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Topic: Doxorubicin

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Doxorubicin induced cardiomyopathy

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		Doxorubicin hydrochloride (HCl) encapsulated in polyethylene glycol (PEG)-stabilized liposomes was approved by the FDA on November 17, 1995, for use as first-line therapy for the treatment of advanced AIDS-related Kaposi's sarcoma (KS) disease that has progressed in spite of prior combination chemotherapy, or in patients who are intolerant of such combination therapy.
		Doxorubicin HCl (liposomal) for injection at a concentration of 2 mg/ml: in 10-ml sterile, single-use vials each containing the equivalent of 20 mg doxorubicin and in 30-ml sterile, single-use vials each containing the equivalent of 50 mg doxorubicin.
		Liposomal doxorubicin is contraindicated in patients who have a history of hypersensitivity to a conventional formulation of doxorubicin HCl or the components of the liposomal injection.
	www.aidsinfo.nih.gov /drugs/htmldrug_tech.asp?int_id=0185 (1545 words)

	doxorubicin Consumer Drug Information
		Doxorubicin should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.
		Doxorubicin interferes with the growth of cancer cells and slows their growth and spread in the body.
		Doxorubicin is in the FDA pregnancy category D. This means that doxorubicin is known to be harmful to an unborn baby.
	www.drugs.com /MTM/doxorubicin.html (1336 words)

	Doxorubicin Information on Healthline
		Still another is the so-called EPOCH, which consists of etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone.Doctors may treat stage III and IV non-Hodgkin's lymphoma with the so-called m-BACOD chemotherapy regimen, which consists of methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, and dexamethasone.
		Doxorubicin is a DNA-binding anticancer drug and belongs to an anthracycline antibiotic, although doctors do not use this drug to attack microbial infections.
		To prevent these, doctors may limit the amount of doxorubicin given to each patient so that the total amount of doxorubicin a patient receives over her or his entire lifetime is 550 milligrams per square meter, or less.
	www.healthline.com /galecontent/doxorubicin (571 words)

	doxorubicin liposomal - [Medication]
		Doxorubicin liposomal should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.
		Doxorubicin liposomal interferes with the growth of cancer cells and slows their growth and spread in the body.
		Doxorubicin liposomal is in the FDA pregnancy category D. This means that doxorubicin liposomal is known to be harmful to an unborn baby.
	www.peacehealth.org /kbase/multum/d04004a1.htm (1183 words)

	Time- and Concentration-Dependent Penetration of Doxorubicin in Prostate Tumors
		The concentration of doxorubicin in culture medium was analyzed by high-pressure liquid chromatography (HPLC); the concentration of doxorubicin in tumors was analyzed by HPLC and quantitative fluorescence microscopy.
		However, the 200 nM doxorubicin concentration is sufficient to induce cell death in histocultures of patient tumors.
		The delivery of doxorubicin to cells in a solid tumor is a dynamic process determined by both the drug concentration and the treatment duration and the usual processes involved in drug transport (ie, distribution through vascular space, transport across microvessel walls, and diffusion through interstitial space in tumor tissue).
	www.aapspharmsci.org /view.asp?art=ps030215 (4204 words)

	Doxorubicin Drug Information
		Doxorubicin seems to interfere with the growth of cancer cells, which are then eventually destroyed by the body.
		Doxorubicin is to be administered only by or under the supervision of your doctor.
		Doxorubicin may lower your body's resistance, and there is a chance you might get the infection the immunization is meant to prevent.
	www.drugs.com /cons/Doxorubicin.html (2245 words)

	ACS :: Cancer Drug Guide: doxorubicin hydrochloride
		Doxorubicin hydrochloride belongs to the general group of chemotherapy drugs known as anthracycline antibiotics.
		Doxorubicin stops the growth of cancer cells, causing the cells to die.
		Doxorubicin hydrochloride can cause a decrease in your white blood cell count, especially 10 to 14 days after the drug is given.
	www.cancer.org /docroot/CDG/content/CDG_doxorubicin_hydrochloride.asp (986 words)

	Doxorubicin - Wikipedia, the free encyclopedia
		Doxorubicin or adriamycin or hydroxyldaunorubicin is a DNA-interacting drug widely used in chemotherapy.
		Doxorubicin acts by binding to DNA where it can inhibit the progression of the enzyme topoisomerase II, which unwinds DNA for transcription.
		Doxorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.
	en.wikipedia.org /wiki/Doxorubicin (437 words)

	Drug Dictionary (Site not responding. Last check: 2007-11-06)
		Doxorubicin is used for the treatment of several cancers, including bladder, breast, head and neck, leukemia, liver, lung, lymphomas, mesothelioma, multiple myeloma, neuroblastoma, ovary, pancreas, prostate, sarcomas, stomach, testis (germ cell), thyroid, and uterus.
		Doxorubicin produces its anti-cancer effects by binding to DNA and inhibiting the production of proteins necessary for sustaining life of a cell.
		If doxorubicin escapes from the vein in which it is being administered, it may cause serious damage to tissue that it comes in contact with.
	patient.cancerconsultants.com /drug_dictionary.aspx?id=651 (1163 words)

