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	Duloxetine (Cymbalta®)
		Duloxetine hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) that is indicated for the treatment of major depressive disorder (MDD) and for the management of neuropathic pain associated with diabetic peripheral neuropathy (DPN).
		Duloxetine was approved in August 2004 for treating MDD and is considered an alternative to other antidepressants to treat the emotional and painful physical symptoms of depression.
		Duloxetine and thioridazine should not be co-administered because of the increased risk of ventricular arrhythmias and sudden death associated with elevated plasma levels of thioridazine.
	uuhsc.utah.edu /pharmacy/bulletins/duloxetine.html (951 words)

	DULOXETINE (MDXexchange)
		Duloxetine is the (+)-isomer of the racemic compound (Wong et al, 1993).
		Duloxetine is a secondary amine, whereas venlafaxine and milnacipran are tertiary amines.
		The dose of duloxetine in 2 studies (n=245 and n=267) was 60 milligrams (mg) once daily for 8 weeks; in one study (n=266), the dose was 20 or 40 mg twice daily for 8 weeks; and in a fourth study (n=281), the dose was 40 or 60 mg twice daily for 8 weeks.
	www.micromedex.com /products/updates/drugdex_updates/de/duloxetine.html (3750 words)

	Duloxetine Information on Healthline
		Duloxetine is used to treat major depressive disorder (MDD) and for the management of pain associated with diabetic peripheral neuropathy.
		Duloxetine is in the FDA pregnancy category C. Babies exposed to duloxetine and/or other drugs of the same class during the third trimester of pregnancy may develop medical complications.
		Duloxetine capsules should be swallowed whole and should not be chewed or crushed, nor should the contents be sprinkled on food or mixed with liquids.
	www.healthline.com /multumcontent/duloxetine (1608 words)

	duloxetine Cymbalta
		Duloxetine 80 mg/d was superior to placebo for most other measures, including overall pain severity, and was superior to paroxetine on 17-item Hamilton Depression Rating Scale improvement (by 2.39 points; 95% CI 0.14, 4.65; P = 0.037) and estimated probability of remission (57% for duloxetine 80 mg/d, 34% for paroxetine; P = 0.022).
		Duloxetine (3-15 mg/kg, intraperitoneal) significantly attenuated late phase paw-licking behavior in a dose-dependent manner in the formalin model and was more potent than venlafaxine, milnacipran and amitriptyline.
		Duloxetine is a potent and balanced dual inhibitor of serotonin and norepinephrine reuptake being investigated for the treatment of depression and urinary incontinence.
	www.rxbyfax.com /duloxetine.htm (2964 words)

	Institute for rational pharmacotherapy Yentreve (duloxetine)
		Duloxetine is indicated for the treatment of women with moderate to severe stress incontinence.
		Duloxetine is considerable oxidised by CYP1A2 and the polymorphic CYP2D6.
		The median IEF was reduced by 41% for placebo, 54% for duloxetine 20mg/dy (not significant), 59% for duloxetine 40 mg/dy.
	www.irf.dk /en/reviews/yentreve_02.htm (756 words)

	Possible New Treatment for Fibromyalgia
		Sept. 10, 2004 — Duloxetine, a serotonin and norepinephrine reuptake inhibitor, is effective for the treatment of fibromyalgia with or without major depressive disorder, according to the results of a randomized trial published in the September issue of Arthritis and Rheumatism.
		Independent of baseline status of major depressive disorder, duloxetine treatment improved fibromyalgia symptoms and pain severity, and the treatment effect on significant pain reduction in women was independent of the effect on mood or anxiety.
		Participants in the duloxetine group experienced a mean increase in heart rate of 3.53 beats/minute at the end of the study.
	www.healingtides.net /duloxetine.htm (1498 words)

	Cymbalta, Duloxetine Hydrochloride Pharmacology - HealthyPlace.com
		Preclinical studies have shown that duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake.
		Because it is possible that duloxetine and alcohol may interact to cause liver injury or that duloxetine may aggravate pre-existing liver disease, Cymbalta should ordinarily not be prescribed to patients with substantial alcohol use or evidence of chronic liver disease.
		Additionally, duloxetine was not genotoxic in an in vitro mammalian forward gene mutation assay in mouse lymphoma cells or in an in vitro unscheduled DNA synthesis (UDS) assay in primary rat hepatocytes, and did not induce sister chromatid exchange in Chinese hamster bone marrow in vivo.
	concernedcounseling.com /Medications/cymbalta.asp (9127 words)

	duloxetine Consumer Drug Information
		While you are taking duloxetine you will need to be monitored for worsening symptoms of depression and/ or suicidal thoughts during the first weeks of treatment, or whenever your dose is changed.
		Duloxetine is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs).
		Duloxetine affects chemicals in the brain that may become unbalanced and cause depression.
	www.drugs.com /MTM/duloxetine.html (1715 words)

