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Topic: Diphenoxylate

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	Diphenoxylate - Wikipedia, the free encyclopedia
		Diphenoxylate is an opioid agonist used for the treatment of diarrhea that acts by slowing down intestinal contractions.
		Because of this, diphenoxylate is manufactured and marketed as a combination drug with atropine (Lomotil®).
		This medication is classifed as a Schedule V under the Controlled Substances Act by the Food and Drug Administration (FDA) and the DEA in the United States when used in preparations.
	en.wikipedia.org /wiki/Diphenoxylate (169 words)

	Data Sheet
		Approximately 10% of a dose of diphenoxylate is excreted in the urine and 40% in the faeces.
		Diphenoxylic acid is also eliminated from plasma in a biphasic manner, and is excreted principally in urine.
		DIASTOP is contraindicated in patients with known hypersensitivity to diphenoxylate hydrochloride or atropine, and in patients with jaundice.
	www.medsafe.govt.nz /Profs/Datasheet/d/Diastoptab.htm (1295 words)

	ACS :: Cancer Drug Guide: diphenoxylate hydrochloride with atropine
		Diphenoxylate hydrochloride with atropine is a drug used to control diarrhea.
		Diphenoxylate hydrochloride with atropine combination is a synthetic opiate–like drug that slows intestinal smooth muscle.
		Diphenoxylate hydrochloride with atropine is given as a pill or liquid by mouth.
	www.cancer.org /docroot/CDG/content/CDG_Diphenoxylate_hydrochloride_with_atropine.asp (750 words)

	PetPlace.com - Article: Diphenoxylate (Logen®, Lomotil®, Lonox®)
		Diphenoxylate is primarily used to treat diarrhea and colitis.
		Diphenoxylate should be avoided in animals with an overactive thyroid, kidney impairment, head trauma, colic,lung disease or liver disease.
		Diphenoxylate’s use in cats is controversial and should be avoided.
	www.petplace.com /netscape/nsArtShow.asp?artID=1566 (374 words)

	Diarrhea, Diarrhoea - Issue 43 Dialogue on Diarrhoea Online - Prevention, Control, Management and Treatment of ...
		Diphenoxylate may help relieve symptoms of mild chronic diarrhoea in adults, but there is no evidence of a beneficial effect in the treatment of acute diarrhoea.
		Diphenoxylate is converted in the liver to a biologically active form which is excreted mainly in the urine and bile.
		Diphenoxylate hydrochloride therapy in diarrhoea of malnourished infants.
	www.rehydrate.org /dd/dd43.htm (6518 words)

	Welcome to Zellers Pharmacy Online
		Diphenoxylate - atropine is used to treat diarrhea that is not caused by infection with bacteria.
		Breast-feeding: Diphenoxylate - atropine passes into breast milk and the effects of the medication may be seen in the infants of nursing mothers who take it.
		Diphenoxylate - atropine should be kept out of the reach of children, since accidental overdose may cause severe or even fatal breathing problems.
	www.mediresource.com /zellers/health/DrugInfo.asp?BrandNameID=871&dowhat=accept_disclaimer (900 words)

	MedlinePlus Drug Information: Diphenoxylate and Atropine
		Diphenoxylate and atropine is used to control diarrhea.
		Diphenoxylate and atropine comes as a tablet and liquid to take by mouth.
		If you are taking scheduled doses of diphenoxylate and atropine, take the missed dose as soon you remember it.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601045.html (677 words)

	Lomotil Online, Description, Chemistry, Ingredients - Diphenoxylate & Atropine - RxList Monographs
		Diphenoxylate HCl and atropine sulfate is classified as a Schedule V controlled substance by federal law.
		Diphenoxylate hydrochloride is chemically related to the narcotic meperidine.
		DIPHENOXYLATE HCI AND ATROPINE SULFATE IS NOT AN INNOCUOUS DRUG AND DOSAGE RECOMMENDATIONS SHOULD BE STRICTLY ADHERED TO, ESPECIALLY IN CHILDREN.
	www.rxlist.com /cgi/generic3/diphenoxylate.htm (204 words)

