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Topic: Dihydrocodeine

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	Dihydrocodeine - Wikipedia, the free encyclopedia
		Dihydrocodeine was developed in Germany during the early 1900s during the great search for more effective antitussives, and is similar in chemical structure, pharmacological activity, and potency as codeine.
		Dihydrocodeine is available in Japan as tablets which contain 2½ mg of dihydrocodeine phosphate and caffeine, the decongestant d,l-methylephedrine HCl, and the antihistamine chlorpheniramine, and packets of granules which effervesce like Alka-Seltzer® with 10 mg of dihydrocodeine with lysozyme and chlorpheniramine, marketed for OTC sale as SS Bron.
		Dihydrocodeine is also the original member and chemical base of a number of similar semi-synthetic opiates such as acetyldihydrocodeine, dihydrocodeine enol acetate, dihydroisocodeine, nicocodeine, nicodicodeine, and thebacon.
	en.wikipedia.org /wiki/Dihydrocodeine (1957 words)

	Pan American Laboratories - Product Information (Site not responding. Last check: 2007-10-20)
		PANLOR SS® tablets contain dihydrocodeine which is a semi-synthetic narcotic analgesic related to codeine, with multiple actions qualitatively similar to those of codeine; the most prominent of these involve the central nervous system and organs with smooth muscle components.
		Dihydrocodeine may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery.
		Dihydrocodeine, like all opioid analgesics, may cause hypotension in patients whose ability to maintain blood pressure has been compromised by a depleted blood volume or who receive concurrent therapy with drugs such as phenothiazines or other agents which compromise vasomotor tone.
	www.panlor.com /panlorss_insert.shtml (2257 words)

	Data Sheet
		Dihydrocodeine is a semi-synthetic narcotic analgesic with potency between morphine and codeine.
		Dihydrocodeine acts on opioid receptors in the brain to reduce the patients perception of pain and improve the psychological reaction to the pain by reducing the associated anxiety.
		Dihydrocodeine should not be co-administered with monoamine oxidase inhibitors or within two weeks of such therapy as the respiratory depressant effects of dihydrocodeine may be enhanced.
	www.medsafe.govt.nz /Profs/datasheet/d/DHCContinustab.htm (1268 words)

	[No title]
		Dihydrocodeine is increasingly used in slow-release preparations for the treatment of chronic pain on step 2 of the "analgesic ladder" of the World Health Organization.
		Dihydrocodeine and dihydromorphine were equieffective when administered by intrathecal injection at a dose of 100 microg.
		PMID: 9190849, UI: 97334152 ---------- [Excerpts from article] "Dihydrocodeine administered by intravenous injection to rats depressed the nociceptive activity in neurons of the ventrobasal complex of the thalamus that was evoked by electrical stimulation of afferent C fibers in the sural nerve.
	balder.prohosting.com /adhpage/arc_np/pharm_dihydromorphine.txt (567 words)

	dihydrocodeine, guaifenesin, and pseudoephedrine - [Medication]
		Dihydrocodeine, guaifenesin, and pseudoephedrine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants.
		Dihydrocodeine, guaifenesin, and pseudoephedrine is used to treat nasal congestion and dry, non-productive cough associated with upper respiratory tract infections.
		Dihydrocodeine, guaifenesin, and pseudoephedrine is in the FDA pregnancy category C. This means that it is not known whether dihydrocodeine, guaifenesin, and pseudoephedrine will be harmful to an unborn baby.
	www.peacehealth.org /kbase/multum/d04870a1.htm (1449 words)

	Single dose dihydrocodeine for acute postoperative pain (Cochrane Review)
		Dihydrocodeine is a synthetic opioid analgesic developed in the early 1900s.
		Its structure and pharmacokinetics are similar to that of codeine and it is used for the treatment of postoperative pain or as an antitussive.
		For a single dose of dihydrocodeine 30 mg in moderate to severe postoperative pain the NNT for at least 50% pain relief was 8.1 (95% confidence interval 4.1 to 540) when compared with placebo over a period of 4-6 hours.
	www.update-software.com /abstracts/AB002760.htm (584 words)

	DIHYDROCODEINE (Site not responding. Last check: 2007-10-20)
		Dihydrocodeine is a semisynthetic analogue of codeine which also relieves pain and cough, and causes constipation.
		Like codeine, dihydrocodeine is a substrate for CYP2D6 and its partial metabolism to dihydromorphine is limited in poor metabolisers and is blocked by CYP2D6 inhibitors such as fluoxetine, paroxetine and quinidine.
		Dihydrocodeine is about twice as potent as codeine by injection parenterally but, because its oral bio-availability is low, the two drugs are essentially equipotent by mouth.
	www.palliativedrugs.com /content/monographs/DIHYDROCODEINE.html (244 words)

