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Topic: Dysgerminoma

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	Dysgerminoma -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-10)
		Dysgerminomas are one of the (additional info and facts about germ cell tumour) germ cell tumour (additional info and facts about ovarian neoplasm) ovarian neoplasms.
		Most dysgerminomas occur in (The time period between the beginning of puberty and adulthood) adolescence and early adult life; 5% occur in pre-pubertal children, and they are extremely rare after age 50.
		Dysgerminomas present as bilateral tumours in 10% of patients and, in a further 10%, there is microscopic tumour in the other ((vertebrates) one of usually two organs that produce ova and secrete estrogen and progesterone) ovary.
	www.absoluteastronomy.com /encyclopedia/d/dy/dysgerminoma.htm (317 words)

	Dysgerminoma - IKE (Site not responding. Last check: 2007-10-10)
		Dysgerminomas are one of the germ cell tumours of the ovaries.
		Most dysgerminomas occur in adolescence and early adult life; 5% occur in pre-pubertal patients, and they are extremely rare after age 50.
		Metastases are most often lymphatic, and dysgerminomas are exquisitely sensitive to chemotherapy and radiotherapy, making prognosis excellent.
	tarek.2y.net /wiki/Dysgerminoma (184 words)

	Expression of CD117 (c-kit) receptor in dysgerminoma of the ovary: diagnostic and therapeutic implications
		Dysgerminoma of the ovary is a neoplasm that is histologically, biologically, and clinically similar to testicular seminoma.
		Dysgerminoma has a better prognosis than other malignant ovarian tumors, as it is highly sensitive to cisplatin- or carboplatin-based chemotherapy and to radiotherapy.
		Dysgerminoma is a relatively rare malignant germ cell tumor of the ovary seen in young adults.
	www.nature.com /modpathol/journal/v18/n11/full/3800463a.html (3822 words)

	Dysgerminoma with syncytiotrophoblastic giant cells arising from 46,XX pure gonadal dysgenesis -- Morimura et al. 92 ...
		BACKGROUND: Dysgerminoma with syncytiotrophblastic giant cells is a rare ovarian tumor.
		This report presents a case of dysgerminoma with syncytiotrophoblastic giant cells arising in a patient with 46,XX pure gonadal dysgenesis.
		Her karyotype was 46,XX and the sex-determining region Y gene was not detected in tumor DNA by polymerase chain reaction analysis.
	www.greenjournal.org /cgi/content/abstract/92/4/654 (218 words)

	Ovarian Dysgerminomas (Site not responding. Last check: 2007-10-10)
		Testicular seminomas are the histologic counterparts to dysgerminomas in males.
		Since dysgerminoma tumors affect women of a reproductive and sexually active age, cultures for gonorrhea and chlamydia and a wet mount are indicated at the time of speculum examination, especially if patients experience abdominopelvic pain.
		Dysgerminomas (a germ cell subtype) are an exception to this rule.
	www.cgmh.com.tw /intr/intr5/c6700/OBGYN/f/web/Dysgerminoma (3278 words)

	Ovarian germ cell tumor: 103125 (Site not responding. Last check: 2007-10-10)
		For dysgerminoma confined to the ovary, less than 10 centimeters in size, with an intact, smooth capsule unattached to other organs and without ascites, the 10-year survival following conservative surgery was 88.6% in a series, and a number of patients had 1 or more successful pregnancies following unilateral salpingo-oophorectomy.
		Standard treatment options: For patients with stage I dysgerminoma, unilateral salpingo-oophorectomy conserving the uterus and opposite ovary is accepted treatment of the younger patient anxious to preserve fertility or to preserve a pregnancy.
		For all tumors other than pure dysgerminoma and low-grade (grade I) immature teratoma, chemotherapy is usually given postoperatively, although a series demonstrated excellent survival for all types of stage I tumors managed by surveillance, reserving chemotherapy for cases in which post-surgery recurrence is documented.
	www.acor.org /cnet/103125.html (2851 words)

