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Topic: Dopamine receptor

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	Dopamine
		Dopamine is a major neurotransmitter in the central nervous system, and its receptors are associated with a number of neuropathological disorders such as Parkinson's disease and schizophrenia.
		To investigate whether dopamine receptor D5 (DRD5) T978C polymorphism is associated with the risk of developing motor fluctuations in PD, we studied this polymorphism in a case-control study of 120 subjects with sporadic PD and 110 control subjects.
		The EC(50) for dopamine versus GABA toxicity was 1.5 versus 6.5 nM, respectively, and was consistent with an inhibition of phosphatase 2A.
	lansbury.bwh.harvard.edu /Literature/PD2001/dopamine.htm (15433 words)

	Dopamine Receptor Expression in the Central Nervous System
		receptor mRNA in the medial vestibular, hypoglossal, cuneate, and gracilis nuclei.
		receptor mRNA are similarly distributed in the caudate-putamen, nucleus accumbens, olfactory tubercle, globus pallidus, substantia nigra, ventral tegmental area, locus coeruleus, lateral parabrachial nucleus, and the nucleus of the solitary tract.
		receptor binding are observed in the entopeduncular nucleus and the substantia nigra, pars reticulata (
	www.acnp.org /g4/gn401000019/ch019.html (4784 words)

	Molecular Biology of the Dopamine Receptor Subtypes
		Pharmacologically, the hallmark of the D1 receptor is to bind the benzazepine antagonist SCH 23390, while that of the D2 receptor is to recognize with high affinity the butyrophenones: spiperone and haloperidol.
		These putative receptors were expressed by DNA transfection and were shown to bind D1 receptor ligands and to stimulate adenylyl cyclase activity, the two hallmarks of the D1 receptor.
		It is noteworthy that dopamine binds to the D3, D4, and D5 receptors with nanomolar or submicromolar affinity constants, while its corresponding constants for the D1 and D2 receptors are in the micromolar ranges.
	www.acnp.org /g4/GN401000014/CH014.html (3591 words)

	Dopamine receptor - Wikipedia, the free encyclopedia
		The dopamine receptors are a class of metabotropic G protein-coupled receptors with the neurotransmitter dopamine as their endogenous ligand.
		The D1 and D5 receptors are members of the D1-like family of dopamine receptors whereas the D2, D3 and D4 receptors are members of the D2-like family.
		D1-like: Activation of the D1-like family receptors is coupled to increases in cAMP and is typically excitatory.
	en.wikipedia.org /wiki/Dopamine_receptor (300 words)

	Dopamine Receptor Agonists Information on Healthline
		Dopamine receptor agonists are a class of drugs with similar actions to dopamine, a neurotransmitter that occurs naturally in the brain.
		Therefore, dopamine and dopaminergic agonist drugs are administered to treat shock and congestive heart failure and to improve motor functions in patients with Parkinson's disease and other movement disorders.
		In Parkinson's disease, either dopamine levels or the number of dopamine receptors are progressively decreased, resulting in tremors, slowness of movements, muscle rigidity, and poor posture and gait (manner of walking).
	www.healthline.com /galecontent/dopamine-receptor-agonists (841 words)

	InterPro: IPR002185 Dopamine D4 receptor
		Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [ 2, 3, 4 ].
		Dopamine neurons in the vertebrate central nervous system are involved in the initiation and execution of movement, the maintenance of emotional stability, and the regulation of pituitary function [ 5 ].
		D4 receptor mRNA has also been detected in peripheral tissues, and the protein appears to be expressed preferentially in the cardiovascular system in the rat.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR002185 (3194 words)

	Increase Dopamine with Natural Supplements : By Ray Sahelian, M.D.
		In studies in which the activating neurotransmitters (serotonin and dopamine) were assayed in urine, an average increase of 28% was noted for serotonin and an average increase of 31% was noted for dopamine.
		Dopamine agonists also appear to reduce the loss of functional dopamine transporters when used early in the disease course, and these factors combine to build a case for the use of dopamine agonists in early-stage Parkinson's disease.
		Indirect comparisons of dopamine agonists show that ergot derivatives, such as pergolide and cabergoline, are as effective as non-ergot derivatives, such as ropinirole and pramipexole, in ameliorating Parkinson's disease symptoms in patients in early or advanced stages of the condition.
	www.raysahelian.com /dopamine.html (2211 words)

	project.htm
		For this reason, the system of neurons that either release dopamine or are receptors of dopamine in the brain is often referred to as the "dopamine reward system".
		Dopamine is believed to play a role in the addictive nature of these drugs, thus the name "dopamine reward system" is appropriate.
		Uptake of dopamine in the synapses is accomplished by a high-affinity membrane transporter.
	www.cem.msu.edu /~cem181h/projects/97/dopamine (2354 words)

