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Topic: Dothiepin

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	Dothiepin (UK PID) (Site not responding. Last check: 2007-08-17)
		Dothiepin is metabolised by demethylation and S-oxidation in the liver, resulting in the active metabolites, nordothiepin (also known as northiaden or desmethyldothiepin), dothiepin sulphoxide and nordothiepin sulphoxide, all of which contribute to the antidepressant effect (Rees 1981).
		Concentrations of dothiepin, nordothiepin, dothiepin-S-oxide and nordothiepin-S-oxide were measured in blood and milk samples from five breast feeding women, and in plasma samples from their infants.
		Dothiepin overdose should be managed on a clinical basis rather than on the amount ingested, but as a guide, doses of 1 g in adults have been associated with severe toxicity.
	www.intox.org /databank/documents/pharm/dothiepn/ukpid22.htm (4501 words)

	Dosulepin hydrochloride - Wikipedia, the free encyclopedia
		Dosulepin hydrochloride (formerly known as dothiepin hydrochloride) is an antidepressant of the tricyclic family.
		Dosulepin is relatively mild and is used for low level anxiety depression and similar disorders, particularly where insomnia and/or loss of appetite are present.
		Tricyclic antidepressants: {Amitriptyline} {Clomipramine} {Desipramine} {Dothiepin} {Doxepin} {Imipramine} {Lofepramine} {Nortriptyline} {Protriptyline} {Trimipramine} {Iprindole} {Opipramol}
	en.wikipedia.org /wiki/Dothiepin (415 words)

	Data Sheet
		Dothiepin is contraindicated for the treatment of depression in patients 12 years of age and under.
		Dothiepin is contraindicated for the treatment of nocturnal enuresis.
		Small amounts of dothiepin have been observed in breast milk and its possible effect on the child must be carefully considered if it is necessary to give the medicine to nursing mothers.
	www.medsafe.govt.nz /profs/datasheet/d/Dopresscap.htm (1830 words)

	PROTHIADEN 25 mg : Capsules; PROTHIADEN 75 mg: Tablets
		Dothiepin is readily absorbed from the gastro-intestinal tract, and extensively demethylated by first pass metabolism in the liver to its primary active metabolite, northiaden.
		Dothiepin is excreted in the urine, mainly in the form of metabolites; small amounts are also excreted in the faeces.
		Dothiepin has an adverse effect on the myocardium and can cause conduction defects and cardiac arrhythmias; an increased risk of sudden death has been suspected in cardiac patients receiving tricyclic antidepressants.
	home.intekom.com /pharm/knoll/prothiad.html (1156 words)

	Data Sheet
		It is postulated that the aetiology of depression is associated with a functional abnormality of one or more of the biogenic amines, particularly the catecholamines, in the brain.
		Dothiepin is present in low concentrations in breast milk.
		Dothiepin is metabolised in the liver and in man 12 basic metabolites were found in the urine, the bulk of which are northiaden sulphoxide and dothiepin sulphoxide.
	www.medsafe.govt.nz /Profs/Datasheet/p/prothiadencaptab.htm (1392 words)

	Dothiepin (dosulepin)
		Dothiepin should not be taken with a monoamine oxidase inhibitor antidepressant (MAOI).
		Dothiepin blood levels may be decreased by barbiturates.
		There may be a sudden and marked increase in blood pressure and heart rate when dothiepin is taken with medicines causing vessel constriction such as phenylephrine and adrenaline.
	www.tiscali.co.uk /lifestyle/healthfitness/health_advice/netdoctor/archive/100000844_2.html (451 words)

	Prothiaden
		Dothiepin is a member of a class of drugs called tricyclic antidepressants.
		Dothiepin (Prothiaden) can cause dry mouth but quite often this unwanted effect wears off.
		Since Prothiaden (dothiepin) has been so widely used, its side–effect profile is very well known and overall it is a very safe drug, even when taken long–term.
	health.ninemsn.com.au /asktheexperts/richardday.aspx?id=1377 (382 words)

