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Topic: Doxorubicin induced cardiomyopathy

Related Topics

Hypertrophic cardiomyopathy

Dilated cardiomyopathy

Hypertrophic obstructive cardiomyopathy

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Cardiomyopathy cataract hip spine disease

Doxorubicin induced cardiomyopathy

Idiopathic dilation cardiomyopathy

Ischemic cardiomyopathy

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	Doxorubicin (Adriamycin®) - PetPlace.com
		Doxorubicin is prescribed in the treatment of many cancers and tumors including lymphoma in dogs and cats, carcinoma of the thyroid and mammary glands in dogs and for a variety of different sarcomas.
		Doxorubicin is a potent anticancer agent and should be always kept out of reach of children and other pets in the household.
		Doxorubicin is available in lyophilized form for injection (10 mg, 20 mg, 50 mg, 100 mg and 150 mg) and 2 mg/ml solution for injection (5 ml, 10 ml, 20 ml, 25 ml and 100 ml).
	www.petplace.com /drug-library/doxorubicin-adriamycin/page1.aspx (574 words)

	THERAPY22 (Site not responding. Last check: 2007-10-26)
		Doxorubicin is effective in the treatment of several types of tumors.
		Cardiomyopathy and congestive heart failure are dose-dependent, and the incidence is unacceptably high when the cumulative dose of the drug exceeds 550 mg per square meter of body-surface area.
		Since the decision to discontinue doxorubicin treatment because of adverse cardiac effects is a difficult one, prevention of cardiac effects and early diagnosis should be the new goals.
	www.hmc.org.qa /hmc/heartviews/heartviews/ther22.htm (588 words)

	Doxorubicin (Site not responding. Last check: 2007-10-26)
		Doxorubicin is a chemotherapy that is given as treatment for certain types of cancer.
		Doxorubicin (pronounced docks e rou bi sin) is chemotherapy that is given as a treatment for many...
		Doxorubicin is used alone and in combination with other drugs for treatment of tumors including malignant lymphomas and leukemias.
	chemotherapytreatment.quotechemotherapy.com /doxorubicin (906 words)

	eMedicine - Cardiomyopathy, Dilated : Article Excerpt by: Murat Celebi, MD
		Cardiomyopathy is an important cause of morbidity and mortality among the world’s aging population.
		Cardiomyopathies are conditions in which the normal muscular function of the myocardium has been altered by specific or multiple etiologies, with varying degrees of physiologic compensation for that malfunction.
		Dilated cardiomyopathy (DCM) manifests hemodynamically as decreased cardiac output and increased pulmonary venous pressure.
	www.emedicine.com /med/byname/cardiomyopathy-dilated.htm (661 words)

	[No title]
		Dovinová, M. Barancik Institute for Heart Research, 1Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic Doxorubicin (Dox) is a chemotherapeutic agent that induces apoptosis of cardiomyocytes, causes cardiomyopathy and contributes to the development of myocardial dysfunction and heart failure.
		Although the mechanism underlying the severe cytotoxicity of doxorubicin is not fully understood, there is evidence that drug toxicity may be mediated through free radical formation and that the major factor contributing to doxorubicin cardiotoxicity is the depletion of the antioxidant defense mechanisms of the heart induced by doxorubicin.
		Doxorubicin was administered to rats in intraperitoneal injections over a period of 6 weeks (cumulative dose of 15 mg/kg).
	www.biomed.cas.cz /fd2004/ABSTRAKTA/PetraSimoncikova.doc (432 words)

	NEJM -- Doxorubicin-Induced Cardiomyopathy
		Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.
		of the ejection fraction during therapy with doxorubicin and
		and corresponding reductions in the dose of doxorubicin did
	content.nejm.org /cgi/content/short/340/8/653 (165 words)