	Study highlights new and cheaper way to treat heroin addiction
		In a study spanning three and a half years, researchers found that the prescription painkiller dihydrocodeine is equally as effective as methadone to help drug users kick the habit.
		In contrast to methadone —which comes in liquid not tablet form — dihydrocodeine is much easier to store and comes under less stringent regulations because it is not as toxic and less likely to cause a fatal overdose.
		Dihydrocodeine has been used by GPs and specialists for many years to treat drug users.
	www.eurekalert.org /pub_releases/2006-12/uoe-shn120606.php (473 words)

	Analgesia by Dihydrocodeine Is Not Due to Formation of Dihydromorphine: Evidence from Nociceptive Activity in Rat ...
		Dihydrocodeine differs in its chemical structure from codeine by the saturation of the double bond between C7 and C8 (fig.
		Dihydrocodeine administered by intravenous injection to rats depressed the nociceptive activity in neurons of the ventrobasal
		Dihydrocodeine and dihydromorphine were equieffective when administered by intrathecal injection at a dose of 100 µg.
	jpet.aspetjournals.org /cgi/content/full/281/3/1164 (4240 words)

	chlorpheniramine, dihydrocodeine, and pseudoephedrine
		Chlorpheniramine, dihydrocodeine, and pseudoephedrine is used to treat cough and nasal congestion associated with upper respiratory tract infections and allergies.
		Chlorpheniramine, dihydrocodeine, and pseudoephedrine is in the FDA pregnancy category C. This means that it is not known whether chlorpheniramine, dihydrocodeine, and pseudoephedrine will be harmful to an unborn baby.
		Symptoms of a chlorpheniramine, dihydrocodeine, and pseudoephedrine overdose include severe drowsiness, dizziness, headache, seizures, dry mouth, cold and clammy skin, flushing, nausea, vomiting, difficulty or decreased breathing, and unconsciousness.
	hw.healthdialog.com /kbase/multum/d04869a1.htm (1597 words)

	Dihydrocodeine in postoperative pain
		Dihydrocodeine is a synthetic opioid analgesic which was developed in the early 1900s.
		Inclusion criteria were full journal publication of trials of dihydrocodeine in acute postoperative pain; single oral dose; postoperative administration; randomised; placebo-controlled; double-blind; moderate to severe baseline pain; adult populations.
		Dihydrocodeine 30 mg (dihydrocodeine tartrate) was not significantly different from placebo.
	www.jr2.ox.ac.uk /Bandolier/booth/painpag/Acutrev/Analgesics/AP015.html (371 words)

	Pan American Laboratories - Product Information (Site not responding. Last check: 2007-10-20)
		PANLOR® DC capsules contain dihydrocodeine which is a semi-synthetic narcotic analgesic related to codeine, with multiple actions qualitatively similar to those of codeine; the most prominent of these involve the central nervous system and organs with smooth muscle components.
		Psychic dependence, physical dependence, and tolerance may develop upon repeated administration of dihydro-codeine, and it should be prescribed and administered with the same degree of caution appropriate to the use of other oral narcotic containing medications.
		Toxicity from dihydrocodeine is typical of opiates and includes pinpoint pupils, respiratory depression, and loss of consciousness.
	www.panlor.com /panlordc_insert.shtml (1192 words)

	Dihydrocodeine - Patient UK
		Dihydrocodeine is used to treat severe pain and severe coughs.
		Dihydrocodeine is available in tablet, oral liquid and injection form.
		Dihydrocodeine may cause dizziness, particularly when getting up from a sitting or lying position.
	www.patient.co.uk /showdoc/30003102 (837 words)

	BioMed Central \| Full text \| The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) project: An open-label ...
		Dihydrocodeine is attractive to clinicians as it has a shorter half-life than methadone, seems equally acceptable to users, and is less open to abuse by injecting than methadone tablets.
		Therefore the reducing regimen of dihydrocodeine will be at the discretion of the prescribing doctor and within the standard regimen shown in table 3.
		The authors recognise that dihydrocodeine or buprenorphine in the final urine sample indicates that the user is not opiate free.
	www.biomedcentral.com /1471-2296/5/9 (3427 words)

	aspirin/caffeine/dihydrocodeine
		Dihydrocodeine (related to codeine) is in a class of drugs called narcotic analgesics.
		Dihydrocodeine may cause addiction and withdrawal symptoms as well as other harmful effects in an unborn baby.
		Dihydrocodeine may also cause addiction and withdrawal symptoms in a nursing baby.
	hw.healthdialog.com /kbase/multum/d03430a1.htm (1515 words)

	Why is it so hard to get some prescription drugs in the needed quantities? - Page 8 - Antionline Forums - Maximum ... (Site not responding. Last check: 2007-10-20)
		Dihydrocodeine isn't codeine phosphate, it's rather like the UK equivalent of vicodin, but there isn't the tylenol/paracetamol/acetamorphin (sp) content as a "filler".
		Dihydrocodeine is pure dihydrocodeine tartrate, ie hydrodocone to all intents and purposes.
		The reason dihydrocodeine can become such a problem is that there is nothing to stop you taking large amounts - if it had some paracetamol (tylenol) in, then there'd be a natural barrier to overdoing it, ie you wouldn't want to risk an overdose.
	antionline.com /showthread.php?p=913911#post913911 (3623 words)

