
	Where results make sense

Topic: Edrophonium

In the News (Tue 15 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Edrophonium Injection BP 10mg/1ml (Cambridge Laboratories) , SPC from the eMC
		Edrophonium Injection BP is for intramuscular or intravenous injection.
		Edrophonium Injection BP should not be given to patients with mechanical intestinal or urinary obstruction.
		Edrophonium Injection BP is contra-indicated in patients with known hypersensitivity to the drug.
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?DocumentID=375 (1053 words)

	Edrophonium is the most interesting pharmacological agent for the diagnosis but cannot be regarded as physiologic
		Edrophonium test is the most frequently used as a pharmacological agent for esophageal chest pain.
		Edrophonium chloride is a relatively safe, rapidly acting cholinesterase inhibitor.
		Edrophonium injection produces in normals and in noncardiac chest pain patients an increase in the amplitude and duration of esophageal contractions.
	www.hon.ch /OESO/free/Vol_4_Prim_Motility/Articles/ART370.HTML (270 words)

	Effects of the Anticholinesterase Edrophonium on Spectral Analysis of Heart Rate and Blood Pressure Variability in ...
		Edrophonium was administered as bolus doses and steady state plasma concentrations were not achieved.
		Breen PJ, Doherty WG, Donati F and Bevan DR (1985) The potencies of edrophonium and neostigmine as antagonists of pancuronium.
		Yost CS and Maestrone E (1994) Clinical concentrations of edrophonium enhance desensitization of the nicotinic acetylcholine receptor.
	jpet.aspetjournals.org /cgi/content/full/300/1/112 (3922 words)

	Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium ...
		Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium: [L'edrophonium antagonise efficacement le blocage neuromusculaire des adducteurs larynges induit par le rapacuronium, le rocuronium et le cisatracurium, mais non par le mivacurium] -- Suzuki et al.
		Incomplete reversal of pancuronium neuromuscular blockade by neostigmine, pyridostigmine, and edrophonium.
		Antagonism of vecuronium-induced neuromuscular blockade with edrophonium or neostigmine.
	www.cja-jca.org /cgi/content/full/50/9/879 (2741 words)

	A Comparison Between Chronotropic Effects of Neostigmine and Edrophonium in Isolated Guinea Pig Right Atrium -- Endou ...
		Effects of edrophonium and neostigmine on the spontaneous beating rate that is modulated by endogenous ACh released by electrical FS.
		Typical effect of edrophonium (3 µM) on the negative chronotropic response of the spontaneously beating right atrium to FS (fl bar) in the presence of 1 µM propranolol.
		Influences of neostigmine and edrophonium on the negative chronotropic effect of CCh and adenosine.
	jpet.aspetjournals.org /cgi/content/full/282/3/1480 (4393 words)

	Edrophonium
		Edrophonium chloride increases the amount of acetylcholine at the nerve endings.
		Edrophonium chloride is a short-acting (about 5 minutes) medicine which is administerd by injection.
		Edrophonium chloride should not be used with muscle relaxants such as suxamethonium as this may result in breathing difficulties.
	www.netdoctor.co.uk /medicines/100000892.html (502 words)

	University of Iowa Anesthesia Publications (Site not responding. Last check: 2007-09-17)
		The effect of different priming doses of edrophonium were studied in 77 patients divided into seven groups (n = 11 in each).
		Edrophonium 1.0 mg.kg-1 was administered either in a single bolus dose (Group I; controls) or in an initial dose of 0.05, 0.1, 0.15, 0.2, 0.25 or 0.3 mg.kg-1 followed one minute later by the remainder of the 1.0 mg.kg-1 dose in Groups II to VII respectively.
		It is concluded that 0.2 mg.kg-1 appears to be the optimal priming dose for administration of edrophonium in divided doses.
	www.anesth.uiowa.edu /readabstract.asp?PMID=0003349555 (226 words)

	Edrophonium chloride Dosage, Interactions, Side Effects, How to Use
		By increasing the duration of action at the motor end plate, edrophonium causes a transient increase in muscle strength in myasthenia gravis clients and either no change or a slight weakness in muscle strength in clients with other disorders.
		Edrophonium combined with atropine in the differential diagnosis of myasthenia gravis.
		Edrophonium combined with atropine is not effective against depolarizing neuromuscular blocking agents.
	www.healthdigest.org /drug-prescribing-database/edrophonium-chloride-1664.htm (455 words)

