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Topic: Digoxin

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	Digoxin - Wikipedia, the free encyclopedia
		Digoxin is a cardiac glycoside extracted from the foxglove plant, digitalis.
		Digoxin also increases vagal activity via its central action on the central nervous system, thus decreasing the conduction of electrical impulses through the AV node.
		The use of digoxin in congestive heart failure during sinus rhythm is controversial.
	en.wikipedia.org /wiki/Digoxin (772 words)

	Digoxin - AFF (Site not responding. Last check: 2007-10-08)
		Digoxin is one of a group of naturally-occurring substances, glycosides, which serve to augment the contraction of the heart muscle, as well as to slow transmission of the electrical signals through the AV node thereby regulating the heart rate in atrial fibrillation or other atrial arrhythmias.
		Digoxin is not very effective at preventing recurrences of atrial fibrillation so it is used, therefore, as a drug largely to help slow down the pulse rate and make it more regular in people with fibrillation.
		Digoxin is frequently combined with beta blockers or calcium channel blockers to slow down the ventricular (pulse rate) in patients with atrial fibrillation.
	www.affacts.org /Medications/digoxin.html (799 words)

	Digoxin: Just the facts... (Site not responding. Last check: 2007-10-08)
		Digoxin is a cardiac glycoside (Obtained from a number of plants and used to stimulate the heart in cases of heart failure) extracted from the foxglove plant, digitalis (A powerful cardiac stimulant obtained from foxglove).
		It is widely used in the treatment of various heart (The hollow muscular organ located behind the sternum and between the lungs; its rhythmic contractions pump blood through the body) conditions, and has two distinct actions on the heart.
		Digoxin inhibits the Na (A nucleotide derived from adenosine that occurs in muscle tissue; the major source of energy for cellular reactions) ase pump in the membranes (A pliable sheet of tissue that covers or lines or connects organs or cells of animals) of the heart cells (myocytes).
	www.absoluteastronomy.com /encyclopedia/d/di/digoxin.htm (223 words)

	Digoxin for congestive heart failure
		Subgroup analyses: The effect of digoxin in the prespecified subgroups is reported in terms of the combined outcome of death from CHF or hospitalization for CHF.
		In the overall study population, the RR for this outcome was 0.75 (95% CI 0.69 to 0.82), digoxin vs. placebo.
		Those in favor of digoxin will be able to point to the beneficial effects on hospitalization noted here and to the lack of a deleterious effect on mortality (unlike other positive inotropes, which have been found to increase mortality).
	www.journalclub.org /vol2/a42.html (1462 words)

	Digoxin
		Abstract: The effect of guar gum on the absorption of digoxin and phenoxymethyl penicillin was studied in a double blind study in 10 healthy volunteers.
		Guar gum reduced serum digoxin concentration during the early absorption period, but a similar amount of digoxin was found in 24 h urine whether given with or without guar gum.
		Digoxin therapy was maintained at a constant daily dose, the ginseng was stopped once more, and the serum digoxin levels again returned to within the therapeutic range.
	home.caregroup.org /clinical/altmed/interactions/Drugs/Digoxin.htm (4453 words)

	[No title]
		Digoxin is not effectively removed from the body by dialysis, exchange transfusion or during cardiopulmonary by-pass because most of the drug is in tissue rather than circulating in the blood.
		Therefore, in patients in whom digoxin may be difficult to regulate, or in whom the risk of toxicity may be great (e.g patients with unstable renal function or whose potassium levels tend to fluctuate) a cautious withdrawal of digoxin may be considered.
		Digoxin is is not indicated for the treatment of sinus tachycardia unless it is associated with heart failure.
	www.druginfonet.com /lanoxin.htm (5778 words)

	Treating Heart Disease with Digoxin
		Digoxin is usually taken once a day, especially in the elderly and those with kidney dysfunction.
		Digoxin is often prescribed in combination with diuretics (water pills), an ACE inhibitor or angiotensin receptor blocker (ARB), and a beta blocker for the treatment of heart failure.
		Digoxin can be passed to a nursing baby through breast milk, the effect of which is not clear.
	www.webmd.com /content/pages/9/1675_57817.htm (634 words)

	digoxin (Lanoxin) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
		Digoxin increases the strength and vigor of the heart muscle contractions, and is useful in the treatment of heart failure.
		Digoxin also slows the electrical conduction between the atria and the ventricles of the heart, and is useful in treating abnormally rapid atrial rhythms such as atrial fibrillation, atrial flutter, and atrial tachycardia.
		Digoxin alleviates these symptoms by blocking the electrical conduction between the atria and ventricles, thus slowing ventricle contractions.
	www.medicinenet.com /digoxin/article.htm (645 words)