	Duloxetine (Site not responding. Last check: 2007-10-12)
		Duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake.
		Aims Duloxetine, an inhibitor of serotonin and noradrenaline reuptake that is licensed in Europe, the USA and elsewhere for the treatment of depressive episodes...
		Duloxetine May Have a Clinically Important Interaction with the Following Other Drugs: Alcohol: When Duloxetine and ethanol were administered several hours apart so that peak concentrations of each would coincide, Duloxetine did not increase the impairment of mental and motor skills caused by alcohol.
	www.mongabay.com /health/medications/Duloxetine.html (2174 words)

	MedlinePlus Drug Information: Duloxetine (Systemic) (Site not responding. Last check: 2007-10-12)
		Duloxetine belongs to a group of medicines known as selective serotonin and norepinephrine reuptake inhibitors (SSNRIs).
		Duloxetine should only be used during pregnancy if the potential benefit outweighs the potential risk to the baby.
		Duloxetine may cause some people to be agitated, irritable or display other abnormal behaviors.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/500549.html (1544 words)

	Duloxetine - Wikipedia, the free encyclopedia
		Duloxetine hydrochloride (brand names: Cymbalta/Yentreve and in Europe known as Xeristar) is a medically used drug that primarily targets major depressive disorders (MDD), pain related to diabetic peripheral neuropathy and stress urinary incontinence (SUI).
		Duloxetine is labeled an SNRI for seratonin norepinephrine reuptake inhibitor.
		Duloxetine is also used to treat nerve pain in the feet, legs or hands that is due to nerve damage caused by poorly controlled diabetes.
	en.wikipedia.org /wiki/Duloxetine (1656 words)

	Newly Approved Drug Therapies (865): Cymbalta (duloxetine), Eli Lilly
		Cymbalta (duloxetine hydrochloride) is a oral dual reuptake inhibitor that enhances the levels of the neurotransmitters, serotonin and norepinephrine, which are involved in depression.
		Duloxetine is also believed to affect stress urinary incontinence (SUI) by blocking the reuptake of serotonin and norepinephrine in the spinal cord.
		Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.
	www.centerwatch.com /patient/drugs/dru865.html (531 words)

	IDF: Duloxetine Relieves Pain Associated With Diabetic Neuropathy (Site not responding. Last check: 2007-10-12)
		A 20-mg dose of duloxetine was numerically superior to placebo, but the difference in pain reduction failed to reach statistical significance.
		The adverse-event profiles of duloxetine 60 mg and placebo were similar, although duloxetine patients reported more constipation and nausea than did placebo patients.
		Detke said that duloxetine therapy was investigated for diabetic neuropathy because pre-clinical studies demonstrated that the drug was useful in reversing mechanical allydonia in nerve-injury models of neuropathic pain.
	www.pslgroup.com /dg/2390f2.htm (459 words)

	Duloxetine
		If your child's doctor has prescribed duloxetine for your child, you should watch his or her behavior very carefully, especially at the beginning of treatment and any time his or her dose is increased or decreased.
		Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes).
		When duloxetine is used to treat the pain of diabetic neuropathy, it is usually taken once a day with or without food.
	www.safemedication.com /displaydrug.cfm?id=604030 (1200 words)

	Lilly: Duloxetine Hydrochloride Capsules
		Duloxetine, the active ingredient, is harmful if swallowed, may cause burns or permanent tissue damage to the eyes, and may be slightly irritating to the skin.
		Duloxetine has a large volume of distribution and forced diuresis, hemoperfusion, and exchange perfusion are unlikely to be beneficial.
		Duloxetine hydrochloride - Material is highly toxic to green algae and fish, moderately toxic to aquatic invertebrates and slightly toxic to activated sludge microorganisms.
	ehs.lilly.com /msds/msds_duloxetine_hydrochloride_capsules.html (1510 words)

	National MS Society \| Cymbalta (Duloxetine hydrochloride) (Site not responding. Last check: 2007-10-12)
		Duloxetine hydrochloride is used in MS to treat mental depression and neuropathic pain.
		Duloxetine should be swallowed whole and not chewed or crushed.
		It is not known whether duloxetine is excreted into breast milk, but nursing while on duloxetine is not recommended.
	www.nationalmssociety.org /Meds-Duloxetine.asp (411 words)

	BioMed Central \| Full text \| Duloxetine in the treatment of Major Depressive Disorder: A comparison of efficacy in ... (Site not responding. Last check: 2007-10-12)
		The efficacy of duloxetine in the treatment of MDD has been established in randomized, double-blind, placebo-controlled studies of up to 9 weeks duration [38].
		In the present study, pooled data from 8 clinical trials of duloxetine were utilized to compare treatment outcomes in melancholic patients with those in non-melancholic patients.
		Contrasts between duloxetine and placebo within the melancholic and non-melancholic subgroups were used to assess the clinical relevance of treatment effects.
	www.biomedcentral.com /1471-244X/5/1 (6045 words)

	Duloxetine - Drugs & Vitamins - Drug Library - DrugDigest
		DULOXETINE (Cymbalta®) is an antidepressant, a medicine that helps to lift mental depression.
		Duloxetine may also be prescribed for other uses as decided by your health care provider.
		Duloxetine may cause an increase in blood pressure.
	www.drugdigest.org /DD/DVH/Uses/0,3915,8180\|Duloxetine,00.html (720 words)