	BBC NEWS \| Scotland \| Edinburgh and East \| Pill 'alternative' to methadone
		The three-and-a-half year study is the first time the effectiveness of dihydrocodeine has been tested.
		Dihydrocodeine offers an alternative treatment for those who can't tolerate methadone, or find it hard to deal with the stigma of having to take their dose
		Dihydrocodeine has been used by GPs and specialists for several years to treat drug users.
	news.bbc.co.uk /go/rss/-/1/hi/scotland/edinburgh_and_east/6219096.stm (451 words)

	Efficacy and safety of levodropropizine and dihydrocodeine on nonproductive cough in primary and metastatic lung cancer ...
		Efficacy and safety of levodropropizine and dihydrocodeine on nonproductive cough in primary and metastatic lung cancer -- Luporini et al.
		Efficacy and safety of levodropropizine and dihydrocodeine on nonproductive cough in primary and metastatic lung cancer
		Subjective cough severity was significantly reduced during treatment with either levodropropizine and dihydrocodeine, the antitussive effect and its time-profile being similar for both drugs.
	erj.ersjournals.com /cgi/content/abstract/12/1/97 (411 words)

	Dihydrocodeine vs placebo RCTs
		Dihydrocodeine 30 mg was not significantly different to placebo.
		Dihydrocodeine 30 mg: 1/49 with 1 AE Placebo: 1/50 with 3 AE [Galasko et al, 1989]
		No significant difference was found between dihydrocodeine and placebo.
	www.jr2.ox.ac.uk /bandolier/painres/dihydro/dhcplac.html (374 words)

	Pharmacy Times: Narcotic Analgesics Metabolized by CYP2D6
		Several common analgesics are substrates of the enzyme CYP2D6—including codeine, dihydrocodeine, and tramadol.
		Dihydrocodeine is metabolized to the active metabolite dihydromorphone.
		It would appear that dihydrocodeine or another metabolite that is not dependent on CYP2D6 has analgesic activity, but further studies in patients with pain are needed.5 Little information on the effect of CYP2D6 inhibitors on other codeine derivatives is available.
	www.pharmacytimes.com /article.cfm?ID=2238 (660 words)

	Codeine Information - Articles
		Analgesia by dihydrocodeine is not due to formation of dihydromorphine: evidence from nociceptive activity in rat thalamus
		Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans
		Postmortem distribution of dihydrocodeine and metabolites in a fatal case of dihydrocodeine intoxication
	codeinepub.tripod.com /info/articles.html (438 words)

	Painkiller Dihydrocodeine May Replace Methodone In Treating Heroin Addicts (Site not responding. Last check: 2007-10-20)
		This three and a half year long study is the first of its kind in the world, which assessed 235 people requiring treatment for heroin addiction in the city over three years.
		The researchers added that dihydrocodeine is easier to store in contrast to methadone, which comes in the liquid form and also comes under less stringent regulations as it is less toxic and is less likely to cause fatal overdoses.
		Dihydrocodeine has been used for years to treat drug addicts and is often preferred in situations where methadone is seen as hazardous, such as police custody or prison.
	www.medindia.net /news/view_news_main.asp?x=16563 (436 words)

	Activation of G-Proteins by Morphine and Codeine Congeners: Insights to the Relevance of O- and N-Demethylated ...
		potency or efficacy at the µ-receptor relative to dihydrocodeine.
		Jurna I, Komen W, Baldauf J, and Fleischer W (1997) Analgesia by dihydrocodeine is not due to formation of dihydromorphine: evidence from nociceptive activity in rat thalamus.
		Wilder-Smith CH, Hufschmid E, and Thormann W (1998) The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine.
	jpet.aspetjournals.org /cgi/content/full/308/2/547 (4375 words)

	Dihydrocodeine
		I'm sorry about the loss of Tropical, but have had success with Buymeds and would recommend it, for anyone one wondering.
		I'm now looking at Bigcitymeds.com, which is offering "Dihydrocodeine" for anyone who wants to order vicodin or lortab.
		Active Vicodin Board is maintained by Administrator with WebBBS 5.12.
	www.rxlist.com /rxboard/vicodin_arc2.pl?noframes;read=27216 (103 words)

	Co-dydramol - Wikipedia, the free encyclopedia
		Co-dydramol (BAN) is a non-proprietary name used to denote a combination of dihydrocodeine tartrate and paracetamol.
		All formulations contain 500 mg of paracetamol per tablet and may only be sold at a pharmacy as an over-the-counter item without prescription if containing less than 7.5 mg of dihydrocodeine per tablet.
		10 mg dihydrocodeine, BAN of Co-dydramol 10/500, this is also the preparation to be dispensed if no strength is specified on a prescription.
	en.wikipedia.org /wiki/Co-dydramol (159 words)

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