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Topic: Effector


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In the News (Sun 27 Dec 09)

  
  Effector cell - Wikipedia, the free encyclopedia
Effector cells are a type of lymphocyte that are actively engaged in secreting antibodies.
The clonal selection theory stipulates that when naïve cells encounter antigens for the first time, they are stimulated to proliferate and differentiate into effector cells and memory cells.
The specific immunity class cells release the effector cells after being activated by an antigen.
en.wikipedia.org /wiki/Effector_cell   (133 words)

  
 Effector - Wikipedia, the free encyclopedia
An effector is a small molecule that binds to a macromolecule.
The album Effector by the Experimental Techno group Download.
This is a disambiguation page: a list of articles associated with the same title.
en.wikipedia.org /wiki/Effector   (89 words)

  
 Effector cell mediated cytotoxicity measured by intracellular Granzyme B release in HIV infected subjects
The effector cells are triggered when their antigen specific receptors and either the CD4 or the CD8 co- receptors bind to the peptide: MHC complex on a target cell.
Effector cells (PBMC isolated from HIV patients and normal controls) are stimulated with PMA (25 ng/ml) and calcium ionophore (50ng/ml), and rIL-2 (20U/ml) are incubated at 37°C, 5% CO for a period of 7 days for CTL induction.
PBMC effector cells and the PKH67 labelled target cells are mixed at E:T ratios of 1:1, 10:1, 25:1, and 50:1 (shown in table 1) and incubated together at 37°C, 5% CO for 4 hours.
www.biologicalprocedures.com /bpo/arts/1/60/m60.htm   (4112 words)

  
 Robotic end effector - Patent 4657470
A pressure spring mechanism is included in the end effector permits the flat pack to be held in the desired position with a predetermined force by utilizing the robot arm to compress the pressure spring a predetermined amount.
An end effector for use in a robot in accordance with claim 1, wherein said tactile sensor means comprises a piezoelectric sensor positioned around said quill and between said collar and said bidirectional actuator.
In use the robot would be programmed to move the end effector 16 to acquire components from a predetermined location within the working range of the movable arm 12 and to place these components on printed circuit boards 19 supported on the table 18 of the robot.
www.freepatentsonline.com /4657470.html   (2234 words)

  
 ENHANCED CIRCULATION EFFECTOR COMPOSITION AND METHOD (WO9421235A1)
The effector molecules are attached to the distal ends of the polymer chains.
In one embodiment, the effector is polymyxin B, for treatment of septic shock.
Such effectors can include F ab antibody fragments, for use in active immunity; cytokines and cellular growth factors, for stimulating immunological inflammatory responses; hormones; and polysaccharides, which are capable of interacting with endothelial cell receptors to competitively block neutrophil binding to activated endothelial cells lining the blood vessel (Katre, Philips, Waldmann).
www.delphion.com /details?pn=WO09421235A1   (792 words)

  
 Journal of Translational Medicine | Full text | Evaluating the cytotoxicity of innate immune effector cells using the ...
Upon recognition and conjunction of the effector cell with the target, preformed granules containing GrB polarize in cytolytic lymphocytes at the point of contact and are secreted into the intercellular space formed between the effector and target cell [9-14].
Effector cells run in the absence of target cells were evaluated for baseline expression of CD107a.
NK cells are a key part of innate immunity due to their ability to secrete cytokines and mediate cytolytic activity and act as an important first line of defense against virally infected cells and tumor cells [30].
www.translational-medicine.com /content/2/1/31   (5614 words)

  
 An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the ...
An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine -- Scita et al.
An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin–polymerizing machine
mimicked by the enucleation of the effector region from the
www.jcb.org /cgi/content/full/154/5/1031   (7425 words)

  
 Amazon.com: Effector: Music: Download   (Site not responding. Last check: 2007-11-01)
Their knack at rhythmic layering is still in effect, but it all sounds a little too well behaved and haltered on this album.
Instead of industrial starkness, this album is filled with lush and ethereal pads and atmopsheric structures along with complex progrmmed beats that take on a groove and head bobbing feel.
Effector is a body of music that is more in common with Bjork's musical backdrops, Authecre or a more modern version of Analogue Bubblebath era Aphex Twin.
www.amazon.com /Effector-Download/dp/B00004ZDMH   (1473 words)

