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Topic: Donepezil

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	Alzforum: Drugs In Clinical Trials - Donepezil
		Donepezil is contraindicated in patients with known hypersensitivity to the drug or to other piperidine derivatives.
		Pratt RD. Patient populations in clinical trials of the efficacy and tolerability of donepezil in patients with vascular dementia.
		Donepezil therapy in clinical practice: a randomized crossover study.
	www.alzforum.org /dis/tre/drc/detail.asp?id=86 (636 words)

	Donepezil - Wikipedia, the free encyclopedia
		Donepezil, marketed under the trade name Aricept® (Eisai), is a centrally acting reversible acetyl cholinesterase inhibitor.
		Donepezil is sometimes used in combination with Memantine, a new agent for Alzheimer's disease which is in the same chemical class.
		Donepezil has been tested in other disorders which cause dementia including Lewy body dementia and Vascular dementia, but it is not currently approved for these indications.
	en.wikipedia.org /wiki/Donepezil (344 words)

	Donepezil - RxList Monographs
		Donepezil is both excreted in the urine intact and extensively metabolized to four major metabolites, two of which are known to be active, and a number of minor metabolites, not all of which have been identified.
		Donepezil is metabolized by CYP 450 isoenzymes 2D6 and 3A4 and undergoes glucuronidation.
		Donepezil HCl is contraindicated in patients with known hypersensitivity to donepezil hydrochloride or to piperidine derivatives.
	www.scs.unr.edu /~goodman/brain/donepezil.html (4354 words)

	Facts about Donepezil (Site not responding. Last check: 2007-10-18)
		Donepezil inhibits the action of cholinesterase, one of the enzymes that breaks down acetylcholine.
		No differences in the effectiveness of donepezil were observed based on the age, sex, or race of the individuals who were treated during clinical trials.
		Donepezil is administered once daily at bedtime, and can be taken with or without food.
	www.alz.org /grtrcinc/aaMedDonepezil.htm (507 words)

	Aricept (Donepezil Hydrochloride) drug description - prescription drugs and medications at RxList
		(donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as (±)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride.
		Donepezil hydrochloride is commonly referred to in the pharmacological literature as E2020.
		Donepezil hydrochloride is a white crystalline powder and is freely soluble in chloroform, soluble in water and in glacial acetic acid, slightly soluble in ethanol and in acetonitrile and practically insoluble in ethyl acetate and in n-hexane.
	www.rxlist.com /cgi/generic/donepezil.htm (173 words)

	Neuromedia - Our articles - Care & prescription drugs - Donepezil
		The efficacy of donepezil as a symptomatic treatment for Alzheimer’s disease was evaluated in 16 clinical trials involving 4365 participants.
		Treatment with donepezil is generally started at 5 mg a day (for 4-6 weeks) and may be raised to 10 mg/day for those who do not respond to the 5 mg/day dose.
		Donepezil is contraindicated in patients with known hypersensitivity to donepezil and with severe liver impairment.
	www.neuromedia.ca /en/nos_articles/donepezil.asp (487 words)

	DONEPEZIL HYDROCHLORIDE Drug Information DONEPEZIL HYDROCHLORIDE
		(donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as (±)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1 H -inden-1-one hydrochloride.
		Donepezil was not mutagenic in the Ames reverse mutation assay in bacteria, or in a mouse lymphoma forward mutation assay in vitro.
		Donepezil was not clastogenic in the in vivo mouse micronucleus test and was not genotoxic in an in vivo unscheduled DNA synthesis assay in rats.
	www.drugs.com /pdr/DONEPEZIL_HYDROCHLORIDE.html (5182 words)

	Donepezil as an adjuvant to constraint-induced therapy for upper-limb dysfunction after stroke: An exploratory ... (Site not responding. Last check: 2007-10-18)
		Donepezil, a reversible inhibitor of central and peripheral acetylcholinesterase, acts to increase acetylcholine concentrations in cholinergic synapses.
		Donepezil may have an adjuvant effect primarily when cortical and hippocampal neural activity is not reliably deemed valuable-perhaps not the case in the intense environment of rehabilitation or when enriched environments are provided for animals.
		Medullary and spinal efferents of the pedunculopontine tegmental nucleus and adjacent mesopontine tegmentum in the rat.
	www.vard.org /jour/04/41/4/nadeau.html (4303 words)

	January (Site not responding. Last check: 2007-10-18)
		Approximately 96% of donepezil is bound to plasma proteins (75% to albumin and 21% to alpha acid glycoproteins).
		Donepezil is extensively metabolized in the liver by oxidation via the cytochrome P450 2D6 and 3A4 isoenzymes and glucuronidation.
		Donepezil is excreted in the urine as unchanged drug and in the form of urinary metabolites.
	www.cc.nih.gov /phar/updates/98janfeb.html (2394 words)

	MedlinePlus Drug Information: Donepezil
		Donepezil is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) associated with Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities).
		Donepezil may improve the ability to think and remember or slow the loss of these abilities in people who have AD.
		Donepezil comes as a tablet and an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a697032.html (758 words)

