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Topic: Dissociation constant


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In the News (Sat 11 Oct 08)

  
  D - Glossary of chemical terms
Dielectric constant or permittivity (ε) is an index of the ability of a substance to attenuate the transmission of an electrostatic force from one charged body to another.
Dissociation is the process by which a chemical combination breaks up into simpler constituents as a result of either added energy (dissociated by heat), or the effect of a solvent on a dissolved polar compound (electrolytic dissociation).
Dissociation constant is a constant whose numerical value depends on the equilibrium between the undissociated and dissociated forms of a molecule.
www.ktf-split.hr /periodni/en/abc/d.html   (830 words)

  
  Dissociation constant - Wikipedia, the free encyclopedia   (Site not responding. Last check: 2007-10-19)
In chemistry and biochemistry, a dissociation constant or an ionization constant is a specific type of equilibrium constant used for reversible reactions or processes.
The dissociation constant is represented by the symbol K
Stronger acids, for example sulfuric or phosphoric acid, have larger dissociation constants; weaker acids, like acetic acid, have smaller dissociation constants.
en.wikipedia.org /wiki/Dissociation_constant   (229 words)

  
 Acid dissociation constant - Wikipedia, the free encyclopedia
This is the dissociation constant for the equilibrium
Some factors that influence the strength of the acid or base are the polarity of the ionic bond holding the hydrogen atom to the parent (conjugate base or acid, respectively) ion, the size of the parent ion, the total charge on the molecule, and the oxidation state of the central atom.
Yet another factor that influences the dissociation of acids and bases is the oxidation number on the central atom in the molecule.
en.wikipedia.org /wiki/PKa   (595 words)

  
 dissociation. The Columbia Encyclopedia, Sixth Edition. 2001-05   (Site not responding. Last check: 2007-10-19)
Dissociation is generally reversible; when the atoms or ions of the dissociated substance are returned to the original conditions, they recombine in the original form of the substance.
The dissociation constant is a measure of the extent of dissociation.
The dissociation constant is measured at equilibrium, and its value is usually affected by changes in temperature.
www.bartleby.com /65/di/dissocia.html   (239 words)

  
 PH - Wikipedia, the free encyclopedia
Due to this dissociation constant a neutral solution (hydrogen ion activity equals hydroxide ion activity) has a pH of approximately 7.
Instead it is related to the dissociation constant for the specific solvent used.
It is necessary to know the value of the equilibrium constant of the reaction for each acid in order to calculate its pH.
en.wikipedia.org /wiki/PH   (1148 words)

  
 dissociation — FactMonster.com
Dissociation is generally reversible; when the atoms or ions of the dissociated substance are returned to the original conditions, they recombine in the original form of the substance.
The dissociation constant is a measure of the extent of dissociation.
The dissociation constant is measured at equilibrium, and its value is usually affected by changes in temperature.
www.factmonster.com /ce6/sci/A0815642.html   (274 words)

  
 JCE 1997 (74) 868 [Jul] Ionization or Dissociation?
The use of the terms Dissociation and Ionization in the teaching of chemistry is discussed.
The contexts in which the term dissociation and dissociation constant cause problems is primarily in the area of ionization of weak and strong acids and of weak bases.
The term dissociation should be used only in the context of species breaking into their component parts; it should no longer be used to describe processes that are actually ionizations.
jchemed.chem.wisc.edu /Journal/Issues/1997/Jul/abs868.html   (205 words)

  
 [No title]
Thus, in an ionization constant expression, the concentrations of the ions are always in the numerator, that of the un-ionized molecules in the denominator.
In regard to the acid dissociation constants of polyprotic acids, we have already noted (Section 12.4B) that polyprotic acids ionize stepwise and that each anion is less ionized than its conjugate acid.
An Acid dissociation constant expression has the concentrations of the ions in the numerator and that of the un-ionized acid molecules in the denominator.
www.chem.uiuc.edu /rogers/Text12/Tx125/tx125.html   (660 words)

  
 Dissociation and association of the HIV-1 protease dimer subunits: equilibria and rates.
The equilibrium dissociation constant (Kd) of the dimeric protease as well as the monomer association rate were obtained by monitoring the fluorescence change of an active-site-directed fluorescent probe (L-737244) upon its binding to the protease.
Dimer dissociation was further scrutinized in the presence of an inactive, point mutant form of the enzyme.
The slow dissociation, coupled with the high stability for dimer association, attests to the importance of allowing sufficient time for dimer-monomer equilibration in kinetic assays in order to avoid reaching erroneous conclusions in studies of dimer dissociation.
www.aegis.com /aidsline/1994/apr/M9440308.html   (523 words)