	Dothiepin Vs. Fluoxetine (Mechanism Of Action And Pharmacodynamics)
		Comparison Between Mechanism of Action and Pharmacodynamics of Dothiepin and Fluoxetine Description of medicines Mechanism of action and pharmacodynamics Dothiepin Dothiepin is a tricyclic antidepressant.
		Fatalities associated with dothiepin include cardiac failure, neonatal cardio-respiratory failure, myocardial infarction, arrhythmia, cardiac arrest, ventricular fibrillation, stroke, congenital heart disease, haematemesis, aplastic anemia, leukopenia, hepatorenal syndrome, cholestatic jaundice, coma, neuroleptic malignant syndrome, aggravated Parkinson’s disease, intrauterine death, renal failure, respiratory arrest.
		Dothiepin is largely metabolized in the liver, and just over half is excreted in urine during the next 24 hours.
	www.freeessays.cc /db/31/mwc41.shtml (1357 words)

	Antidepressants
		The following antide-pressants were included in the study: the tricyclic antidepressants amitriptyline, dothiepin, and lofepramine and the atypical antidepressant bupropion, which all have considerable market shares in the UK and/or US markets; the selective serotonin reuptake inhibitors (SSRIs) citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline; and the recently approved antidepressants venlafaxine and nefazodone.
		Dothiepin has equipotent 5-HT and NA reuptake inhibitory activity, whereas northiaden shows a slight selectivity for NA reuptake inhibition.
		The slow elimination rate of northiaden (36-46 hr) compared to dothiepin (14-24 hr) suggests that northiaden contributes significantly to the therapeutic effect of dothiepin.
	www.psychopharmacology.net /comp.htm (505 words)

	RemedyFind: Prothiaden (Dothiepin) - Dothiepin - A Good Anti-depresssant and Sleep Aid
		I found dothiepin to be very effective in both the early stages and long-term maintenance.
		Dothiepin quickly reversed this (from about the second day), and also helped me sleep better at night, since I took the tablet at bedtime (as recommended).
		Before, during and after I was taking Dothiepin I watched the quiz show 'The Weakest Link' (sad I know, I apologize), but the speed of my responses to the questions was substantially reduced while I was taking dothiepin.
	www.remedyfind.com /review_long.asp?id=5473&review_id=9819 (410 words)

	Buy Dothiepin - FDA approved Prescription Drug at AllFDAMeds.com
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	www.allfdameds.com /rx/Dothiepin.htm (397 words)

	News - Home Recorded Sleep With Fluvoxamine Similar To That Seen In Laboratory With Other Antidepressants (Site not responding. Last check: 2007-08-17)
		Participants included 12 normal volunteers who were given a single dose of fluvoxamine 100 mg, dothiepin 100 mg or placebo.
		There was increased total sleep time, latency in rapid eye movement, sleep, stage 2 sleep and decreased arousal with dothiepin, which also affected wake after sleep onset and stage 1 sleep.
		Dothiepin shortened sleep latency in daytime naps, but proved longer with fluvoxamine.
	www.docguide.com /news/content.nsf/news/691AB2B361EBB7B4852569D9005CA568 (511 words)

	DARE abstract961490 (Site not responding. Last check: 2007-08-17)
		Amitriptyline, nortriptyline, desipramine, clomipramine, doxepin, dothiepin, fluoxetine, sertraline, and bupropion.
		Amitriptyline, nortriptyline, desipramine, clomipramine, dothiepin and sertraline were not found in quantifiable amounts in nurslings, and no adverse effects were reported.
		With the exception of dothiepin, tricyclic parent drugs were not detectable at levels as low as 1 to 10 ng/ml in nursling serum.
	nhscrd.york.ac.uk /online/dare/961490.htm (615 words)

	Compliance With Antidepressant Medication in the Treatment of Major Depressive Disorder in Primary Care: A Randomized ... (Site not responding. Last check: 2007-08-17)
		of dothiepin and fluoxetine, recovery from illness was assessed
		dothiepin group gave lack of efficacy as the reason for withdrawal.
		and for the dothiepin group it was –0.56 (p<0.001).
	ajp.psychiatryonline.org /cgi/content/full/157/3/338 (4237 words)

	statesman.com
		The controversy led the U.S. Food and Drug Administration recently to ask manufacturers of 10 different antidepressants to include a new warning section and British authorities to issue warnings against SSRI use in children.
		Amitriptyline and dothiepin are older medicines called tricyclics, while fluoxetine and paroxetine are SSRIs.
		Dothiepin is not available in the United States.
	www.statesman.com /health/content/shared-auto/healthnews/depr/520148.html (690 words)

