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Topic: Diffuse optical tomography

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Medical imaging

optical tomography imaging for in situ tissue microstructure optical biopsy; projection of near-infrared light across an object in parallel beams to an array of sensitive photodetectors; this is repeated at various angles and a mathematical reconstruction provides three dimensional medical imaging of tissues. crisp.cit.nih.gov /Thesaurus/00019028.htm

Diffuse optical imaging - Wikipedia, the free encyclopedia Diffuse optical imaging is a medical imaging modality which uses near infrared light to generate images of the body. Typical applications include rapid 2D optical topographic imaging of the evoked response following brain activity and tomographic reconstruction of an entire 3D volume of tissue to diagnose breast cancer or neonatal brain haemorrhage. This page was last modified 22:11, 15 April 2005. en.wikipedia.org /wiki/Diffuse_optical_imaging

yodh Diffuse optical tomography with spectral constraints and wavelength optimization. Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia. Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrest. www.lrsm.upenn.edu /pmi/papers

Concurrent diffuse optical tomography, spectroscopy and magnetic resonance imaging of breast cancer. The feasibility of Diffuse Optical Tomography to image tissue in-vivo is demonstrated by direct comparison of contrast-enhanced MRI and DOT images obtained from the same breast under identical geometrical and physiological conditions. Diffuse Optical Tomography (DOT) in the Near Infrared NIR offers the potential to perform non-invasive three-dimensional quantified imaging of large-organs in vivo. Concurrent diffuse optical tomography, spectroscopy and magnetic resonance imaging of breast cancer. repository.upenn.edu /dissertations/AAI9976463

Laser Focus World - Optical imaging offers new biological insight Ultrasonically modulated optical tomography uses a focused ultrasound beam to modulate the intensity of the detected speckle pattern with a modulation depth that depends on the optical properties at the ultrasound focus. Optoacoustic tomography uses the localized optical absorption of areas of interest (such as tumors) to induce pressure waves that are detected with ultrasonic transducers. Optical coherence tomography is an interferometric, backscattering imaging technique that provides cross-sectional images of tissue. lfw.pennnet.com /Articles/Article_Display.cfm?Section=ARTCL&ARTICLE_ID=201664&VERSION_NUM=1

Non-Contact Diffuse Optical Tomography We have shown that two fluorescent regions within a diffuse, arbitrarily shaped object can be separated and localized using non-contact optical tomography and that accurate boundary extraction and theoretical models for free-space photon propagation and detection are required. Optical tomography of turbid media has so far been limited by systems that require fixed geometries or fiber measurements. This novel theory is validated with experiments for a diffusive volume of known geometry in a non-contact situation, both with and without the presence of an embedded absorber. optics.sgu.ru /SFM/2003/internet/ripoll

Optical Tomography Optical Tomography is a method of using light in a narrow wavelength band in the near-infrared part of the spectrum to transilluminate tissue and to use the resulting measurement of intensity on the tissue boundary (both due to transmission and reflection) to reconstruct a map of optical properties within the tissue. Optical tomography using the SCIRun problem solving environment: Preliminary results for three-dimensional geometries and parallel processing. Primarily applications of this imaging technique is a monitoring of cerebral blood and tissue oxygenation of newborn infants, functional mapping of brain activation during physical or mental exercise and imaging of the breast to detect tumor. www.gg.caltech.edu /~zhukov/research/optical_tomography/tomography.htm

Calibration methods and systems for diffuse optical tomography and spectroscopy - US Patent 6549284 However, the calibration techniques described herein can also be applied to other diffuse optical measurement techniques in which the sources do not provide CW radiation. The sources couple optical radiation into a sample at spatially separated locations and the detectors are positioned to receive optical radiation emitted from the sample at spatially separated locations and generate signals in response to the optical radiation from the sources. A diffuser was used to reduce the spatial coherence of the source, which prevented modal noise in the fibers from interfering with the measurement. www.patentstorm.us /patents/6549284.html

