| | Sloan-Kettering - Projects: AML1/ETO |
 | | The AML1-ETO fusion protein contains the first 177 amino acids of AML1 (including the DNA-binding domain but not the transcriptional activation domain of AML1) and almost the full length of the ETO protein. |
 | | The role of the ETO domain in causing this repression has recently been clarified; ETO binds the co-repressors N-CoR and mSin3, and recruits histone deacetylase (HDAC) activity, allowing AML1-ETO to repress transcription. |
 | | AML1-ETO interferes with the function of AML1 (RUNX1, CBFA2), but we have shown that it also represses transcription via protein:protein interactions with other transcription factors, including MEF and Smads. |
| www.mskcc.org /mskcc/html/11376.cfm (403 words) |