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Topic: Drosophila

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	Drosophila Information Service
		Drosophila is one of the premier organisms for studies of genetics, development, population biology, and evolution.
		Drosophila Information Service is a journal devoted to disseminating information useful to researchers, teachers, and students.
		This policy has proved to be a great stimulus for the use of Drosophila material in genetic research and is directly responsible for many important contributions." During the many decades since that first issue, DIS has continued to promote open communication.
	www.ou.edu /journals/dis (164 words)

	Drosophila - Wikipedia, the free encyclopedia
		Drosophila is a genus of small flies whose members are often called small fruit flies, or more appropriately vinegar flies, wine flies, pomace flies, grape flies, and picked fruit-flies.
		Drosophila melanogaster is a popular experimental animal because it is easily cultured in mass out of the wild, it has a short generation time and because mutant animals are readily obtainable.
		Drosophila are extensively used as a model organism in genetics, cell-biology, biochemistry, and especially developmental biology.
	en.wikipedia.org /wiki/Drosophila (1072 words)

	Drosophila melanogaster - Wikipedia, the free encyclopedia
		Drosophila melanogaster is the most studied organism in biological research, particularly in genetics and developmental biology.
		Determination of sex in Drosophila occurs by the ratio of X chromosomes to autosomes, not because of the presence of a Y chromosome as in human sex determination.
		Drosophila is being used as a genetic model for several human diseases including the neurodegenerative disorders Parkinson's, Huntington's, and Alzheimer's disease.
	en.wikipedia.org /wiki/Drosophila_melanogaster (2450 words)

	Drosophila (Site not responding. Last check: 2007-10-10)
		Drosophila melonogaster, or the fruit fly, has an adult size of about 3mm, and has been used extensively as a model organism to study animal genetics since early 20th century.
		Another critical concern with Drosophila research is that the Pax6-dependent vertebrate homologs of eya, so and dac genes are found as members of gene families (Wawersik and Maas.
		Drosophila genes sine oculis, eyes absent and dachshund share homology with the mice and human genes six, eye absent (eya) and dachsund (dach) gene family (Wawersik and Maas, 2000).
	dragon.zoo.utoronto.ca /~B03T0801B/drosophila.html (927 words)

	Drosophila gene families: cytoskeleton
		Genetic analysis in Drosophila has shown that one of these factors, SCAR, is essential for numerous actin-based processes during development, while WASP, another activator, mediates a subset of Arp2/3 functions in neuronal cell fate determination.
		Slingshot is a protein phosphatase that activates the actin-severing activity of cofilin; loss-of-function experiments in Drosophila have demonstrated that tissues mutant for slingshot exhibit abnormal accumulations of f-actin.
		Drosophila has three BBS orthologs, and all three were selected in this screen (BBS1 and BBS8 as part of the compartment subset, and BBS4 as part of the prototypical-cilia subset).
	www.sdbonline.org /fly/aignfam/cytoskel.htm (10448 words)

	Drosophila limb development
		However, the specification of different cellular fates is still controlled by gradients of regulatory proteins, in the case of the limb, the proteins are secreted signaling molecules instead of transcription factors.
		In Drosophila, a technique called mitotic recombination (refer to Figure 4) is used to induce a genetically marked cell and follow the fate of the clone of cells that derive from the marked cell.
		It involves generating patches of homozygous mutant tissue in the limb primordia of animals heterozygous for an innocuous cell marker mutation, and subsequently assessing the size, shape and distribution of clones in adult tissues.
	www.ucalgary.ca /UofC/eduweb/virtualembryo/D_m_limb.html (3569 words)

	Princeton University Senior Theses brief display
		Bernsley, Curtis (1984): Characterization of the Rudimentary Locus in Drosophila Pseudoobscura and Drosophila Persimilis.
		Bernsley, Curtis Neil (1984): Characterization of the Rudimentary Locus in Drosophila Pseudoobscura and Drosophila Persimilis.
		Eschenlaurer, Arthur Copeland (1984): Characterization of the Rudimentary Locus in Drosophila Pseudoobscura and Drosophila Persimilis.
	libweb5.princeton.edu /theses/thesesvw.asp?Lname=&Fname=&Submit=Search&Title1=drosophila&department=&Class=&Adviser= (3155 words)

	[No title]
		Abstract: Experimental lines of Drosophila melanogaster derived from a natural population, which had been isolated in the laboratory for approximately 70 generations, were crossed to determine if the expression of additive, dominance and epistatic genetic variation in development time and viability was associated with the environment.
		Abstract: Body size in Drosophila is known to be closely related to a number of traits with important life history consequences, such as fecundity, dispersal ability and mating success.
		Abstract: The Adh-2 gene of Drosophila mulleri is expressed in the larval fat body and the adult fat body and hindgut, and a 1500-bp element located 2-3 kb upstream of the Adh-2 promoter is necessary for maximal levels of transcription.
	www.nal.usda.gov /awic/pubs/Labinsects/Drosophila.htm (8841 words)

