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Topic: Elastase

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	Elastase - Wikipedia, the free encyclopedia
		In molecular biology, elastase is an enzyme from the class of proteases (or better peptidases) that break down proteins.
		Elastase breaks down elastin, an elastic fibre that—together with collagen—determines the mechanical properties of connective tissue.
		Neutrophil elastase is responsible for the blistering in bullous pemphigoid, a skin condition, in the presence of antibodies.
	en.wikipedia.org /wiki/Elastase (295 words)

	Emphysema - Wikipedia, the free encyclopedia
		Chemicals released during the inflammatory response (trypsin, elastase, etc.) are released and begin breaking down the walls of alveoli.
		In A1AD, inflammatory enzymes (such as elastase) are able to destroy the alveolar tissue (the elastin fibre, for example).
		Studies for the better part of the past century have focused primarily upon the putative role of leukocyte elastase (also neutrophil elastase), a serine protease found in neutrophils, as a primary contributor to the connective tissue damage seen in the disease.
	en.wikipedia.org /wiki/Emphysema (1114 words)

	Presence of the M-type sPLA2 receptor on neutrophils and its role in elastase release and adhesion -- Silliman et al. ...
		Presence of the M-type sPLA2 receptor on neutrophils and its role in elastase release and adhesion -- Silliman et al.
		elastase release in the presence or absence of enzymatically inactive
		Elastase release into the supernatant was measured as described.
	ajpcell.physiology.org /cgi/content/full/283/4/C1102 (6778 words)

	Fecal elastase - Wikipedia, the free encyclopedia (Site not responding. Last check: 2007-10-08)
		Fecal elastase refers to the testing of the concentration of the pancreatic elastase-1 enzyme found in fecal matter with an enzyme-linked immunosorbent assay (ELISA).
		Results of this test can give a good indication of exocrine pancreatic status and is less invasive and expensive that the current “gold standard”, secretin-cholecystokinin test.
		Levels of fecal elastase lower than 200 μg / g of stool indicate an exocrine insufficiency.
	en.wikipedia.org /wiki/Fecal_elastase (142 words)

	Worthington Elastase
		Porcine pancreatic elastase has a molecular weight of 25.9 kDa, and an optimum pH of 8.5.
		While elastase will hydrolyze a wide variety of protein substrates, it is unique among proteases in its ability to hydrolyze native elastin, a substrate not attacked by trypsin, chymotrypsin or pepsin.
		Elastase is assayed using a method adapted from that of Feinstein et al., BBRC, 50, 1020, 1973 and using the more soluble substrate of Bieth et al., Biochem.
	www.worthington-biochem.com /ES/cat.html (262 words)

	Leukocyte Elastase . Physiological Functions and Role in Acute Lung Injury -- LEE and DOWNEY 164 (5): 896 -- American ...
		Membrane-bound Elastase: Vectorial Migration of the Neu- trophil?
		Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha-2-macroglobulin.
		The presence of neutrophil elastase and evidence of oxidation activity in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome.
	ajrccm.atsjournals.org /cgi/content/full/164/5/896 (7029 words)

	Worthington Elastase
		Elastase is distinctive in that it acts upon elastin.
		Elastase is the enzyme of choice for the isolation of Type II cells from the lung.
		Inhibitors: Elastase is inhibited by diisopropyl-phosphofluoridate and alkyl isocyanates (Brown and Wold 1971).
	www.worthington-biochem.com /ES (2330 words)

	Inhibition of Human Neutrophil Elastase-Induced Acute Lung Injury in Hamsters by Recombinant Human Pre-elafin ...
		Neutrophil elastase (EC 3.4.21.37) is a potent serine protease
		Neutrophil elastase was preincubated with an equimolar quantity of elafin or pre-elafin, or vehicle only at 37°C for 15 min and then added to the chromogenic substrate N-methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide.
		The residual hydrolytic activity of neutrophil elastase was determined as the kinetic changes in absorbance at 405 nm.
	www.chestjournal.org /cgi/content/full/121/2/582 (3223 words)

	Synergistic neutrophil elastase-cytokine interaction degrades collagen in three-dimensional culture -- Zhu et al. 281 ...
		Effect of neutrophil elastase and cytomix on degradation of collagen in three-dimensional collagen gel culture.
		induced by elastase in the presence of cytomix was markedly attenuated.
		Activation of MMP-9 by neutrophil elastase in an in vivo model of acute lung injury.
	ajplung.physiology.org /cgi/content/full/281/4/L868 (5942 words)