	MedlinePlus Drug Information: Diphenoxylate and Atropine (Systemic) (Site not responding. Last check: 2007-10-29)
		Diphenoxylate and atropine (dye-fen-OX-i-late and A-troe-peen) is a combination medicine used along with other measures to treat severe diarrhea in adults.
		Diphenoxylate and atropine combination medicine should not be used in children.
		Children with diarrhea should be given solutions of carbohydrates (sugars) and important salts (electrolytes) to replace the water, sugars, and important salts that are lost from the body during diarrhea.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202200.html (2204 words)

	Lomotil - Wikipedia, the free encyclopedia
		Lomotil is the trade name of a popular oral anti-diarrheal drug in the United States, manufactured by Pfizer.
		Diphenoxylate is chemically related to the narcotic drug meperidine.
		Atropine is used to treat diarrhea that is not caused by infection with bacteria.
	en.wikipedia.org /wiki/Lomotil (376 words)

	Howstuffworks "Diphenoxylate and Atropine: A Profile of a Diarrhea Drug"
		Diphenoxylate and atropine combination is used to treat severe diarrhea.
		Diphenoxylate is related to the narcotic analgesics and acts by slowing the movement of the gastrointestinal tract.
		Small amounts of atropine are added to this medication to prevent abuse of the narcotic diphenoxylate.
	health.howstuffworks.com /define-diphenoxylate-and-atropine-combination.htm (689 words)

	Canadian pharmacy - Prescription Warehouse Rx Drug Index - diphenoxylate and atropine, Lomotil
		Diphenoxylate reduces diarrhea by interfering with the propulsion of intestinal contents through the intestines.
		Although diphenoxylate is chemically related to narcotics, it does not have pain- relieving (analgesic) actions like most other narcotics.
		NURSING MOTHERS: Diphenoxylic acid, a metabolite of diphenoxylate (that is, diphenoxylate that has been changed chemically by the body) is excreted into breast milk, as is atropine.
	www.prescriptionwarehouse.com /drugs/d/diphenoxylate_and_atropine.html (583 words)

	Diphenoxylate and Atropine (Systemic)
		Diphenoxylate helps stop diarrhea by slowing down the movements of the intestines.
		Since diphenoxylate is chemically related to some narcotics, it may be habit-forming if taken in doses that are larger than prescribed.
		Although both diphenoxylate and atropine pass into the breast milk, this medicine has not been shown to cause problems in nursing babies.
	allnutritionals.com /drugs/d/diphenoxylateatropine-systemic.shtml (2194 words)

	sixthseal.com: Diphenoxylate (Dhamotil) experience report (Site not responding. Last check: 2007-10-29)
		Diphenoxylate is chemically an opioid and has a structure that resembles meperidine (Demerol).
		Diphenoxylate is primarily obtained from diphenoxylate and atropine preparations, which is used to control diarrhea.
		The diphenoxylate was obtained in the form of Dhamotil, which contains 2.5 mg of diphenoxylate hydrochloride per tablet and 0.025 mg of atropine sulphate.
	www.sixthseal.com /2005/06/diphenoxylate_dhamotil_experie.html (1715 words)

	Diphenoxylate Hydrochloride (Lomotil, Lonox, Lomanate) - VeterinaryPartner.com - a VIN company!
		Despite its inability to produce recreational euphoria, diphenoxylate hydrochloride is actually a member of the opiate class of drugs.
		Since diphenoxylate hydrochloride is an opiate, tranquilization is a possible side effect.
		In these cases, the absorption enhancing effects of diphenoxylate hydrochloride could be a serious problem as one would not want to enhance the absorption of intestinal toxins.
	www.veterinarypartner.com /Content.plx?P=A&A=2159 (556 words)