	Dysgerminoma in a Patient with Partial Deletion of X Chromosome
		However, only 50% of the dysgerminomas arise in abnormal gonads and may be associated with gonadoblastomas when they occur in abnormal gonads.
		All stages of evolution of dysgerminomas from germ cells in gonadoblastomas were observed.
		Dysgerminoma in a pure 45, X Turner syndrome: report of a case and review of literature.
	www.kfshrc.edu.sa /annals/203_204/99-298R.htm (1349 words)

	Archive of Oncology
		Dysgerminoma is best known as the ovarian counterpart of seminoma of the testis.
		Microscopic examination showed typical characteristics of ovarian dysgerminoma, with a micrometastasis in the omentum (in the vicinity of the tumor).
		We believe that conservative surgery followed by adjuvant radiotherapy and chemotherapy seems to be ideal treatment in case of pure ovarian dysgerminoma when careful surgical staging confirmed the unilaterality of disease.
	www.onk.ns.ac.yu /archive/Vol10/V10n4p281.htm (232 words)

	Dysgerminoma of the ovary with hypercalcemia associated with elevated parathyroid hormone-related protein. (Site not responding. Last check: 2007-10-10)
		Dysgerminoma of the ovary with hypercalcemia associated with elevated parathyroid hormone-related protein.
		Dysgerminoma of the ovary with hypercalcemia associated with elevated parathyroid hormone-related protein.The purpose of the present paper is to present a rare case of dysgerminoma of the ovary with hypercalcemia showing elevation of multiple serum tumor markers including parathyroid hormone-related protein (PTH-rP).
		An 18-year-old unmarried woman, with ovarian dysgerminoma showing hypercalcemia and elevated serum PTH-rP, received six courses of a combination chemotherapy consisting of bleomycin, etoposide and cisplatin after her first surgery, and had no evidence of recurrence approximately 30 months after completing the chemotherapy.
	www.ihop-net.org /UniPub/iHOP/gp/273454.html (97 words)

	eMedicine - Ovarian Dysgerminomas : Article by Allan Y Wu, MD
		Seventy-five percent of dysgerminomas occur in patients in the third and fourth decades of life, with the mean age being 22 years.
		Because dysgerminoma tumors affect women of a reproductive and sexually active age, cultures for gonorrhea and chlamydia and a wet mount are indicated at the time of speculum examination, especially if patients experience abdominopelvic pain.
		Five percent of all dysgerminomas are associated with genetic disorders of the ovaries (ie, karyotypic abnormalities [46,XY testicular feminization], gonadal dysgenesis, 45,X/46,XY mixed gonadal dysgenesis).
	www.emedicine.com /med/topic601.htm (3589 words)

	Increased Expression of 25-Hydroxyvitamin D-1{alpha}-Hydroxylase in Dysgerminomas: A Novel Form of Humoral ...
		-hydroxylase in dysgerminoma tissue and a non-neoplastic ovary.
		Dietl J, Horny HP, Ruck P, Kaiserling E: Dysgerminoma of the ovary: an immunohistochemical study of tumor-infiltrating lymphoreticular cells and tumor cells.
		T cells in human dysgerminoma and seminoma: roles in autologous tumor killing and granuloma formation.
	ajp.amjpathol.org /cgi/content/full/165/3/807 (3680 words)

	Dysgerminoma (Site not responding. Last check: 2007-10-10)
		Although the prognosis of patients with dysgerminoma is generally good, this receptor could potentially serve as a target for site-specific immunotherapy as an alternative and/or complement to conventional treatment options.
		Formalin-fixed, paraffin-embedded cell blocks of 33 cases of dysgerminoma including 2 cases of gonadoblastoma associated with dysgerminoma and 3 cases of metastatic dysgerminoma, and 111 cases of nondysgerminomatous neoplasms involving the ovary were stained using the antibody against OCT4.
		OCT4 is a sensitive and relatively specific biomarker for the detection of dysgerminoma.
	www.thedoctorsdoctor.com:16080 /diseases/dysgerminoma.htm (755 words)

