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Topic: Dystrophic calcification

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Calcinosis

Soft tissue

Calcinosis cutis

Skin

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	IPLab
		This is a gross specimen of a heart with dystrophic calcification of the aortic valve (arrow).
		This particular example of dystrophic calcification is associated with a degenerative change of the aortic valve due to an unknown cause.
		Dystrophic calcification occurs in necrotic tissue with normal serum calcium levels; metastatic calcification occurs in normal tissue and requires elevated serum calcium levels.
	peir.path.uab.edu /iplab/messages/598/446.html (502 words)

	Tropical Medicine Central Resource
		Such calcification is usually in the kidneys, in blood vessels, or around joints; very rarely, it occurs in the lungs, alimentary tract, or conjunctiva.
		Calcification within parasites can usually be recognized by the shape and pattern of the calcified worm or may present as an amorphous mass: calcified parasites are often multiple and more superficial.
		In the various types of metabolic calcification, such as occurs in hyperparathyroidism, chronic nephritis, vitamin D intoxication, and the milk-alkali syndrome, there are two distinguishing features: there is associated bone emineralization and in many cases there is visceral calcification.
	tmcr.usuhs.mil /tmcr/chapter29/differential.htm (669 words)

	[No title] (Site not responding. Last check: 2007-11-06)
		Dystrophic calcification is (A) associated with an elevated serum calcium level (B) commonly observed in the lungs, stomach, and small intestine (C) frequently associated with renal impairment (D) generally seen in foci of degeneration and necrosis (E) observed in tissues which normally secrete acid 2.
		Dystrophic calcification is (A) premalignant (B) found in necrotic or damaged tissue (C) due to hyperparathyroidism (D) accompanied by elevated serum calcium (E) accompanied by elevated serum phosphate Answers to Questions 5-8 5.
		Dystrophic calcification may occur in patients with (1) psammoma bodies (2) tuberculous lymph nodes (3) pleural fibrous plaques (4) atheromas of advanced atherosclerosis 80.
	members.aol.com /shawnhowie/wsu/nutrition.txt (2673 words)

	Calcinosis - Symptoms, Treatment and Prevention
		The classifications are metastatic calcification and dystrophic calcification, respectfully.
		This condition is characterized by the rapid development of large, multi-lobulated, calcific masses in the subcutaneous (under the skin) tissue and muscles surrounding the hips, shoulders, elbows, hands, and chest walls.
		Dystrophic calcification is often seen at sites of previous inflammation or damage to the skin.
	www.healthscout.com /ency/1/666/main.html (610 words)

	NYU SoM - Dept. of Dermatology
		Cutaneous calcification, which is the deposition of insoluble calcium salts in cutaneous tissues, is referred to as calcinosis cutis.
		Dystrophic calcification is the most common form of calcinosis cutis and results from local tissue injury or from underlying abnormalities in the tissue.
		Cutaneous calcification as a complication of intravenous calcium chloride and calcium gluconate therapy remains the most common cause of iatrogenic calcinosis cutis.[5] Cutaneous calcification may develop after prolonged contact with calcium salts with minor local tissue trauma in the setting of electroencephalography (saturated calcium chloride electrode paste), and skin graft donor sites (calcium alginate dressings).
	www.med.nyu.edu /dermatology/sem_conf/111803-2.html (779 words)

	Le Magazine, August 2005 - Ask The Doctor: Calcium Intake And Vascular Calcification (Site not responding. Last check: 2007-11-06)
		In fact, the opposite is true: people with arterial calcification tend to have less calcium in bones, and are therefore at risk for osteopenia (low bone mass) and osteoporosis.
		Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans: a histologic study of 723 coronary artery segments using nondecalcifying methodology.
		Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads.
	www.lef.org /magazine/mag2005/aug2005_atd_01.htm (639 words)

	Soft Tissue Calcifications (via CobWeb/3.1 planetlab2.cs.umd.edu) (Site not responding. Last check: 2007-11-06)
		Patient with dystrophic calcification in the Achilles tendon due to recurrent trauma and tendinitis.
		Since most calcifications are dystrophic, your biggest job now is to pick the most likely causes of it.
		CPPD is also associated with calcifications in the soft tissues of the spine.
	www.rad.washington.edu.cob-web.org:8888 /mskbook/softtissueca.html (1216 words)