	Dopamine
		Dopamine also is synthesized by neurons in the ventral tegmental area, which projects to the prefrontal cortex and the basal forebrain, including the nucleus accumbens.
		Dopamine receptors are involved in neurological disorders such as Parkinson's disease and schizophrenia.
		Dopamine is very basic and probably exists in the protonated form in solution rendering it inaccessable to the brain.
	www.neurosci.pharm.utoledo.edu /MBC3320/dopamine.htm (870 words)

	BioMed Central \| Full text \| Dibenzazecine compounds with a novel dopamine/5HT2Areceptor profile and 3D-QSAR analysis
		Dopamine is an important neurotransmitter in the mammalian CNS which has influence on physiological, behavioural and neuroendocrine functions, mediated through receptors on the cell surface.
		Dopamine receptors are clinically important drug targets for the treatment of disorders such as Parkinson's disease and schizophrenia [3].
		receptors were chosen as characteristic representatives of each of the two dopamine receptor subtype groups allowing a comparison of functional and binding data.
	www.biomedcentral.com /1471-2210/6/11 (6354 words)

	Clinical Trial: Dopamine Receptor Imaging in Mood Disorders
		This study seeks to increase the understanding of dopamine receptor function in the brain during major depressive disorder and bipolar depression, as well as genetic changes that may be behind changes in those receptors' actions.
		Dopamine is a natural messenger in the brain, involved in reward, motivation, and mood.
		D(1) receptor binding will be decreased in the frontal cortex and unaltered in the striatum of BD subjects compared to healthy controls.
	clinicaltrials.gov /ct/show/NCT00116077 (1719 words)

	Dopamine Receptors: From Structure to Function -- MISSALE et al. 78 (1): 189 -- Physiological Reviews
		For a decade, the dual receptor concept served as the foundation for the study of DA receptors.
		receptors in the septal pole of the nucleus accumbens inhibit
		An indication of the importance of DA receptors in the regulation of gene expression is the modulation of the expression of
	physrev.physiology.org /cgi/content/full/78/1/189 (7579 words)

	Dopamine-Deficient Mice Are Hypersensitive to Dopamine Receptor Agonists -- Kim et al. 20 (12): 4405 -- Journal of ...
		Dopamine-Deficient Mice Are Hypersensitive to Dopamine Receptor Agonists
		Locomotor response of DA mice to dopamine receptor agonists and antagonists.
		of DA mice to dopamine receptor agonists and the reversal of
	www.jneurosci.org /cgi/content/full/20/12/4405 (5474 words)

	SELECTIVE ACTIVATION OF DOPAMINE RECEPTOR SUBPOPULATIONS
		While this hypothesis is proposed to generalize to all G-protein coupled receptor systems, I propose to test and refine this hypothesis by studying D2-like dopamine (DA) receptors.
		Surprisingly, however, these same drugs have little or no effect on D2 receptors known (or presumed) to be coupled to potassium (K+) channels (e.g., they do not inhibit dopamine cell firing or dopamine release, and they induce only weak activation of K+ channels in pituitary lactotrophs).
		The first aim is to collect concentration/response data to determine the potencies and efficacies of DHX and analogs at D2 receptors linked to adenylate cyclase or K+ channels.
	www.med.unc.edu /wrkunits/1dean/research/Mailman243.html (414 words)

	Dopamine Receptor, Dopamine Transporter & Dopamine Decarboxylase Antibodies
		Dopamine Receptor, Dopamine Transporter and Dopamine Decarboxylase Antibodies
		Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intracellular ion transport.
		It may play a role in the coupling of the receptor to G-proteins.
	www.4adi.com /flr/dopamine.html (470 words)

	Chemicon - Product #AB1784P - Anti-Dopamine D1A Receptor, 4th Extracellular Domain
		The rat D1A receptor is a 446 amino acid, G-protein coupled transmembrane receptor protein (Monsma, 1990; Zhou, 1990; Zhou, 1992; O'Dowd, 1990).
		The immunogen is absolutely conserved in the mouse D1A receptor and shows 88% homology with human and 77% with porcine and bovine D1A receptors.
		Molecular cloning and expression of the gene for a human D1 dopamine receptor.
	www.chemicon.com /Product/ProductDataSheet.asp?ProductItem=AB1784P (633 words)

	Chemicon - Product #AB1765P - Anti-Dopamine D1A Receptor, C-terminus, cytoplasmic
		Immunohistochemical localization of the D1 dopamine receptor in rat brain reveals its axonal transport, pre- and postsynaptic localization, and prevalence in the basal ganglia, limbic system, and thalamic reticular nucleus.
		Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation.
		Cloning and expression of human and rat D1 dopamine receptors.
	www.chemicon.com /Product/ProductDataSheet.asp?ProductItem=AB1765P (525 words)

	Renal Dopamine Receptor Function in Hypertension -- Hussain and Lokhandwala 32 (2): 187 -- Hypertension
		receptors at the gene level causes hypertension in mice.
		dopamine receptor gene in the kidney and development of hypertension.
		Renal dopamine D1 receptor dysfunction is acquired and not inherited in obese Zucker rats
	hyper.ahajournals.org /cgi/content/abstract/32/2/187 (1536 words)

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