	N101 \| Digoxin (Site not responding. Last check: 2007-10-08)
		Digoxin is used primarily to improve the pumping ability of the heart in congestive heart failure (CHF).
		Although digoxin therapy does not usually lead to excess potassium in the blood (hyperkalemia), an overdose of digoxin could cause a potentially fatal hyperkalemia.
		People taking digoxin should therefore avoid taking potassium supplements, or eating large quantities of fruit (e.g., bananas), unless directed to do so by their doctor.
	www.n101.com /Static/HNs/Drug/Digoxin.htm (1463 words)

	Digoxin
		Digoxin is eliminated chiefly by the liver/kidneys (Choose one).
		Digoxin increases vagal tone which leads to slowed conduction through the AV node.
		Both digitoxin and digoxin are conjugated and dumped into the GI tract, de-conjugated and reabsorbed.
	www.vin.com /vin_ce/abvp/html/digoxin.html (721 words)

	Digoxin: Maryland Poison Center
		Digoxin causes an increase in vagal tone which decreases the rate of SA node depolarization.
		Digoxin naive patients, with no preexisting cardiac abnormalities, are relatively resistant to developing ventricular arrhythmias.
		Digoxin serum levels will increase dramatically after Digoxin Immune Fab administration as digoxin is pulled from cardiac sites and bound to antibody in the blood.
	www.mdpoison.com /Site/Education/Dig.htm (845 words)

	Digoxin - (Foxglove)
		The humble poisin "Digoxin" a steroid-like (in structure) glycoside is both lethal and a lifeline for people with heart problems.
		The potential of Digoxin for use in treatment for heart problems was realised many years ago, but little research was carried out until much later.
		Digoxin as previously mentioned is a glycoside and when the sugar (trisaccharide) group is digested the active part of the molecule (Digitoxin or Digitonin) is released (similar to saponin behaviour).
	www.chm.bris.ac.uk /webprojects2001/gerrard/digoxin.html (336 words)

	Digoxin news articles (Site not responding. Last check: 2007-10-08)
		Digoxin: Concomitant administration of a single dose of digoxin in healthy male volunteers receiving simvastatin resulted in a slight elevation (less than 0.3...
		Digoxin is used to increase the power of each heart beat and slows a too fast rate.
		Digoxin, which is used to control heart troubles, when combined with bran fiber which can be found in many cereals and breads may cause the the drugs...
	www.mongabay.com /drugs/drugs/Digoxin.html (3990 words)

	Lanoxin Online, Description, Chemistry, Ingredients - Digoxin - RxList Monographs
		Digoxin is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium.
		Digoxin exists as odorless white crystals that melt with decomposition above 230°C. The drug is practically insoluble in water and in ether; slightly soluble in diluted (50%) alcohol and in chloroform; and freely soluble in pyridine.
		Pediatric Elixir: Lanoxin elixir pediatric is a stable solution of digoxin specially formulated for oral use in infants and children.
	www.rxlist.com /cgi/generic/dig.htm (445 words)

	Digoxin (Site not responding. Last check: 2007-10-08)
		Digitalis drugs such as digoxin enhance and strengthen the force of the heart's contractions, and help to regulate the rate and the rhythm of the heartbeat.
		Digoxin should be used during pregnancy only if your doctor decides it is clearly needed.
		Digoxin causes impotence and enlarged breasts in a third of the men who take it.
	www.wholehealthmd.com /refshelf/drugs_view/1,1524,197,00.html (547 words)

	Digoxin Immune Fab (Systemic) Drug Information, Professional
		As free serum digoxin is removed, tissue-bound digoxin is also released into the serum to maintain the equilibrium and is bound and removed by digoxin immune Fab.
		Skin-testing for allergy to digoxin immune Fab (ovine) may be performed prior to administration in high-risk patients (i.e., those previously treated with the Fab antibody or with known allergy, especially to sheep proteins).
		Digoxin immune Fab (ovine) for injection is reconstituted for intravenous administration by dissolving 38 mg in 4 mL of sterile water for injection and mixing gently, to produce a solution containing 9.5 mg per mL.
	www.drugs.com /MMX/Digoxin_Immune_Fab___Systemic_.html (1954 words)

	Digoxin at Sobieraj.Com
		Digoxin is a medication that previosly had a high use for its inotropic effect.
		Yet, digoxin would be a fine alternative, and espeically if the doses of verapamil and diltiazem were having an adverse effect on the blood pressure.
		Digoxin increases myocardial contractility in the face of beta blockade, which suggests a direct inotropic effect, as LVEDD is not changed.
	users.rcn.com /sobieraj/papers/dig.html (643 words)