	Role of phospholipase in the genesis of doxorubicin-induced cardiomyopathy in rats -- Ogawa et al. 47 (5): 1239 -- ...
		Role of phospholipase in the genesis of doxorubicin-induced cardiomyopathy in rats -- Ogawa et al.
		Role of phospholipase in the genesis of doxorubicin-induced cardiomyopathy in rats
		cardiomyopathy was investigated in the heart mitochondria of Wistar rats.
	cancerres.aacrjournals.org /cgi/content/abstract/47/5/1239 (257 words)

	eMedicine - Cardiomyopathy, Dilated : Article by Murat Celebi, MD
		Idiopathic cardiomyopathy is the second most common cause, although this may partially reflect undiagnosed etiologies such as infectious (viral) or toxic (ethanol-induced) cardiomyopathies.
		Viruses have been implicated in cardiomyopathies as early as the 1950s, when coxsackievirus B was isolated from the myocardium of a newborn baby with a fatal infection.
		In a person with restrictive cardiomyopathy, RHC demonstrates a pattern in the ventricular hemodynamic tracing referred to as the "square root sign" or "dip-and-plateau pattern." This pattern is similar to that observed in patients with constrictive pericarditis.
	www.emedicine.com /MED/topic289.htm (9824 words)

	IngentaConnect Carvedilol Protects against Doxorubicin-Induced Mitochondrial Car... (Site not responding. Last check: 2007-10-26)
		Doxorubicin treatment also caused a decrease in RCR for liver mitochondria (3.9 ± 0.9 versus 5.6 ± 0.7 for control rats) and inhibition of hepatic cytochrome oxidase activity.
		Coadministration of carvedilol decreased the extent of cellular vacuolization in cardiac myocytes and prevented the inhibitory effect of doxorubicin on mitochondrial respiration in both heart and liver.
		It is concluded that this protection by carvedilol against both the structural and functional cardiac tissue damage may afford significant clinical advantage in minimizing the dose-limiting mitochondrial dysfunction and cardiomyopathy that accompanies long-term doxorubicin therapy in cancer patients.
	www.ingentaconnect.com /content/ap/to/2002/00000185/00000003/art09532 (435 words)

	Management options: Anthracycline-induced cardiomyopathy -- Fisher and Marshall 75 (883): 265 -- Postgraduate Medical ... (Site not responding. Last check: 2007-10-26)
		Atrophic nerve fibres in regions of reduced MIBG uptake in doxorubicin cardiomyopathy.
		Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukaemia in childhood.
		Hermansen K, Wasserman K. The effects of vitamin E and selenium on doxorubicin induced delayed toxicity in mice.
	pmj.bmjjournals.com /cgi/content/full/75/883/265 (2134 words)

	IngentaConnect Phosphodiesterase 5A as a target in cardiac disease (Site not responding. Last check: 2007-10-26)
		Cardiac hypertrophy and doxorubicin cardiotoxicity are causes of heart failure.
		Doxorubicin treatment decreased heart rate and left ventricular developed pressure, and these decreases were inhibited by pretreatment with sildenafil.
		As experiments, in animal models of cardiac hypertrophy and doxorubicin-induced cardiomyopathy, with the PDE5A inhibitor sildenafil have shown beneficial effects, this clearly establishes PDE5A as a target in cardiac disease.
	www.ingentaconnect.com /content/apl/ett/2005/00000009/00000005/art00015 (240 words)

	Molecular biology of doxorubicin-induced cardiomyopathy
		The anthracycline doxorubicin is an antineoplastic agent, eliciting chronic cardiac toxicity.
		It occurs in patients after prolonged administration of doxorubicin, leading to congestive heart failure.
		The pathogenesis of the doxorubicin-induced cardiomyopathy is not well understood.
	www.pulsus.com /europe/07_01/umla_ed.htm (122 words)

	2002 William B
		Doxorubicin, a commonly used drug to treat cancer, causes heart failure.
		We are trying to understand the various effects of this drug on physiologic processes and their relationship to cardiotoxicity.
		Research from this generous support has provided me with an opportunity to pursue this important study and help me understand an important mechanism which may prevent cardiac damage in a significant population of cancer patients.
	www.cviphiladelphia.org /ResearchProgram/2003Recipients.htm (153 words)

	Anthracycline-Induced Cardiotoxicity -- Shan et al. 125 (1): 47 -- Annals of Internal Medicine
		Prospective study of cardiomyopathy induced by adjuvant doxorubicin therapy in patients with soft-tissue sarcomas.
		Doxorubicin cardiomyopathy: evaluation by phonocardiography, endomyocardial biopsy, and cardiac catheterization.
		Early detection of doxorubicin and daunorubicin cardiotoxicity by echocardiography: diastolic versus systolic parameters.
	www.annals.org /cgi/content/full/125/1/47 (6791 words)