	Ovarian germ cell tumor
		For stage I dysgerminoma, unilateral salpingo-oophorectomy conserving the uterus and opposite ovary is accepted treatment for the younger patient anxious to preserve fertility or to preserve a pregnancy.
		For stage III dysgerminoma, total abdominal hysterectomy and bilateral salpingo-oophorectomy are recommended with removal of as much gross tumor as can be done safely without resection of portions of the urinary tract or large segments of small or large bowel.
		For stage III germ cell tumors other than pure dysgerminoma, total abdominal hysterectomy and bilateral salpingo-oophorectomy is recommended with removal of as much tumor in the abdomen and pelvis as can be done safely without resection of portions of the urinary tract or large segments of small or large bowel.
	www.med.muni.cz /monkin/nador16/ovagerm.htm (2908 words)

	Reproductive Unit - Case 9 Answers - Pathology 6000 Laboratory - Department of Pathology - UCHSC (Site not responding. Last check: 2007-10-10)
		Dysgerminoma is a malignant neoplasm capable of metastasis and local spread.
		Treatment in young patients, if the tumor is localized to one ovary, is typically by oophorectomy after careful examination of the opposite ovary and pelvic structures.
		Dysgerminoma may be part of mixed germ cell tumors.
	www.uchsc.edu /pathology/6000/a-rep-female-c9.htm (210 words)

	46,XX gonadal dysgenesis, gonadoblastoma, dysgerminoma,...
		A 20-years-old woman 46,XX without Y-chm by PCR is described with primary amenorrhea, normal height, rudimentary uterus and streak gonads, in which histopathological analysis disclosed a focal gonadoblastoma with dysgerminoma associated to hillus cell hyperplasia in the left gonad.
		A few cells of dysgerminoma were positive for WT1, and negative for all others markers.
		In the present case dysgerminoma developed in a 46,XX milieu, in the absence of Y-chm pointing to the possibility of other markers alone or associated to the high levels of FSH.
	www.cancerprev.org /Journal/Issues/26/101/1291/4515 (343 words)

	CancerNetwork.com:Cancer Screening, Diagnosis, and Treatment
		A 34-year-old female, interested in having children, was found to have dysgerminoma of the ovaries on frozen section at exploratory laparotomy for ovarian mass.
		The risk of bilaterality of ovarian dysgerminoma tumors is quoted to be about 10% to 15%.
		Following treatment, close surveillance for the early detection of a recurrence is required in all of these patients, whether or not the situation warrants adjuvant chemotherapy.
	www.cancernetwork.com /consults/ccp9809b.htm (746 words)

	Ovarian Cancer Germ Cell
		Treatment of dysgerminoma may be either: - hysterectomy and bilateral salpingo-oophorectomy followed by radiation therapy or combination chemotherapy; or - unilateral salpingo-oophorectomy followed by chemotherapy.
		Treatment of dysgerminoma may include the following: - Hysterectomy and bilateral salpingo-oophorectomy, with removal of as much of the cancer in the pelvis and abdomen as possible.
		Treatment of dysgerminoma may include the following: - Hysterectomy and bilateral salpingo-oophorectomy followed by chemotherapy, with removal of as much of the cancer in the pelvis and abdomen as possible.
	www.medhelp.org /lib/cancernet/203125.htm (2949 words)

	Outcome and reproductive function after chemotherapy for ovarian dysgerminoma (Site not responding. Last check: 2007-10-10)
		Twenty-six patients were identified as having been treated with BEP chemotherapy for pure ovarian dysgerminoma from January 1984 to January 1998.
		One patient apparently developed a second primary dysgerminoma in her remaining ovary after BEP and was clinically disease-free after further treatment.
		Of the 16 patients who underwent fertility-sparing surgery, one was lost to follow-up when she was pregnant, and one was still premenarchal.
	www.meb.uni-bonn.de /cgi-bin/mycite?ExtRef=MEDL/20030069 (281 words)

	GONADOBLASTOMA: A CLINICOPATHOLOGIC STUDY
		Gonadoblastoma may be overgrown by dysgerminoma, however, there is a good prognosis.
		The nature of the gonad in which a gonadoblastoma originates is frequently not determined because there is often a mixed pattern of growth by the gonadoblastoma or a neoplastic germ cell element, most frequently a dysgerminoma.
		Gonadoblastoma and dysgerminoma associated with XY gonadal dysgenesis in an adolescent with chronic renal failure: a case of Frasier syndrome.
	www.ams.ac.ir /AIM/0254/0254259.htm (978 words)