	Contribution of Aromatic Moieties of Tyrosine 133 and of the Anionic Subsite Tryptophan 86 to Catalytic Efficiency and ...
		It was therefore quite surprising that the specific active center inhibitor edrophonium exhibited a 30-fold decrease in affinity relative to the wild type enzyme (Table 2).
		Thus, modeling of complexes of edrophonium with HuAChE enzymes mutated at positions 86 and 133, together with the measured reactivities of the corresponding mutants toward ATC and edrophonium, may provide insight as to the particular roles of Trp-86 and Tyr-133 in catalysis.
		Edrophonium and decamethonium were docked into the active center of W86F and Y133F enzymes according to their positions in the complexes with the wild type enzyme (Barak et al.
	www.jbc.org /cgi/content/full/270/5/2082 (8525 words)

	Lincolnshire Post-Polio Library [Anticholinesterases in Post-Poliomyelitis Syndrome]
		Edrophonium (2.0 mg i.v., followed by 8.0 mg in 2 min) was then injected, and jitter was measured at the time of injection and every 30 s thereafter for at least 3.5 min.
		Reduction of fatigue with pyridostigmine is associated with reduction of jitter on edrophonium injection.
		The fact that not all neuromuscularjunctions studied were ameliorated with edrophonium suggests the presence of a variety of neuromuscular junction defects in patients with past paralytic poliomyelitis.
	www.ott.zynet.co.uk /polio/lincolnshire/library/trojan/anticholinesterases.html (4257 words)

	Edrophonium - Wikipedia, the free encyclopedia
		Because its duration of action is only about 10 minutes, edrophonium is used to differentiate myasthenic crisis from cholinergic crisis.
		In myasthenic crisis, where a person is not able to produce enough neuromuscular stimulation, edrophonium will reduce the muscle weakness.
		In a cholinergic crisis, where a person has too much neuromuscular stimulation, edrophonium will make the muscle weakness worse.
	en.wikipedia.org /wiki/Edrophonium (154 words)

	Edrophonium infrared optokinetic nystagmography in the diagnosis of myasthenia gravis -- Spector et al. 25 (4): 317 -- ...
		Edrophonium infrared optokinetic nystagmography in the diagnosis of myasthenia gravis -- Spector et al.
		Edrophonium infrared optokinetic nystagmography in the diagnosis of myasthenia gravis
		edrophonium chloride in 16 patients wtih proved myasthenia gravis.
	www.neurology.org /cgi/content/abstract/25/4/317 (129 words)

	Myasthenia Gravis: Diagnostic Tests
		Edrophonium (Tensilon) is a rapid-onset, short-acting medication that inhibits acetylcholinesterase, thereby prolonging the presence of the neurotransmitter, acetylcholine, in the NMJ.
		Initially, 2 mg of edrophonium is administered intravenously as a test dose while monitoring the heart rate, as bradycardia or ventricular fibrillation may develop.
		Atropine should be readily available to reverse the effects of edrophonium in case of hemodynamic instability.
	www.neuro.wustl.edu /neuromusstore2/xfiles/xmgdx.html (1026 words)

	Lincolnshire Post-Polio Library [Anticholinesterase-responsive neuromuscular junction transmission defects in ...
		After edrophonium studies were performed on the 17 patients, oral pyridostigmine was initiated at 30 mg per day, and increased every other day by 30 mg to a maximum dosage of 180 mg/day in 3 divided doses.
		Reduction of jitter with edrophonium was not associated with the severity of pre-edrophonium jitter.
		The decline and subsequent increase in jitter on edrophonium injection is consistent with the known pharmacokinetics of edrophonium (Fig.
	www.ott.zynet.co.uk /polio/lincolnshire/library/trojan/anticholinesterase_rnjtd.html (5255 words)

	MedicineHouse.com
		Edrophonium may be more effective in converting supraventricular tachyarrhythmias to normal sinus rhythm when underlying organic heart disease is not present.
		(3) Edrophonium overdose may induce a cholinergic crisis characterized by nausea, vomiting, bradycardia or tachycardia, excessive salivation and sweating, bronchospasm, weakness and paralysis.
		(5) Due to the brief duration of action of edrophonium, neostigmine or pyridostigmine are generally preferred for reversal of the effects of nondepolarizing muscle relaxants.
	www.medicinehouse.com /cgi-bin/drug1.php?drug=edrophonium_chloride (611 words)