	Dothiepin - Health Therapies / Treatments Shopping at dooyoo.co.uk
		Dothiepin works by preventing this re-absorption of noradrenaline and serotonin back into the nerve...
		I have been on prothiedan and Dothiepin and have found that the Dothiepin has increased my weight where as Prothiedan did not.
		I have now been taking Dothiepin 75mg at night for nearly two weeks and I have to say I am delighted with the results.
	www.dooyoo.co.uk /health-therapies-treatments/dothiepin (244 words)

	A controlled trial of dothiepin and placebo in treating benzodiazepine withdrawal symptoms -- Tyrer et al. 168 (4): 457 ...
		A controlled trial of dothiepin and placebo in treating benzodiazepine withdrawal symptoms -- Tyrer et al.
		A controlled trial of dothiepin and placebo in treating benzodiazepine withdrawal symptoms
		dothiepin this was independent of any antidepressant effect as depression
	bjp.rcpsych.org /cgi/content/abstract/168/4/457 (319 words)

	SignOnSanDiego.com > News > Features -- A wife: 'Every man's nightmare'
		Thompson, dubbed "The Black Widow," was acquitted of the attempted murder of her third husband, but police exhumed Webb's body.
		He had died from an overdose of aspirin and the anti-depressant dothiepin.
		"Dothiepin is a drug with a bitter taste and it would be hard to administer it to someone unless it was disguised in some way," said Michael Birnbaum, prosecuting.
	www.signonsandiego.com /news/features/20031216-0649-odd.html (860 words)

	Entrez-PubMed
		AIM: To assess the toxicity in overdose of venlafaxine and SSRIs compared to TCAs, and of dothiepin compared to other TCAs.
		The odds ratio (OR) for seizures with dothiepin vs. other TCAs was 3.4 (95%CI 1.2-9.9).
		DISCUSSION: Venlafaxine and dothiepin are pro-convulsant in overdose.
	www.antidepressantsfacts.com /effexor-serotonin-toxicity.htm (274 words)

	Bipolar Disorder Medications (Dothiepin) (Site not responding. Last check: 2007-08-17)
		At my last visit to the pdoc on Wednesday I was put on dothiepin to help with the depression.
		Is dothiepin a good drug to treat this and will it have any effect on the efficacy of the lithium ?
		No change or worsening is not good, and thus the lithium may not appear to be working as well, when it is actually the dothiepin causing the problem.
	www.mental-health-today.com /bp/bipolardr/120.HTM (238 words)

	PsychiatryMatters.MD (Site not responding. Last check: 2007-08-17)
		To determine whether concerns surrounding SSRIs are warranted, the team estimated the relative risks of nonfatal suicidal behavior associated with four antidepressant medications — the SSRIs fluoxetine and paroxetine, and the tricyclics amitriptyline and dothiepin — using the UK General Practice Research Database for 1993 to 1999.
		In all, 159,810 patients starting treatment with one of these four antidepressants were identified, with data for 555 patients who showed suicidal behavior and 2062 individuals who did not used for the current study.
		The results, published in the Journal of the American Medical Association, showed that the relative risks for newly diagnosed nonfatal suicidal behavior were similar for the four antidepressants, at 0.83 for amitriptyline, 1.16 for fluoxetine, and 1.29 for paroxetine compared with the reference drug dothiepin.
	www.psychiatrymatters.md /International/News/2004/Week_31/Day_1/Suicide_risk_similar_across_antidepressant_types.asp?C=74426381969504398148 (383 words)

	Effect of exposure to dothiepin and northiaden in breast milk on child development -- Buist and Janson 167 (3): 370 -- ...
		Effect of exposure to dothiepin and northiaden in breast milk on child development -- Buist and Janson 167 (3): 370 -- The British Journal of Psychiatry
		Effect of exposure to dothiepin and northiaden in breast milk on child development
		postpartum; half had breast-fed while on dothiepin (study group).
	bjp.rcpsych.org /cgi/content/abstract/167/3/370 (247 words)

	Dothiepin without prescription at lowest price.Dothiepin Prescriptions online buy -Outlet Dothiepin Drugstore.Used in ... (Site not responding. Last check: 2007-08-17)
		Dothiepin without prescription at lowest price.Dothiepin Prescriptions online buy -Outlet Dothiepin Drugstore.Used in the long-term treatment of depression, and is particularly useful when depression is accompanied by anxiety and insomnia.
		Importation of prescription Dothiepin is legal in most countries (including the US,US territory,Canada, Great Britain -UK, EU-(France, Germany,Sweden,Italy,Spain etc.,.,), Hong Kong, Japan and S. Korea etc.,) provided the Dothiepin is for personal use.
		Some international pharmacies may be able to legally distribute Dothiepin without a prescription, but that does not mean you may not require a prescription in your country.
	www.freedoms-pharmacy.com /l/Dothiepin.html (530 words)

