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Topic: DsRNA virus

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	Those magnificent molecular machines: logistics in dsRNA virus transcription -- Bamford 3 (4): 317 -- EMBO Reports (Site not responding. Last check: 2007-10-15)
		virus genomes are often segmented (up to 12 segments).
		A schematic illustration of a dsRNA virus genome replication cycle.
		Makeyev, E. and Bamford, D.H. (2000b) The polymerase subunit of a dsRNA virus plays a central role in regulation of viral RNA metabolism.
	emboreports.npgjournals.com /cgi/content/full/3/4/317 (1204 words)

	dsRNA viruses: Bluetongue virus - The dsRNA genome segments and proteins of BTV-10 ( genus Orbivirus: family Reoviridae)
		Trimer [15], controls virus serotype, serotype specific antigen [6, 19, 32, 33, 39], cell attachment protein [17, 29, 30], outer layer of the outer capsid [15, 19, 29, 39], contains neutralising epitopes [17, 30], most variable protein [32, 38, 39], involved in determination of virulence [35] cleaved by proteases [19, 29, 30].
		Cowley, J. A., and Gorman, B. (1989) Cross-neutralisation of genetic reassortants of bluetongue virus serotypes 20 and 21.
		Mertens, P. C., Burroughs, J. and Anderson, J. (1987) Purification and properties of virus particles, infectious subviral particles, and cores of bluetongue virus serotype 1 and 4.
	www.iah.bbsrc.ac.uk /dsRNA_virus_proteins/BTV.htm (1911 words)

	Activation of NF-{kappa}B by Double-Stranded RNA (dsRNA) in the Absence of Protein Kinase R and RNase L Demonstrates ... (Site not responding. Last check: 2007-10-15)
		dsRNA triggers the phosphorylation, polyubiquitinylation, and proteosome-mediated degradation of I
		the dsRNA response (lanes 3, 6, 9, and 12).
		An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs.
	mcb.asm.org /cgi/content/full/21/1/61 (6414 words)

	ILL ANNUAL REPORT 2002
		Typical lifecycle of a dsRNA virus is exemplified in figure 1 using bacteriophage φ6, a model organism for studying assembly and replication of other dsRNA viruses.
		The virion, containing 3 dsRNA segments S (small), M (medium), L (large) attaches to the host cell (a) and the polymerase complex penetrates the host membranes and loses both the envelope and the nucleocapsid coat (b).
		This indicates that the position of the polymerase machinery is conserved across a wide range of dsRNA virus species and is dictated by similar genomic organisation and replication mode.
	www.ill.fr /AR-02/site/areport/fb_60.htm (1099 words)

	Jack Johnson/Anette Schneemann Lab Page,Research (Site not responding. Last check: 2007-10-15)
		L-A virus is a yeast virus with dsRNA genome.
		Unlike other static virus capsids, the coat protein in L-A virus is an enzyme important for the survival of this virus.
		The structure of this T=4 virus was determined in 1996 to 2.8 Å resolution, and surprisingly many similarities existed between its structure and those of the nodaviruses, even though the coat protein is much larger and shows no sequence similarity.
	lav.scripps.edu /research.shtml (1330 words)

	A Comprehensive View of Regulation of Gene Expression by Double-Stranded RNA-Mediated Cell Signaling.
		Virtually nothing is known about how dsRNA affects viral and cellular gene expression and functions in a virally infected cell, although the role of PKR, the dsRNA-activated protein kinase, in inhibiting protein synthesis has been studied in cells infected with a variety of viruses (2).
		Those in Group A are induced by dsRNA, IFN, or several viruses; genes in Group B are induced by IFN and viral infection; those in Group C are induced by dsRNA and viruses; and the Group D genes are induced by dsRNA and IFN.
		In the context of the equilibrium maintained between a virus and its host cells, some of these proteins may contribute to the host defense mechanisms whereas others may be used by the virus to evade the host defense.
	www.euchromatin.org /Geiss01.htm (4255 words)