	Chest pain (non-cardiac): the results of edrophonium provocative testing may be influenced by the tester.
		Chest pain (non-cardiac): the results of edrophonium provocative testing may be influenced by the tester.
		There were wide differences in patients reporting chest pain during edrophonium testing depending on the clinician performing the test.
		In a retrospective survey of 260 patients (36% male; aged mean ~ 49) seen in the previous 2 years showed significant differences in the number of patients who reported chest pain depending on the physician performing the test.
	www.eboncall.org /CATs/2232.htm (382 words)

	The Motor-Sensory Unit System
		Edrophonium has maximal effects in 3 to 5 minutes and it lasts for 10 to 15 minutes.
		These tests should be performed after choosing a quantifiable clinical sign and atropine must be readily available to eliminate the possible side-effects of neostigmine and edrophonium (bradycardia, diarrhea, and profuse tracheal secretions).
		The treatment of neonatal transient myasthenia gravis consists of nasogastric feeding and respiratory support when necessary, and the use of anticholinesterase therapy.
	pediatricneuro.com /alfonso/pg141.htm (325 words)

	Mahidol University Annual Research Abstracts
		Further prospective randomized studies including a control group are required to determine the effectiveness of AMT in acute chemical and thermal burns of the eye.
		The edrophonium and neostigmine tests in 57 consecutive patients who presented with symptoms of ptosis and/or binocular upon exertion were studied prospectively in Neuroophthalmologic Unit, Siriraj Hospital.
		The edrophonium test was positive in 44 patients (97.8%) and the neostigmine test was positive in 38 patients (84.4%) in myasthenic group.
	www.mahidol.ac.th /abstracts/annual2000/0118.htm (691 words)

	eMedicine - Myasthenia Gravis : Article by Edward Newton, MD (Site not responding. Last check: 2007-09-17)
		Tensilon (edrophonium) challenge test is useful in diagnosing MG and in distinguishing myasthenic crisis from cholinergic crisis.
		The effects of edrophonium are brief, and repeated doses may be required before oral anticholinesterase medication can take effect.
		Edrophonium primarily is used as a diagnostic tool because its half-life is so brief.
	www.emedicine.com /emerg/topic325.htm (4534 words)

	Edrophonium Chloride - Learn about Edrophonium Chloride Side Effects and Precautions (Site not responding. Last check: 2007-09-17)
		The pharmacology action of Edrophonium Chloride is that it facilitates myoneural junction impulse transmission by inhibiting acetylcholine destruction by cholinesterase
		Edrophonium Chloride is used in differential diagnosis of myasthenia gravis; adjunct in evaluating treatment of myasthenia gravis; evaluation of emergency treatment of myasthenic crises; reversal of neuromuscular blockade by curare gallamine or tubocurarine; treatment of respiratory depression caused by curare overdose.
		Contraindication of Edrophonium Chloride - Hypersensitivity to anticholinesterases; mechanical intestinal and urinary obstruction
	www.health-care-clinic.com /drugs/e/edrophonium-chloride.htm (342 words)

	Heart Rhythm Society - Advocacy (Site not responding. Last check: 2007-09-17)
		In the case of the head-up tilt table test, two alternative pharmacologic provocation techniques (i.e., nitroglycerine, edrophonium) have been reported to be of comparable sensitivity and specificity to isoproterenol.
		Intravenous administration of edrophonium 10mg (an acetylcholine esterase inhibitor) has also been studied (7), and may be helpful especially in patients who do not tolerate nitroglycerine.
		In conclusion, two reasonable alternatives (i.e., sublingual nitroglycerine, edrophonium) are available to replace isoproterenol provocation as a diagnostic step in the head up tilt table test.
	www.hrsonline.org /swAdvocacyFiles/advocacy103480117.asp (991 words)

	MYASTHENIA GRAVIS - A SUMMARY
		Some patients who don't respond to intravenous edrophonium chloride may respond to intramuscular neostigmine, because of the longer duration of action.
		Intramuscular neostigmine is particularly useful in infants and children whose response to intravenous edrophonium chloride may be too brief for adequate observation.
		Intravenous edrophonium chloride is often diagnostic in patients with ptosis or ophthalmoparesis, but is less useful when other muscles are weak.
	www.myasthenia.org /information/summary.htm (3152 words)

	Review of Ophthalmology
		Edrophonium (Tensilon) testing remains the gold standard for the diagnosis of ocular MG.
		The estimated sensitivity of edrophonium testing is 86 percent in ocular and 95 percent in systemic myasthenia.
		Additionally, edrophonium administration may produce serious side effects including significant bradycardia, loss of consciousness and death.
	www.revophth.com /index.asp?page=1_219.htm (1610 words)