	Outcome and Reproductive Function After Chemotherapy for Ovarian Dysgerminoma -- Brewer et al. 17 (9): 2670 -- Journal ...
		dysgerminoma in her remaining ovary after BEP chemotherapy.
		Approximately 15% of ovarian dysgerminomas are bilateral, a
		Gordon A, Lipton D, Woodruff JD: Dysgerminoma: A review of 158 cases from the Emil Novak Ovarian Tumor Registry.
	www.jco.org /cgi/content/full/17/9/2670 (3249 words)

	dysgerminoma Post 363 Forums PLAB AIPPG USMLE (Site not responding. Last check: 2007-10-10)
		shaws mentions granulosa cell tm and dysgerminoma as radiosensitive and from what is given granulosa tms are far more common.
		dysgerminoma is most radio sen and currently is the main ind for radiotherapy, bcos whole abdo red is not advocated.
		Dysgerminomas are highly radiosensitive granulosa cell tumours & arrhenoblastomas are moderately sensitive.
	www.aipge.com /postp363.html (245 words)

	Health Library -
		For patients with stage I dysgerminoma, unilateral salpingo-oophorectomy conserving the uterus and opposite ovary is accepted treatment of the younger patient anxious to preserve fertility or to preserve a pregnancy.
		For patients with stage II dysgerminoma, total abdominal hysterectomy and bilateral salpingo-oophorectomy are usually performed.
		Patients with recurrent germ cell tumors of the ovary other than pure dysgerminoma should be treated with chemotherapy, the type of which is determined by previous treatment.[2] Radiation therapy is not effective in this setting.
	www.amh.org /library/healthguide/en-us/illnessconditions/topic.asp?hwid=ncicdr0000062935 (3188 words)

	Germ cell tumors, ovarian: Treatment - Health Professional Information [NCI PDQ] -- Stage IV Ovarian Germ Cell Tumors
		Stage IV dysgerminoma is not treated with radiation therapy, but rather with chemotherapy, preferably with 3 to 4 courses of cisplatin-containing combination chemotherapy such as BEP.[1] A second-look operation following treatment is rarely beneficial.
		For patients with stage IV germ cell tumors other than pure dysgerminoma, total abdominal hysterectomy and bilateral salpingo-oophorectomy is recommended with removal of as much tumor from the abdomen and pelvis as can be done safely without resection of kidney or large segments of small or large bowel.
		Patients with stage IV germ cell tumors of the ovary (including pure dysgerminoma) are candidates for clinical trials.
	www.webmd.com /hw/ovarian_cancer/ncicdr0000062935-stage-iv-ovarian-germ-cell-tumors.asp (414 words)

	Intracranial metastases from an ovarian dysgerminoma in a 2-year-old dog -- Fernandez et al. 37 (6): 553 -- Journal of ...
		Intracranial metastases from an ovarian dysgerminoma in a 2-year-old dog -- Fernandez et al.
		Exploratory laparotomy revealed a mass in the left ovary that was diagnosed histopathologically as an ovarian dysgerminoma.
		The histopathological diagnosis of the mass was metastases from the ovarian dysgerminoma.
	www.jaaha.org /cgi/content/abstract/37/6/553 (160 words)

	Fertility Preserved Through Conservative Treatment of Rare Ovarian Cancer
		Ovarian dysgerminoma is the most common malignant germ cell tumour of the ovary, accounting for approximately two percent of all ovarian malignancies.
		Historically, surgery for this rare form of tumour usually included the removal of both ovaries and fallopian tubes and often removal of the uterus, he said.
		In the M. Anderson retrospective study, researchers reviewed the cases of 26 females with ovarian dysgerminoma who underwent surgery and received a chemotherapy regimen of bleomycin, etoposide and cisplatin beginning in 1984.
	www.docguide.com /dg.nsf/PrintPrint/9BA81D7F3918B025852567E0004BDDD8 (671 words)

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