	The polymerase subunit of a dsRNA virus plays a central role in the regulation of viral RNA metabolism (Site not responding. Last check: 2007-10-15)
		The mature virus particles are released by lysis of the host cell.
		The positions of the three different forms of the labeled RNA probe are marked on the right: the bold line represents the labeled (shorter) strand and the thin line shows the unlabeled (longer) strand.
		Figure 8 Role of the (-)strand 3' penultimate nucleotide in the differential transcription of dsRNA.
	www.nature.com /emboj/journal/v19/n22/fig_tab/7593440ft.html (1388 words)

	From the Cover: RNA interference acts as a natural antiviral response to O'nyong-nyong virus (Alphavirus; Togaviridae) ... (Site not responding. Last check: 2007-10-15)
		genome, virus replication in the mosquito was compromised significantly.
		of virus and dsRNA, dsRNA was diluted to a concentration of
		dsRNAs derived from AgAgo1, AgAgo3, AgAgo4, and AgAgo5 (20).
	www.pnas.org /cgi/content/full/101/49/17240 (3712 words)

	Double-Stranded RNA Mycovirus from Fusarium graminearum -- Chu et al. 68 (5): 2529 -- Applied and Environmental ... (Site not responding. Last check: 2007-10-15)
		The presence or absence of the 7.5-kb dsRNA was
		A 7.5-kb dsRNA was present in all of the F.
		Conserved sequence motifs in the RNA-dependent RNA polymerases (RdRp) (A) and helicases (B) of positive-strand RNA viruses, related dsRNA viruses, and the 7.5-kb dsRNA of strain DK21.
	aem.asm.org /cgi/content/full/68/5/2529 (4320 words)

	Precise Packaging of the Three Genomic Segments of the Double-Stranded-RNA Bacteriophage phi 6 -- Mindich 63 (1): 149 ... (Site not responding. Last check: 2007-10-15)
		P511 is a lytic endopeptidase that is associated with the surface of the nucleocapsid (4, 43).
		Lanes: v, wild-type virus, a, virus missing gene 3 of segment M; b and c, virus as in lane a that has acquired transcript RNA as a fourth segment.
		dsRNA from a virion that has the entire genome in one 14-kbp segment with the pac sequence of S. Lanes: v, RNA from wild type virus; a, RNA from the virus with the entire genome in one segment (62).
	mmbr.asm.org /cgi/content/full/63/1/149 (7171 words)

	Molecular characterization of the genome of a partitivirus from the basidiomycete Rhizoctonia solani -- Strauss et al. ... (Site not responding. Last check: 2007-10-15)
		solani strain 717 infected with the bisegmented dsRNA virus 717.
		Lakshman, D. K., Jian, J. and Tavantzis, S. A double-stranded RNA element from a hypovirulent strain of Rhizoctonia solani occurs in DNA form and is genetically related to the pentafunctional AROM protein of the shikimate pathway.
		Molecular characterization of Penicillium chrysogenum virus: reconsideration of the taxonomy of the genus Chrysovirus
	vir.sgmjournals.org /cgi/content/full/81/2/549 (3337 words)

	Paul Ahlquist
		Because virus diversity and rapid evolution pose great barriers to control, one of our goals is to identify broadly conserved virus features that can serve as a basis for broad-spectrum antiviral strategies.
		The results show that these three virus classes share similarities in the form and function of their replication complexes and may have evolved from common precursors, supporting a significant unification across virology.
		In nearly 60 cases, deleting a particular cell gene inhibited virus replication, showing that this gene is exploited by the virus to support its replication.
	www.hhmi.org /research/investigators/ahlquist.html (1298 words)

