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Topic: Droperidol

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	ACS :: Cancer Drug Guide: droperidol
		Droperidol belongs to a general class of drugs called butyrophenones that are used to treat nausea and vomiting.
		Droperidol is useful in preventing nausea and vomiting resulting from chemotherapy.
		Droperidol is given as an injection in a vein or muscle.
	www.cancer.org /docroot/CDG/content/CDG_droperidol.asp (382 words)

	Droperidol
		El droperidol o dehidrobenzolperidol es un neuroléptico antisicótico de corta acción derivado de la tetrahidroperidina de la familia de las butirofenonas.
		La absorción del droperidol por vía intramuscular e incluso por vía oral es rápida (20 y 60 minutos).
		Esta dosis débiles de droperidol deben tenerse en cuenta en la cirugía ambulatoria, ya que pueden disminuir los test de aptitud y producir fenómenos extrapiramidales.
	www.uam.es /departamentos/medicina/anesnet/agenda/farmacologia/droperidol.htm (569 words)

	Droperidol: An effective adjuvant for difficult cases of conscious sedation?
		Ninety-eight patients were randomly assigned to receive placebo (saline) or droperidol (Inapsine, Janssen Pharmaceutical, Canada) (5 mg) along with the conscious sedation regimen of midazolam and meperidine in doses adjusted by the endoscopist to the individual case.
		One-half of the droperidol (or placebo) dose was administered at the time of the initial midazolam/meperidine administration, with the second half given 2 min later.
		Overall ratings of sedation quality by the endoscopy staff were higher in the droperidol group, the percentage of procedures with poor ratings was about one-half that of the placebo group, and the percentage of cases in which sedation-related interruptions occurred was reduced from 32.6% to 12.8%.
	www.pulsus.com /Gastro/15_07/sem1_ed.htm (898 words)

	Droperidol facts and comparsions at Drugs.com
		Droperidol should only be used in patients who have developed serious side effects from or are intolerant to other therapies.
		Droperidol should be used with extreme caution in patients at risk for QTc prolongation (eg, patients with heart failure, a slow heart rate, an enlarged heart, or low potassium or magnesium levels, or patients who are elderly, abuse alcohol, or are taking other medicines known to increase the QTc interval).
		Droperidol is usually administered as an injection at your doctor's office, hospital, or clinic.
	www.drugs.com /cdi/droperidol.html (1254 words)

	MedicineHouse.com
		Droperidol produces marked tranquilization and sedation inducing a state of mental detachment and indifference while maintaining a state of reflex alertness.
		Independent of alpha adrenergic blockade, droperidol prolongs the duration of the refractory period, and decreases the rate of upstroke of the action potential.
		Droperidol is combined with fentanyl to produce neuroleptanalgesia.; a state of tranquilization, amnesia, detachment and analgesia.
	www.medicinehouse.com /cgi-bin/drug1.php?drug=droperidol (591 words)

	FDA Strengthens Warnings For Droperidol
		FDA has strengthened the warnings and precautions sections in the labeling for droperidol, a tranquilizer used most often as a premedication for anesthesia, as treatment for nausea after anesthesia, and for sedation of agitated patients.
		The new warning is intended to increase the physician's focus on the potential for cardiac arrhythmias during drug administration, and to consider use of alternative medications for patients at high risk for cardiac arrhythmias.
		Droperidol currently carries a warning about cases of sudden death at high doses (greater than 25 mg) in patients at risk for cardiac arrhythmias.
	www.locateadoc.com /Patient_Resources/Allergists/droperidol.cfm (393 words)

	NeLH Medicine in the News Project; 'New jab to tackle migraine pain' (Site not responding. Last check: 2007-11-04)
		The trial was designed to identify the minimum and optimal effective dose of intra-muscular droperidol for the acute treatment of migraine headache in adults and to evaluate the tolerability of droperidol in the patients that were treated.
		Patients were randomised to receive either intramuscular droperidol (0.1 mg, 2.75 mg, 5.5 mg, or 8.25 mg) or placebo during an acute migraine attack of moderate to severe intensity.
		Droperidol appears to be highly effective in the treatment of moderate and severe acute migraine headache, with an optimal therapeutic dose range around the 2.75 mg dose.
	www.nelh.nhs.uk /hth/droperidol.asp (961 words)