	Doxorubicin liposomal – Doxil - Chemotherapy Drugs - Chemo
		Doxorubicin (liposomal) is used to treat AIDS-related Kaposi's sarcoma, breast cancer, ovarian cancer, and other solid tumors.
		The side effects of doxorubicin (liposomal) and their severity depend on how much of the drug is given.
		You may be given doxorubicin (liposomal) for as long as the disease does not progress and you show no evidence of heart toxicity.
	www.chemocare.com /bio/doxorubicin_liposomal.asp (1941 words)

	Doxorubicin
		Doxorubicin is an effective drug in the treatment of solid tumors as well as leukemia.
		The current goals are to develop techniques to analyze the drug metabolism on a subcellular level and to examine different aspects, which might modify the drugs efficacy such as drug formulation (liposomal formulation and prodrugs) or the presence of p-glycoprotein.
		This technique has been used to analyze the metabolism of doxorubicin, a liposomal formulation of doxorubicin and will be used to examine prodrugs (an oligopeptide attached to the drug to increase specificity to cancerous cells) of doxorubicin.
	www.chem.umn.edu /groups/arriaga/doxorubicin.htm (359 words)

	Doxorubicin
		Doxorubicin is an anthracyline (a three aromatic ring based molecule) that has proven to be an effective chemotherapy drug..
		Doxorubicin has been shown to intercalate between the bases in double stranded DNA, poison topoisomerase II, generate free radicals, and possibly disrupt the functioning of the cell membrane.
		Many doxorubicin derivatives that have proven beneficial in the treatment of other types of cancers share the anthracyline structure, and have simple functional group substitutions in various positions.
	faculty.gvsu.edu /carlsont/chemo/463webproject~doxorubicin.html (583 words)

	CancerQuest : Closer Look : Genotoxic Agents
		Doxorubicin is an anthracycline antibiotic first isolated from the fungus Streptomyces peucetius by the Farmitalia Research Laboratories of Milan in the early 1960's.
		Doxorubicin is a Class I anthracycline antibiotic which means that it blocks RNA and DNA synthesis equally.
		The cardiotoxicity that results from administering doxorubicin is thought to result primarily from the generation of damaging free oxygen radicals but might be partly due to the inhibition of topoisomerase II.
	www.cancerquest.org /index.cfm?page=506 (559 words)

	MedlinePlus Drug Information: Doxorubicin
		The risk of heart damage after stopping doxorubicin is higher in children.Tell your doctor if you have ever had chemotherapy with daunorubicin (Cerubidine, DaunoXome), doxorubicin, idarubicin (Idamycin), or radiation therapy to the chest and if you have or have had heart or liver disease.
		Doxorubicin is a type of antibiotic that is only used in cancer chemotherapy.
		Doxorubicin is also used to treat Ewing's tumor; squamous cell carcinomas of the head, neck, cervix, and vagina; carcinomas of the testes, prostate, and uterus; and refractory multiple myeloma.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682221.html (708 words)

	Doxorubicin - [Medication] (Site not responding. Last check: 2007-11-06)
		Doxorubicin slows or stops the growth and spread of cancer cells in the body.
		Doxorubicin should be given only under the supervision of a medical oncologist.
		Doxorubicin can damage the tissue around a vein if it leaks into the tissue while it is being given.
	www.bcbswny.com /kbase/topic/detail/drug/tv6586/detail.htm (413 words)

	Doxil® (Doxorubicin HCl Liposome Injection)
		Also, doxorubicin is a highly toxic agent with the potential for cardiac and other serious adverse effects as a result of drug accumulation, and the high-dose steroids often used with this regimen.
		The indicated dosage for ovarian cancer is 50 mg doxorubicin HCl in a sterile, translucent, red liposomal dispersion of 30 mL, at an initial rate of 1 mg/min to minimize the risk of infusion reactions.
		Myocardial toxicity is a risk of cumulative doxorubicin therapy, and therefore, careful assessment of cardiovascular function should be undertaken first, and patients at risk should be monitored for cardiac damage.
	www.multiplemyeloma.org /treatments/3.10.html (2573 words)

	Doxorubicin
		Doxorubicin may be used alone or in combination with other cancer medicines.
		Mixing the doxorubicin with another liquid and giving it into the vein is a type of infusion.
		Doxorubicin is given in a clinic or hospital setting.
	www.umm.edu /altmed/ConsDrugs/Doxorubicincd.html (802 words)