	Drosophila Genome Project
		The Drosophila Genome Project at the HGSC is sequencing the second Drosophila species: Drosophila pseudoobscura.
		The euchromatic portion of the genome (125 Mb) is being sequenced to approximately 7-fold coverage using a whole genome shotgun approach and is being assembled using the HGSC's assembly engine, Atlas.
		Annotation of the Drosophila pseudoobscura genome, primarily by comparison to the finished Drosophila melanogaster genome
	www.hgsc.bcm.tmc.edu /projects/drosophila (257 words)

	Drosophila genes
		Drosophila development is characterized by the existence of four types of cycles of DNA replication, each appearing successively after fertilization.
		The expression of Drosophila E2F in later stage embryos occurs in a segmentally restricted group of neural cells, whereas it is widely expressed in early embryos (Hao, 1995).
		Although all the extant results on Drosophila cells strongly suggest an interdependence of the central spindle and the contractile ring, it is currently unclear whether this is true in all animal cells.
	www.sdbonline.org /fly/aignfam/cellcycl.htm (4941 words)

	Trans-NIH Fly Initiative- Drosophila White Paper 2001
		Drosophila melanogaster is an extraordinarily attractive model organism owing to a combination of its easy to manipulate genetic system, relatively low cost, and biological complexity comparable to that of a mammal.
		Together with the information on the Drosophila genome and proteome, the past years of investment in Drosophila research and the anticipated completion of the genomic sequence will catalyze an explosion in outstanding research and insights into normal and disease mechanisms if harnessed properly.
		Thus, our community agrees that to seriously meet the opportunities and challenges in Drosophila genomics and genetics, there must be targeted development of shared genetic resources such as libraries of transposon mutants in all genes, adequate databases, stock centers, complete genomic expression analyses, polymorphism databases, and related resources and enabling technologies.
	www.nih.gov /science/models/fly/whitepaper2001.html (1575 words)

	P Elements in Drosophila
		The Drosophila genome has many families of transposable elements (Flybase), some of which have been studied in detail, and others are known only superficially (Berg and Howe 1989).
		Drosophila has long been a favorite organism for genetic and developmental research, but it was largely through the use of P elements that the powerful tools of molecular biology were fully employed.
		However, P elements have undoubtedly enhanced the fitness of Drosophila geneticists, forming the basis for a variety of techniques that have become essential to most current research with this species.
	engels.genetics.wisc.edu /Pelements/Pt.html (6407 words)

	The Drosophila melanogaster Malpighian tubule (Site not responding. Last check: 2007-10-10)
		In collaboration with Kim Kaiser (Glasgow) and Simon Maddrell (Cambridge), we have established that the Drosophila Malpighian tubule is amenable to physiological, biochemical, molecular and genetic analysis.
		We aim to identify the major transport and cell signalling genes involved in the function of this model epithelium, and then to intervene genetically to study their relative significance in physiological function.
		Drosophila homologues of vertebrate transport and cell signalling genes.
	www.mblab.gla.ac.uk /~julian/DowLab.html (805 words)

	Drosophila (Site not responding. Last check: 2007-10-10)
		Drosophila melanogaster has been used as a model organism for experimental studies of multicellular eukaryotic biology for over a century.
		The value of Drosophila as a model for other eukaryotic systems has been amply demonstrated by the fact that many genes and processes first discovered in Drosophila have proven to be conserved in other organisms, including humans.
		Drosophila genetics is very sophisticated, and well suited for genetic screens and studies of gene interactions.
	taputea.lbl.gov /research/flies (508 words)

	Drosophila Development
		The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily.
		Drosophila Wingless: a paradigm for the function and mechanisms of Wnt signaling (1994) E Siefgried, N Perrimon BioEssays 16, 395-404.
		atonal is the proneural gene for Drosophila photoreceptors.
	zebra.biol.sc.edu /~vogt/drosdev.html (3057 words)

	Drosophila.htm
		McGill Drosophila Genome Project was originally launched to generate genetic and molecular data from the 37-38 polytene region.
		DMPL Drosophila Membrane Protein Library is a collection of polytopic membrane protein sequences (containing two or more predicted membrane spanning domains) from Drosophila melanogaster.
		olfactory receptors of Drosophila, from the Olfactory Receptor Database
	biol.org /Drosophila.htm (2837 words)

	CiteULike: Tag drosophila (Site not responding. Last check: 2007-10-10)
		Uncoupling Dorsal-mediated activation from Dorsal-mediated repression in the Drosophila embryo.
		The Drosophila caspase DRONC is regulated by DIAP1.
		Gene Transposition as a Cause of Hybrid Sterility in Drosophila
	www.citeulike.org /tag/drosophila (1242 words)

	Drosophila Sequencing Stands As Genetic Research Milestone
		BERKELEY, CA — In 90 years of study, the diminutive fruit fly Drosophila melanogaster has yielded many of the most fundamental discoveries in genetics -- beginning with proof, in 1916, that the genes are located on the chromosomes.
		The Berkeley Drosophila Genome Project (BDGP) is supported by the Department of Energy, the National Human Genome Research Institute, and HHMI, with the largest of its facilities operated by the Life Sciences Division of the Department of Energy's Lawrence Berkeley National Laboratory.
		The purpose of the collaboration was to test whether a strategy known as whole-genome shotgun sequencing could be used on organisms having many thousands of genes encoded in millions of DNA base pairs; the strategy had proven effective for small bacterial genomes.
	www.lbl.gov /Science-Articles/Archive/drosophila-sequenced.html (855 words)