	Initial days of antidepressant therapy associated with greatest risk of suicidal behavior - Formulary
		The study focused on the 4 most widely used antidepressants in the United Kingdom—the selective serotonin reuptake inhibitors (SSRIs) fluoxetine (n=176) and paroxetine (n=135), and the tricyclic antidepressants amitriptyline (n=77) and dothiepin (n=167), with dothiepin serving as a reference group.
		The adjusted odds ratio estimates comparing dothiepin with amitriptyline, fluoxetine, and paroxetine for nonfatal suicidal behavior were 0.83 (95% CI, 0.61-1.13), 1.16 (95% CI, 0.90-1.50), and 1.29 (95% CI, 0.97-1.70), respectively.
		The OR comparing dothiepin and paroxetine approached statistical significance; however, according to the study authors, it was low enough that it could have been attributed to uncontrolled confounding by severity of depression.
	www.actmagazine.com /formulary/article/articleDetail.jsp?id=128769 (701 words)

	Dothiepin restrictions? (Site not responding. Last check: 2007-08-17)
		SIR,-The Office of National Statistics gave figures of 562 cases of death associated with paracetamol and 235 associated with dothiepin in 1997 (PJ, April 8, p530).
		Restrictions on the pack sizes of paracetamol were introduced but the outcome on the death rate has not yet been assessed.
		Having recently and not infrequently dispensed prescriptions for both 6 x 28 dothiepin 25mg and 75mg, should there be restrictions on the quantity prescribed?
	www.pharmj.com /Editorial/20000513/letters/mclusky.html (79 words)

	Can you experience withdrawal from antidepressants?
		I have been taking the antidepressant dothiepin for seven years and am finding it really tough to come off the drug.
		I was originally prescribed it for CFS by an unsympathetic GP.
		The implications for you personally are to create as supportive an environment as you can for withdrawal (like one you might construct to make sure you enjoyed a drug in the first place), but while continuing to fulfill your job and other obligations, albeit not during a period of intense work activity.
	www.healthyplace.com /communities/Addictions/stanton_peele/faq/antidepressants.html (351 words)

	dothiepin
		One year ago I had depression problem and take dothiepin (HCL capsule 25MG, 1 capsule per day) for nearly 3 months and then recovered.
		However, due to life pressure and numerous reason my depression occured again so I took the dothiepin again, same amount and frequency as last time.But this time I did not feel any difference before and after taking the drug.So, should I double my amount?Is it I have a resistance to this drug?
		The reason that the doctor didnt recognize the drug is that dothiepin is not a U.S. FDA regulated drug, so the forum doctor may not be able to give you any information about a dosage increase.
	www.medhelp.org /forums/MentalHealth/messages/31676a.html (336 words)

	Rapid Worsening of Depressive Symptoms in a Patient With Depression After Switching From a TCA to an SSRI -- S
		back to dothiepin 75 mg/day and mianserin was continued.
		on the next day and did not recur under dothiepin treatment.
		with fluvoxamine when her medication was switched from dothiepin
	neuro.psychiatryonline.org /cgi/content/full/14/3/357 (438 words)

	Dothiepin prescription Dothiepin buy Online Dothiepin without prescription
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	La Leva di Archimede (ENG): SSRI: Antidepressants and the Risk of Suicidal Behaviors (Site not responding. Last check: 2007-08-17)
		Participants could have used only 1 of these antidepressants and had to have received at least 1 prescription for the study antidepressant within 90 days before their index date (the date of suicidal behavior or ideation for cases and the same date for matched controls).
		Main Outcome Measures Frequency of first-time exposure to amitriptyline, fluoxetine, paroxetine, and dothiepin of patients with a recorded diagnosis of first-time nonfatal suicidal behavior or suicide compared with comparable patients who did not exhibit suicidal behavior.
		The RR for suicidal behavior among patients first prescribed an antidepressant within 1 to 9 days before their index date was 4.07 (95% CI, 2.89-5.74) compared with patients who were first prescribed an antidepressant 90 days or more before their index date.
	www.laleva.org /eng/2004/07/ssri_antidepressants_and_the_risk_of_suicidal_behaviors.html (798 words)

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