	New dementia drug [Jun 1997; 40-2]
		Donepezil (Aricept) is an expensive new drug for the treatment of dementia, costing about £1,000 per patient per year.
		It might be argued that because when donepezil is stopped, the small difference in scores disappears, it could maintain improvements over longer periods.
		The conclusion is that donepezil probably produces an improvement corresponding to "turning the clock back" by about three or six months.
	www.jr2.ox.ac.uk /bandolier/band40/b40-2.html (974 words)

	British Journal of Pharmacology - Donepezil modulates nicotinic receptors of substantia nigra dopaminergic neurones
		The effects of donepezil, one of the most common cholinesterase inhibitors used for treatment of Alzheimer's disease, were studied on nicotinic receptors (nAChRs)-mediated postsynaptic currents, in dopaminergic neurons of the substantia nigra pars compacta, using the patch-clamp recording technique in slice preparations.
		The deactivation of the current evoked by brief puffer pulses of nicotine (50 ms) was left unchanged by donepezil application, indicating that the reduction in the peak amplitude was not due to a change in the kinetics of the channel.
		Donepezil, a tertiary amine which is almost fully protonated at physiological pH, may block receptor channels opened by nicotine in a manner similar to that of other substances, like local and general anaesthetics (Neher and Steinbach, 1978; Mori et al.
	www.nature.com /bjp/journal/v141/n4/full/0705660a.html (5917 words)

	Donepezil (Site not responding. Last check: 2007-10-18)
		Donepezil prevents the breakdown of acetylcholine, a brain chemical crucial to memory.
		Donepezil is not intended for use in children.
		Donepezil will not cure Alzheimer's disease and will not stop the disease from getting worse, but it will improve cognitive ability of some patients.
	www.wholehealthmd.com /refshelf/drugs_view/0,1524,689,00.html (373 words)

	DG DISPATCH - AAGP: Donepezil Preserves Functional Status In Alzheimer's Patients (Site not responding. Last check: 2007-10-18)
		In a press statement, Dr. Mohs also said that the findings of this study suggest that prolonged treatment with donepezil is an important weapon to help patients improve or maintain their independence while living with the disease.
		The study shows that about 56 percent of the placebo group compared with 41 percent of the donepezil group had criteria for clinically evident functional decline and were removed from the study.
		The risk of clinically evident functional decline of the patients receiving donepezil was practically 62 percent of that of the placebo group.
	www.pslgroup.com /dg/18FB36.htm (864 words)

	Alzheimer's prevention trial early results, July 16, 2004 Press Release - National Institutes of Health (NIH)
		The reduced risk of progressing from MCI to a diagnosis of AD among participants on donepezil disappeared after 18 months, and by the end of the study, the probability of progressing to AD was the same in the two groups.
		Donepezil was selected because of its current approval as a drug for treating patients already diagnosed with AD.
		These secondary analyses suggest that decline among the group on donepezil occurred at a slower rate on tests of global cognition, memory, and language than the other participants during the first half of the study but progressed at the same rate thereafter.
	www.nih.gov /news/pr/jul2004/nia-18.htm (816 words)

	MedForumsLive.com - donepezil, Aricept (Site not responding. Last check: 2007-10-18)
		Donepezil inhibits acetylcholinesterase, an enzyme responsible for the destruction of one neurotransmitter, acetylcholine.
		Donepezil was approved by the FDA in 1996.
		Donepezil is metabolized (eliminated) by enzymes in the liver.
	www.medforumslive.com /drugs/d/donepezil.html (448 words)

	Donepezil - Patient UK
		Donepezil is used to treat mild to moderate dementia associated with Alzheimer's disease.
		Donepezil cannot cure dementia or Alzheimer's disease but it can slow down the progression of dementia and can help to ease the symptoms.
		Donepezil works by increasing the amount of a natural chemical in the brain which is known to be lower in people suffering from Alzheimer's dementia.
	www.patient.co.uk /showdoc/30002419 (579 words)

	Absorption, Distribution, Metabolism, and Excretion of Donepezil (Aricept) after a Single Oral Administration to Rat -- ...
		Donepezil hydrochloride (Aricept) is a drug for the treatment of Alzheimer's disease.
		Unlabeled donepezil, synthesized at Eisai Co., Ltd., was used as a standard for quantitative determination by HPLC.
		The levels of unchanged donepezil in plasma and brain were determined by HPLC with UV detection.
	dmd.aspetjournals.org /cgi/content/full/27/12/1406 (4184 words)

	Clinical Trial: Donepezil to Treat Dementia in Parkinson's Disease
		Donepezil is approved for treating patients with Alzheimer's disease, whose memory and cognition problems are similar to those of patients with Parkinson's disease who are affected by dementia.
		Donepezil prevents the breakdown of a chemical messenger called acetylcholine, which is involved in memory and other cognitive functions, and may improve cognition in patients.
		The proposed study will determine whether a therapeutic intervention with donepezil, an acetylcholinesterase inhibitor, shown to be effective in AD, will improve cognitive function in PD. The study is planned as a 26-week, randomized, double-blind, placebo-controlled, cross-over study of the efficacy and safety of donepezil in PD with dementia.
	www.clinicaltrials.gov /ct/show/NCT00030979?order=5 (878 words)

	donepezil Consumer Drug Information
		However, it is believed that donepezil prevents the breakdown of acetylcholine in your brain.
		Donepezil is used to improve thinking and memory in patients with Alzheimer's disease.
		Donepezil is in the FDA pregnancy category C. This means that it is not known whether donepezil will harm an unborn baby.
	www.drugs.com /mtm/donepezil.html (963 words)