	Dose-response relationships for edrophonium and neostigmine antagonism of atracurium and cisatracurium-induced ...
		Dose-response relationships for edrophonium and neostigmine antagonism of atracurium and cisatracurium-induced neuromuscular block -- Naguib and Riad 47 (11): 1074 -- Canadian Journal of Anesthesia
		Dose-response relationships for edrophonium and neostigmine antagonism of atracurium and cisatracurium-induced neuromuscular block
		edrophonium during antagonism of neuromuscular block induced by atracurium
	www.cja-jca.org /cgi/content/abstract/47/11/1074 (307 words)

	Myasthenia gravis: Screening and diagnosis - MayoClinic.com
		Injection of the chemical edrophonium (Tensilon) may result in a sudden, although temporary, improvement in your muscle strength, an indication that you may have myasthenia gravis.
		Edrophonium acts to block an enzyme that breaks down acetylcholine, the chemical that transmits signals from your nerve endings to your muscle receptor sites.
		During the first part of this test, a small electrical impulse is applied to your skin, stimulating your nerves in order to test the strength of your muscle contraction.
	www.mayoclinic.com /health/myasthenia-gravis/DS00375/DSECTION=5 (272 words)

	The District of Columbia Academy of Veterinary Medicine
		The response to intravenous edrophonium chloride may be useful in the diagnosis of myasthenia gravis while waiting for the results of confirmative antibody testing.
		In the focal form of MG, with muscular weakness limited to the pharyngeal and esophageal musculature, the response to edrophonium chloride may not be useful.
		While the edrophonium prolongs the action of acetylcholine at the neuromuscular junction, adequate numbers of receptors are not present to bind to.
	www.dcavm.org /dec99.htm (8718 words)

	Cecil Textbook of Medicine : />
		Edrophonium given intravenously acts within a few seconds, and its effects last for a few minutes (Fig.
		The edrophonium (Tensilon) test can be used to confirm the diagnosis.
		B, Edrophonium chloride, a short-acting anticholinesterase, is then injected intravenously-initially 2 mg as a test dose, followed after 1 minute by a further 8 mg if there are no adverse effects.
	www.merckmedicus.com /ppdocs/us/common/cecils/chapters/464_004.htm (668 words)

	1996-3 Q17-24
		Edrophonium is not recommended for using to reverse neuromuscular blockade that is considered a ‘deep’ block, i.e., 0-1 of 4 twitches on the train-of-four.
		edrophonium’s clinical duration of action is shorter than either pyridostigmine or neostigmine
		Of the antimuscarinic agents, ______ raises the heart rate the most, _______ produces no sedation, and ________ is the most effective antisialogogue.
	www.courses.vcu.edu /ptxed/m2/1996/96-3_q17-24.htm (382 words)

	Myasthenia Gravis (Site not responding. Last check: 2007-09-17)
		The patient must be monitored carefully during this procedure as edrophonium can cause significant bradycardia, heart block and asystole.
		If muscle strength fails to improve following the maximum dose of edrophonium, the patient is having a cholinergic crisis or has another cause of weakness unrelated to myasthenia.
		These include edrophonium, which is primarily used as a diagnostic tool because its half-life is so brief.
	members.tripod.com /~enotes/myasthenia.htm (1656 words)

	edrophonium test - General Practice Notebook (Site not responding. Last check: 2007-09-17)
		The Tensilon test is used to diagnose myasthenia gravis.
		Edrophonium is a very short acting anticholinesterase and therefore increases the effective amount of acetylcholine at the neuromuscular junction in patients with myasthenia gravis.
		It is advisable to have atropine to hand to counter the edrophonium and for there to be full resuscitative equipment.
	www.gpnotebook.co.uk /simplepage.cfm?ID=-1328545769 (967 words)

	eMedicine - Assessment of Neuromuscular Transmission : Article by Donald B Sanders, MD (Site not responding. Last check: 2007-09-17)
		In some cases, a paradoxical response to edrophonium may be observed in which a decrement worsens or appears only after administration of Tensilon.
		In patients with MG who have normal RNS studies in the hand muscles, this enhancing technique has been shown to be slightly more sensitive than repetitive stimulation of the trapezius; however, it is only 60% as sensitive as single-fiber electromyography (EMG) of the hand muscle.
		Abnormal neuromuscular transmission may be seen in EMG recordings as variability in the shape or amplitude of motor unit action potentials (MUAPs) (see Figure 5).
	www.emedicine.com /neuro/topic23.htm (4357 words)

Try your search on: Qwika (all wikis)