	Leukocyte elastase induces epithelial apoptosis: role of mitochondial permeability changes and Akt -- Ginzberg et al. ...
		Epithelial cells were treated with purified leukocyte elastase or buffer control, and cell fractions (cytosol and mitochondrial) were collected after 0, 2, 4, and 12 h of incubation.
		Neutrophil transmigration and purified leukocyte elastase are both associated with late decreases in phosphorylation of epithelial Akt.
		The effects of elastase in vivo and in vitro are complex.
	ajpgi.physiology.org /cgi/content/full/287/1/G286 (7219 words)

	A Novel Notch Protein, N2N, Targeted by Neutrophil Elastase and Implicated in Hereditary Neutropenia -- Duan et al. 24 ...
		Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia.
		Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis.
		Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases.
	mcb.asm.org /cgi/content/full/24/1/58 (5544 words)

	DNase I Acutely Increases Cystic Fibrosis Sputum Elastase Activity and its Potential to Induce Lung Hemorrhage in Mice ...
		Elastase activity was determined using the chromogenic substrate methoxysuccinyl alanyl-analyl-prolyl-valine p-nitroanilide
		The effect of different DNase I concentrations on sputum elastase activity is shown in Figure 2.
		In summary, the DNase I-mediated increase in CF sputum elastase activity is associated with an increase in the potential of
	ajrccm.atsjournals.org /cgi/content/full/157/2/464 (3348 words)

	Biochemical and Pharmacological Characterization of ...
		elastase in the BAL fluid from 3 to 20 mg/kg (Fig.
		Rice A and Banda MJ (1995) Neutrophil elastase processing of gelatinase A is mediated by extracellular matrix.
		Skiles JW and Jeng A (1999) Therapeutic promises of leukocyte elastase and macrophage metalloelastase inhibitors for the treatment of pulmonary emphysema.
	jpet.aspetjournals.org /cgi/content/full/305/2/451 (5165 words)

	Lysophosphatidic acid inhibition of the accumulation of Pseudomonas aeruginosa PAO1 alginate, pyoverdin, elastase and ...
		Lysophosphatidic acid inhibition of the accumulation of Pseudomonas aeruginosa PAO1 alginate, pyoverdin, elastase and LasA -- Laux et al.
		A zone of elastase activity of 19·5 mm (including the 6·5 mm diameter of the well) in diameter on casein agar plates was equivalent to 100%.
		expression and the accumulation of pyoverdin and elastase.
	mic.sgmjournals.org /cgi/content/full/148/6/1709 (7235 words)

	Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion -- Takayama et ...
		neutrophil elastase in humans, rats, hamsters, and mice (17).
		PAF-induced elastase-dependent neutrophil transendothelial migration is associated with the mobilization of elastase to the neutrophil surface and localization to the migrating front.
		High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis.
	jap.physiology.org /cgi/content/full/91/4/1800 (4254 words)

	Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells -- Fischer et al. 284 (4): 671 ...
		Human neutrophil elastase releases cell surface mucins from primary cultures of hamster tracheal epithelial cells.
		Elastase contributes to antigen-induced mucociliary dysfunction in ovine airways.
		-antitrypsin and leukocyte elastase in infected and noninfected sputum.
	ajplung.physiology.org /cgi/content/full/284/4/L671 (5206 words)

	Nitric oxide reduces vascular smooth muscle cell elastase activity through cGMP-mediated suppression of ERK ...
		of elastase was reversed by coadministration of a cGMP-PKG inhibitor
		Cowan, K. N., Jones, P. L., Rabinovitch, M. (1999) Regression of hypertrophied rat pulmonary arteries in organ culture is associated with suppression of proteolytic activity, inhibition of tenascin-C, and smooth muscle cell apoptosis.
		Thompson, K., Rabinovitch, M. (1996) Induction of vascular elastase is mediated by integrins and is associated with phosphorylation of focal adhesion kinase and activation of the transcription factor AML1.
	www.fasebj.org /cgi/content/full/14/5/805 (6490 words)

	Diet Modifies Elastase I and II Activities and mRNA Levels during Postnatal Development and Weaning in Piglets -- ... (Site not responding. Last check: 2007-10-08)
		activity of elastase I was 140% higher and that of elastase II was 50% lower than in piglets of Group 5.
		In contrast, the specific activity of elastase II declined sharply throughout the 56-d experimental period.
		Gertler A., Weiss Y., Burstein Y. Purification and characterization of porcine elastase II and investigation of its elastolytic specificity.
	www.nutrition.org /cgi/content/full/127/11/2205 (4630 words)