  
 Role of Type III Effector Secretion during Bacterial Pathogenesis in Another Kingdom -- Bretz and Hutcheson 72 (7): ...
effectors are modular in nature, irrespective of the source.
effectors are essential virulence factors for mammalian pathogens.
Effector protein recognition initiates signal cascades that culminate in the PCD of the responding cell.
iai.asm.org /cgi/content/full/72/7/3697   (6655 words)

  
 Mutation of Ha-Ras C Terminus Changes Effector Pathway Utilization -- Booden et al. 275 (31): 23559 -- Journal of ...
Several of the Ras effectors proteins and some of the pathways through which they are proposed to contribute to neurite outgrowth are depicted.
Not all effectors, proposed pathways, or connections are shown.
of the remaining effectors (65), and the cumulative biological
www.jbc.org /cgi/content/full/275/31/23559   (7910 words)

  
 SwRI Robotic End Effector Development Brochure
SwRI has developed end effectors to advance manufacturing processes such as drilling, tape laying, sanding, and blasting, as well as for inspection applications using machine vision, eddy current, ultrasonic, and other techniques.
This end effector's gripping, sensing, and transfer mechanisms handle multiple wires for an automated wire harness assembly system.
This end effector is a compliant-mounted orbital sander for force-controlled wet sanding and slurry polishing.
www.swri.org /3pubs/brochure/d10/robend/robend.htm   (368 words)

  
 Effector Cell-Derived Lymphotoxin {alpha} and Fas Ligand, but not Perforin, Promote Tc1 and Tc2 Effector Cell-Mediated ...
Ovalbumin-specific Tc1 and Tc2 effector cells were generated in vitro from naïve CD8 T cells from OT-I T-cell receptor transgenic mice as described in "Materials and Methods." A, cells were dual-labeled with FITC-conjugated anti-CD8 and phycoerythrin-conjugated FasL monoclonal antibodies.
OVA antigen-specific Tc2 effector cells were adoptively transferred into specified groups of mice bearing established lung metastases, and survival times were monitored.
Role of endogenous nitric oxide in effector cell-mediated therapy of mice with established lung tumor.
cancerres.aacrjournals.org /cgi/content/full/64/1/406   (6222 words)

  
 Effector Tool - Tutorials - LightWave 3D®
Solid Core Radius is how much geometry is going to be affected, keep in mind the size of the object; and Fall of Distance is how far is going to fade in distance from the null.
Effector is a nice option for animation without the need for morphs or bone influence.
Parent the effector to any object in the scene and make some cool animation effects in just minutes.
newtek.com /products/lightwave/tutorials/animation/effector/index.html   (293 words)

  
 Effector Genes of Xanthamonas axonopodis pv. vesicatoria Promote Transmission and Enhance Other Fitness Traits in the ...
Effect of effector gene removal on disease transmission in the field.
Effect of effector gene removal on epiphytic growth in the field.
Effect of effector genes on disease emergence during bacterial growth experiments, including both mutant genotypes and their corresponding restored lines.
www.genetics.org /cgi/content/full/166/2/693   (7854 words)

  
 Glucose Availability Regulates IFN-{gamma} Production and p70S6 Kinase Activation in CD8+ Effector T Cells -- Cham and ...
Effector 2C T cells were stimulated in the presence or the absence
D, Effector 2C T cells were stimulated in complete DMEM/10% FCS with or without 2-DG for the indicated times.
B, Effector cells were stimulated in the presence (25 mM) or the absence of 2-DG for the indicated time periods.
www.jimmunol.org /cgi/content/full/174/8/4670   (4871 words)