	Phosphodiesterase-5 Inhibition With Sildenafil Attenuates Cardiomyocyte Apoptosis and Left Ventricular Dysfunction in a ... (Site not responding. Last check: 2007-10-26)
		In control, sildenafil, and sildenafil+doxorubicin groups (A, B, C), desmin staining is present throughout the entire cytoplasm and is observed at the Z-lines demonstrated as green striations (arrowheads).
		Alterations in electrical activity and membrane currents induced by intracellular oxygen-derived free radical stress in guinea pig ventricular myocytes.
		Structural and functional impairment of mitochondria in Adriamycin-induced cardiomyopathy in mice: suppression of cytochrome c oxidase II gene expression.
	circ.ahajournals.org /cgi/content/full/111/13/1601 (4154 words)

	Doxorubicin Treatment in Vivo Causes Cytochrome c Release and Cardiomyocyte Apoptosis, As Well As Increased ...
		Doxorubicin Treatment in Vivo Causes Cytochrome c Release and Cardiomyocyte Apoptosis, As Well As Increased Mitochondrial Efficiency, Superoxide Dismutase Activity, and Bcl-2:Bax Ratio -- Childs et al.
		The effects of doxorubicin administration (20 mg/kg) on the presence of cytosolic DNA fragments.
		The effects of doxorubicin administration on the levels of cytosolic cytochrome c (A) and caspase-3 activity (B).
	cancerres.aacrjournals.org /cgi/content/full/62/16/4592 (5012 words)

	Annexin V Imaging of Acute Doxorubicin Cardiotoxicity (Apoptosis) in Rats -- Bennink et al. 45 (5): 842 -- The Journal ...
		Annexin V Imaging of Acute Doxorubicin Cardiotoxicity (Apoptosis) in Rats -- Bennink et al.
		Annexin V Imaging of Acute Doxorubicin Cardiotoxicity (Apoptosis) in Rats
		group of 5 rats was scanned without doxorubicin treatment.
	jnm.snmjournals.org /cgi/content/abstract/45/5/842 (365 words)

	Cardiotoxicity Bibliography
		Anthracycline-induced cardiomyopathy: long-term effects on myocardial cell integrity, cardiac adrenergic innervation and fatty acid uptake.
		Abstract The aim of this study was to assess the physical performance in long-term survivors of of anthracycline therapy.
		Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood.
	www.acor.org /ped-onc/survivors/cardio/cardiobiblio.html (1603 words)

	Doxorubicin-induced second degree and complete atrioventricular block -- Kilickap et al. 7 (3): 227 -- Europace
		Doxorubicin is one of the most effective chemotherapeutic agents
		Doxorubicin should be carefully used because of its cardiotoxic
		Effects of first-dose doxorubicin on cardiac rhythm as evaluated by continuous 24-hour monitoring.
	europace.oxfordjournals.org /cgi/content/full/7/3/227 (1004 words)

	Doxorubicin-Induced Cardiomyopathy Treated with Carvedilol (Site not responding. Last check: 2007-10-26)
		Summary: Even today, heart failure due to doxorubicin-induced dilated cardiomyopathy seems to have a poor prognosis, as it is often irreversible and relatively unresponsive to standard medical treatment.
		This paper describes the first case of a patient complaining of severe symptoms of congestive heart failure due to doxorubicin-induced dilated cardiomyopathy unresponsive to standard medical treatment (digoxin, diuretics, and angiotensin-converting enzyme inhibitor), who showed complete clinical recovery and significant improvement of left ventricular dysfunction after carvedilol treatment.
		It also illustrates the possibility that carvedilol may be a first-choice drug for the treatment of this disease.
	clinicalcardiology.org /productcart/pc/briefs/9810briefs/21-777.html (142 words)

	Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a ...
		by inhibiting reduction of cardiac contractile genes and inducing
		Doxorubicin (Dox), an antitumor drug, is effective for a variety of soft and solid human malignancies, but its long-term use
		Ventricular hypertrophy induced by pressure or volume overload reportedly accompanies the induction of several specific genes,
	www.pnas.org /cgi/content/full/97/1/315 (3938 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		The patient died of congestive heart failure due to doxorubicin-induced cardiomyopathy 10 mo later.
		At necropsy, the left ventricle was markedly dilated and the apical anterior, inferior and lateral walls were thin, stiff and whitish.
		MIBG imaging may detect cardiac sympathetic denervation in doxorubicin-induced cardiomyopathy before cardiac symptoms are manifest and cardiac function deteriorates.
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=482540 (290 words)

