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Topic: Drug-drug interaction

    Note: these results are not from the primary (high quality) database.

Center for Drug Safety Offers E-Prescribing, CPOE, After Hours Review, Drug Interaction and Patient Safety Drug interaction is how one or more drugs interact with each other, food and patient specific conditions such as height, weight, age, gender, race, and existing disease states. Checking for drug interactions is critical to your good health. The truth is drugs of all types can cause drug interaction problems including over-the-counter drugs, vitamins, herbs and other alternative medicines. www.centerfordrugsafety.org

Drug Interaction Disclaimer Drug interaction information in Healthnotes is not intended to replace information supplied by a doctor or pharmacist; neither is it intended to replace package inserts or other printed material that may be available or accompany a particular drug. It is always wise for people seeking information about interactions between a prescription drug and food, specific nutrients, or herbs to talk with their pharmacist, prescribing physician, or both. Instead, Healthnotes reviews known major interactions between pharmaceutical drugs and food, specific nutrients, and herbs—for example, inhibition of vitamin K caused by antibiotics or iron deficiency triggered by long-term use of aspirin. www.pugetconsumerscoop.org /health/Drug/Drug_Disclaimer.htm

Drug Interaction Information Drug interactions may make your drug less effective, cause unexpected side effects or increase the action of a particular drug. Reading the label every time you use a nonprescription or prescription drug and taking the time to learn about drug interactions may be critical to your health. For example, mixing a drug you take to help you sleep (a sedative) and a drug you take for allergies (an antihistamine) can slow your reactions and make driving a car or operating machinery dangerous. www.cfhinfo.org /educationResources/drug.html

Drug Interaction Classification Systems It is common for drug interaction studies done in healthy individuals under controlled conditions to demonstrate a 5- to 7-fold difference in effect between participants. Knowledge of the mechanisms of drug interactions has increased markedly in the past few years, yet almost nothing is known about their epidemiology. The unpredictability of drug interaction outcomes hinders one's ability to generalize interaction severity classifications. www.pharmacytimes.com /article.cfm?ID=1436

Drug Interaction Significance Rating Scale Adverse Drug Interactions in Dentistry: Sedatives and Anxiolytics These articles discussed ways that drug interactions could be classified for their relative importance and the interactions with drugs that dentists commonly use in practice. With the exception of the antituberculosis drug rifampin, clinical studies have failed to demonstrate an interaction. www.db.uth.tmc.edu /faculty/vlewis/Vahnspage/2561/Drug_Interactions.htm

Holistic Heart Health Holistic Heart Health (“HHH”) is not responsible for the results of your decisions resulting from the use of the Drug/Supplement Interaction page service, including, but not limited to, your choosing to seek or not to seek professional medical care, or from choosing or not choosing a specific treatment. Disclaimer: The information provided regarding drug/supplement side effects and interactions are presented as being the most up-to-date and accurate data available to the best of Holistic Heart Health’s (“HHH”) current knowledge. To view drug/supplement interactions, select one or more of the following cardiovascular supplements as well as other potentially interacting supplements and prescription drugs and press search. www.holistichearthealth.com /interaction.asp

Herb-Drug Interaction The nature of herb-drug interactions is not a chemical interaction between a drug and an herb component to produce something toxic. In the UK, where the drug was prescribed to 400,000 patients, experts estimate nearly 1000 people may have developed heart failure as a result of taking Vioxx, The Scotsman reports. The constitution and overall heath of the patient, the strength and severity of the pathogen, diet and lifestyle, are some of the most critical factors in determining drug intervention. www.happyherbalist.com /herb-drug_interaction.htm

The Body: Drug Interactions With the number of drugs available to treat HIV and with those that prevent or treat opportunistic infections (OIs), the potential for drug interactions increases. Drug interactions may play a major role in the success of any treatment plan. Not everyone experiences side effects; and many drug interactions can be managed by monitoring carefully, adjusting the doses, or stopping the therapy as needed. www.thebody.com /pinf/interact.html

Drug-DNA interaction DNA as carrier of genetic information is a major target for drug interaction because of the ability to interfere with transcription (gene expression and protein synthesis) and DNA replication, a major step in cell growth and division. Improvement of anticancer drugs based on intercalating activity is not only focussed on DNA-ligand interaction, but also on tissue distribution and toxic side effects on the heart (cardiac toxicity) due to redox reduction of the aromatic rings and subsequent free radical formation. This type of interaction is found in intercalating substrates because the hydrophobic, aromatic sidechains interactive favorably with the aromatic environment of the base pair stacking. www.whatislife.com /reader/drugbinding/drugDNA.html

