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Topic: Drug discovery

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	Drug discovery articles, jobs and information: drug discovery @ nature.com
		Drug discovery@nature.com is an information resource for everyone with an interest in drug discovery and development, bringing you regularly updated content from Nature Publishing Group titles.
		Sign up for our e-mail alert and have the latest drug discovery articles delivered straight to your inbox.
		Proteins, drug targets and the mechanisms they control: the simple truth about complex networks
	www.nature.com /drugdisc (151 words)

	New Web tool may speed drug discovery - The Boston Globe
		A clinical trial for that drug, which is already approved for another use, is likely to begin in the next few months -- a testament to the speed of the new approach.
		The utility of the database needs to be verified with a larger study, but scientists said it promises to accelerate drug discovery at a time when developing a new drug is frustratingly slow and expensive.
		Different types of cells typically respond slightly differently to drugs, but the team found that analyzing just a few types of cells, such as skin cells, was enough to make connections to diseases that affect organs as diverse as the brain and the prostate.
	www.boston.com /news/nation/articles/2006/09/29/new_web_tool_may_speed_drug_discovery (914 words)

	PPD About Drug Discovery and Development: Frequently Asked Questions (FAQ)
		PPD provides a broad array of discovery and development services and products to pharmaceutical, biotechnology and medical device companies to expedite drug development, from drug discovery through clinical studies and post-approval support.
		Drugs usually act on either cellular or genetic chemicals in the body, known as targets, which are believed to be associated with disease.
		For example, a drug that is intended to act on the sinuses may be formulated as a time-release capsule or as a nasal spray.
	www.ppdi.com /corporate/faq/about_drug_development/home.htm (1598 words)

	Drug Discovery at the NCI: Fact Sheet - National Cancer Institute
		A drug is first screened in a variety of human tumor cell lines growing in tissue culture dishes to test for its ability to prevent the growth of specific kinds of tumor cells.
		To expedite drug discovery, NCI is providing sample sets of more than 140,000 synthetic chemicals, 80,000 natural products extracted from plants and marine organisms, and other biological materials to investigators who might have discovered potential cancer-associated molecular targets.
		The drugs are administered to the mice at various dosages, and those compounds that kill or slow down the growth of specific tumors with minimal toxicity to the animal will proceed to the next stage of testing.
	www.cancer.gov /cancertopics/factsheet/NCIdrugdiscovery (2307 words)

	Biotechnology Information Directory - Genomics (Site not responding. Last check: )
		Drug Discovery Ltd. Library of plant-derived natural products formatted into microtiter plates ready for high throughput screening; isolation of active compounds and determination of chemical structures; integrated drug discovery service to provide lead compounds against client-specified therapeutic targets.
		Rigel drug discovery efforts are focused in the areas of cancer and immune diseases via technology that enables the discoverery of novel drug targets that can be regulated by small molecule drugs (formulated as pills that can be taken orally) without first having to know the genes involved.
		Scriptgen Pharmaceuticals Discovery of drugs to control the expression of genes; developing a variety of orally active antifungal, antibacterial and antiviral compounds that are suitable for development as new commercial therapeutics.
	www.cato.com /biotech/bio-genomics.html (5268 words)

	Johnson & Johnson: Research & Development: Drug Discovery
		A key component of our approach to drug discovery is using the latest information technology to mine genomic sequence data from public and private sources.
		The biological side of our drug discovery process is focused on particular protein families, from which we are currently studying drug targets in the areas of Immunology, Neuroscience, Bacterial Genomics, and Molecular Virology.
		In addition to screening small molecules as potential drugs, La Jolla has also developed proprietary technology for the isolation and expansion of antigen-specific T lymphocytes, for use in Cell Therapy of malignancies and viral and immunologic disorders.
	www.jnjpharmarnd.com /research/drugdisc.html (383 words)

	C&EN: Cover Story - Drug Discovery
		The report acknowledges disappointment over how few drugs have emerged in the 10 years since major HTS labs were established, but it argues that only in the past few years have scientists amassed the equipment, libraries, targets, and expertise necessary to advance compounds into the clinic with any efficiency.
		At Aventis, HTS is a core technology, according to Tina K. Garyantes, the firm's head of lead discovery technologies in the U.S. "It is the bread-and-butter way for pharmaceutical companies to figure out what chemical space to explore during lead optimization," she says.
		PTC Therapeutics, a drug discovery company that recently moved its first compound into clinical trials, makes extensive use of HTS as part of its post-transcriptional-control discovery platform, which aims to develop drugs that treat genetic disorders and diseases by altering how ribonucleic acid produces proteins.
	pubs.acs.org /cen/coverstory/8230/8230drugdiscovery.html (3655 words)

	Apath,LLC \| Drug Discovery
		There is an urgent need for drugs to treat the numerous viral diseases caused by RNA viruses for which limited or no therapeutic options are currently available.
		Drugs that inhibit viral proteins are more likely to be virus-specific, are more prone to the development of resistance, and, theoretically, are less toxic.
		Drugs that target cellular proteins are thought to be less likely to promote resistance, but are presumed to be more prone to toxicity.
	www.apath.com /Directory/Antiviral_Drug_Discovery/Drug_Discovery.asp (1733 words)