	Epidural Droperidol
		Bolus injection of droperidol 2.5 mg was not useful to prevent nausea or vomiting caused by continuous epidural infusion of buprenorphine.
		While, continuous infusion of droperidol 5 mg was effective in decreasing nausea or vomiting caused by continuous epidural infusion of buprenorphine.
		To assess a potential reduction of opioid side effects by droperidol, 4 mg morphine with either placebo or 2.5 mg droperidol was injected epidurally in a double-blind, randomized, postoperative trial.
	www.csen.com /anesthesia/droperidol.htm (1336 words)

	Drug Information: Droperidol (Systemic) (Print Version)
		Droperidol (droe-PER-i-dole) is used to reduce the amount of nausea and vomiting you may have after surgery or other procedures.
		However, based on experience with similar drugs, children may be more likely than older patients to experience side effects after receiving droperidol, such as muscle spasms in the tongue, face, neck, and back, and inability to move the eyes.
		Droperidol and other medicines that may be given during surgery may cause some people to feel drowsy, tired, or weak for up to a few days afterwards.
	www.nlm.nih.gov /medlineplus/print/druginfo/uspdi/203411.html (925 words)

	New Page 0 (Site not responding. Last check: 2007-11-04)
		Droperidol is a medication used in a variety of therapeutic situations including: as a sedative and antiemetic agent in surgical and diagnostic procedures, as a preoperative medication, and as an antiemetic for cancer chemotherapy.
		Droperidol should be reserved for use in patients who do not respond, or exhibit intolerable side effects to, other therapeutic alternatives.
		Administer droperidol with caution to patients at risk of development of QT prolongation.
	www.uic.edu /pharmacy/services/di/droperidol.htm (305 words)

	Droperidol - Drug Information, Research, Clinical Trials, News
		Droperidol should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval).
		Droperidol should be initiated at a low dose and adjusted upward, with caution, as needed to achieve the desired effect.
		Droperidol injection is indicated to reduce the incidence of nausea and vomiting associated with surgical and diagnostic procedures.
	www.druglib.com /druginfo/droperidol (462 words)

	FDA STRENGTHENS WARNINGS FOR DROPERIDOL
		FDA has strengthened the warnings and precautions sections in the labeling for droperidol, a tranquilizer used most often as a premedication for anesthesia, as treatment for nausea after anesthesia, and for sedation of agitated patients.
		The new warning is intended to increase the physician's focus on the potential for cardiac arrhythmias during drug administration, and to consider use of alternative medications for patients at high risk for cardiac arrhythmias.
		Droperidol currently carries a warning about cases of sudden death at high doses (greater than 25 mg) in patients at risk for cardiac arrhythmias.
	www.fda.gov /bbs/topics/ANSWERS/2001/ANS01123.html (323 words)

	FDA Issues Box Warning for Droperidol - Arrythmia Concerns Cited
		While it has been long known that droperidol has the potential to lengthen the QT interval, concern has been heightened by reports of symptomatic arrhythmias, torsades, and death associated with dosages within, and even below, the recommended range of 1.25-2.5 mg.
		"[Droperidol] should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval).
		Droperidol has played a role in anesthesia for many years and most anesthesiologists have extensive experience with this drug.
	www.apsf.org /resource_center/newsletter/2001/winter/11warning.htm (533 words)

	Droperidol - Wikipedia, the free encyclopedia
		Droperidol (Dropletan®) is an antidopaminergic drug used as an antiemetic and antipsychotic.
		Droperidol is a butyrophenone, and is a potent D
		It appears that the QT-prolongation is a dose-related effect and that in low doses, droperidol is not a significant risk.
	en.wikipedia.org /wiki/Droperidol (263 words)