Update on Natural Product-Drug Interaction Interactions between natural products and drugs are based on the same pharmacokinetic and pharmacodynamic principles as drug-drug interactions. There are no specific requirements for including warnings about known or potential drug interactions on supplement labels, despite improved FDA requirements developed in response to findings by the Commission on Dietary Supplement Labels. In addition to interacting pharmacokinetically with drugs or with other natural products, a natural product may interact pharmacodynamically. www.fmaware.org /patient/coping/update_naturalprod.htm

Drug Topics - Drug interaction monitoring: Good, bad, and ugly The drug interactions that trigger an alert should be user-defined, thus reducing the number of insignificant alerts and minimizing the misuse of the software. Community pharmacists should be fully knowledgeable of those drug interactions known to cause harm and not have to over-rely on computers to prevent harm (Table 3). Most of the information about drug interactions is based on case reports, leading to an overabundance of drug interactions in databases. www.drugtopics.com /drugtopics/article/articleDetail.jsp?id=111079

Grapefruit/Drug Interaction The mechanism of the drug-drug interaction appears to primarily result from inhibition of CYP3A4 in the intestinal wall and is most important for drugs with high first pass metabolism. For drugs that are significantly impacted by this interaction, one glass (8 ounces or 250 mL) of grapefruit juice is enough to cause the interaction, and following regular ingestion, the effect can last for up to three days following the last glass. The authors of this study concluded that it would be necessary to withhold grapefruit juice for at least three days before administration of this drug in order to avoid a drug interaction. www.yafferuden.com /html/grapefruit_drug_interaction.html

Drug Interaction The Drug Interaction Service is not a substitute for the care provided by licensed health care providers and you are urged to consult with your health care provider in all instances. The Drug Interaction Service is an informational resource designed to assist licensed health care providers in caring for their patients and provide consumers with drug-specific information. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate. www.personalmd.com /drug_02.shtml

CollectiveMed - iFacts (Drug Interaction Facts) Drug interactions are rated for significance, (on a scale of 1 to 5, 1 being the most serious, e.g. Drug interaction screening tool with more than 1,300 detailed monographs covering 20,000 brand and generic drugs. Drug Interaction Facts is a registered trademark of Facts and Comparisons. www.collectivemed.com /jump/ifact.shtml

Saga Health News - What is a drug interaction? Many drug interactions have been well recognised for a long time, but their effects in individuals are somewhat complex and unpredictable. If a drug interaction occurs, it may mean that one of the drugs doesn't work as well as intended or doesn't work at all. One way is for one drug to combine with another or with a food or a vitamin in the intestine to form a compound that is not so readily absorbed. www.saga.co.uk /health_news/article/20EEC09C-E4DC-11D5-B882-00508BAEC55C.asp

CHEST: Gemfibrozil-warfarin drug interaction resulting in profound hypoprothrombinemia Numerous drug interactions with warfarin have been well documented.[1] One interaction that may be over looked is the combination of gemfibrozil and warfarin. The paucity of reported drug interactions with gemfibrozil suggests that this agent does not significantly interfere with the disposition or action of most drugs, including warfarin. Few other drug interactions have been described with gemfibrozil. www.findarticles.com /p/articles/mi_m0984/is_n2_v114/ai_21081763

Drug Interaction & Dietary Supplements Safety Information Drug interaction information provided in Healthnotes is not intended to replace information supplied by a doctor or pharmacist; neither is it intended to replace package inserts or other printed material that may be available or accompany a particular drug. A special concern is potential interaction between a dietary supplement and any prescription or OTC (over the counter) drugs you may be taking. A special concern is potential interaction between a supplement and any prescription or OTC drugs you may be taking. www.myvitaminguide.com /public/department48.cfm

Discovery Health :: Drug Reference Once you have identified a couple of different drugs, get an idea of the interaction between the drugs with our drug interaction checker. To get more information on another drug, simply select the letter in the pulldown which corresponds to the first letter of the drug you are interested in. The leading global real-world media and entertainment company. health.discovery.com /encyclopedias/checker/checker.jsp?jspLetter=A

Forum for Collaborative HIV Research These interactions have tremendous impact on the effectiveness of anti-viral treatment regimens and other medications, can create additional toxicities, but, too often, the interactions are not well researched prior to or after marketing of the drugs. The Forum agreed to seek ways to facilitate the sharing of investigational agents for drug interaction studies by acting as a conduit for requests to industry for the compounds. The Forum is now in the process of developing an internet-based system to assist investigators seeking to undertake drug interaction studies by linking them with the appropriate contact persons at pharmaceutical companies. www.hivforum.org /projects/interaction.htm

