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Topic: DnaA

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	The binding of two dimers of IciA protein to the dnaA promoter 1P element enhances the binding of RNA polymerase to ...
		The binding of DnaA protein to the DnaA box between the two promoters is followed by subsequent oligomerization of DnaA proteins over the two promoter regions (12).
		As the intracellular level of DnaA protein is critical for initiation of chromosomal DNA replication (11), E.coli might adopt a fine tuning regulatory mechanism, rather than a simple on-off switch, for dnaA expression by using the DnaA protein concentration- dependent oligomerization as a controlling mechanism.
		IciA function is dominant over that of DnaA protein and the mechanism may involve the ability of IciA protein to counteract the DnaA protein-dependent occlusion of RNA polymerase from the promoter 1P (12).
	nar.oxfordjournals.org /cgi/content/full/25/17/3486 (2769 words)

	Inhibitory Effects of Basic or Neutral Phospholipid on Acidic Phospholipid-mediated Dissociation of Adenine Nucleotide ...
		ATP dissociation was measured as a function of incubation time in the absence (square) or presence of PG (8 µg, egg yolk; circle) on ice (open symbol) or at 37 °C (closed symbol) as described in the legend for Fig.
		PE inhibited PG-mediated release of ATP from DnaA
		aureus DnaA protein in the presence of total lipid extracted from the mprF mutant during the exponentially growing phase (closed circle) or stationary phase (open circle) was measured as described in the legend for Fig.
	www.jbc.org /cgi/content/full/278/31/28778 (5604 words)

	Mutations in DnaA protein suppress the growth arrest of acidic phospholipid-deficient Escherichia coli cells -- Zheng ... (Site not responding. Last check: 2007-09-19)
		DnaA within a cell is located at the membrane (Newman and Crooke, 2000).
		of the chromosomally encoded wild-type DnaA and plasmid-encoded
		Torrey,T., Atlung.T. and Kogoma,T. dnaA suppressor (dasF) mutants of Escherichia coli are stable DNA replication (sdrA/rnh) mutants.
	embojournal.npgjournals.com /cgi/content/full/20/5/1164 (5009 words)

	A hybrid bacterial replication origin -- Seitz et al. 2 (11): 1003 -- EMBO Reports (Site not responding. Last check: 2007-09-19)
		The regions of oriC that are unwound by DnaA protein in E.
		Krause, M. and Messer, W. (1999) DnaA proteins of Escherichia coli and Bacillus subtilis: coordinate actions with single-stranded DNA-binding protein and interspecies inhibition during open complex formation at the replication origins.
		Speck, C. and Messer, W. (2001) Mechanism of origin unwinding: sequential binding of DnaA initiator protein to double-stranded and single-stranded DNA in the AT-rich region of the replication origin.
	emboreports.npgjournals.com /cgi/content/full/2/11/1003 (1930 words)

	Molecular mechanism of DNA replication-coupled inactivation of the initiator protein in Escherichia coli: interaction ...
		Molecular mechanism of DNA replication-coupled inactivation of the initiator protein in Escherichia coli: interaction of DnaA with the sliding clamp-loaded DNA and the sliding clamp-Hda complex -- Su’etsugu et al.
		Parada, C.A. and Marians, K.J. (1991) Mechanism of DnaA protein-dependent pBR322 DNA replication: DnaA protein-mediated trans-strand loading of the DnaB protein at the origin of pBR322 DNA.
		Sekimizu, K., Bramhill, D. and Kornberg, A. (1987) ATP activates dnaA protein in initiating replication of plasmids bearing the origin of the E. coli chromosome.
	www.genestocellsonline.org /cgi/content/full/9/6/509 (5822 words)

	Where does bacterial replication start? Rules for predicting the oriC region -- Mackiewicz et al. 32 (13): 3781 -- ... (Site not responding. Last check: 2007-09-19)
		the dnaA gene on the chromosome was that of the database annotations.
		is in the vicinity of the cluster of DnaA
		Madiraju,M.V., Qin,M.H., Yamamoto,K., Atkinson,M.A. and Rajagopalan,M. ((1999)) The dnaA gene region of Mycobacterium avium and the autonomous replication activities of its 5' and 3' flanking regions.
	nar.oxfordjournals.org /cgi/content/full/32/13/3781 (4917 words)