	Droperidol-QT Prolongation/Benzocaine Spray: Rx Update:Virtual Hospital (Site not responding. Last check: 2007-11-04)
		The manufacturer of droperidol (Inapsine®), an agent used to reduce the incidence of nausea and vomiting associated with surgical and diagnostic procedures, recently issued a "fl box" warning after reports of QT prolongation and torsades de pointes were received in patients treated with droperidol.
		Therefore, droperidol should not be administered to patients with known or suspected prolonged QT interval.
		Due to its potential for serious proarrhythmic effects and death, droperidol should be reserved for use in the treatment of patients who fail to show an acceptable response to other adequate treatments.
	www.healthcare.uiowa.edu /pharmacy/RxUpdate/2002/04RXU.html (465 words)

	Droperidol advanced consumer information \| Drugs.com
		Droperidol (droe-PER-i-dole)is used to reduce the amount of nausea and vomiting you may have after surgery or other procedures.
		However, based on experience with similar drugs, children may be more likely than older patients to experience side effects after receiving droperidol, such as muscle spasms in the tongue, face, neck, and back, and inability to move the eyes.
		Droperidol and other medicines that may be given during surgery may cause some people to feel drowsy, tired, or weak for up to a few days afterwards.
	www.drugs.com /cons/Droperidol.html (1224 words)

	Droperidol Better Antiemetic, but It Causes Akathisia - July 1, 2006 -- American Family Physician
		Synopsis: A total of 97 patients with moderate to severe nausea (score of at least 40 on a 100-point visual analog scale) were randomly assigned to receive 1.25 mg droperidol, 10 mg metoclopramide, 10 mg prochlorperazine, or saline placebo.
		However, when comparing the change in nausea scores, droperidol was 15 points more effective in reducing nausea from baseline at 30 minutes than any of the other agents.
		Droperidol also was more noxious, causing akathisia in 71 percent of patients at the 24-hour follow-up interview compared with 23 percent of patients treated with any of the other medications (number needed to harm = 2.1; 95% confidence interval, 1.5 to 5.3).
	www.aafp.org /afp/20060701/tips/5.html (369 words)

	Droperidol (Site not responding. Last check: 2007-11-04)
		In addition, clinical investigators have reported a dose-related increase in QT prolongation with droperidol and replication of cardiac changes in a patient rechallenged with droperidol.
		Droperidol should be initiated at a low dose and adjusted upward, with caution, as needed to achieve the desired effect.
		Some of the factors to be considered in determining the dose are age, body weight, physical status, underlying pathological condition, use of other drugs, type of anesthesia to be used and the surgical procedure involved.
	www.theairwaysite.com /droperidol.html (623 words)

	Stronger warnings and precautions for droperidol - Letters - Brief Article AORN Journal - Find Articles
		The US Food and Drug Administration (FDA) has strengthened the warnings and precautions section in the labeling for droperidol, a tranquilizer most often used as a premedication for anesthesia, as a treatment for nausea after anesthesia, and for sedation of agitated patients.
		The new warning is intended to increase a physician's focus on the potential for cardiac arrhythmias during drug administration and to suggest consideration of alternative medications for patients at high risk for cardiac arrhythmias.
		Droperidol currently carries a warning about cases of sudden death at high doses (ie, greater than 25 mg) in patients at risk for cardiac arrhythmias.
	www.findarticles.com /p/articles/mi_m0FSL/is_2_75/ai_83141039 (333 words)

	Inapsine / Droperidol: Overview Lawsuit Overview - Find Trial Lawyers and Attorneys with Experinece in Inapsine / ...
		FDA has strengthened the warnings and precautions sections in the labeling for droperidol, also known as inapsine, a tranquilizer used most often as a premedication for anesthesia, as treatment for nausea after anesthesia, and for sedation of agitated patients.
		Droperidol has been associated with fatal cardiac arrhythmias.
		The manufacturer, Akorn Pharmaceuticals, is sending a "Dear Healthcare Professional" letter to physicians, pharmacists, and other healthcare professionals in the U.S. The letter explains the fl box warnings and highlights the potential for QT prolongation or torsades when this drug is administered.
	www.injuryboard.com /view.cfm/Topic=842 (501 words)