	Drug Discovery
		Major goal of drug discovery is the identification of a New Chemical Entity (NCE) with a particular biological activity and the determination of the profiles of the NCEs' other activities, e.g.
		Discovery for an NCE ends when the commercial development of that (or a closely related) compound begins.
		The driving forces to do drug discovery and later on drug development is the lack of suitable drugs on the market to cure e.
	www.bertholdtech.com /ww/en/pub/bioanalytik/biointerpages/drugdiscovery.cfm (154 words)

	Novel Targets in Drug Discovery
		Under the old paradigm, drug discovery began with the identification of a human disease and the development of an animal model of it.
		Using specific examples, it discusses the development of receptor theory, describes the role of second messengers in mediating the effects of drugs, and shows how the concept of drug receptors was gradually overtaken by an appreciation of targets in the wider sense.
		It describes benefits that genomic and post-genomic sciences promise to bring to the process of drug discovery, and discusses some of the criticisms leveled against the genetic reductionist approach to drug discovery.
	www.piribo.com /publications/drug_discovery/novel_targets_drug_discovery.html (872 words)

	Drug discovery - Drug research - Drug screening and development
		A new 3D model of the human liver that even has its own blood supply could pump new life into drug safety tests by predicting problems earlier and cut down on animal experiments, writes Mike Nagle.
		Talks between the drug industry and World Health Organization (WHO) member states over how narrow the health gap between rich and poor countries have stalled.
		Tripos Discovery Research (TDR) has risen from the ashes surrounding the liquidation of its previous owners Tripos, Inc. to land a 'library enrichment' deal with Schering-Plough.
	www.drugresearcher.com (465 words)

	Drug Discovery News: Genomics and Proteomics
		Vioxx and other withdrawn drugs are foremost in everybody’s mind, but in most cases it is the poor success rate of the routine discovery process that is driving the costs to unsustainable levels.
		Off-pathway or off-target drug effects are generally to blame for the failure of targeted therapeutics.
		Drug Discovery News is a monthly publication focused on covering issues, trends and product news that impacts decision makers in the pharmaceutical drug development and discovery arena.
	www.drugdiscoverynews.com /index.php?newsarticle=874 (735 words)

	Drug discovery & drug development glossary
		Drug 'developability' assessment has become an increasingly important addition to traditional drug efficacy and toxicity evaluations, as pharmaceutical scientists strive to accelerate drug discovery and development processes in a time- and cost-effective manner.
		Of poor drug candidates is central to the new drug discovery paradigm.
		The input of biocomputing in drug discovery is twofold: firstly the computer may help to optimise the pharmacological profile of existing drugs by guiding the synthesis of new and "better" compounds.
	www.genomicglossaries.com /content/drug_discovery_gloss.asp (7084 words)

	Drug Discovery Outsourcing Market in India and China: Industry Research Report
		Since drug discovery involves tremendous risks as well as painstaking research and testing, market participants have invested heavily in emerging markets and processes, as they are glad for any catalyst.
		A drug for a previously incurable disease can generate as much as $1 billion in revenues and the first mover in the market can potentially acquire 75 per cent of the market shares.
		The Indian and Chinese drug discovery industries are evolving, with both gaining an edge in the global arena by producing a continual pipeline of drugs that are approved faster than those produced in Western countries.
	www.mindbranch.com /products/R1-4469.html (609 words)

	Mass Spectrometry - Elemental Analysis - Drug Discovery Thermo Scientific
		Drug discovery is a rapidly growing sector of pharmaceutical industry.
		Drug research encompasses diverse disciplines united by a common goal: the development of novel therapeutic agents.
		A dedicated LIMS for early stage discovery in biotechnology RandD, Nautilus' new functionality was developed to better serve customers in drug discovery and extends your informatics capabilities for high throughput environments.
	www.thermo.com /com/cda/market/landing_page/0,1092,1,00.html (223 words)

	MEDICURE
		The objective of Medicure's Drug Discovery Program is to develop new chemical entities with commercial potential to meet unmet cardiovascular and cerebrovascular market needs.
		Through this approach, the Drug Discovery Program has produced hundreds of new chemical entities and several new leads have been generated for pre-clinical development.
		A drug of this type currently is non-existent within the antithrombotic marketplace.
	www.medicure.com /drugdiscovery.html (344 words)

	BD (Becton, Dickinson and Company) - Global Initiatives - Drug Discovery
		For scientists engaged in basic research or drug discovery, this combination of competencies makes BD Biosciences a supplier of choice.
		It also complements BD's expertise in drug toxicity testing, which remains a hurdle in the drug discovery process; it links well with Pharmingen's expertise in fluorescent proteins; and it fits well with Discovery Labware's plates for imaging.
		For drug companies involved in the high throughput screening used for drug discovery, the Pathway HT™ system delivers high content analysis earlier in the process.
	www.bd.com /aboutbd/global/drug_discovery.asp (660 words)