	BioMed Central \| Full text \| Duloxetine compared with fluoxetine and venlafaxine: use of meta-regression analysis for ... (Site not responding. Last check: 2007-10-12)
		Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) that claims greater affinity for the serotonin and norepinephrine transporters compared with venlafaxine [1,2].
		While we recognize that none of the trials involving duloxetine used venlafaxine as an active comparator, our results are in accordance with a recent meta-analysis comparing duloxetine and venlafaxine in the treatment of MDD [45] and a review comparing second-generation antidepressants [46].
		The fluoxetine treatments groups were underpowered qualitative control arms: [1] half patients included compared with duloxetine and placebo reaching low numbers (33 [9] and 37 [4]), [2] comparison of a fixed dose at the minimum recommended range for fluoxetine (20 mg/day) with the highest tested dose for duloxetine (120 mg/day).
	www.biomedcentral.com /1471-244X/6/30 (5563 words)

	Duloxetine (Cymbalta) Effective for Women With Fibromyalgia, With or Without Comorbid Depression (Site not responding. Last check: 2007-10-12)
		The researchers randomized 118 women to duloxetine 60 mg once daily, 116 women to 60 mg twice daily of duloxetine, and 120 women to placebo.
		Treatment effects of both doses of duloxetine on significant pain did not depend on its effect on mood or on a baseline diagnosis of major depression.
		Duloxetine 60 mg twice daily showed superiority over placebo in improving mean tender point threshold (P =.003) and reducing the number of tender points with low threshold (P =.046).
	www.pslgroup.com /dg/24dab2.htm (603 words)

	Clinical Trial: Duloxetine for the Treatment of Dysthymia
		The purpose of this study is to test the hypothesis that duloxetine (Cymbalta), in doses of 60 or 120 mg/day, is an effective and tolerable treatment for adult outpatients suffering from dysthymia.
		The use of duloxetine for treatment of dysthymia is considered experimental.
		Duloxetine has not been studied in the treatment of dysthymia, but has shown results in the treatment of major depression.
	clinicaltrials.gov /ct/show/NCT00185575 (677 words)

	duloxetine . co .uk
		...It is possible that duloxetine (Cymbalta, Xeristar, Yentreve), licensed by the FDA in autumn 2004, and milnacipran (Ixel, Dalcipran, Toledomin), available in Europe, may be more effective than Weyth's older venlafaxine (Effexor) for a segment of the population that can benefit from dual serotonin-noradrenaline reuptake inhibition.
		Duloxetine also weakly inhibits the reuptake of dopamine, and shows minimal affinity for the histamine and cholinergic muscarinic receptors.
		Early expectations that duloxetine would show superior efficacy in melancholic depressives have not yet been convincingly borne out in controlled clinical trials.
	www.duloxetine.co.uk (281 words)

	Cymbalta Side Effects, and Drug Interactions - Duloxetine Hcl - RxList Monographs
		Because CYP2D6 is involved in duloxetine metabolism, concomitant use of duloxetine with potent inhibitors of CYP2D6 may result in higher concentrations of duloxetine.
		Paroxetine (20 mg QD) increased the concentration of duloxetine (40 mg QD) by about 60%, and greater degrees of inhibition are expected with higher doses of paroxetine.
		It is unknown whether the concomitant administration of proton pump inhibitors affects duloxetine absorption.
	www.rxlist.com /cgi/generic/cymbalta_ad.htm (2515 words)

	Duloxetine Clinical Study Results Show Improvement in Stress Urinary Incontinence in Women (Site not responding. Last check: 2007-10-12)
		Clinical studies of duloxetine for the treatment of SUI have shown the most commonly reported adverse events (incidence of > 5 percent and at least twice the placebo rate) reported by patients receiving duloxetine have been nausea, dry mouth, fatigue, insomnia, constipation, headache, dizziness, somnolence (drowsiness) and diarrhea.7
		Duloxetine is a balanced dual reuptake inhibitor of the neurotransmitters serotonin and norepinephrine,8 which play a key role in normal urethral sphincter closure, the weakening of which can result in SUI.
		By increasing neurotransmitter concentration, duloxetine is believed to increase the tone and contraction of the external urethral sphincter,9 which helps prevent accidental urine leakage during physical activities such as sneezing, coughing, laughing, lifting or exercise.
	www.medilexicon.com /medicalnews.php?newsid=11404 (1187 words)

	Drug trial stopped after link to suicide - SpecialsHealthScience - www.smh.com.au
		The drug manufacturer, Eli Lilly and Co, has been ordered not to accept new participants in the US trial of the compound duloxetine after the 19-year-old was found hanged in a room at a company research laboratory in Indianapolis this week.
		She was one of 25 volunteers in the trial of the drug compound, which the company hopes to use as the main ingredient in an anti-depressant, and as a treatment for stress urinary incontinence.
		Professor Moore, who was involved in clinical trials of duloxetine at Sydney's Prince of Wales and St George hospitals, said the compound was revolutionary and offered the first effective drug treatment for stress incontinence - estimated to affect at least 78 million women over the age of 20 worldwide.
	www.smh.com.au /articles/2004/02/13/1076548225189.html (584 words)

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