	Subclinical Late Cardiomyopathy After Doxorubicin Therapy for Lymphoma in Adults -- Hequet et al. 22 (10): 1864 -- ...
		doxorubicin was 47 years (range, 15 to 69 years).
		Doxorubicin is considered a major drug for treatment of lymphoma
		Aviles A, Arevila A, Diaz Maqueo JC, et al: Late cardiac toxicity of doxorubicin, epirubicin, and mitoxantrone therapy for Hodgkin's disease in adults.
	www.jco.org /cgi/content/full/22/10/1864 (3309 words)

	Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy -- Lou et al. 288 (4): H1925 -- ...
		Cytokines are not upregulated in adriamycin-induced cardiomyopathy and heart failure.
		Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family.
		Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.
	ajpheart.physiology.org /cgi/content/full/288/4/H1925 (3589 words)

	Molecular Mechanisms of Doxorubicin-induced Cardiomyopathy. SELECTIVE SUPPRESSION OF REISKE IRON-SULFUR PROTEIN, ...
		Doxorubicin is a highly effective cytotoxic antineoplastic agent used in a wide variety of malignancies.
		Cumulative and Irreversible Cardiac Mitochondrial Dysfunction Induced by Doxorubicin
		Bicarbonate exacerbates oxidative injury induced by antitumor antibiotic doxorubicin in cardiomyocytes
	www.jbc.org /cgi/content/full/272/9/5828 (4395 words)

	Doxorubicin-induced Cardiomyopathy
		Influence of the Severity of Doxorubicin Induced Cardiomyopathy of...
		Aggressive management of doxorubicin-induced cardiomyopathy associated with 'low' doses of doxorubicin...
		Signal transducer and activator of transcription 3 in the heart...
	www.medicality.org.uk /diseases/doxorubicin-induced-cardiomyopathy.php (166 words)

	Phase I/II Study of the Rituximab-EPOCT Regimen in Combination with Granulocyte Colony-Stimulating Factor in Patients ... (Site not responding. Last check: 2007-10-26)
		doxorubicin; therefore, when the total dose of doxorubicin is
		use of doxorubicin is limited by its cumulative dose-related
		Phase I study of rituximab-CHOP regimen in combination with granulocyte colony-stimulating factor in patients with follicular lymphoma—effects on ADCC activity and Fc RI (CD64) expression on neutrophils.
	clincancerres.aacrjournals.org /cgi/content/full/11/2/697 (3484 words)

	NEJM -- Doxorubicin-Induced Cardiomyopathy (Site not responding. Last check: 2007-10-26)
		to doxorubicin when it is given as a single agent or in combination
		Chicco, A. J., Schneider, C. M., Hayward, R. Voluntary exercise protects against acute doxorubicin cardiotoxicity in the isolated perfused rat heart.
		Lou, H., Danelisen, I., Singal, P. Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy.
	content.nejm.org /cgi/content/extract/339/13/900 (2205 words)

	Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from ...
		induced by hypoxia/reoxygenation (H/R) were examined using rat
		caSTAT3 on the intracellular ROS formation induced by H/R, DCF-DA was used as a fluorescent probe.
		Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.
	circ.ahajournals.org /cgi/content/full/104/9/979 (2426 words)

	Left Ventricular Assist Device as Destination Therapy in Doxorubicin-Induced Cardiomyopathy -- Simsir et al. 80 (2): ...
		Left Ventricular Assist Device as Destination Therapy in Doxorubicin-Induced Cardiomyopathy -- Simsir et al.
		Left Ventricular Assist Device as Destination Therapy in Doxorubicin-Induced Cardiomyopathy
		Doxorubicin-induced cardiomyopathy is not uncommon and may progress
	ats.ctsnetjournals.org /cgi/content/abstract/80/2/717 (160 words)

	Response to "Increased Creatine Kinase MB and Cardiac Troponin T with Normal Cardiac Troponin I in Metastatic Alveolar ...
		of doxorubicin, but the authors did not state the dosages (1).
		is dose dependent (7)(8), with cardiomyopathy developing in
		In addition to overt cardiomyopathy, it has been suggested that patients
	www.clinchem.org /cgi/content/full/46/3/432 (1762 words)

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