The Haidekker Lab: Research Interests - Optical Tomography Diffuse optical tomography: By using wave theory rather than ray theory, DOT allows the reconstruction of strongly scattering objects. Optical coherence tomography: Often viewed as the optical equivalent to ultrasound imaging, OCT uses a laser diode with very short coherent length (few microns) to obtain an echo of scattered light inside of tissue. Optical transillumination tomography: This imaging method uses primary (unscattered) photons to acquire projections; Since unscattered photons travel through the sample in a straight path, image reconstruction algorithms known from X-ray computed tomography can be used. biophotonics.missouri.edu /tomography

CSE Seminar Diffuse optical tomographic (DOT) medical imaging makes use of modulated, near-infrared light transmitted into tissue from photodiodes placed on the body. Optical detectors then measure the photon fluence resulting from the scattering and absorption of photons within the region of interest. We parameterize the diffusion (related to the scattering) and absorption in terms of a small number of unknown parameters. www.cse.uiuc.edu /seminars/kilmer.html

Harvard BioRobotics Laboratory: Research Areas DOT is a noninvasive optical imaging wherein near-infrared light is applied to the tissue surface and then detected some distance from the source. This optical imaging window used by DOT is illustrated in the absorption spectra for hemoglobin and water in figure 1. DOT uses a pattern of near-infrared light sources and detectors positioned on the scalp to generate maps of spatially variant hemodynamics in the underlying tissue. biorobotics.harvard.edu /research/sol.html

Optics Express, the international electronic journal of optics - About Recovery of piecewise constant coefficients in optical diffusion tomography 3D optical tomography in the presence of void regions Scattering and absorption transport sensitivity functions for optical tomography www.opticsexpress.org /issue.cfm?issue_id=98

Turgut Durduran's Research Two qualitatively different methods, diffuse optical tomography and diffuse correlation tomography, were hybridized permitting simultaneous measurement of total hemoglobin concentration, blood oxygen saturation and blood flow. Diffuse optical techniques were used to measure hemodynamics of tissues non-invasively. In total, the research has pioneered the development of diffuse optical measurements of blood flow, oxygenation and oxygen metabolism in a large range of research and clinical applications. www.stwing.upenn.edu /~durduran/research

6/03/02 Diffuse optical tomography takes baby steps on Earth before launching into space Bright dots "floating" above the head are actually vitamin E capsules used to localize the optical probe with respect to the MRI. DOT uses a sensing probe that collects multiple overlapping near-infrared spectroscopy measurements. While the researchers look forward to using the brain imaging cap in space, most DOT research is focused on such Earth-based applications as mammography and detection of hemorrhagic or ischemic stroke. www.dimag.com /dinews/2002060301.shtml

BORL Publications Arridge, SR, and Lionheart, WRB (1998): Non-uniqueness in diffusion-based optical tomography. Eddowes, MH, Mills, TN, and Delpy, DT (1995): Monte Carlo simulations of coherent backscatter for identification of the optical coefficients of biological tissues in vivo. Eddowes, MH, Mills, TN, and Delpy, DT (1995): Monte Carlo simulations of coherent backscatter for identification of the optical coefficients of biological tissues in-vivo. www.medphys.ucl.ac.uk /research/borg/pub_chro.htm

ÃÀ¹úרÀûÉêÇ빫¿ªËµÃ÷Êé 20040087862 - Diffuse optical tomography system and method of use An improved diffuse optical tomography system for in vivo non-contact imaging includes an illumination source for illuminating a specimen, a spectrum source for projecting a spectrum onto the specimen, at least one sensor configured to capture the response of the specimen to the illumination and to the projection of said spectrum. Diffuse optical tomography system and method of use ÃÀ¹úרÀûÉêÇ빫¿ªËµÃ÷Êé 20040087862 - Diffuse optical tomography system and method of use cxp.paterra.com /uspregrant20040087862cn.html

Diffuse optical reflection tomography using continuous wave illumination Diffuse optical reflection tomography is used to reconstruct absorption images from continuous-wave measurements of diffuse light re-emitted from a "semi-infinite" medium. Farrell, M. Patterson and B. Wilson, "A diffusion theory model of spatially resolved, steady state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo," Med. Boas, Diffuse Photon Probes of Structural and Dynamical Properties of Turbid Media: Theory and Biomedical Applications, A Ph.D. Dissertation in Physics, University of Pennsylvania, 1996. www.opticsexpress.org /oearchive/source/5663.htm

