3140 words)

	[No title] (Site not responding. Last check: 2007-10-29)
		Disseminated intravascular coagulation (DIC) is an acute or subacute or chronic thrombohemorrhagic disorder occurring as a secondary complication in a variety of diseases.
		It is characterized by activation of the coagulation sequence that leads to the formation of microthrombi throughout the microcirculation.
		As a consequence of the thrombotic diathesis, there is consumption of platelets, fibrin and coagulation factors and secondary activation of fibrinolytic mechanisms.
	medic.med.uth.tmc.edu /edprog/Path/CV1/CV1QA.htm (2685 words)

	MEDSTUDENTS-INTENSIVE CARE
		Chronic DIC is usually associated with carcinomatosis, retained dead fetus syndrome or an aneurysm or hemangioma.
		Carcinoma may cause DIC by invasion of tissues and release of tissue factor, activation of leucocytes, secretion of tissue factor and direct activation of the prothrombinase complex.
		Also, as therapy for sepsis is improved, less cases of DIC are expected, so that we have good reasons to be optimistic and continue research on this topic, which is one of the most challenging issues in the Intensive Care field.
	www.medstudents.com.br /terin/terin2.htm (1949 words)

	Disseminated intravascular coagulation : Epilepsy.com/Professionals
		Disseminated intravascular coagulation (DIC) is a process in which the coagulation system is abnormally activated to form excess fibrin.
		Thrombotic complications of DIC occur more often with chronic underlying diseases; the coexistence of liver disease enhances the severity of DIC.
		The laboratory diagnosis of acute DIC is based on prolongation of the prothrombin time, activated partial thromboplastin time, and thrombin time, due to consumption of clotting factors and inhibition of their function.
	professionals.epilepsy.com /page/hematologic_dic.html (714 words)

	Disseminated intravascular coagulation - Patient UK
		DIC is characterized by evidence of both thrombin and plasmin.
		Understanding the role of thrombin and plasmin in DIC permits comprehension of the manifestations of the disease.
		In acute disseminated intravascular coagulation PT and aPTT are prolonged, and the platelet count and fibrinogen decrease.
	www.patient.co.uk /showdoc/40001040 (936 words)

	Sepsis - One Language (Site not responding. Last check: 2007-10-29)
		This may progress to dysfunction of the circulatory system and, even under optimal treatment, multiple organ dysfunction syndrome and eventually death.
		This may include hemodialysis in kidney failure, mechanical ventilation in pulmonary dysfunction, transfusion of blood plasma, platelets and coagulation factors to stabilize blood coagulation, and drug and fluid therapy for circulatory failure.
		However, drotrecogin (activated protein C, one of the coagulation factors) has been shown to decrease mortality from about 31% to about 25% in severe sepsis (Bernard et al 2001).
	www.onelang.com /encyclopedia/index.php/Septicemia (471 words)

	Dorlands Medical Dictionary
		the sequential process by which the multiple coagulation factors of the blood interact in the coagulation cascade, ultimately resulting in the formation of an insoluble fibrin clot.
		coagulation of the spinal fluid so as to form an almost solid clot; a condition seen in some cases of Froin's syndrome in meningomyelitis or tumor of the cord.
		(ko-ag´u-lə-tiv) associated with coagulation or promoting a process of coagulation; of the nature of coagulation.
	www.mercksource.com /ppdocs/us/common/dorlands/dorland/dmd_c_42.htm (1945 words)

	Final Diagnosis -- Case 127
		Histologic evidence of disseminated intravascular coagulation manifested as microvascular thrombosis and perivascular fibrin deposits are commonly seen in allogeneic immune reactions.
		It is unclear whether our patient suffered from disseminated intravascular coagulation as a result of rapid deterioration and multiorgan failure secondary to TR-GVHD or disseminated intravascular coagulation was responsible for the rapid progression of TR-GVHD.
		They describe a mechanism whereby gamma-interferon, released from activated donor T cells, enhances the procoagulant activity in monocytes and vascular endothelial cells, in addition to tumor necrosis factor-alpha and gamma interferon stimulating the expression of class I and II antigens on vascular endothelial cells.
	path.upmc.edu /cases/case127/dx.html (659 words)

	Lalisio - Literature Search (Site not responding. Last check: 2007-10-29)
		The rapidity of the patient's recovery, as well as the lack of positive cultures, suggest that sepsis was not the cause of his hemodynamic decompensation, although this possibility cannot be totally ruled out.
		This mechanism has been implicated as a trigger to the cascade of cytokines thought to be causative agents of SIRS, among them interleukin-1 and tumor necrosis factor [14].
		Animal studies suggest that agents such as heparin [10] and lidocaine [15] attenuate the thrombo-inflammatory response of the endothelium to luminal air.
	www.gallileus.info /search/bmc_detail?id=cc2362 (1719 words)