Personal Health Zone: Drug Interactions Drug interactions and side effects can vary from person to person and can be mild or severe. Consult with your primary care physician about any potential drug interactions before taking other medications, herbs or supplements. The drug database presented here may not be all inclusive or completely up to date since information is constantly evolving. www.personalhealthzone.com /pg000059.html

Drug Interaction Charts Intro The exact mechanism of interaction with drugs such as didanosine and atazanavir remains unclear although it is likely that this involves alteration of cellular transport mechanisms. The charts on this site are a guide to interactions that may occur between different anti-HIV drugs and other medications that the HIV+ patient may be prescribed. For this reason some drug combinations should not be given at all, while other drugs may be used together with caution, possibly requiring adjustments to dosage or time of administration. www.hiv-druginteractions.org /drug/drg_main.htm

Drug Interactions The other drug interaction tool is a part of the drkoop.com site. But its Drug Interactions database is easy to use once you find it. Either the MedicineNet.com or Drugstore.com drug interactions areas are worthy of your attention. www.mendosa.com /interactions.htm

Drug Interactions A drug interaction occurs when the effect of a particular drug is altered when it is taken with another drug, or with food. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. www.drugs.com /index.cfm?pageID=1150

FDA/National Consumers League - Pamphlet on Food and Drug Interactions Many medicines have powerful ingredients that interact with the human body in different ways, and diet and lifestyle can sometimes have a significant impact on a drug's ability to work in the body. It is also important to remember that many drugs interact with other drugs and may cause serious medical conditions. These drugs are often used in combination to enhance their effectiveness. vm.cfsan.fda.gov /~lrd/fdinter.html

Drug Interaction Web Site For example, warfarin is a blood thinning agent that has the largest number and most severe drug interactions associated with its use. If you are concerned about potentially harmful interactions between drugs you are taking, you can easily check any combination of drugs at DrugDigest®, Express Scripts' consumer health and drug information website. The top ten drugs checked for interaction were: aspirin, warfarin, acetaminophen, ibuprofen, phentermine, Prozac®, Xanax®, Zoloft®, digoxin, and furosemide. www.compukiss.com /populartopics/healthhtm/article956.htm

Drug Lawsuit: Drug-Drug Interaction: Serious Reaction The Law Offices of Thomas J. Lamb, P.A. represents patients and their families when there is a death or injury caused by a medication mistake, a drug-drug interaction, or a serious reaction to a prescription drug. Drug injury situations such as these are often caused by medical error, hospital negligence, or negligence on the part of doctors, nurses, or pharmacists. If you, relatives, or friends need legal advice or legal representation for a possible claim for legal compensation involving a drug injury which may have been caused by medical errors or hospital negligence, the Law Offices of Thomas J. Lamb, P.A. is available to discuss the case at any time, free of charge. www.druginjurylaw.com /prescription-drug-injury.html

Prescription Drug Interaction Problems Statistically, a person taking eight medications can expect at least one drug interaction problem that will negatively affect his or her health, Anderson says. About one in every three people over 65 will have some sort of adverse medication event that requires a hospital visit, according to Duxbury, and some 10% to 15% of all emergency room visits are related to medication reactions or drug interaction problems in seniors. For example, if you're taking a medication that has blood-thinning properties and then begin to take aspirin on a regular basis, and your doctor doesn't know about both, it can put you in danger of uncontrolled bleeding. my.webmd.com /content/article/61/67565.htm

Drug-Interactions.com A drug appears in a column if there is published evidence that it is metabolized, at least in part, via that isoform. It does not necessarily follow that the isoform is the principal metabolic pathway in vivo, or that alterations in the rate of the metabolic reaction catalyzed by that isoform will have large effects on the pharmacokinetics of the drug. The table contains lists of drugs in columns under the designation of specific cytochrome P450 isoforms. medicine.iupui.edu /flockhart

Drug Interaction Checker Drug interactions may result in potentially serious side effects or they can prevent a medicine from working as intended. A drug interaction database is available at Drugs.com. Drugs.com is a prescription drugs information web search engine for use by both professionals and consumers. www.drug-interaction.com

Drug Interaction Checker Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. The Drug Interaction Checker uses information provided by Micromedex. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. www.drugstore.com /pharmacy/drugchecker?aid=332828&aparam=sespider

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