	Doxorubicin (via CobWeb/3.1 planetlab2.netlab.uky.edu) (Site not responding. Last check: 2007-11-06)
		Doxorubicin is a very serious anti-cancer medication with definite potential to do great harm as well as great good.
		Because doxorubicin attacks rapidly dividing cells it is also toxic to some normal cells: hair follicle cells, bone marrow cells, and intestinal cells.
		Doxorubicin is famous for “cumulative cardiotoxicity.” This means that there is a maximum amount of doxorubicin a patient can take during its lifetime before its heart will be poisoned.
	www.marvistavet.com.cob-web.org:8888 /html/body_doxorubicin.html (855 words)

	Heart Risks of Doxorubicin - National Cancer Institute
		A new study suggests that the drug doxorubicin (Adriamycin®), widely used in cancer chemotherapy, causes congestive heart failure more frequently and at lower doses than has been reported in the past.
		Doxorubicin is a highly effective anti-cancer drug but treatment with it increases patients’ risk of congestive heart failure (CHF).
		To more accurately evaluate the risk of CHF from treatment with doxorubicin, Swain and her colleagues looked back at the medical records of 630 patients who received a placebo instead of dexrazoxane in the three trials conducted in the 1990s.
	www.cancer.gov /clinicaltrials/results/congestive-heart-failure0503 (680 words)

	Doxorubicin : Cancerbackup (Site not responding. Last check: 2007-11-06)
		Doxorubicin (pronounced docks-e-rou-bi-sin) is a chemotherapy drug that is given as a treatment for many different types of cancer.
		This information describes doxorubicin, how it is given and some of its possible side effects.
		This may last up to 48 hours after you have had the doxorubicin, and is due to the colour of the drug.
	www.cancerbackup.org.uk /Treatments/Chemotherapy/Individualdrugs/Doxorubicin (1256 words)

	(Adriamycin) Doxorubicin (via CobWeb/3.1 planetlab2.netlab.uky.edu) (Site not responding. Last check: 2007-11-06)
		Doxorubicin is used widely in the treatment of cancers, including breast, ovarian, bladder and lung cancer, as well as non-Hodgkin's lymphoma, Hodgkin’s disease and sarcoma.
		Doxorubicin is a red liquid that you have as an injection into a vein (intravenously) or as a drip (infusion) through a fine tube put into a vein (cannula).
		Doxorubicin can cause temporary damage to the muscles of the heart, which may change the rhythm of the heartbeat.
	www.cancerhelp.org.uk.cob-web.org:8888 /help/default.asp?page=4025 (1464 words)

	Doxorubicin & Epirubicin [Adriamycin, Doxil, Epiadriamycin]
		Doxorubicin hydrochloride, or Adriamycin, belongs to the general group of drugs known as anthracyclines.
		Doxorubicin [Adriamycin] is exceedingly toxic and it is especially cardiotoxic.
		Doxorubicin can cause a decrease in the white blood cell count, especially 10-14 days after the drug is given.
	www.leiomyosarcoma.info /chemo47doxo.htm (2191 words)

	Doxorubicin, Adriamycin, and Rubex - Chemotherapy Drugs & Side Effects
		Cancers treated with Doxorubicin include: bladder, breast, head and neck, leukemia (some types), liver, lung, lymphomas, mesothelioma, multiple myeloma, neuroblastoma, ovary, pancreas, prostate, sarcomas, stomach, testis (germ cell), thyroid, uterus.
		Doxorubicin is given through a vein by intravenous injection (IV).
		The amount of Doxorubicin you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have.
	www.chemocare.com /BIO/doxorubicin.asp (1535 words)

	Doxorubicin (Site not responding. Last check: 2007-11-06)
		Doxorubicin is a chemotherapy drug used primarily to treat people with cancer.
		Human trials exploring the cardioprotective action of vitamin E in people taking doxorubicin remain inconclusive; however, some evidence suggests that vitamin E may allow for higher drug doses without increasing toxicity.
		Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.
	www.kroger.com /hn/Drug/Doxorubicin.htm (776 words)

	In Vitro and in Vivo Characterization of Doxorubicin and Vincristine Coencapsulated within Liposomes through Use of ...
		Doxorubicin or vincristine encapsulation in 1,2 distearoyl-sn-glycero-3-phosphocholine/cholesterol (55/45 mol%) liposomes using (A and C) the manganese-sulfate loading procedure alone or (B and D) with A23187.
		Doxorubicin was added to the liposomes to achieve a 0.2:1.0 (wt:wt) drug:lipid ratio, and vincristine was added to the liposomes to achieve a 0.05:1.0 (wt:wt) drug:lipid ratio, and all preparations were incubated at 60°C. Doxorubicin was quantitated by the A
		In vivo release of doxorubicin and vincristine from 1,2 distearoyl-sn-glycero-3-phosphocholine/cholesterol (55/45 mol%) liposomes.
	clincancerres.aacrjournals.org /cgi/content/full/10/2/728 (6923 words)

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