	Lanoxin Side Effects & Drug Interactions - Digoxin - USA Today
		Therapeutic doses of digoxin may cause heart block in patients with pre-existing sinoatrial or AV conduction disorders; heart block can be avoided by adjusting the dose of digoxin.
		High doses of digoxin may produce a variety of rhythm disturbances, such as first-degree, second-degree (Wenckebach), or third-degree heart block (including asystole); atrial tachycardia with block; AV dissociation; accelerated junctional (nodal) rhythm; unifocal or multiform ventricular premature contractions (especially bigeminy or trigeminy); ventricular tachycardia; and ventricular fibrillation.
		Digoxin produces PR prolongation and ST segment depression which should not by themselves be considered digoxin toxicity.
	www.healthscout.com /rxdetail/68/29/2/main.html (425 words)

	Lanoxicaps - Drugs & Vitamins - Drug Library - DrugDigest
		Digoxin increases the strength of the heart muscle, helps to maintain a normal heart rhythm, and helps to remove excess water from the body.
		Digoxin can relieve symptoms of congestive heart failure, a condition that reduces the ability of the heart to pump enough blood through the body.
		Less digoxin may be absorbed from the stomach if you have a diet high in bran fiber.
	www.drugdigest.org /DD/DVH/Uses/0,3915,205\|Lanoxicaps,00.html (874 words)

	Digoxin
		Digoxin helps an injured or weakened heart to work efficiently and to send blood through the body.
		If you develop an illness with vomiting or diarrhea, the amount of digoxin absorbed into your bloodstream and reaching your heart can be affected.
		Before you take digoxin, tell your doctor or pharmacist what medicines you are currently taking, including vitamins, herbals, dietary supplements, and other prescription and non-prescription (over-the-counter) medicines.
	clevelandclinic.org /health/health-info/docs/0600/0678.asp?...&src=news (970 words)

	MedlinePlus Drug Information: Digoxin Oral
		Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias).
		Different brands of digoxin have different amounts of active drug and your dose would need to be changed.
		Digoxin is also used to treat heart pain (angina) and may be used after a heart attack.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682301.html (738 words)

	Digoxin dosing review
		Digoxin is one of the most commonly used drugs in medicine.
		Two of the most prominent features of the clinical use of digoxin are its narrow therapeutic index and an endpoint of therapy which is difficult to define and measure.
		The great variability in serum digoxin concentrations in patients given the same dose has led to the development of nomograms and equations designed to estimate the optimal digoxin dosage.
	www.rxkinetics.com /dig.html (865 words)

	Digoxin Blood Level / Metabolism Of Digoxin / Imodium (Site not responding. Last check: 2007-10-08)
		The blood level of digoxin that is needed for it to be effective is quite close to the blood level that causes unwanted effects.
		As mentioned, measuring a blood level of digoxin may be helpful to the physician in determining an effective dose and to monitor her for increased...
		Too high a level of blood digoxin can be dangerous so your doctor may need to reduce the dose of digoxin and measure the blood digoxin level.
	digoxin.pharmacy-world.biz /digoxin_blood_level (918 words)

	Digoxin for Women: A Note of Caution - Journal Watch (General)
		digoxin than with placebo among men (35% vs. 37%), but was slightly
		Moreover, digoxin therapy was associated with a 9-percentage-point
		Sex-based differences in the effect of digoxin for the treatment of heart failure.
	general-medicine.jwatch.org /cgi/content/full/2002/1115/1 (264 words)

	Digoxin
		Digoxin is used to treat conditions such as congestive heart failure and atrial fibrillation/atrial flutter (types of fast heartbeats).
		Digoxin is in the FDA pregnancy category C. This means that it is not known whether digoxin will be harmful to an unborn baby.
		Symptoms of a digoxin overdose include nausea, vomiting, decreased appetite, diarrhea, confusion, seizures, hallucinations, light "halos" around objects, green or yellow vision, fatigue, irregular heartbeats, and abnormally fast or slow heartbeats.
	www.drugs.com /digoxin.html (1178 words)

	Digoxin (Lanoxin) Injection:
		Digoxin is a cardiac glycoside affecting the myocardium; it is used to treat congestive heart failure (CHF), atrial fibrillation, and atrial flutter.
		Previously you measured from both compartments in terms of mass.
		Now pretend you’re aiding a clinician in the ER, who has already given one digoxin dose to an adult (500ug).
	www.cs.ucla.edu /classes/fall03/csM196B/LAB/Lab2.html (312 words)

	Lanoxin Indications & Dosage - Digoxin - HealthScout
		Recommended dosages of digoxin may require considerable modification because of individual sensitivity of the patient to the drug, the presence of associated conditions, or the use of concurrent medications.
		In general, the dose of digoxin used should be determined on clinical grounds.
		However, measurement of serum digoxin concentrations can be helpful to the clinician in determining the adequacy of digoxin therapy and in assigning certain probabilities to the likelihood of digoxin intoxication.
	www.healthscout.com /rxdetail/1/29/7/main.html (334 words)

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