	Opiate Antidiarrheals
		Diphenoxylate is metabolized into diphenoxylic acid, an active metabolite.
		The serum half-lives of diphenoxylate and diphenoxylic acid, are approximately 2.5 hours and 3-14 hours respectively.
		Many clinicians recommend not using diphenoxylate or loperamide in dogs weighing less than 10 kg, but this is probably a result of the potency of the tablet or capsule forms of the drugs.
	www.elephantcare.org /Drugs/opiate.htm (1158 words)

	RemedyFind: patient ratings of Lomotil etc. (Diphenoxylate; Atropine) for IBS Alternating (IBS-A)
		Lomotil etc. (Diphenoxylate; Atropine) is an antidiarrheal medicine used to treat severe diarrhea in adults.
		Diphenoxylate is an opioid agonist medication which helps stop diarrhea by slowing down the movements of the intestines.
		Atropine is an muscarinic antagonist drug which lowers the "rest and digest" activity of all muscles and glands regulated by the parasympathetic nervous system.
	www.remedyfind.com /treatments/125/2377 (301 words)

	atropine and diphenoxylate - [Medication]
		Atropine and diphenoxylate is in the FDA pregnancy category C. This means that it is not known whether atropine and diphenoxylate will harm an unborn baby.
		Symptoms of an atropine and diphenoxylate overdose include headache; nausea; vomiting; dry mouth; restlessness; flushing; difficulty swallowing; blurred vision; dilated pupils; hot, dry skin; dizziness; drowsiness; confusion; anxiety; seizures; weak pulse; difficulty breathing; and an irregular heartbeat.
		Atropine and diphenoxylate may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants.
	www.peacehealth.org /kbase/multum/d03506a1.htm (1200 words)

	opiate equivalents
		I was put on a high dose of the diphenoxylate, and seem to experience WD symptoms similiar to any other opiate when I just stopped.
		Diphenoxylate is found in the RX drug Lomotil that is an antidiarria med.
		Atropine is combined w/ diphenoxylate to discourage abuse of the narcotic agent.
	www.medhelp.org /perl6/Addiction/messages/31620a.html (2552 words)

	diphenoxylate and atropine - Digestion and digestive-related information on MedicineNet.com
		Diphenoxylate is a man-made narcotic chemically related to meperidine (Demerol).
		Reduced effectiveness: The combination of diphenoxylate and monoamine oxidase inhibitors (MAO's) - for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane)] - can cause severe high blood pressure with the possibility of a cerebrovascular accident (stroke).
		SIDE EFFECTS: The most common side effects reported in persons taking diphenoxylate include drowsiness (1 in 25), dizziness (1 in 20), and headache (1 in 40), nausea or vomiting (between 1 in 30 and 1 in 14), and dry mouth (1 in 30).
	www.medicinenet.com /diphenoxylate_and_atropine/article.htm (624 words)

	LOMOTIL (Tablets)
		Diphenoxylate is a piperidine opioid that is structurally related to meperidine.
		Diphenoxylate may potentiate the effects of other central nervous system depressants such as alcohol, barbiturates and tranquilisers.
		In susceptible individuals or in cases of overdosage, subtherapeutic doses of atropine sulphate in preparations containing diphenoxylate may cause the following side-effects: dryness of the mouth, thirst, dilatation of the pupils, photophobia, flushing and dryness of the skin, transient bradycardia followed by tachycardia, with palpitations and arrhythmias, urinary urgency, difficulty and retention, constipation.
	home.intekom.com /pharm/pharmaca/lomotil.html (497 words)

	Lonox - Drugs & Vitamins - Drug Library - DrugDigest
		Small amounts of atropine are combined with diphenoxylate in available products.
		Elderly patients may be more sensitive to the effects of diphenoxylate.
		If your symptoms do not improve after taking diphenoxylate for two days, check with your prescriber or health care professional, you may have a problem that needs further evaluation.
	www.drugdigest.org /DD/DVH/Uses/0,3915,209\|Lonox,00.html (602 words)