	A Locus on Chromosome 7 Determines Dramatic Up-Regulation of Osteopontin in Dystrophic Cardiac Calcification in Mice -- ...
		that Opn inhibits in vivo ectopic calcification of glutaraldehyde-fixed
		debridement in the absence of necrotic calcification and the
		Brunnert SR: Morphologic response of myocardium to freeze-thaw injury in mouse strains with dystrophic cardiac calcification.
	ajp.amjpathol.org /cgi/content/full/164/4/1379 (4180 words)

	eMedicine - Calcinosis Cutis : Article by Julia R Nunley, MD (Site not responding. Last check: 2007-11-06)
		Dystrophic calcinosis cutis: Calcification is usually localized to a specific area of tissue damage, though it may be generalized in some disorders.
		Calcification occurs most frequently with long-standing systemic disease, and though calcification may develop in lesions of lupus profundus, it usually is not associated with panniculitis.
		Calcification occurs in the intima of the blood vessels and subcutaneous tissue.
	www.emedicine.com /DERM/topic66.htm (4039 words)

	Unknown 14
		In chronic infections, residual foamy material and organisms frequently undergo dystrophic calcification, a helpful sign for diagnosis when the foamy exudate is absent [1].
		Multiple calcifications represent the tombstones of previous organisms and their foamy exudate.
		Dystrophic calcification occurs in necrotic tissue: serum calcium and phosphorus levels are normal.
	pathhsw5m54.ucsf.edu /cts/unknown14/calcification.html (162 words)

	Calcium Deposition with or without Bone Formation in the Lung -- Chan et al. 165 (12): 1654 -- American Journal of ...
		the classification of the pulmonary parenchymal calcific and
		calcification occurs commonly in the lung apices (48–50).
		calcification is confined to the epitheloid granulomas, and
	ajrccm.atsjournals.org /cgi/content/full/165/12/1654 (7120 words)

	Endovascular Today
		For the past 150 years, medical experts have recognized that dystrophic calcification (calcification of normal tissue) is a common component of the atherosclerotic lesion.
		The cause of the calcification is unclear, although an apoptotic mechanism resulting in cell death is thought to contribute to dystrophic calcification.
		The majority of the published literature indicates that dystrophic calcification and possibly bone formation do not increase the risk of stroke, but rather may be a stabilizing influence conferring protection from embolic events.
	www.evtodayarchive.com /03_archive/0902/et0902_15.html (619 words)

	Enhanced coronary calcification determined by electron beam CT is strongly related to endothelial dysfunction in ... (Site not responding. Last check: 2007-11-06)
		Aims: We sought to test the hypothesis that enhanced coronary artery calcification, a marker of atherosclerosis and plaque burden, was related to endothelial dysfunction in patients with suspected coronary artery disease (CAD).
		There was an inverse association between the degree of coronary artery calcification and the endothelium-dependent FMD in the three groups (6.9 [+ or -] 0.6% vs 5.3 [+ or -] 0.3% vs 3.7 [+ or -] 0.3%, respectively; p < 0.001) but not the endothelium-independent NMD.
		Coronary artery calcification has been shown to play an important role in the development of atherosclerosis and is strongly associated with the total plaque burden proved in previous histopathologic studies.
	www.findarticles.com /p/articles/mi_m0984/is_2_128/ai_n15622783 (863 words)

	In-Vitro Dystrophic Calcification Occurs in the Shape of Apatite Crystallization (Site not responding. Last check: 2007-11-06)
		Calcification is the main cause of late failure of glutaraldehyde fixed valve xenografts implanted in humans and occurs in the shape of apatite crystals.
		Whether calcific deposits obtained in vitro are similar to those found in vivo is unknown.
		All bioprostheses were heavily calcific with intrinsic Von Kossa positive deposits and with a mean of calcium content of 205.285 mg/g dry weight.
	www.ctsnet.org /doc/4603 (378 words)

