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Topic: Diphenylmethane diisocyanate


In the News (Fri 24 May 19)

  
  U.S. Patent: 5104904 - Use of aromatic petroleum oils as surfactant for polyurethane foams - April 14, 1992
A process for reducing the crystallization temperature of a diisocyanate by forming a mixture consisting of a toluene diisocyanate or a diphenylmethane diisocyanate and about 3-8% by weight of a hydrocarbon oil having an aromaticity of at least 85% and a boiling point of about 281.degree.
The toluene diisocyanate used in flexible, open cell foams is typically an 80/20 mixture of the 2,4- and 2,6-isomers.
Diphenylmethane diisocyanates are also referred to as polymethylene polyphenylisocyanates depending upon the manufacturer.
www.everypatent.com /comp/pat5104904.html   (4646 words)

  
 Low temperature storage stable liquid diphenylmethane diisocyanates - Patent 4332742
However, diisocyanates which are liquid at room temperature and which are used on a large technical scale, such as toluene diisocyanate or hexamethylene diisocyanate, are as a rule physiologically harmful due to their high vapor pressure and, therefore, can only be used if certain safety precautions are taken.
For this reason, various attempts have been made, either to start with diisocyanates that are normally liquid at room temperature and to reduce their physiological effects by certain procedures or to start with diisocyanates that are solid at room temperature and to convert these into liquid form.
The diphenylmethane diisocyanates usable according to the present invention generally contain the 4,4'-isomer, the 2,4'-isomer and/or the 2,2'-isomer and may contain small amounts of higher oligomers of diphenylmethane diisocyanate.
www.freepatentsonline.com /4332742.html   (1758 words)

  
 Transparent, compact polyurethane casting compositions that are sterilizable with superheated steam, process for ...
A polyurethane composition as described in claim 1 wherein, in terms of 100 parts by weight, the diphenylmethane diisocyanate mixture comprises from about 60 to about 90 parts by weight of 4,4'-diphenylmethane diisocyanate, 40 to 8 parts by weight of 2,4'-diphenylmethane diisocyanate, and 0.1 to 5 parts by weight of 2,2'-diphenylmethane diisocyanate.
A polyurethane composition as described in claim 1 wherein the reaction of the modified diphenylmethane diisocyanate with the compound having at least two reactive hydrogen atoms is performed in the presence of a catalyst.
A transparent, substantially compact polyurethane casting composition which is sterilizable with superheated steam, as defined by claim 1, wherein the modified diphenylmethane diisocyanate is produced so that it has an NCO content of from 17 to 26% by weight, based on weight of the modified diphenylmethane diisocyanate.
www.freepatentsonline.com /5182354.html   (3161 words)

  
 NIOSH-Alert Preventing Asthma and Death from Diisocyanate Exposure DHHS (NIOSH) Publication No. 96-111
Diisocyanates are a group of low-molecular-weight aromatic and aliphatic compounds.
Diisocyanates are increasingly used in the automobile industry, autobody repair, and building insulation materials.
Long-term toxicity and carcinogenicity studies with 2,4/2,6-toluene diisocyanate (80/20) in rats and mice.
www.cdc.gov /niosh/asthma.html   (3743 words)

  
 Johnson Matthey Catalysts - Markets - Glossary
A mixture of 4,4’ diphenylmethane diisocyanate, 4,2’ diphenylmethane diisocyanate and 2,2’ diphenylmethane diisocyanate.
When the isocyanate is in excess of the amount that will react with the polyol, and when the water is present, the excess isocyanate will react with water to produce carbon dioxide (and the corresponding amine), which expands the mixture.
A mixture of 2, 4 toluene diisocyanate and 2,5 toluene diisocyanate.
www.jmcatalysts.com /pct/marketshome.asp?marketid=18&id=238   (680 words)

  
 Toluene diisocyanate (UK PID)
1.12 Toxicokinetics 1.12.1 Absorption Absorption of toluene diisocyanates through the respiratory tract is suggested by their high acute toxicity for animals via inhalation and reports of systemic effects and antibody formation in individuals exposed to toluene diisocyanates primarily via inhalation (Sharonova and Kryzahanovskaya, 1976; Steinmetz et al, 1976; White et al, 1980).
As far as the general population is concerned, intake of toluene diisocyanates, apart from their use in the form of polyurethane lacquers and paints, is of a very low order, because of the short persistence of TDI.
However, when toluene diisocyanates come into contact with water without agitation, as in spills, a hard crystalline crust of polymeric ureas forms slowing down further degradation of the toluene diisocyanates, unless the crust is mechanically broken.
www.intox.org /databank/documents/chemical/toluedii/ukpid30.htm   (9023 words)