A Multi-Resolution Algorithm for Admissible Solution Diffuse Optical Tomography Diffusion Optical Tomography (DOT) imaging is a relatively new technique for imaging inside biological tissues by using near infrared light. The DOT imaging problem is typically ill-posedness due to the large attenuation and scattering of the diffuse photon density wave. All these lead to poor quality reconstructions of optical absorption and ultimately of blood volume and oxygenation. www.censsis.neu.edu /Education/StudentResearch/2001/abstracts/zhang_y.html

BORL: MONSTIR Our efforts to pursue optical tomography as a clinical technique has also involved the development of highly sophisticated image reconstruction algorithms which enable the internal distribution of optical properties to be derived from our experimental measurements. Absorption of light (visible and near-infrared radiation) by haemoglobin and other natural chromophores enables optical tomography to reveal information about tissue oxygenation, haemodynamics and metabolism, harmlessly and at the bedside. is a novel medical imaging instrument built to exploit a new technique known as optical tomography. www.medphys.ucl.ac.uk /research/borg/research/monstir/index.htm

Untitled Document Diffuse Optical Tomography (DOT) is a growing and viable imaging and diagnostic solution for applications in the biomedical research community. The detector is essentially a differential amplifier that compares the dark current of the photodiode and the current of the photodiode when detecting diffuse light, which must be synchronized with the optoelectronic sources. Recent advances have made integration of state-of-the-art optoelectronics and standard CMOS electronics possible and economically feasible. www.ece.neu.edu /news/seminars/20040413.html

Medical imaging - Encyclopedia.WorldSearch A CT scan, also known as a CAT scan (Computed Axial Tomography scan), traditionally produces a 2D image of the stuctures in a small section of the body. With the use of radioactive dyes, such as barium, they can also be used to visualize the structure of the intestines - this can help diagnose certain types of colon cancer. It uses radiation, just like radiographs, and thus repeat scans are not recommended for children. encyclopedia.worldsearch.com /medical_imaging.htm

Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations Using a perturbation approach, we relate through a matrix K a bulk heterogeneous distribution of the optical absorption coefficient{mu}{sub a} that characterizes the heterogeneity in an otherwise homogeneous turbid medium to the diffuse photon flux that emerges from its surface. In a numerical study, we investigate a diffuse-photon computed tomography of a turbid medium. By studying the condition number (N{sub C}) of the matrix K as a function of illumination-detection schemes and choices of reconstruction grids, we explore strategies that optimize the fidelity and spatial resolution of the computed tomography. www.osti.gov /energycitations/product.biblio.jsp?osti_id=20217354

Journal of Cerebral Blood Flow & Metabolism - Abstract of article: Diffuse Optical Tomography of Cerebral Blood Flow, Oxygenation, and Metabolism in Rat During Focal Ischemia The sensitivity of this method of DOT analysis is discussed in terms of assumptions about baseline physiology, and the diffuse optical results are compared with positron emission tomography, magnetic resonance imaging, and histology observations in the literature. Diffuse optical tomography (DOT) is an attractive approach for evaluating stroke physiology. Journal of Cerebral Blood Flow and Metabolism - Abstract of article: Diffuse Optical Tomography of Cerebral Blood Flow, Oxygenation, and Metabolism in Rat During Focal Ischemia www.nature.com /jcbfm/journal/v23/n8/abs/9591439a.html

Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement -- Ntziachristos et al. 97 (6): 2767 -- Proceedings of the National Academy of Sciences Diffuse optical tomography (DOT) in the near-infrared (NIR) is an emerging imaging modality with potential application in Optical imaging of large organs such as breast is often feasible because of the low absorption of tissue in the 700-to 850-nm 1, the optical protocol aims at imaging both the intrinsic and extrinsic breast optical contrast. www.pnas.org /cgi/content/full/97/6/2767