	Negative control of replication initiation by a novel chromosomal locus exhibiting exceptional affinity for Escherichia ...
		Relative concentrations of free DnaA molecules are expressed by the degree of shading.
		DnaA protein is sensitive to a soluble factor and is specifically inactivated for initiation of in vitro replication of the Escherichia coli minichromosome.
		The initiator function of DnaA protein is negatively regulated by the sliding clamp of the E. coli chromosomal replicase.
	www.genesdev.org /cgi/content/full/12/19/3032 (6502 words)

	DnaD Protein of Bacillus subtilis Interacts with DnaA, the Initiator Protein of Replication -- Ishigo-oka et al. 183 ...
		Entry of the replicative DNA helicase at the replication origin is a very important step in replication initiation (1).
		DnaA protein directs the binding of DnaB protein in initiation of DNA replication in Escherichia coli.
		Isolation of a dnaA mutant of Bacillus subtilis defective in initiation of replication: amount of DnaA protein determines cells' initiation potential.
	jb.asm.org /cgi/content/full/183/6/2148 (1771 words)

	Conditional expression of Mycobacterium smegmatis dnaA, an essential DNA replication gene -- Greendyke et al. 148 (12): ...
		Arrows corresponding to wt, mut and SCO copies of the dnaA gene are shown to the left; genotypes of the strains used are shown at the top of the image.
		Marszalek, J. and Kaguni, J. DnaA protein directs the binding of DnaB protein in initiation of DNA replication in Escherichia coli.
		Skovgaard, O., Olesen, K. and Wright, A. The central lysine in the P-loop motif of the Escherichia coli DnaA protein is essential for initiating DNA replication from the chromosomal origin, oriC, and the F factor origin, oriS, but is dispensable for initiation from the P1 plasmid origin, oriR.
	mic.sgmjournals.org /cgi/content/full/148/12/3887 (7079 words)

	DnaA, the Initiator of Escherichia coli Chromosomal Replication, Is Located at the Cell Membrane -- Newman and Crooke ...
		DnaA, the Initiator of Escherichia coli Chromosomal Replication, Is Located at the Cell Membrane -- Newman and Crooke 182 (9): 2604 -- The Journal of Bacteriology
		DnaA, the Initiator of Escherichia coli Chromosomal Replication, Is Located at the Cell Membrane
		Zheng, W., Li, Z., Skarstad, K., Crooke, E. Mutations in DnaA protein suppress the growth arrest of acidic phospholipid-deficient Escherichia coli cells.
	jb.asm.org /cgi/content/abstract/182/9/2604 (363 words)

	Pfam 18.0 : Bac_DnaA (Site not responding. Last check: 2007-09-19)
		The bacterial dnaA protein MEDLINE:8110826, MEDLINE:1779750, MEDLINE:2558436 plays an important role in initiating and regulating chromosomal replication.
		It binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are found in the chromosome origin of replication (oriC).
		DnaA is a protein of about 50 kDa that contains two conserved regions: the first is located in the N-terminal half and corresponds to the ATP-binding domain, the second is located in the C-terminal half and could be involved in DNA-binding.
	pfam.wustl.edu /cgi-bin/getdesc?name=Bac_DnaA (117 words)

	Occlusion of RNA Polymerase by Oligomerization of DnaA Protein over the dnaA Promoter of Escherichia coli -- Lee and ...
		DnaA protein is essential for the initiation of Escherichia coli chromosomal DNA replication in vivo and in vitro (1, 2,
		the dnaA gene was inhibited by DnaA protein (15).
		DnaA protein has been shown to repress the transcription of the dnaA gene in vivo (13) and in vitro (15).
	www.jbc.org /cgi/content/full/272/1/83 (3944 words)