  
 U.S. Patent: 5538531 - Controlled release fertilizers and methods of production - July 23, 1996
The fertilizer of claim 1 wherein said polyisocyanate is polymeric diphenylmethane diisocyanate and said polyol is hydrogenated castor oil.
The method of claim 10 wherein said polyisocyanate is polymeric diphenylmethane diisocyanate, said polyol is hydrogenated castor oil and said wax is a C30.sup.+ alpha olefin.
The method of claim 16 wherein the amount said polymeric diphenylmethane diisocyanate, hydrogenated castor oil and C.sub.30+ alpha olefin added to said fertilizer particles each constitutes between about 1 to 3% by weight of the weight of said fertilizer particles.
www.everypatent.com /comp/pat5538531.html   (4067 words)

  
 Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI) (CASRN 101-68-8, 9016-87-9), IRIS, ...
Section II provides information on three aspects of the carcinogenic assessment for the substance in question; the weight-of-evidence judgment of the likelihood that the substance is a human carcinogen and quantitative estimates of risk from oral exposure and from inhalation exposure.
Asthma caused by diphenylmethane diisocyanate in foundry workers.
Albumin adducts, hemoglobin adducts and urinary metabolites in workers exposed to 4,4'-methylenediphenyl diisocyanate.
www.epa.gov /iris/subst/0529.htm   (6383 words)

  
 Methylene diphenyl diisocyanate - Wikipedia, the free encyclopedia
Methylene diphenyl diisocyanate, most often abbreviated as MDI, is an aromatic diisocyanate.
MDI is reacted with a polyol in the manufacture of polyurethane.
It is the most produced diisocyanate, accounting for 61.3 % of the global market in the year 2000.
en.wikipedia.org /wiki/4,4'-MDI   (428 words)

  
 Patent 6,150,489
The diisocyanates which are preferably used are 1,6-hexamethylene diisocyanate, isophorone diisocyanate, dicyclohexylmethane diisocyanate, mixtures of diphenylmethane diisocyanate isomers with a 4,4'-diphenylmethane diisocyanate content of >96% by weight, and particularly 4,4'-diphenylmethane diisocyanate and 1,5-naphthylene diisocyanate.
The molar ratio of diisocyanates to polyols is preferably 1.2:1 to 30:1.
In the prepolymer method, an isocyanate-containing prepolymer is formed from the polyol and the diisocyanate, and this prepolymer is reacted with the chain extender in a second step.
www.pharmcast.com /Patents/November2000/112100OG/6150489_Polyurethanes112100.htm   (2444 words)

  
 Study of the products emitted in the heating of diphenylmethane diisocyanate (MDI)
Isocyanates, which are used in many industrial processes, are known as being respiratory irritants and sensitizers, with asthma being one of the most serious manifestations.
For several years now, the method of diagnosing occupational asthma caused by diphenylmethane diisocyanate (MDI) consists of exposing workers to this substance in the laboratory in solid form, which is heated.
The aim of this study is to verify whether MDI is then effectively present and to determine the other compounds generated in order to establish objectively and ultimately the products responsible for this asthma.
www.irsst.qc.ca /en/_projet_3391.html   (147 words)

  
 1
Initially, diphenylmethane diisocyanate (MDI) (Table 1.2) was developed due to TDI toxicity problems.
According to another method, pure MDI is reacted with a diol in a 2/1 ratio (Figure 1.17), obtaining a liquid diisocyanate, of higher molecular weight and functionality 2.0.
The non reacted diisocyanate excess is removed by vacuum distillation, until a final concentration of less than 1% is obtained.
www.poliuretanos.com.br /Ingles/Chapter1/132comercial.htm   (2070 words)

  
 DIPHENYLMETHANE DIISOCYANATE (MDI)
Diphenylmethane diisocyanate (MDI) is the generic name of a product used in industrial settings.
P-postlabeling of a DNA adduct derived from 4,4’-methylenedianiline in the olfactory epithelium of rats exposed by inhalation to 4,4’-methylenediphenyl diisocyanate.
The draft CICAD on diphenylmethane diisocyanate (MDI) was sent for review to institutions and organizations identified by IPCS after contact with IPCS national Contact Points and Participating Institutions, as well as to identified experts.
www.inchem.org /documents/cicads/cicads/cicad27.htm   (17600 words)

  
 EPA: Federal Register: Polymeric Diphenylmethane Diisocyanate; Toxic Chemical Release Reporting; Community Right-to-Know
Polymeric diphenylmethane diisocyanate (PMDI) is a diisocyanate chemical reportable under the diisocyanates category which was added to the EPCRA section 313 list of toxic chemicals on November 30, 1994 (59 FR 61432) (FRL-4922-2).
In one study (Ref. 15), subjects exposed to a prepolymer of toluene diisocyanate (TDI) in wood varnish exhibited an asthmatic reaction, but exposure to monomeric TDI did not elicit the same response.
Based on a review of the available data on PMDI and other diisocyanates, EPA has determined that there is sufficient evidence to reasonably anticipate that the higher molecular weight oligomers of PMDI can cause chronic pulmonary toxicity.
www.epa.gov /fedrgstr/EPA-TRI/1997/March/Day-05/tri5307.htm   (2486 words)