	Calcification in Large Cell Neuroendocrine Carcinoma of the Lung -- Takamochi et al. 33 (1): 10 -- Japanese Journal of ...
		Calcification in Large Cell Neuroendocrine Carcinoma of the Lung -- Takamochi et al.
		of lung cancer are not correlated with calcification (1,3).
		CT demonstration of calcification in carcinoma of the lung.
	jjco.oxfordjournals.org /cgi/content/full/33/1/10 (1435 words)

	Calcification and osteopontin localization in the peritoneum of patients on long-term continuous ambulatory peritoneal ... (Site not responding. Last check: 2007-11-06)
		Calcification and osteopontin localization in the peritoneum of patients on long-term continuous ambulatory peritoneal dialysis therapy -- Nakazato et al.
		Calcification and osteopontin localization in the peritoneum of patients on long-term continuous ambulatory peritoneal dialysis therapy
		calcifications were detected in the autopsy specimens of 5 HD patients or the biopsy specimens of 3 pre-CAPD patients.
	ndt.oxfordjournals.org /cgi/content/full/17/7/1293 (3588 words)

	Dystrophic calcification in haepatic cyrrosis (Site not responding. Last check: 2007-11-06)
		Dystrophic calcification is the most common type of calcinosis cutis and is associated with a variety of disorders: collagen vascular diseases, panniculitis, porphyria cutanea tarda, Ehlers-Danlos s., Werner's s., pseudoxanthoma elasticum, Rothmund-Thompson s., cutaneous neoplasms, infections, trauma.
		This is a cutaneous calcification in a patient with haepatic cyrrosis.
		The big calcification was asported from his leg.
	www.alimentari.org /renata/cirrosi.htm (67 words)

	Clinical Trial: Alendronate for Vascular Calcification in Peritoneal Dialysis Patients?
		The aim of this study is to evaluate the safety and efficacy of alendronate to suppress coronary artery and aortic calcifications, as well as to improve bone density in chronic peritoneal dialysis (PD) patients.
		The extent of coronary artery and aortic calcification is evaluated by using multi-detector spiral computed tomography, whereas bone mineral density is measured by dual-energy X-ray absorptiometry.
		（4）Measurement of Coronary Artery and Aortic Calcification Multi-detector spiral computerized tomography (CT) of the chest is performed at week 0, 16 and 32 for each participant to measure the extent of coronary and aortic calcification.
	www.clinicaltrials.gov /show/NCT00299572 (1119 words)

	Calcification - Page 1
		Calcification refers to a process in which calcium is deposited on the walls of the
		Critics of the new tests point out that not all plaque is calcified, and not all calcification is a sign of narrowed
		An elevated calcium score may be a helpful indicator that other testing is necessary, but most physicians do not rely solely on these tests for diagnosis.
	heart.healthcentersonline.com /cholesterol/calcification.cfm (318 words)

	dystrophic calcification (Site not responding. Last check: 2007-11-06)
		dystrophic calcification is characterised by the deposit of calcium salts in injured, degenerating or dead tissues
		example: in systemic sclerosis, subcutaneous calcification (often around the phalanges) may occur; these calcific deposits can be sufficiently extensive to break through the skin as toothpaste-like material
		example: in dermatomyositis, sheets of subcutaneous calcification can be deposited some time after the initial inflammatory episode characterised by a systemic illness and painful weak muscles
	www.fortunecity.com /bennyhills/mayall/3/dystrophiccalcification.htm (77 words)

	Calcification of Vascular Smooth Muscle Cell Cultures : Inhibition by Osteopontin -- Wada et al. 84 (2): 166 -- ... (Site not responding. Last check: 2007-11-06)
		The mechanisms regulating dystrophic calcification are not known.
		to induce calcification in the absence of an exogenous phosphate
		Calcification in the coronary arteries and its relationship to arteriosclerosis and myocardial infarction.
	circres.ahajournals.org /cgi/content/full/84/2/166 (6657 words)