  
 What is End Effector? Robotic Gripping Mechanism Wrist Task   (Site not responding. Last check: 2007-11-01)
It is used as a sensor, gripping device, paint gun, drill, are welding device, etc. See Wrist, and Sensor.
END- EFFECTOR - The end-effector is the "hand" connected to the robot's arm.
It is often different from a human hand - it could be a tool such as a gripper, a vacuum pump, tweezers, scalpel, blowtorch - just about anything that helps it do its job.
bugclub.org /beginners/robotics/EndEffector.html   (130 words)

  
 Yale Immunobiology Faculty (Flavell)
Upon activation, precursor (naive) T-cells undergo numerous cell divisions and differentiate into effector cells; some of the products of this activation become what are known as long term memory T-lymphocytes, which upon restimulation, even up to many years after the initial activation, can respond more rapidly and effectively to the immune insult.
Activation of 'effector' caspases are the penultimate step committing the cell to apoptosis.
JNK is required for effector T cell function but not for T cell activation.
info.med.yale.edu /immuno/fac_flavell.html   (1507 words)

  
 Analysis of Tyrosine Phosphorylation-dependent Interactions between Stimulatory Effector Proteins and the B Cell ...
Analysis of Tyr(P)-dependent Recruitment of Effector Proteins to CD22-- The cytoplasmic domain of CD22 contains six tyrosine residues that are conserved between mouse and man (1).
Precipitation of specific effector proteins was visualized by the addition of secondary antibody coupled to HRP, after which the blots were developed using ECL detection reagents.
Binding of the GST-PI3K fusion protein to CD22 was detected by the addition of a secondary goat anti-rabbit Ig antibody coupled to HRP followed by development of the blots with ECL.
www.jbc.org /cgi/content/full/274/26/18769   (6355 words)

  
 Secretion and Function of Salmonella SPI-2 Effector SseF Require Its Chaperone, SscB -- Dai and Zhou 186 (15): 5078 -- ...
SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells.
Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages.
SseF and SseG are translocated effectors of the type III secretion system of Salmonella pathogenicity island 2 that modulate aggregation of endosomal compartments.
jb.asm.org /cgi/content/full/186/15/5078   (4808 words)

  
 Role of the Salmonella Pathogenicity Island 1 Effector Proteins SipA, SopB, SopE, and SopE2 in Salmonella enterica ...
Role of the Salmonella Pathogenicity Island 1 Effector Proteins SipA, SopB, SopE, and SopE2 in Salmonella enterica Subspecies 1 Serovar Typhimurium Colitis in Streptomycin-Pretreated Mice -- Hapfelmeier et al.
HE-stained sections of cecal tissue were scored with respect to edema in the submucosa, PMN infiltration (PMN inf.), reduction in the number of goblet cells, and desquamation, erosion, or ulceration of the epithelial layer (see Materials and Methods), and the scores were plotted as stacked vertical bars.
A secreted effector protein of Salmonella dublin is translocated into eukaryotic cells and mediates inflammation and fluid secretion in infected ileal mucosa.
iai.asm.org /cgi/content/full/72/2/795   (8455 words)

  
 CD7 Is a Differentiation Marker That Identifies Multiple CD8 T Cell Effector Subsets -- Aandahl et al. 170 (5): 2349 -- ...
Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes.
Effector and memory T-cell differentiation: implications for vaccine development.
Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression
www.jimmunol.org /cgi/content/full/170/5/2349   (3881 words)

  
 PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver -- Iwai et al. 198 (1): 39 -- The Journal of ...
PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver -- Iwai et al.
The absence of PD-1 induced proliferation of effector
Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals.
www.jem.org /cgi/content/full/198/1/39   (5078 words)

  
 End Effector offers product flexibility., Columbia Okura LLC
End effector is equipped with push-down grippers, and can be modified to pick and place pallets or sheets.
Columbia/Okura's bag/box end effector enables a single robot to simultaneously palletize bags and boxes without changing tools.
The end effector is equipped with push-down grippers for higher speed bag or box applications, and can be modified to pick and place pallets or sheets.
news.thomasnet.com /fullstory/7616/1450   (603 words)