  
 4,4-Methylenediphenyl Diisocyanate and Polymeric 4,4-Methylenediphenyl Diisocyanate (IARC Summary & ...   (Site not responding. Last check: 2007-10-30)
The risk of cancer associated with occupational exposure to isocyanates has been examined in three industrial cohort studies and in a population-based case—control study of several types of cancer.
-Methylenediphenyl diisocyanate is an irritant and a sensitizer; exposure by inhalation produces asthma among workers.
-Methylenediphenyl diisocyanate forms low-level DNA adducts in vivo and induces mutations in bacteria and chromosomal aberrations and sister chromatid exchanges in human lymphocyte cultures.
www.inchem.org /documents/iarc/vol71/041-44methdip.html   (203 words)

  
 ARS | Publication request: Characteristics of Particleboard Bound with Rice Bran Based Adhesive
In this study, rice bran was chemically and thermally modified by using alkaline and heat to develop its adhesive property.
The characteristics of rice straw-based particleboard bound with a combination of rice bran-based adhesive and PMDI (polymeric diphenylmethane diisocyanate) were evaluated.
The rice bran was modified at pH 12 and temperature 100°C. The characteristics of rice straw-based particleboard bound with a combination of rice bran based-adhesive and PMDI (polymeric diphenylmethane diisocyanate) were evaluated.
www.ars.usda.gov /research/publications/publications.htm?SEQ_NO_115=165165   (334 words)

  
 Long-term Follow-up of Hexamethylene Diisocyanate-, Diphenylmethane Diisocyanate-, and Toluene Diisocyanate-induced ...
Long-term Follow-up of Hexamethylene Diisocyanate-, Diphenylmethane Diisocyanate-, and Toluene Diisocyanate-induced Asthma -- PIIRILÄ et al.
Long-term Follow-up of Hexamethylene Diisocyanate-, Diphenylmethane Diisocyanate-, and Toluene Diisocyanate-induced Asthma
Toluene diisocyanate induced asthma: outcome according to persistence or cessation of exposure.
ajrccm.atsjournals.org /cgi/content/full/162/2/516   (4635 words)

  
 (T84) Asthme Professionnel Occupational Asthma : abstract from Medline NLM NCBI PubMed database
Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject.
A diagnosis of occupational asthma induced by diphenylmethane diisocyanate (MDI) had been assessed 5 years in advance through a 0.005-ppm exposure inhalation challenge.
Postmortem microscopic examination of the lung showed epithelial desquamation, eosinophilic/neutrophilic infiltration of the mucosa, dilatation of bronchial vessels, edema, hypertrophy and disarray of smooth muscle.
www.remcomp.com /asmanet/asmapro/abstracts/carino.htm   (169 words)

  
 P9411 PROBOND ULTIMATE GLUE
Diphenylmethane 4,4'-Diisocyanate 101-68-8 Lung tumors have been observed in laboratory animals exposed to aerosol droplets of diphenylmethane 4,4'-diisocyanate (MDI)/polymeric MDI (6 mg/m³) for their lifetime.
Polymeric Diphenylmethane Diisocyanate 9016-87-9 Lung tumors have been observed in laboratory animals exposed to aerosol droplets of diphenylmethane 4,4'-diisocyanate (MDI)/polymeric MDI (6 mg/m³) for their lifetime.
Diphenylmethane 4,4'-Diisocyanate 101-68-8 LC50: rat=178 mg/m³ (RTECS) LD50: orl-mus=2200 mg/kg (RTECS) Polymeric Diphenylmethane Diisocyanate 9016-87-9 LC50: rat=490 mg/m³/4H (respirable aerosol) LD50: orl-rat>5000 mg/kg; skn-rbt>5000 mg/kg Modified Polymeric MDI LC50: Not available LD50: Not available
www.elmers.com /products/msds/mP9411_c.htm   (1400 words)

  
 The Bench - March 17, 2006
Two aliphatic diisocyanate monomers are the primary building blocks in the preparation of major commercial polyisocyanate crosslinkers (Figure 1).
Isophorone diisocyanate based polyisocyanates are also useful crosslinkers in the production of light-stable polyurethanes.
Aromatic polyisocyanates are most commonly based on toluene diisocyanate (TDI) and diphenylmethane diisocyanate (MDI) (Figure 2).
www.paint.org /thebench/thebench_031706.htm   (590 words)