	Seeding Drug Discovery scheme
		With these considerations in mind, the Wellcome Trust wishes to facilitate interdisciplinary research groups to engage in early drug discovery projects where this builds on novel perspectives from the study of disease mechanisms or the activity of compounds.
		Where necessary, applicants should access the many specialist resources and skills of drug discovery that are available from contract research organisations or laboratories able to offer fee-for-service or other assistance (e.g.
		Engagement with drug discovery experts will be key for designing and implementing the project and troubleshooting particular problems, as they arise.
	www.wellcome.ac.uk /node2630.html (773 words)

	Discovery Health :: Drug Reference :: Select Drug
		Discovery Health :: Drug Reference :: Select Drug
		To get more information on another drug, simply select the letter below which corresponds to the first letter of the drug you are interested in.
		Once you have identified a couple of different drugs, get an idea of the interaction between the drugs with our drug interaction checker.
	health.discovery.com /encyclopedias/checker/checker.jsp (94 words)

	CHI - Drug Discovery Japan
		Drug Discovery Japan brings together leading researchers from around the world to discuss their experiences with many aspects of the drug discovery process from bioinformatics, proteomics, target identification and validation, to screening of combinatorial libraries, structure-based drug design, and ADME/Tox studies.
		At the drug discovery stage, it is very important to provide information about critical aspects of PK/ADME of a candidate, including extent of absorption (transporter and insolubility), half-life, bioavailability, occurrence of active metabolite, major interspecies differences, inhibition and induction of CYPs (CYP1A1 or CYP3A4), and early in vitro studies in human tissues.
		In keeping with other parts of the drug discovery process, lead optimization is thus heading for the age of informatics-driven predictive models to aid decision making and drug design.
	www.healthtech.com /2002/mhj (5412 words)

	Drug Discovery - The Pending Crisis
		As an academician, government researcher, and drug industry executive, he understands only too well how drug research is done and when it is leading us.
		It seems that a constant flow of obstacles has created a socially dangerous and administratively ponderous milieu that hinders drug evaluation in man. Yet history clearly teaches that drugs are discovered in man. More exploratory clinical research, therefore, must be done.
		This book's important message-to me at least-is that we are stressing the nonclinical aspects of drug development too much and not stressing sufficiently the early and adequate study of drug candidates in man.
	www.fimdefelice.org /books/books.drugdiscover.html (884 words)

	Forum on Drug Discovery, Development, and Translation - Institute of Medicine
		The Institute of Medicine (IOM) Forum on Drug Discovery, Development, and Translation (the Forum) provides a unique opportunity for stakeholders to meet and discuss issues of mutual interest in a neutral setting.
		The range of issues the Forum addresses includes the full drug development pipeline—from drug discovery and regulatory approval to translation of research into clinical practice.
		Workshops slated for 2007 include topics such as: resource requirements for effectively regulating drug safety; managing conflicts of interest in drug research; streamlining intellectual property right negotiations; regulation of follow-on biologics; and development of drugs for neglected diseases.
	www.iom.edu /?id=30087 (272 words)

	In the Pipeline:
		Surveillance, everyone agrees, is probably the best way to get useful data on drugs and their performance in the real world, but (as has been pointed out), no one wants to hear about how that's surely going to drive up drug costs.
		Noting the similarities between drug launches and movie launches (an idea that's been floating around for a few years now), he (or she) advocates learning from the studios that have been best at developing and managing creativity.
		I have over seventeen years of drug discovery experience that I'd be glad to use on the behalf of anyone who feels that it might be valuable.
	www.corante.com /pipeline (13341 words)

	Mycology Workshop: Drug Discovery (Site not responding. Last check: )
		Although azoles continue to be an important component of the patent literature, natural products continue to be an important source for drug discovery.
		An overview of the antifungal discovery program based at pharmaceutical companies was presented through three representative examples: Shaman Pharmaceuticals, Abbott Laboratories, and Merck.
		Such screening has led to the discovery of the pneumocandins: potent inhibitors of fungal glucan synthase.
	www.niaid.nih.gov /dmid/meetings/mycology94/drug.htm (539 words)

	Institute for Tuberculosis Research - Projects to Drug Discovery
		The ITR is pursuing several strategies for discovery of new anti-TB agents.
		This library is being screened for the Global Alliance for TB Drug Development.
		Indirect determinations of viability (and thus drug activity) can be completed in a less than a week by measuring some aspect of metabolism.
	www.uic.edu /pharmacy/research/itr/content/projects.htm (536 words)

	Drug Discovery 2005: Science Online Special Collection
		News articles in Science provide inside perspectives on the drug discovery process and on working in pharma both in the U.S. and in other countries.
		And Science's Next Wave profiles Johnson and Johnson's associate director of clinical drug evaluation, as part of a special feature on careers in industrial research.
		Michael King is the associate director of clinical drug evaluation at Johnson and Johnson.
	www.sciencemag.org /sciext/drugdisc05 (336 words)

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