	Drosophila sites
		Lee, C.-M.., Yu, D.-S., Crews, S. and Kim, S.-H. The CNS midline cells and spitz class genes are required for proper patterning of Drosophila ventral neuroectoderm affect cell fate determination and formation of Drosophila ventral neuroblasts.
		Matthews, B. and Crews, S. The Drosophila center divider gene is expressed in the CNS midline cells and encodes a developmentally regulated protein kinase orthologous to human TESK1.
		Nambu, J. R., Franks, R. G., Hu, S., and Crews, S. The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells.
	www.unc.edu /~crews/Publications.htm (865 words)

	The Universe of Drosophila Genes -- Jasny 287 (5461): 2181 -- Science (Site not responding. Last check: 2007-10-10)
		The initial attempts to annotate the sequence in order to identify genes and begin to predict their function were made in a unique meeting that is described as "a Woodstock for science nerds" in the News story by Elizabeth Pennisi.
		The fruits of this labor can be found in a foldout summarizing the coding content of Drosophila and in discussions of the gene complement needed for fundamental operations, including DNA replication, transcription, and translation.
		The Drosophila genome provides further evidence that evolution to more complex forms of life does not principally depend on the generation of new genes, but on new combinations of protein domains or novel interactions.
	www.sciencemag.org /cgi/content/summary/287/5461/2181 (645 words)

	Drosophila genes/microbial infection (Site not responding. Last check: 2007-10-10)
		Drosophila genes with potential relevance to the immune response were identified via WU-BLAST 2.0 searches with recognition, signaling, and effector protein sequences against the Drosophila Genome Project blast server that contains 13601 predicted protein-coding genes representing about 99.7% of the genome.
		Protein matches with significant probability were examined further, often by identifying the closest nonfly match to the Drosophila gene in a blast search of the NCBI nonredundant databases.
		Some components of the Drosophila JAK/STAT pathway are involved in hemocyte proliferation and differentiation and in the expression of TEP genes in the fat body.
	www.cnrs-gif.fr /cgm/immunity/drosophila_immunity_genes.html (1084 words)

	96.05.01: Using Drosophila to Teach Genetics
		Drosophila melanogaster, or the red-eyed pomace fly, is classified in the family Drosophilidae, and order Diptera (which also includes flies, mosquitoes and midges.) Scientists study simple model systems in hopes of understanding principles that can apply to complex systems.
		Drosophila Chromosomes: In Drosophila melanogaster there are 4 homologous pairs of chromosomes: 2 pairs of large autosomes, (one slightly smaller than the other pair), 1 pair of very small autosomes, and a pair of sex chromosomes.
		In Drosophila, the genes for these recessive mutations are linked on the 1st or X chromosome: vermillion eyes (v), cross-veinless wings (cv), and cut wings (ct).In this activity, we will observe the phenotypes of offspring from a genetic cross(based on the experiental data of Thomas Hunt Morgan).
	www.yale.edu /ynhti/curriculum/units/1996/5/96.05.01.x.html (7261 words)

	WWW-VL: Drosophila
		Questions regarding Drosophila research should be posted to bionet.drosophila.
		The TIGR Drosophila gene index is a collection of known and predicted gene sequences from EST, cDNA and genomic data.
		The best source of up-to-date news on Drosophila, and a good place to ask and answer requests is the bionet.drosophila newsgroup on Usenet.
	ceolas.org /VL/fly (765 words)

	William Mattox, Ph.D.
		In Drosophila we have found that fusion of the testis with the reproductive tract depends on the morphogenesis of an epithelial layer at the posterior tip of the testis.
		The mechanism by which this occurs is almost entirely unknown but we have found that proteins from the DM family of transcription factors play a required role.
		Unni, E., Su, S. and Mattox W. (2003) Analysis of a null mutation in the Drosophila splicing regulator Tra2 suggests its function is restricted to sexual differentiation.
	www.mdanderson.org /~genedev/mattox.html (569 words)

	Amazon.com: Drosophila Protocols: Books: William Sullivan,M. Ashburner,R. Scott Hawley (Site not responding. Last check: 2007-10-10)
		Many of the topics discussed are cutting edge, such as the chapter on RNA interference, targeted cell ablation, and biochemical preparations from Drosophila (such as soluble nuclear extracts and membrane proteins).
		If the researcher is familiar with the techniques the troubleshooting sections need not be consulted, but if the researcher is a novice the troubleshooting sections are invaluable.
		Unfortunately a Drosophila manual is not available from either of these publishers, but this CSHL manual makes a good substitute.
	www.amazon.com /Drosophila-Protocols-William-Sullivan/dp/0879695862 (1596 words)

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