	Elastase-Induced Suppression of Endothelin-Mediated Ca2+ Entry Mechanisms of Vascular Contraction -- Chew et al. 42 ...
		Elastase is a serine protease enzyme that acts predominantly
		Aortic strips were stimulated with 96 mmol/L KCl, then treated with increasing concentrations of elastase (1 to 30 U/mL), and the inhibition of KCl contraction was observed.
		Aortic strips were stimulated with 96 mmol/L KCl, then treated with elastase (5 U/mL) in the absence (A) or presence of elastin (10 mg/mL) (B), and the inhibition of KCl contraction was observed.
	hyper.ahajournals.org /cgi/content/full/42/4/818 (4181 words)

	Serum Elastase Activity, Serum Elastase Inhibitors, and Occurrence of Carotid Atherosclerotic Plaques: The Etude sur le ... (Site not responding. Last check: 2007-10-08)
		Relation of serum elastase activity to ultrasonographically assessed carotid artery wall lesions and cardiovascular risk factors: the EVA study.
		Effects of elastase on the stiffness and elastic properties of arterial walls in cholesterol-fed rabbits.
		Saeki T, Tanaka K. Antiatheromatous properties of elastase in cholesterol-fed rabbits and ex vivo suppressive effect of elastase on smooth muscle cell proliferation in the presence of hypercholesterolemia.
	circ.ahajournals.org /cgi/content/full/105/22/2638 (3973 words)

	Cleavage of CD14 on Human Gingival Fibroblasts Cocultured with Activated Neutrophils Is Mediated by Human Leukocyte ... (Site not responding. Last check: 2007-10-08)
		Increased release of elastase from in vitro activated peripheral neurophils in patients with adult periodontitis.
		Elastase release of basic fibroblast growth factor in pulmonary fibroblast cultures results in down-regulation of elastin gene transcription: a role for basic fibroblast growth factor in regulating lung repair.
		Peripheral PMN cells in juvenile periodontitis: increased release of elastase and of oxygen radicals after stimulation with opsonized bacteria.
	www.jimmunol.org /cgi/content/full/165/10/5807 (5896 words)

	Role of Leukocyte Elastase in Preventing Cellular Re-Colonization of the Mural Thrombus -- Fontaine et al. 164 (6): ...
		Neutrophil elastase in the luminal layer of the mural thrombus.
		Elastase activity largely predominated in the luminal extracts of aneurysmal thrombus.
		whereas elastase is present in the azurophilic granules.
	ajp.amjpathol.org /cgi/content/full/164/6/2077 (6078 words)

	Elastase
		This elastase assay works under a variety of conditions.
		The measured Km of this substrate with porcine pancreatic elastase is in the 800 nM range, in contrast to the Km values of 6.2 and 0.8 mM for other chromogenic substrates based on pNA and AMC chromophores, respectively [see M.J. Castillo, K.
		This is truly an example of technology-driven science, when you consider that elastase activity can now be measured under conditions you did not think possible.
	www.phiphilux.com /elas1.htm (181 words)

	Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow ...
		Neutrophils from MMP-9 or elastase null mice and
		in the acute inflammatory response, neutrophil elastase or MMP-9
		Elastase Release by Transmigrating Neutrophils Deactivates Endothelial-bound SDF-1{alpha} and Attenuates Subsequent T Lymphocyte Transendothelial Migration
	www.jleukbio.org /cgi/content/abstract/71/5/821 (880 words)

	Elastase definition - Medical Dictionary definitions of popular medical terms
		Elastase definition - Medical Dictionary definitions of popular medical terms
		Elastase: An enzyme that digests and degrades a number of proteins including elastin, an elastic substance in the lungs and some other organs that supports their structural framework.
		Chronic Obstructive Pulmonary Disease - Learn about COPD - Chronic Obstructive Pulmonary Disease which is primarily two related diseases - chronic bronchitis and emphysema.
	www.medterms.com /script/main/art.asp?articlekey=33860 (175 words)

	Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte ...
		Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production -- Nemoto et al.
		Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production
		Cleavage of PDGF Receptor on Periodontal Ligament Cells by Elastase
	www.jleukbio.org /cgi/content/abstract/72/3/538 (320 words)

	Deficiency in Neutrophil Elastase Does Not Impair Neutrophil Recruitment to Inflamed Sites -- Hirche et al. 30 (4): 576 ...
		Deficiency in Neutrophil Elastase Does Not Impair Neutrophil Recruitment to Inflamed Sites -- Hirche et al.
		Deficiency in Neutrophil Elastase Does Not Impair Neutrophil Recruitment to Inflamed Sites
		neutrophil elastase (NE) plays a role in neutrophil recruitment
	www.ajrcmb.org /cgi/content/abstract/30/4/576 (532 words)

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