  
 Mechanism of Reduced T-Cell Effector Functions and Class-Switched Antibody Responses to Herpes Simplex Virus Type 2 in ...
Mechanism of Reduced T-Cell Effector Functions and Class-Switched Antibody Responses to Herpes Simplex Virus Type 2 in the Absence of B7 Costimulation -- Thebeau and Morrison 77 (4): 2426 -- The Journal of Virology
Mechanism of Reduced T-Cell Effector Functions and Class-Switched Antibody Responses to Herpes Simplex Virus Type 2 in the Absence of B7 Costimulation
Effector and target cells were cultured together in triplicate
jvi.asm.org /cgi/content/full/77/4/2426   (5708 words)

  
 Engineering of antibodies for therapy
Changes in the amino acids in positions that normally interact with sugar residues typically lead to modifications in the composition of the oligosaccharides, and this alters the ability of antibodies to activate effector functions.  It is therefore difficult to separate the direct influence of amino acid substitutions (such as those discussed in the section on
2000], but their influence on effector functions remains to be adequately explored.  Insect cells produce simple truncated N-linked oligosaccharides and may also attach xylose [Wright and Morrison 1997].  As a result, they are probably not appropriate for the production of therapeutic antibodies in cases where the native immune system effector functions need to be stimulated.
The extent and consistency of glycosylation depends in part on the growth medium, environmental conditions, and manipulations employed during the culture of the cells used to produce antibodies.  Stress can lead to low galactose levels, high mannose levels, and in some cases complete failure to glycosylate [Jefferis et al.
polaris.umuc.edu /~psalmon/ab/effector.htm   (1859 words)

  
 Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo -- ...
Differentiation of naive CTL to effector and memory CTL: correlation of effector function with phenotype and cell division.
The repertoires of circulating human CD8(+) central and effector memory T cell subsets are largely distinct.
Immediate early effector functions of virus-specific CD8+CCR7+ memory cells in humans defined by HLA and CC chemokine ligand 19 tetramers.
www.jem.org /cgi/content/full/201/4/579   (5757 words)

  
 audioMIDI.com - Pioneer - EFX-1000 Dj Effector   (Site not responding. Last check: 2007-11-01)
The EFX-1000 is equipped with the same automatic BPM counter/beat effector made popular by the EFX-500, which allows effect processing on single selected bands in sync with the track tempo (BPM), for greater expressive possibilities than with conventional all-band effectors.
With the capability of a far wider range of unique effects compared to previous beat effectors, you have the potential for a new level of DJ performance.
External Midi signals (control signals and timing clock signals) can be used to control the effector and as a medium for using the effector to control a sequencer or other Midi component.
www.audiomidi.com /EFX-1000-Dj-Effector-P7241.aspx   (380 words)

  
 Pfam 20.0 : RPH3A_effector   (Site not responding. Last check: 2007-11-01)
The crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A shows that the effector domain of rabphilin-3A contacts Rab3A in two distinct areas.
It has been suggested that RabCDRs could be major determinants of effector specificity during vesicle trafficking and fusion PUBMED:10025402.
Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A.
pfam.wustl.edu /cgi-bin/getdesc?name=RPH3A_effector   (200 words)

  
 Determination of Antigen-specific Memory/Effector CD4+ T Cell Frequencies by Flow Cytometry . Evidence for a Novel, ...
Ag-specific effector frequency for these cytokines was only 0.03%.
CMV-specific, but not mumps virus-specific, effector T cell frequencies are frequently increased in HIV+ subjects.
effectors to IL-2-producing effectors was 1.6:1 for the overall
www.jci.org /cgi/content/full/99/7/1739   (8373 words)

  
 Dominant effector genetics in mammalian cells.: Rigel Pharmaceuticals
Of several peptides selected, one, termed RGP8.5, was linked to upregulation of expression of the gene ABCB1 (also known as MDR1, for multiple drug resistance) in HeLa cells.
Our data indicate that trans-dominant effector peptides can point to potential mechanisms by which signaling systems operate.
Such tools may be useful in functional genomic analysis of signaling pathways in mammalian disease processes.
www.rigel.com /rigel/Dominant_effector   (143 words)

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