	Adverse Effects of Donepezil in Treating Alzheimer's Disease Associated With Down's Syndrome -- HEMINGWAY-ELTOMEY and ...
		She started treatment with donepezil, 5 mg/day, and after 8 weeks, she had improvement in mood and was less confused.
		A's dose of donepezil was increased to 10 mg/day, and 2 weeks later, she became agitated and aggressive.
		Her donepezil treatment was then discontinued, resulting in decreased agitation and aggression.
	ajp.psychiatryonline.org /cgi/content/full/156/9/1470 (689 words)

	TopSearch10 - Search Results - donepezil cognitive impairment alzheimer (Site not responding. Last check: 2007-10-18)
		TopSearch10 - Search Results - donepezil cognitive impairment alzheimer
		Find Donepezil Cognitive Impairment Alzheimer any many other great deals at MonsterMarketplace!
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	donepezil-cognitive-impairment-alzheimer.tbl.sytes.net (76 words)

	Ongoing study explores effects of alcohol, nicotine, donepezil on pilots
		(Donepezil is normally prescribed to help Alzheimer’s patients function better.) Pilots in the alcohol portion of the trial drank either four alcoholic drinks or four placebo drinks.
		Also, pilots on nicotine or donepezil were better at the same flight tasks, especially on approach to landing.
		Nicotine and donepezil both affect the cholinergic system of the brain, which is involved in human cognition.
	news-service.stanford.edu /news/2003/july23/pilot.html (635 words)

	Donepezil - Drugs & Vitamins - Drug Library - DrugDigest
		Benefits are usually greater for mild to moderate symptoms seen in the early stages of the disease.
		Generic donepezil tablets or orally-disintegrating tablets are not yet available.
		Take donepezil tablets by mouth, refer to the directions below that match the type of tablets you were prescribed.
	www.drugdigest.org /DD/DVH/Uses/0,3915,219\|Donepezil,00.html (675 words)

	Eisai Reports Results from Latest Donepezil Study in Vascular Dementia
		Patients were randomized to 5 mg of donepezil or placebo in a 2:1 ratio.
		There were 11 deaths reported in the donepezil group of 648 study participants and none in the group of 326 people given placebo.
		Consistent with donepezil's known mechanism of action, adverse events that occurred at a rate of greater than 5% and twice the rate of placebo were abdominal pain (5.1% vs. 2.5%), anorexia (5.7% vs. 2.8%) and nausea (9.9% vs. 4.3%).
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=109&STORY=/www/story/03-16-2006/0004321253&EDATE= (1108 words)

	STANFORD RESEARCHERS STUDY ALCOHOL, NICOTINE, DONEPEZIL EFFECTS ON PILOTS; VOLUNTEERS NEEDED FOR NEW STUDY ON NICOTINE ...
		Pilots given nicotine or donepezil flew better in the simulator than the control group in their respective trials.
		Nicotine and donepezil both affect the cholinergic system of the brain, which is involved in human cognition, Mumenthaler said.
		Donepezil, on the other hand, works indirectly by inhibiting the metabolism of acetylcholine.
	mednews.stanford.edu /releases/2003/july/pilot.html (764 words)

	AACAP: Donepezil (Aricept) May Improve Executive Functioning in ADHD (Site not responding. Last check: 2007-10-18)
		Donepezil has been shown promise in this area among patients with Alzheimer's disease, and earlier research showed clinically significant improvement in ADHD symptoms after donepezil therapy, with the largest gains made in area of executive function.
		The starting dose of donepezil was 2.5 mg daily, with a maximum daily dose of 10 mg.
		"It is also one of the first prospective studies of donepezil's tolerability and efficacy in ADHD children." The results are encouraging and warrant further study, he said.
	www.docguide.com /dg.nsf/PrintPrint/7097F1CE093B978485256C6100530185 (450 words)

	Donepezil
		Donepezil is used to treat memory loss associated with
		Further studies are needed to determine the long-term safety of huperizine A. Until more is known about it’s actions in the body, it is best to avoid using it together with donepezil, which also prevents the breakdown of acetylcholine.
		For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb.
	www.gianteagle.com /healthnotes/Drug/Donepezil.htm (294 words)

	Donepezil for cognitive impairment in Parkinson's disease: a randomised controlled study -- Aarsland et al. 72 (6): 708 ...
		Donepezil for cognitive impairment in Parkinson's disease: a randomised controlled study -- Aarsland et al.
		Intervention was the administration of donepezil or placebo during two treatment sequences of 10 weeks each.
		of donepezil in patients with PD and cognitive impairment.
	jnnp.bmjjournals.com /cgi/content/full/72/6/708 (3360 words)

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