	Structure of L-A Virus: A Specialized Compartment for the Transcription and Replication of Double-stranded RNA -- ... (Site not responding. Last check: 2007-10-15)
		Three-dimensional structures of maturable and abortive capsids of equine herpes virus 1 from cryoelectron microscopy.
		Fungal virus capsids: cytoplasmic compartments for the replication of double-stranded RNA formed as icosahedral shells of asymmetric Gag dimers.
		Uncoating of parental bluetongue virus to core and subcore particles in infected L cells.
	www.jcb.org /cgi/content/full/138/5/975 (6307 words)

	David Stuart, LMB Progress Report '97/'98 (Site not responding. Last check: 2007-10-15)
		This residue is a histidine in field isolates of the virus, switching to an arginine on adaptation to tissue culture.
		Further anomalies of receptor usage relate to multiply passaged C serotype viruses and we are currently investigating the structure of a virus which has a mutation in the RGD motif which is usually required for integrin recognition.
		We are using BTV as a model dsRNA virus and are attempting to illuminate its biological function by a variety of techniques.
	biop.ox.ac.uk /www/lab_journal_1998/Stuart.html (4699 words)

	Johnson & Schneeman Publication Page (Site not responding. Last check: 2007-10-15)
		Influence of 3- dimensional structure on the immunogenicity of a peptide expressed on the surface of a plant virus.
		Taylor, D. J., Krishna, N. K., Canady, M. A., Schneemann, A., and Johnson, J. Large-scale, pH-dependent, quaternary structure changes in an RNA virus capsid are reversible in the absence of subunit autoproteolysis.
		Use of recombinant baculoviruses in synthesis of morphologically distinct viruslike particles of flock house virus, a nodavirus.
	lav.scripps.edu /recpapers/recpapers.shtml (7929 words)

	The Bamford Laboratory - Publications (Site not responding. Last check: 2007-10-15)
		Cloning and sequence analysis of dsRNA segments 5, 6 and 7 of a novel non-group A, B, C adult rotavirus that caused an outbreak of gastroenteritis in China.
		Intermediates in the assembly pathway of the double-stranded RNA virus phi6.
		Assembly of double-stranded RNA Viruses: bacteriophage phi6 and yeast virus.
	www.dblab.helsinki.fi /homepage/publications.html (4864 words)

	van Diepeningen et al FGN 47, pg 99-100
		Similarities between the genome organisation of dsRNA mycoviruses and dsRNA patterns in different fungal species suggest a relatedness between these viruses, which could be the result of co-evolved infections or of interspecies transfer.
		Similarities between the genome organisation of dsRNA mycoviruses and dsRNA patterns in different fungal species, suggest a relatedness between these viruses, which could be the result of coevolved infections or of interspecies transfer.
		The similarity between dsRNA virus patterns as found in all natural isolates of F.poae and in approximately 10% of the wild fl Aspergilli, combined with the observation that dsRNAs from F.
	www.fgsc.net /fgn47/47Diepeningen.htm (922 words)

	Noncoding RNA danger motifs bridge innate and adaptive immunity and are potent adjuvants for vaccination -- Wang et al. ... (Site not responding. Last check: 2007-10-15)
		The T cell response to antigen together with pA:pU was compared with the response to immunization with antigen alone or to influenza virus infection.
		(d and e) The effect of dsRNA from influenza virus–infected cells on the response to an antigen (gp140) was measured subsequent to immunization with antigen + dsRNA.
		(e) Schematic depiction of the involvement of dsRNA danger motifs in the regulation of immunity: detection of dsRNA motifs triggers a "master switch" for B and T cell responses to coexisting antigens.
	www.jci.org /cgi/content/full/110/8/1175 (6223 words)

	The [KIL-d] Cytoplasmic Genetic Element of Yeast Results in Epigenetic Regulation of Viral M Double-Stranded RNA Gene ... (Site not responding. Last check: 2007-10-15)
		Killer virus of yeast is a cytoplasmically inherited dsRNA virus
		yeast cells not harboring the virus, and are resistant to the
		this trait was inherited with the dsRNA genome of killer virus.
	www.genetics.org /cgi/content/full/150/1/21 (4535 words)