	Mutations in the CCGTTCACA DnaA Box of Mycobacterium tuberculosis oriC That Abolish Replication of oriC Plasmids Are ...
		Mutations in the CCGTTCACA DnaA Box of Mycobacterium tuberculosis oriC That Abolish Replication of oriC Plasmids Are Tolerated on the Chromosome -- Dziadek et al.
		The dnaA gene region of Mycobacterium avium and the autonomous replication activities of its 5' and 3' flanking regions.
		Salazar, L., Guerrero, E., Casart, Y., Turcios, L., Bartoli, F. Transcription analysis of the dnaA gene and oriC region of the chromosome of Mycobacterium smegmatis and Mycobacterium bovis BCG, and its regulation by the DnaA protein.
	jb.asm.org /cgi/content/full/184/14/3848 (4380 words)

	Limiting DNA replication to once and only once -- Boye et al. 1 (6): 479 -- EMBO Reports (Site not responding. Last check: 2007-09-19)
		Newman, G. and Crooke, E. (2000) DnaA, the initiator of Escherichia coli chromosomal replication, is located at the cell membrane.
		Sekimizu, K. and Kornberg, A. (1988) Cardiolipin activation of dnaA protein, the initiation protein of replication in Escherichia coli.
		Sekimizu, K., Bramhill, D., and Kornberg, A. (1987) ATP activates dnaA protein in initiating replication of plasmids bearing the origin of the E.coli chromosome.
	emboreports.npgjournals.com /cgi/content/full/1/6/479 (3394 words)

	Negative control of replication initiation by a novel chromosomal locus exhibiting exceptional affinity for Escherichia ...
		Hda inactivation of DnaA is the predominant mechanism preventing hyperinitiation of Escherichia coli DNA replication
		Molecular mechanism of DNA replication-coupled inactivation of the initiator protein in Escherichia coli: interaction of DnaA with the sliding clamp-loaded DNA and the sliding clamp-Hda complex
		Anomalous DnaA protein binding to the regulatory region of the Escherichia coli aldA gene
	www.genesdev.org /cgi/content/abstract/12/19/3032 (902 words)

	Two discriminatory binding sites in the Escherichia coli replication origin are required for DNA strand opening by ...
		DnaA is necessary and sufficient for initial DNA strand separation,
		DnaA was preincubated in reaction buffer with 5 mM ATP or
		DnaA at all R boxes and I sites, would function in vivo (Table 2).
	www.pnas.org /cgi/content/full/101/9/2811 (4217 words)

	Replication and Control of Circular Bacterial Plasmids -- del Solar et al. 62 (2): 434 -- Microbiology and Molecular ... (Site not responding. Last check: 2007-09-19)
		It is composed of four contiguous and identical 22-bp iterons arranged as direct repeats (half arrows), flanked by a 9-bp dnaA box (hatched) and AT- and GC-rich sequences (215).
		DnaA, which also stimulates the DNA-binding activity of RepA (206).
		In vivo replication in the absence of DnaA
	mmbr.asm.org /cgi/content/full/62/2/434 (10505 words)

	Durham & Northumberland Archery Association. (Site not responding. Last check: 2007-09-19)
		D.N.A.A. The Durham and Northumberland Archery Association is a member county of the Grand National Archery Society and one of the five counties of the Northern Counties Archery Society.
		This web site serves the archers of Durham and Northumberland by acting as an on-line source of material referring to local Archery issues.
		Load 2006 D.N.A.A. events calendar and add John Larby as county Junior Organiser.
	www.dnaa.co.uk (186 words)

	Structural basis of replication origin recognition by the DnaA protein -- Fujikawa et al. 31 (8): 2077 -- Nucleic Acids ... (Site not responding. Last check: 2007-09-19)
		The box shows position 7, which is not recognized by DnaA domain IV in the crystal structure.
		Messer,W. (2002) The bacterial replication initiator DnaA: DnaA and oriC, the bacterial mode to initiate DNA replication.
		Katayama,T., Kubota,T., Kurokawa,K., Crooke,E. and Sekimizu,K. (1998) The initiator function of DnaA protein is negatively regulated by the sliding clamp of the E.
	nar.oupjournals.org /cgi/content/full/31/8/2077 (4727 words)