	Lomotil, Diphenoxylate hydrochloride, Atropine sulfate, side effects, drug interactions, overdose, dosage
		If you are sensitive to or have ever had an allergic reaction to the ingredients of Lomotil, diphenoxylate or atropine, you should not take Lomotil.
		Lomotil should be used with caution in children, since side effects may occur even with recommended doses, especially in children with Down's syndrome (congenital mental retardation).
		Since addiction to diphenoxylate hydrochloride is possible at high doses, you should never exceed the recommended dosage.
	www.pdrhealth.com /drug_info/rxdrugprofiles/drugs/lom1233.shtml (881 words)

	Patient Education - Drugs - diphenoxylate & atropine
		This drug is available in a generic form.
		However, diphenoxylate is derived from narcotics and, while it does not have any pain relieving or addiction problems, it is not recommended for chronic use.
		It may be taken on an empty stomach or with food or milk.
	www.gicare.com /pated/diphenoxylate_atropine.htm (764 words)

	gihealth.com - built for patient satisfaction
		Introduced in 1960, Lomotil is the most commonly known brand of a potent anti-diarrheal drug called diphenoxylate (dye-fen-OX-i-late).
		The generic form of diphenoxylate is as safe and effective as the brand-name versions; it is also much less expensive.
		of diphenoxylate and a trace amount of atropine, a chemical that prevents the use of this medication for illicit drug purposes.
	www.gihealth.com /html/education/drugs/lomotil.html (847 words)

	Diphenoxylate and Atropine
		Do not take a double dose to make up for a missed one.
		Although side effects from diphenoxylate and atropine are not common, they can occur.
		To avoid thirst and dry mouth, drink a lot of fluids, chew gum, or suck sugarless hard candies.
	www.safemedication.com /displaydrug.cfm?id=601045 (581 words)

	Lomotil®/Lonox®
		This is a combination drug containing two ingredients, diphenoxylate and
		Diphenoxylate is in a class of drugs known as antidiarrheals.
		Therefore, people taking diphenoxylate should avoid alcohol, especially when staying alert is necessary.
	www.deliciouslivingmag.com /healthnotes/healthnotes.cfm?ContentID=1423007 (376 words)

	Short-course diphenoxylate hydrochloride for treatment of methadone withdrawal symptoms -- Ives and Stults 143 (5): 513 ...
		Short-course diphenoxylate hydrochloride for treatment of methadone withdrawal symptoms -- Ives and Stults 143 (5): 513 -- The British Journal of Psychiatry
		Short-course diphenoxylate hydrochloride for treatment of methadone withdrawal symptoms
		diphenoxylate in the treatment of out-patients with methadone withdrawal
	bjp.rcpsych.org /cgi/content/abstract/143/5/513 (95 words)

	Ulcerative colitis: little benefit gained from anti-diarrhoeal agents in active disease. (Site not responding. Last check: 2007-10-29)
		Patients with active ulcerative colitis who took diphenoxylate had roughly one less bowel motion a day, than those given placebo.
		Side effects were common with diphenoxylate (NNH = 2 at 14 days).
		Engbaek J, Ersboll J, Faurby V, et al: the constipating effect of diphenoxylate (Retardin®) in ulcerative colitis.
	www.eboncall.org /CATs/2367.htm (155 words)

	Lomotil(R), Lonox(R)
		This is a combination drug containing two ingredients, diphenoxylate and atropine, that is used in the treatment of diarrhea.
		Tannins are a group of unrelated chemicals that give plants an astringent taste.
		For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb.
	www.gianteagle.com /healthnotes/Drug/Lomotil.htm (364 words)

	028 Pa. Code § 25.58. Generically equivalent drug products.
		Diphenoxylate HCl w/Atropine Sulfate Henry Schein Mylan Pharmaceuticals
		Diphenoxylate HCl w/Atropine Sulfate Henry Schein Zenith Labs
		Diphenoxylate HCl w/Atropine Sulfate KV Pharmaceutical KV Pharmaceutical
	www.pacode.com /secure/data/028/chapter25/s25.58.html (768 words)

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