	BCM Department of Medicine
		Currently, he is a member of the U.S. Department of Health and Human Services Blood Safety and Availability Advisory Committee to the Secretary of Health, chair of the Medical and Scientific Advisory Committee for the National Hemophilia Foundation and subcommittee co-chair of the DIC Subcommittee of International Society of Thrombosis and Hemostasis.
		His work includes the creation of and longitudinal follow-up of hemophilia cohorts with HIV and hepatitis, gene therapy trials for Hemophilia A and B, clinical trials of new clotting concentrates for Hemophilia A and B, and the impact of care and clotting factor product on Hemophilia patient outcome.
		He also has a 20 year interest in the diagnosis and treatment of diffuse intravascular coagulation (DIC), in particular DIC in head trauma.
	www.bcm.edu /medicine/hoots.htm (451 words)

	Just the Berries: Ecstasy
		Death by ecstasy usually resembles heatstroke or malignant hyperthermia, with ensuing rhabdomyolysis, diffuse intravascular coagulation (DIC), and renal failure.
		Of course, the ABCs (airway, breathing, circulation) should be of concern; laboratory tests should be done to assess co-ingestants, electrolytes, and renal and liver function; and a DIC screen should be performed.
		Rhabdomyolysis and DIC often accompany hyperthermia so, along with intravenous hydration, urine should be alkalinized, furosemide or mannitol used for diuresis, and output monitored closely.
	www.cfpc.ca /cfp/2002/Mar/vol48-mar-clinical-4.asp?stype=quick (851 words)

	Advances in platelet transfusion therapy (Meeting abstract).
		The traditional view that platelets should be transfused whenever the count drops below 20,000/ul has been challenged, with careful studies showing that the risks of using a cutoff of 10,000/ul or even lower are relatively small.
		When patients are bleeding, infected, or suffering from diffuse intravascular coagulation, however, cutoffs between 10,000 and 20,000 ul are more appropriate.
		Antifibrinolytic agents (epsilon aminocaproic acid and tranexamic acid) have been reported to improve hemostasis in thrombocytopenic patients who are refractory to platelet transfusions, but these agents should not be given to patients with diffuse intravascular coagulation because of the risk of thrombosis.
	www.aegis.com /aidsline/1996/jun/M9660083.html (632 words)

	Update on Meningococcal Disease with Emphasis on Pathogenesis and Clinical Management -- van Deuren et al. 13 (1): 144 ...
		Shock is caused by capillary leakage, inappropriate vascular tone, intravascular microthrombi, and myocardial dysfunction.
		DIC and myocardial depression further aggravate the shock state (31, 45, 314).
		In meningococcal infections, severe DIC is associated with a very poor prognosis (211, 507).
	cmr.asm.org /cgi/content/full/13/1/144 (9413 words)

	Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally ... (Site not responding. Last check: 2007-10-29)
		course and the inflammatory cytokine and coagulation responses
		The cytokine-mediated imbalance between coagulation and anticoagulation mechanisms in sepsis and endotoxemia.
		The suprapharmacologic dosing of antithrombin concentrate for Staphylococcus aureus-induced disseminated intravascular coagulation in guinea pigs: substantial reduction in mortality and morbidity.
	www.bloodjournal.org /cgi/content/full/95/4/1117 (4476 words)

	Haema/Αίμα (Site not responding. Last check: 2007-10-29)
		The splenic red pulp and a suprapyloric lymph node were infiltrated with benign histiocytes displaying a striking degree of haemophagocytosis.
		The patient died from multi- system dysfunction as a result of diffuse intravascular coagulation and lung infection.
		According to our knowledge, this is the first reported case of haemophagocytic syndrome that is associated with adrenocor- tical carcinoma.
	www.mednet.gr /eae/haema/h52-7.htm (197 words)

	Viral Hepatitis E (Site not responding. Last check: 2007-10-29)
		The clinical course of hepatitis E is similar to hepatitis A, however, the fatality rate which is due to fulminant hepatitis is much higher: 1-2/1000 in hepatitis A, 1-2/100 in hepatitis E. In pregnant women fatality rate could be up to 22% occurring exclusively in the third trimester.
		These patients develop an unusual form of DIC (diffuse intravascular coagulation) besides fulminant hepatitis.
		In 50% of cases, the hepatitis is "cholestatic type": lobular cholestasis with bile thrombi in bile canaliculi, cytoplasmic cholestasis, absence of diffuse lobular inflammation and degeneration but rather focal lobular necrosis and portal triditis.
	www.meddean.luc.edu /lumen/MedEd/orfpath/virhepe.htm (579 words)