Maria Angela Franceschini, publications (“Optical Tomography ”), in Enciclopedia Medica Italiana, Agg. ("Optical Study of Biological Tissues in the Near-Infrared: Spectroscopy and Tomography "), in Laser e Luce in Chirurgia e Medicina ed in Biotecnologia ( Laser and Light in Surgery and Medicine and in Biotechnology), R. Pratesi, ed., ( Consiglio Nazionale delle Ricerche -Area della Ricerca di Firenze, Florence, Italy, 1995), pp. Optical Mammography with Intensity-Modulated Light,” OSA In Vivo Optical Imaging Workshop, A. Gandjbakhche ed., (Optical Society of America, Washington, DC 2000), 111-117 (2000). www.eotc.tufts.edu /Documents/Faculty/Franceschini/public.html

Diffuse Optical Tomography Application of diffuse near-infrared (NIR) optical methods for imaging and spectroscopy of tissues is attractive for several reasons. In this paper I will discuss our work exploring the tumor contrasts accessible to the diffuse optical method, and I will describe how we extract this optical information using state-of-the-art theoretical, computational, and experimental technologies. Similarly the optical absorption, fluorescence, and scattering of contrast agents such as Indocyanine green (ICG) that occupy vascular and extravascular space provide useful forms of sensitization. flux.aps.org /meetings/YR00/MAR00/abs/S8920005.html

Microscopic Origin of Light Scattering in Tissue (ResearchIndex) A growing number of optical-medical applications such as photodynamic therapy, laser-based microsurgery, optical-coherence tomography, 1 and diffuse-optical tomography 2,3 are based on light--tissue interactions, and thus ultimately on the single-scattering event. 1 Quantification of tissue optical characteristics and hemoglo.. 1 Scat- tering of diffuse photon density waves by spherical in.. citeseer.ist.psu.edu /619047.html

JOURNAL PUBLICATIONS A.D. Klose, G. Abdoulaev, J. Beuthan and A.H. Hielscher, "Optical tomography with the equation of radiative transfer," Technical Digests: Biomedical Topical Meeting on Advances in Optical Imaging and Photon Migration, Optical Society of America, Miami Beach, FL, April 2-5, 2000, pp. Liu, A.H. Hielscher, B. Chance, F.K. Tittel, S.L. Jacques, "Time-resolved photon migration in a heterogeneous tissue-vessel model," in Optical Tomography, Photon Migration, and Spectroscopy of Tissues and Model Media: Theory, Human Studies, and Instrumentation, B. Chance and R.R. Alfano, eds., SPIE-The Internat. A.H. Hielscher, K.M. Hanson, R.E. Alcouffe, J.S. George, "Comparison of discrete ordinate and diffusion theory calculations for photon migration in heterogenous tissues," OSA Trends in Optics and Photonics: Advances in Optical Imaging and Photon Migration, R.R Alfano and J.G. Fujimoto, eds., Optical Society of America, Washington, DC, Vol. www.columbia.edu /~ahh2004/publications/publications_all.html

CWP Research Reports Foss, S-K., Ursin, B., and De Hoop, M.V., 2004, Joint P- and S-wave velocity reflection tomography using PP and PS data: An approach based on co-depthing and differential semblance in scattering angle optimization. Malcolm, A. E., Scales, J. A., and van Tiggelen, B., 2003, Extracting the Green function from diffuse, equipartitioned waves: Physical Review E, Dewangan, P., and Tsvankin, I., 2003, Application of PS-wave moveout asymmetry in parameter estimation for tilted TI media--Part I: Horizontal TTI layer. Spetzler, J., Trampert, J., and Snieder, R., 2002, The effect of scattering in surface wave tomography: Geophys. www.cwp.mines.edu /reports_list.html

Computing in Science and Engineering,November/December 2003 (Vol. 5, No. 6) Diffuse optical tomography (DOT) is a novel functional imaging modality for visualizing and continuously monitoring tissue and blood oxygenation levels, which is useful for brain imaging and tumor detection. Because of the nonlinearity of infrared light propagation in tissue, developing fast and robust reconstruction methods is the main challenge in making DOT a viable tool for clinical diagnostics. Usage of this product signifies your acceptance of the Terms of Use. csdl.computer.org /comp/mags/cs/2003/06/c6033abs.htm

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