	Droperidol For Migraines (Site not responding. Last check: 2007-11-04)
		About 300 patients were randomized to receive droperidol at doses of either 2.75 milligrams, 5.5 milligrams, or 8.25 milligrams, or a placebo dose containing no active drug.
		Researchers found patients on the 2.75-milligram dose of droperidol had significantly greater reduction in migraine-associated symptoms, such as nausea, vomiting, and sensitivity to light and sound.
		There is a word of caution however, since research establishing the effectiveness of droperidol have been lacking, safety concerns need to be addressed since droperidol in other situations has been linked to a potentially dangerous condition called QT prolongation.
	www.indegene.com /pul/home/indPul_Ind_News_04-02-2003_1.asp (242 words)

	MEDLINE_1996-2006 - Resultado de la búsqueda <página 1>
		Comparison of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting after gynecologic surgery.
		This study was performed to compare the efficacy of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting (PONV) and to compare the possible adverse effects of these drugs in gynecologic incontinence surgery.
		With regard to adverse events, the patients in the droperidol group had significantly more anxiety than the placebo group (2-6 h postoperatively), more drowsiness than the tropisetron and placebo groups (0-2 h postoperatively), and more dissatisfaction than the tropisetron (0-6 h postoperatively) and placebo groups (2-6 h postoperatively).
	www.bireme.br /cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE_1996-2006&exprSearch=9052320&indexSearch=UI&lang=e (386 words)

	Spartanburg SC \| GoUpstate.com \| Spartanburg Herald-Journal
		In 2001, the FDA changed the labeling requirements for droperidol injection, to include a so-called "Black Box Warning", citing concerns of QT prolongation and torsades de pointes.
		The evidence for this is disputed, with less than 20 reported cases of torsades in 30 years and most of those having received doses in excess of 50mg in a 24-hour period.
		It appears that the QT-prolongation is a dose-related effect and that in low doses, droperidol is not a significant risk.
	www.goupstate.com /apps/pbcs.dll/section?category=NEWS&template=wiki&text=Droperidol (366 words)

	Inapsine / Droperidol: Overview Lawsuit Government Report - FDA Letter to Doctors Regarding Droperidol - Find Trial ...
		There have been a number of reports of patients who have been treated with droperidol and who developed suspected or established torsades de pointes, at times leading to death.
		There have been additional cases of symptomatic arrhythmia associated with a prolonged QT interval after droperidol administration that have been submitted via ongoing safety surveillance activities.
		INAPSINE (droperidol) is indicated to reduce the incidence of nausea and vomiting associated with surgical and diagnostic procedures.
	www.injuryboard.com /view.cfm/Article=1020 (767 words)

	Augusta Georgia: features@ugusta: New treatment helps pregnant women with severe nausea 7/23/97
		Droperidol is an anti-emetic while diphenhydramine - also known as Benadryl - also works as an anti-emetic and helps reduce anxiety that can be a side effect of the droperidol.
		According to recently published data from the Long Beach team, the droperidol is significantly better than any one of a number of regimens that have been tried in the past.
		The droperidol protocol is still reserved only for women with hyperemesis gravidarum who are severely sick; having, for example, lost 5 percent of their pre-pregnancy weight.
	chronicle.augusta.com /stories/072497/fea_nausea.BAK1 (1150 words)

	ASA April 2002 Newsletter
		Droperidol is a butyrophenone approved in 1970 as an injectable formulation for the reduction of nausea and vomiting associated with surgical and diagnostic procedures.
		While the labeling for droperidol carried warnings about the potential for cardiovascular adverse events at high doses and in the setting of alcoholic withdrawal, these warnings did not reflect what had been reported to FDA over the years since the product¹s initial marketing or in the world literature.
		Droperidol causes a dose-dependent prolongation of the QT interval.
	www.asahq.org /Newsletters/2002/4_02/mccormick.htm (1610 words)

	Droperidol for acute psychosis
		Droperidol, a butyrophenone neuroleptic, has been used for this purpose in several countries.
		When 5 mg intramuscular (im) droperidol was compared with 5 mg im haloperidol, those given droperidol were also less likely to need additional injections by 30 minutes, than those given haloperidol, but this result was not statistically significant (n = 27, RR 0.45 CI 0.2 to 1.01).
		To date, use of droperidol for emergency situations has been justified by experience rather than evidence from well conducted and reported randomised trials, but, as world reserves diminish, droperidol will no longer be a treatment option.
	www.cochrane.org /reviews/en/ab002830.html (559 words)

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