  
 New Recommendations 4.1
As mentioned in Section 3, equilibrium constants of chemical reactions that are used in biochemistry are taken to be functions of T, P, and I.
If the equilibrium constants were determined with a standard state based on molarity, these equilibrium constants should be converted to a molality basis prior to using equation 13.
As an approximation the acid dissociation constants and magnesium complex dissociation constants are taken to be functions of the ionic strength and the different effects of Na and K
www.chem.qmul.ac.uk /iubmb/thermod/th41.html   (1309 words)

  
 QSAR and Drug Design
In this case, the dissociation constant is lower than for the unsubstituted compound, indicating that the ethyl group is electron-donating, thereby destabilizing the negative charge that arises upon dissociation.
That is, the free energy is proportional to the logarithm of the equilibrium constant.
In the aniline and phenol equilibria, the hydrogen ion that is dissociating is one atom removed from the phenyl ring, whereas in the benzoic acid equilibrium it is two atoms removed.
www.netsci.org /Science/Compchem/feature12.html   (3107 words)

  
 Lecture 3: Acid-Base Equilibria & Buffers   (Site not responding. Last check: 2007-10-19)
A quantitative measure of the strength of an acid is given by the acid dissociation constant, K
, is the equilibrium constant for a dissociation reaction.
The equilibrium constant for the ionization of water is:
dwb.unl.edu /Teacher/NSF/C10/C10Links/www.bio.cmu.edu/Courses/03231/LecF99/Lec03/lec03.html   (814 words)

  
 JCE 1997 (74) 880 [Aug] Dissociation Constant for a Monoprotic Acid (re J. Chem. Educ. 1996, 74, ...
JCE 1997 (74) 880 [Aug] Dissociation Constant for a Monoprotic Acid (re J.
Dissociation Constant for a Monoprotic Acid (re J.
Citation: Ramette, Richard W. Dissociation Constant for a Monoprotic Acid (re J.
jchemed.chem.wisc.edu /journal/Issues/1997/Aug/abs880_3.html   (485 words)

  
 Conductivities of electrolyte solutions
To measure the conductivity of acetic acid solutions and calculate the dissociation constant of the acid from the data.
The cell constant is not found by measuring distances but is determined by measuring the conductance of an electrolyte whose specific conductivity is already known.
where α is the degree of dissociation and c is the initial concentration of the acid before dissociation.
wwwchem.uwimona.edu.jm /lab_manuals/c10expt19.html   (611 words)

  
 Myogolobin
The dissociation constant is an equilibrium constant based on the bound myoglobin-azide complex (L-R) in equilibrium with the free myoglobin (receptor, R) and azide (ligand, L).
This expression can be used to determine the dissociation constant for the myoglobin-azide complex from spectroscopic data.
Use the value of alpha (a) and the free azide concentration to calculate a value for the dissociation constant for each sample that has a total azide concentration not in the saturated region.
antoine.frostburg.edu /chem/simon/chm411/lab/myoglobin.htm   (1394 words)

  
 Na+ Occupancy and Mg2+ Block of the N-methyl-D-aspartate Receptor Channel -- Zhu and Auerbach 117 (3): 275 -- The ...
(C) Analyses of the inhibition of the Mg dissociation rate constant by extracellular Na The same four sets of data as in B were fitted simultaneously by Equation 5.
The inhibition of Mg dissociation by extracellular Na was
(with an equilibrium dissociation constant of 88 mM), or one
www.jgp.org /cgi/content/full/117/3/275   (5809 words)

  
 Weak acid K   (Site not responding. Last check: 2007-10-19)
The equilibrium constant for this expression is called the acid dissociation constant, K
When the equilibrium in question occurs in solution, the chemical formulas enclosed in brackets in the equilibrium constant expression represent the molarities of the substances (moles of solute per liter of solution).
For example, acetic acid is a weak acid, because when it is added to water, it reacts with the water in a reversible fashion to form hydronium and acetate ions.
www.mpcfaculty.net /mark_bishop/weak_acid_equilibrium.htm   (579 words)

  
 Sample Lesson for CHEM 013   (Site not responding. Last check: 2007-10-19)
The dissociation of HC1 in water shown in Equation (1) is written, in the Bronsted-Lowry sense, as a transfer of H
Notice that the dissociation of a strong acid is normally not written as an equilibrium reaction since the dissociation is complete.
is the symbol that is used for the equilibrium constant of a weak acid dissociation reaction and it is referred to either as the ionization constant or the acid dissociation constant.
www.worldcampus.psu.edu /il/courses/syl/CHEM_0013l.html   (4551 words)

  
 Dorlands Medical Dictionary
the dissociation constant describing the ionization of an acid.
an equilibrium constant, expressed in concentrations, describing the dissociation of a molecule or ion into its components.
a constant, h, which represents the ratio of the energy of any quantum of radiation to its frequency; the value of h is 6.626 × 10
www.mercksource.com /pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_c_53zPzhtm   (3675 words)