	eMedicine - Neuroleptic Malignant Syndrome : Article Excerpt by: Theodore I Benzer, MD, PhD
		Death usually results from respiratory failure, cardiovascular collapse, myoglobinuric renal failure, arrhythmias, or diffuse intravascular coagulation (DIC).
		Morbidity from NMS includes rhabdomyolysis, pneumonia, renal failure, seizures, arrhythmias, DIC, and respiratory failure.
		Sex: NMS has been reported to be more common in males most likely because of increased use of neuroleptics in males.
	www.emedicine.com /emerg/byname/neuroleptic-malignant-syndrome.htm (360 words)

	thrombosis (Site not responding. Last check: 2007-10-29)
		We investigated the little-characterized role of Lp(a) as a risk factor for venous thromboembolic diseases, alone and in conjunction with established thrombophilic risk factors of proteins regulating blood coagulation and fibrinolysis.
		However genetic and acquired coagulation abnormalities are also identified in children with venous thrombosis who are appropriately studied.
		A careful family history and assays for the LA, AT-III, protein C, protein S and the factor V Leiden mutation should be part of the evaluation of infants and children with venous thrombosis.
	www.up.ac.za /asservices/ais/med/thrombosis.htm (6754 words)

	[Lesions of the spinal cord and spinal roots in human immunodeficiency virus infection]
		Almost all diffuse or multifocal pathological processes involving the central nervous system and/or leptomeninges may also affect the spinal cord.
		Spinal cord ischemic lesions have been documented in two cases: they were related to inflammatory lesions of the blood vessels in one case and to diffuse intravascular coagulation in the other.
		An ascending myelitis syndrome, secondary to spinal cord infection by both herpes simplex virus type 2 and cytomegalovirus, without significant vasculitis has also been reported.
	www.aegis.com /aidsline/1991/jun/M9160549.html (434 words)

	Complement C3 Activator (Site not responding. Last check: 2007-10-29)
		Assay of factor B helps distinguish activation of the alternate from the classical complement pathway.
		Examples of conditions associated with alternate pathway activation are diffuse intravascular coagulation, systemic lupus erythematosus, subacute bacterial endocarditis, bacteremia with shock, paroxysmal nocturnal hemoglobinuria, sickle cell disease, and hypocomplementemic chronic glomerulonephritis.
		Complement proteins are acute phase reactants and have very short half-lives.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/sc003900.htm (147 words)

	Blood Coagulation Disorders (Site not responding. Last check: 2007-10-29)
		Coagulation Protein Disorders [12 more specific term/s, 4 more link/s]
		Kasabach-Merritt Syndrome with Localized Intravascular Coagulation: U. of Pittsburgh Med.
		Meningococcemia and Disseminated Intravascular Coagulation: U. of Pittsburgh Med.
	medir.ohsu.edu /cliniweb/C15/C15.378.100.html (75 words)

	Zyprexa Drug Recalls - Zyprexa Facts
		These could be symptoms of the deadly disease, Neuroleptic Malignant Syndrome.
		In this case, death usually results from respiratory failure, cardiovascular collapse, renal failure, pneumonia, siezures and Diffuse Intravascular Coagulation.
		If you or someone you know has been hurt while taking the antipsychotic Zyprexa, contact us now to speak to an attorney who will inform you of your rights.
	zyprexadrugrecalls.com (450 words)

	Risperdal Side Effects Include NMS
		Also, Risperdal has been shown to cause Neuroleptic Malignant Syndrome (NMS).
		NMS is a syndrome that causes respiratory failure, cardiovascular collapse, myglobinuric renal failure, arrhythmias, rhabdomyolysis, pneumonia, seizures or diffuse intravascular coagulation and is sometimes fatal.
		If you or a loved on has suffered from the dangerous side effects of Risperdal, including stroke, NMS, or tardive dyskinesia, you may be able to pursue a lawsuit against Johnson and Johnson, the manufacturer of Risperdal.
	www.hugesettlements.com /articles/risperdal-lawyer.htm (336 words)

	Summary of Biological Agents (Site not responding. Last check: 2007-10-29)
		Few people born after 1980 have been vaccinated; vaccine wears off after 10-20 years
		Supportive therapy; watch for shock hypotension and diffuse intravascular coagulation
		Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis.
	www.fluwatch.com /bioagents.cfm (1987 words)

	slfasmt
		Broad spectrum antibiotics may be necessary pending culture results.
		Which of the following drugs is (are) recognized to be associated with the sudden onset of hepatic failure with prolonged clotting times and diffuse intravascular coagulation [even though used in appropriate dosage] in some children with systemic onset juvenile rheumatoid arthritis?
		Which of the following findings make the diagnosis of systemic onset JRA less likely?
	www.goldscout.com /slfasmt.html (916 words)

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