  
 Studies on the First DSC Endotherm of Polyurethane Hard Segment Based on 4,4'-Diphenylmethane Diisocyanate and ...
Studies on the First DSC Endotherm of Polyurethane Hard Segment Based on 4,4'-Diphenylmethane Diisocyanate and 1,4-Butanediol
) of polyurethane hard segment based on 4,4'-diphenylmethane diisocyanate (MDI) and 1,4-butanediol (BD) was studied by differential scanning calorimetry (DSC).
The materials contain 69% (w/w) of MDI and BD as the hard segment and hydroxyl-terminated cis-polybutadiene with number average molecular weights of 1650 and 2300, respectively, as the soft segment.
pubs.acs.org /cgi-bin/abstract.cgi/mamobx/1998/31/i04/abs/ma970913m.html   (318 words)

  
 [No title]   (Site not responding. Last check: 2007-10-30)
Polymeric allophanates of diphenylmethane diisocyanate, perpolymers of these polymeric allophanates, and processes for the preparation of the polymeric allophanates and the prepolymers thereof
A process for the production of a prepolymer of a polymeric allophanate modified diphenylmethane diisocyanate, said prepolymer having an NCO group content of about 10 to about 28%, and comprising:
wherein (A) said allophanate-modified diphenylmethane diisocyanate is held at a temperature of from about 20 to 70° C. from about 1 hour to about 30 days to form (B) said polymeric allophanate modified diphenylmethane diisocyanate,
www.uspto.gov /web/patents/patog/week05/OG/html/1302-5/US06991746-20060131.html   (343 words)

  
 Plastics Technology - Bayer Materialscience Coating Raw Material and Polyurethane Raw Material Plants, Shanghai   (Site not responding. Last check: 2007-10-30)
With the construction of modern production plants for polyurethane and coating raw materials near Shanghai, Bayer is all set to increase its long-term competitiveness in the growth market of China.
Aker Kvaerner has been awarded the contract for Engineering, Procurement and Construction management for the coating raw material hexamethylene diisocyanate (HDI) and polyurethane raw material diphenylmethane diisocyanate (MDI) plants.
Bayer is planning to build a facility for the production of TDI (toluene diisocyanate) with an annual capacity of 160,000t, which should be completed in 2009.
www.plastics-technology.com /projects/Materialscience   (646 words)

  
 Material Safety Data Sheet   (Site not responding. Last check: 2007-10-30)
Air purifying (cartridge type) respirators are not approved for protection against diisocyanates.
In the absence of prolonged exposure to high concentrations leading to chronic irritation and lung damage, it is highly unlikely that tumor formation will occur.
There are reports that excessive chronic exposure to diisocyanates may result in permanent decrease in lung function.
www.resintechnology.com /MSDS_RD243-A.html   (1905 words)

  
 Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
Energy Citations Database (ECD) Document #5623528 - Diphenylmethane diisocyanate: the concentration of its saturated vapor
Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link.
Diphenylmethane diisocyanate: the concentration of its saturated vapor
www.osti.gov /energycitations/product.biblio.jsp?osti_id=5623528   (111 words)

  
 Polyisocyanates
Di-isocyanates may be modified in many ways to give products with differing physical and chemical properties.
Polyurethanes are based on one of two polyisocyanates: diphenylmethane diisocyanate (MDI), in which Huntsman Polyurethanes specialises, and toluene diisocyanate (TDI).
Both are derived from readily available petrochemical intermediates and are manufactured by well understood and closely defined chemical processes.
www.huntsman.com /pu/ShowPage.cfm?PageID=182   (205 words)

  
 Diphenylmethane Diisocyanate (MDI): Industry Research Report
Table 29: European 10-Year Perspective for Diphenylmethane Diisocyanate (MDI) in Flexible Foams by Geographic Region - Percentage Breakdown of Unit Sales for France, Germany, Italy, UK and Rest of Europe Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)
Table 31: European 10-Year Perspective for Diphenylmethane Diisocyanate (MDI) in Rigid Foams by Geographic Region - Percentage Breakdown of Unit Sales for France, Germany, Italy, UK and Rest of Europe Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)
Table 33: European 10-Year Perspective for Diphenylmethane Diisocyanate (MDI) in Paints & Coatings by Geographic Region - Percentage Breakdown of Unit Sales for France, Germany, Italy, UK and Rest of Europe Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)
www.mindbranch.com /products/R263-1893_toc.html   (3721 words)

  
 Household Products Database
Lung tumors have been observed in laboratory animals exposed to aerosol droplets of diphenylmethane 4,4'-diisocyanate MDI (6 mg/m³) for their lifetime.
This material has not been listed by NTP, classified by IARC, nor regulated by OSHA as a carcinogen.
Lung tumors have been observed in laboratory animals exposed to aerosol droplets of diphenylmethane 4,4'-diisocyanate (MDI)/polymeric MDI (6 mg/m³) for their lifetime.
householdproducts.nlm.nih.gov /cgi-bin/household/brands?tbl=brands&id=5007013   (481 words)

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