	ATP- and ADP-DnaA protein, a molecular switch in gene regulation -- Speck et al. 18 (21): 6169 -- The EMBO Journal (Site not responding. Last check: 2007-09-19)
		DnaA protein functions by binding to asymmetric 9mer DNA sites, the DnaA boxes.
		A transcriptional response to replication status mediated by the conserved bacterial replication protein DnaA
		Genetic Organization of the Vibrio harveyi dnaA Gene Region and Analysis of the Function of the V. harveyi DnaA Protein in Escherichia coli
	embojournal.npgjournals.com /cgi/content/abstract/18/21/6169 (844 words)

	Anomalous DnaA protein binding to the regulatory region of the Escherichia coli aldA gene -- Ozaki et al. 147 (1): 153 ...
		Anomalous DnaA protein binding to the regulatory region of the Escherichia coli aldA gene -- Ozaki et al.
		fusion gene was suppressed by oversupply of DnaA protein and
		was enhanced by reducing the free DnaA level.
	mic.sgmjournals.org /cgi/content/abstract/147/1/153 (215 words)

	Structural basis of replication origin recognition by the DnaA protein -- Fujikawa et al. 31 (8): 2077 -- Nucleic Acids ...
		Structural basis of replication origin recognition by the DnaA protein -- Fujikawa et al.
		The authors wish it to be known that, in their opinion, the first three authors should be regarded as joint First Authors
		strong DnaA boxes (R1, R2 and R4) than the weak DnaA boxes (R3 and M) in the replication origin.
	nar.oupjournals.org /cgi/content/abstract/31/8/2077 (633 words)

	Sequence analysis of 56 kb from the genome of the bacterium Mycoplasma pneumoniae comprising the dnaA region, the atp ...
		Sequence analysis of 56 kb from the genome of the bacterium Mycoplasma pneumoniae comprising the dnaA region, the atp operon and a cluster of ribosomal protein genes -- Hilbert et al.
		Sequence analysis of 56 kb from the genome of the bacterium Mycoplasma pneumoniae comprising the dnaA region, the atp operon and a cluster of ribosomal protein genes
		the sequence analysis of -56 kb comprising the dnaA region as a potential
	www.nar.oupjournals.org /cgi/doi/10.1093/nar/24.4.628 (479 words)

	The structure of bacterial DnaA: implications for general mechanisms underlying DNA replication initiation -- Erzberger ... (Site not responding. Last check: 2007-09-19)
		The structure of bacterial DnaA: implications for general mechanisms underlying DNA replication initiation
		of the Aquifex aeolicus DnaA protein to 2.7 Å resolution.
		The Box VII Motif of Escherichia coli DnaA Protein Is Required for DnaA Oligomerization at the E. coli Replication Origin
	embojournal.npgjournals.com /cgi/content/abstract/21/18/4763 (639 words)

	Reduced initiation frequency from oriC restores viability of a temperature-sensitive Escherichia coli replisome mutant ...
		Seven mutations in the dnaA gene that partly suppressed
		Each of the mutations caused a single amino acid change in domains
		III and IV of the DnaA protein, where nucleotide binding and
	mic.sgmjournals.org /cgi/content/abstract/151/3/963 (224 words)

	dnaA (Site not responding. Last check: 2007-09-19)
		Information for dnaA, and also upstream and downstream flanking genes:
		DNA biosynthesis; initiation of chromosome replication; can be transcription regulator
		Predictions with an average map value < the critical MAP value (p=0.05):
	bayesweb.wadsworth.org /binding_sites/dnaA.html (101 words)

	Protein Associations in DnaA-ATP Hydrolysis Mediated by the Hda-Replicase Clamp Complex -- Su'etsugu et al. 280 (8): ...
		In Escherichia coli, the activity of ATP-bound DnaA protein
		the DnaA N-terminal domain is required for the functional interaction
		the DnaA N-terminal domain supports this interaction; and the
	www.jbc.org /cgi/content/abstract/280/8/6528 (350 words)

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