  
 AcidDissociationConstant   (Site not responding. Last check: 2007-10-19)
The acid dissociation constant is a special case of a dissociation constant, in that it indicates the extent of hydrogen ion (H
The extent of dissociation determines the concentration of free hydrogen ions (H
The extent of this dissociation, at equilibrium, is represented by the acid dissociation constant (K
www.monashscientific.com.au /AcidDissociationConstant.htm   (164 words)

  
 The GraphPad Guide to Analyzing Radioligand Binding Data   (Site not responding. Last check: 2007-10-19)
Bmax is the total number of receptors expressed in the same units as the Y values (i.e., cpm, sites/cell or fmol/mg protein) and Kd is the equilibrium dissociation constant (expressed in the same units as [L], usually nM).
It is the equilibrium dissociation constant for binding of the unlabeled drug - the concentration of the unlabeled drug that will bind to half the binding sites at equilibrium in the absence of radioligand or other competitors.
If the dissociation rate constant is any faster, it would be difficult to perform radioligand binding experiments as the radioligand would dissociate from the receptors while you wash the filters.
www.graphpad.com /www/radiolig/radiolig1.htm   (6758 words)

  
 [No title]
The micro acidic dissociation constant is obtained from the equilibrium concentration of the conjugated acid-base pairs.
The macro acidic dissociation constant is obtained from the global mass and charge conservation law.
To further understand the difference between micro and macro constants we consider ionization equilibrium of a triprotic acid AH Referring to the different deprotonation sites of the AH molecule we introduce the upper indexes of the protons.
www.chemaxon.com /marvin/chemaxon/marvin/help/pKa.html   (644 words)

  
 CHP - Equilibrium Constant   (Site not responding. Last check: 2007-10-19)
The equilibrium between reactants and products is described by an equilibrium constant.
Only variables will be in a K expression: partial pressure of gases and concentrations of solutes in solution.
Dissociation of water: dissociation constant of water, K
www.chem.vt.edu /chem-ed/equilibr/equil-constant.html   (159 words)

  
 Lesson 4   (Site not responding. Last check: 2007-10-19)
An analysis of dissociation binding data assumes that the law of mass action applies to your experimental situation; dissociation binding experiments also let you test that assumption.
During the incubation, radioligand is binding to the receptors and radioligand is dissociating from receptors.
Assumed to be constant during the experiment (a small fraction binds).
www.med.unc.edu /wrkunits/2depts/pharm/receptor/lesson4.htm   (483 words)

  
 Water, pH and Buffers
Water is said to dissociate and the degree of dissociation is a constant.
] + [Cl This dissociation is 100%, i.e.
The dissociation constant for acetic acid is :
www.prism.gatech.edu /~gh19/b1510/water.htm   (1065 words)

  
 Glossary: B
The equilibrium constant for the reaction in which a weak base reacts with water to form its conjugate acid and hydroxide ion.
The equilibrium constant for the ionization of a weak base.
The statement that the volume of a sample of gas is inversely proportional to the pressure of the gas (at constant temperature).
www.uwplatt.edu /chemep/chem/chemscape/labdocs/glossary/bdef.htm   (651 words)

  
 [No title]
The equation for CT (t) = CF + CB + CN is dCT (t) dt = K1Cp(t) _ k02 CT (t), where K1 is the transfer constant between plasma and the free compartment and k02 = k2 1+B0m = Ki+Nm=KN, is the transfer constant between the effective compartment and plasma.
[Ac] is the endogenous acetylcholine concentration and KAc the corresponding dissociation constant.
In view of the other approximations made in this analysis, mainly that the subjects were homogeneous in relative receptor density and rate constants, further refinement of the results seems unwarranted for this first report.
www.ps.uci.edu /~markm/2fa/smoking/from_eydie.doc   (525 words)

  
 Biophysical Chemistry
If A binds first to the protein, then this decreases the dissociation constant for B by a factor of two, relative to the dissociation constant for B when there is no A bound.
Therefore, the cooperativity coefficient for B binding to PA must be the same as for A binding to PB.
Therefore A’s dissociation constant is decreased by a factor of two when B is bound just as B’s dissociation constant is decreased by a factor of two when A is bound.
www.public.asu.edu /~laserweb/woodbury/classes/chm463/exam3/exam3key.htm   (688 words)

  
 Chapter 4 Translating Your System Diagram to Mathematics
The equilibrium constant for a binding reaction is called the dissociation constant if the numerator of the equilibrium concentration ratio is chosen as the product of the unbound ligand and unbound receptor concentrations.
is the dissociation constant, [m] is the equilibrium concentration of unbound mRNA, r is unbound ribosomes, and mr represents the mRNA-ribosome complex.
This boundary is quantified by specifying the constant numerical values of these variables, or by providing an explicit function of time to be used by the model whenever a value for the variable is required.
www.bioinformaticsservices.com /bis/resources/cybertext/chapter4.html   (3633 words)

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