	INTEGRATING OF KNOWLEDGE ON REGULATION OF MX1 PROTEIN INDUCTION AND ANTIVIRAL ACTION BY A MATHEMATICAL MODELING APPROACH
		Both the course and the outcome of infection are influenced on the one hand by virus cytopathogenicity, rapidity of spread, generation time, susceptibility to interferon etc, and on the other hand by the efficiency of antiviral defense.
		The regularities of influenza virus multiplication and different production strategies of virus- and IFN-inducible Mx1 proteins permit to assume that Mx1 proteins being induced by means of alternative mechanisms inhibit different steps of the virus multiplication cycle and this results in different efficacy of cell protection.
		In this case, Mx1 protein produces in infected cells in late stage of virus replication cycle and therefore is unable to block virus spread.
	www.bionet.nsc.ru /bgrs/thesis/25 (1677 words)

	Transfection of Diaporthe perjuncta with Diaporthe RNA Virus -- Moleleki et al. 69 (7): 3952 -- Applied and ... (Site not responding. Last check: 2007-10-15)
		Transfection of Diaporthe perjuncta with Diaporthe RNA Virus -- Moleleki et al.
		Papain-like protease p29 as a symptom determinant encoded by a hypovirulence-associated virus of the chestnut blight fungus.
		Dodds, J. Revised estimates of the molecular weights of dsRNA segments in hypovirulent strains of Endothia parasitica.
	aem.asm.org /cgi/content/full/69/7/3952 (3006 words)

	Michael R. Roner
		How a virus with a multi-segmented genome assorts its genome to assemble new progeny virus particles has persisted as a difficult question to address.
		Using reovirus, a 10-segmented dsRNA virus producing progeny virus with infectivity approaching 100%, we have taken a major step toward understanding the mechanisms involved.
		Our work has established a firm foundation from which studies can be initiated into the assortment and encapsidation of the segmented dsRNA genomes of the remaining members of the family Reoviridae, and additional viruses with segmented genomes.
	www.uta.edu /biology/roner (511 words)

	Ueda s, Uyeda I, 1997. The rice dwarf phytoreovirus structural protein P7 possesses non-specific nucleic acid binding ...
		The decrease in the activity is probably due to reduction of P1 molecules and is consistent with the proposed function of P1 as a core RNA polymerase predicted from the amino acid sequence (Suzuki et al., 1992).
		RNA polymerase of influenza virus: role of NP in RNA chain elongation.
		Characterization of RNAs synthesized by the virion-associated transcriptase of rice dwarf virus in vitro.
	www.bspp.org.uk /mppol/1997/0123ueda (2934 words)

	Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKR -- Li and ... (Site not responding. Last check: 2007-10-15)
		) mice are not susceptible to virus infection (11, 12) with
		to dsRNA (30-33) and heterodimerize with WT PKR in yeast two-hybrid
		Binding of dsRNA induces PKR homodimerization and exposes the kinase domain, resulting in activation by autophosphorylation (61).
	www.jbc.org /cgi/content/full/276/17/13881 (6613 words)

	A Novel Virus-Host Cell Membrane Interaction: Membrane Voltage-Dependent Endocytic-like Entry of Bacteriophage {phi}6 ... (Site not responding. Last check: 2007-10-15)
		virus utilizes the host cell's machineries to reach its goal.
		virus, canine parvovirus, and simian virus 40 (SV40) infections
		and, in a mature virus, the NC is enclosed by a lipid envelope
	www.jcb.org /cgi/content/full/147/3/671 (6230 words)

	Bamboo Forums - Viruses - National Center for Biotechnology Information
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		Disclaimer: The National Center for Biotechnology Information (NCBI) taxonomy database is not an authoritative source for nomenclature or classification - please consult the relevant scientific literature for the most reliable information.
	www.bamboocraft.net /forums/archive/index.php/t-832.html (279 words)

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