	What causes bone calcification?
		Following an x-ray of both ankles he noticed some bone calcification on the previously injured ankle and has now suggested she have blood tests.
		Without seeing the x-ray it is impossible to be certain what the cause of the calcification might be.
		The calcification is not likely to be due to osteoporosis.
	www.netdoctor.co.uk /ate/musclesjoints/203006.html (337 words)

	Tocotrienols are needed for normal bone calcification in growing female rats Alternative Medicine Review - Find Articles (Site not responding. Last check: 2007-11-06)
		In this study the effects of vitamin E deficiency and supplementation on bone calcification were determined using 4-month-old female Sprague-Dawley rats.
		In conclusion, vitamin E deficiency impaired bone calcification.
		This effect may be attributed to the tocotrienol content of palm vitamin E. Therefore, tocotrienols play an important role in bone calcification.
	www.findarticles.com /p/articles/mi_m0FDN/is_6_7/ai_96416632 (310 words)

	Bone Formation in Carotid Plaques: A Clinicopathological Study -- Hunt et al. 33 (5): 1214 -- Stroke
		Dystrophic calcifications were identified on the basis of the
		Cell death and calcification of canine fibroblasts in vitro.
		Calcification in atherosclerotic plaque of human carotid arteries: associations with mast cells and macrophages.
	stroke.ahajournals.org /cgi/content/full/33/5/1214 (3779 words)

	Fine mapping of Dyscalc1, the major genetic determinant of dystrophic cardiac calcification in mice -- Korff et al. 25 ...
		Fine mapping of Dyscalc1, the major genetic determinant of dystrophic cardiac calcification in mice -- Korff et al.
		In the heart, this recessive trait is referred to as dystrophic
		syndrome, an elastic tissue disorder with cardiovascular calcifications.
	physiolgenomics.physiology.org /cgi/content/abstract/25/3/387 (222 words)

	Imaging of diffuse metastatic and dystrophic pulmonary calcification in children after haematopoietic stem cell ...
		Imaging of diffuse metastatic and dystrophic pulmonary calcification in children after haematopoietic stem cell transplantation -- Guermazi et al.
		Imaging of diffuse metastatic and dystrophic pulmonary calcification in children after haematopoietic stem cell transplantation
		and the other dystrophic in a child with leukaemia.
	bjr.birjournals.org /cgi/content/abstract/78/932/708 (139 words)

	Ichthyosis and keratotic follicular plugs containing dystrophic calcification in newborns: distinctive histopathologic ...
		Ichthyosis and keratotic follicular plugs containing dystrophic calcification in newborns: distinctive histopathologic features of x-linked dominant chondrodysplasia punctata (Conradi-H?nermann-Happle syndrome).
		As demonstrated by our cases and review of the literature, dystrophic calcification in the keratotic plug is a distinctive histopathologic feature of Conradi-H?nermann-Happle syndrome in newborns and is not seen in other known forms of ichthyoses.
		Skin biopsies from both patients showed thick laminated orthokeratosis and prominent keratotic follicular plugs containing dystrophic calcification.
	www.ihop-net.org /UniPub/iHOP/gp/10401853.html (136 words)

	Dystrophic calcification (Site not responding. Last check: 2007-11-06)
		Dystrophic calcification occurs even though serum calcium levels are normal.
		The calcium salts appear as white granules or clumps.
		The end result in dystrophic calcification is the formation of crystalline calcium phosphate mineral.
	www.portfolio.mvm.ed.ac.uk /studentwebs/session3/45/dystrophic.htm (112 words)

	eSynopsis of Dystrophic Calcification of the Soft Tissue
		eSynopsis of Dystrophic Calcification of the Soft Tissue
		•It appears that necrotic material needs to stay unresorbed for prolonged periods for dystrophic calcium deposition.
		•However, if calcification occurs in degenerating heart valves, the ensuing rigidity of the valve leaflets can impede blood flow.
	pathweb.uchc.edu /esynopsis/eSynopsis/S526.htm (130 words)

	Cell Injury
		This is dystrophic calcification in the wall of the stomach.
		At the far left is an artery with calcification in its wall.
		Calcium is more likely to be deposited in tissues that are damaged.
	www-medlib.med.utah.edu /WebPath/CINJHTML/CINJ047.html (45 words)

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