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Topic: Electrospray ionization

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Mass spectrometry

Electrospray ionization - Wikipedia, the free encyclopedia The invention of electrospray ionization was rewarded with the attribution of the Nobel Prize in Chemistry to John Fenn in 2002. Electrospray ionization is the primary ion source used in liquid chromatography-mass spectrometry. The use of the word "ionization" in "electrospray ionization" is criticized by some due to that many of the ions observed are thought to be preformed in solution before the electrospray process or created by simple changes in concentrations as the aerosolized droplets shrink. en.wikipedia.org /wiki/Electrospray_ionization   (1025 words)

Electrospray ionization -- Facts, Info, and Encyclopedia article Electrospray ionization is a technique used in (additional info and facts about mass spectrometry) mass spectrometry to overcome the propensity of (Any very large complex molecule; found only in plants and animals) macromolecules to fragment. of electrospray ionization was rewarded with the attribution of the (additional info and facts about Nobel Prize in Chemistry) Nobel Prize in Chemistry to (additional info and facts about John Fenn) John Fenn in 2002. The liquid contains the substance which is to be studied, the analyte, as well as a large amount of (A liquid substance capable of dissolving other substances) solvent, which is usually much more volatile than the analyte. www.absoluteastronomy.com /encyclopedia/e/el/electrospray_ionization.htm   (325 words)

Introduction to Mass Spectrometry Electrospray ionization generates ions directly from solution (usually an aqueous or aqueous/organic solvent system) by creating a fine spray of highly charged droplets in the presence of a strong electric field (typically 3.5 kV). The FAB ionization technique is a soft ionization method that typically requires the use of a direct insertion probe for sample introduction and a high energy beam of xenon atoms or cesium ions to sputter the sample and matrix from the probe's surface. While electron ionization is one of the most widely used methods of ionization in mass spectrometry, the principal problems associated with it include excessive fragmentation in the ionization source, the involatility of large molecules and thermal decomposition during vaporization. masspec.scripps.edu /information/intro/chapter3.html   (3539 words)

References on Electrospray Ionization "Mechanisms of electrospray ionization of singly and multiply charged salt clusters," M. Gamero-Castaño and J. Fernández de la Mora, Analytica Chimica Acta, 406, 67-91 (2000). Romero-Sanz and J. Fernandez de la Mora, Spatial structure and energy distribution of electrosprays of ionic liquids in vacuo, J. Applied Physics, 95 (4): 2123-2129 FEB 15 2004 Bon Ki Ku and Juan Fernandez de la Mora, Cluster ion formation in electrosprays of acetonitrile seeded with ionic liquids, J. Phys. www.eng.yale.edu /faculty/vita/delamora_electrospray_ioniz.htm   (301 words)

77821.001221&ELEMENT_SET=DECL electrospray ionization by a direct infusion of solutions or the output of a liquid chromatographic separation of analytes, the ion reservoir is an rf multipole ion reservoir and the coherent radiation is applied by a laser. Electrospray ionization mass spectrometry (ESI-MS) is particularly useful for very high molecular weight biopolymers such as proteins and nucleic acids greater than 10 kDa in mass, for it affords a distribution of multiply-charged molecules of the sample biopolymer without causing any significant amount of fragmentation. Electrospray ionization produces several multiply charged ions of the parent nucleic acid, without any significant fragmentation of the nucleic acid. www.wipo.int /cgi-pct/guest/getbykey5?KEY=00/77821.001221&ELEMENT_SET=DECL   (12750 words)

Chemical Principles of Electrospray Ionization Mass Spectroscopy Electrospray Ionization uses an electric field to produce a spray of fine droplets, which is used to create the spectrum. Ions, residual droplets, and vapor formed by electrospray are extracted through a small hole into two more evaporation chambers (evacuated) via a “nozzle” and a “skimmer,” which then passes into the analyzer of the mass spectrometer where a mass spectrum of the original sample is obtained. Even more attractive is the tendency for electrospray to produce multi-charged ions, a benefit that makes accurate measurement of large relative molecular masses much easier. analytical.chem.wisc.edu /524class/Folders/Heiden/electrosprayB.html   (483 words)

Sheathless interface for capillary electrophoresis/electrospray ionization-mass spectrometry using an in-capillary electrode - US Patent 6863790 A Finnigan MAT TSQ 70 mass spectrometer (San Jose, Calif.) with an in house fabricated electrospray ionization source was used for the study of the peptide mixtures. Ions are generated in the electrospray ionization chamber and desolvated as they travel through a 25 mm long, 0.4 mm i.d., 6.35 mm o.d. As a result, the combination of CE with electrospray ionization (ESI) mass spectrometry has proven to be applicable to a wide range of biologically important mixtures. www.patentstorm.us /patents/6863790.html   (13304 words)

New Objective: What is Electrospray? When electrospray is used as a soft ionization method for chemical analysis, the more generally accepted term is "electrospray ionization" (ESI). Ionization is the process of generating a gas phase ion from a typically solid or liquid chemical species. Ionization is a critical event in mass spectrometry as only ions can be can be accurately measured. www.newobjective.com /electrospray   (952 words)

Quattro micro API While electrospray ionization is a popular technique for the analysis of a wide range of compound classes, less polar and neutral compounds may require an alternative approach, such as APCI or APPI. Using electrospray, a strong electric field is applied to the liquid sample stream, which is then nebulized and desolvated with the assistance of high temperature gas flows to produce gas phase ions. Many laboratories, particularly in drug discovery, are tasked with analyzing compounds with a wide range of chemical structures and properties. www.waters.com /watersdivision/Contentd.asp?ref=PSTD-5MBFQM   (1541 words)

52735.000908&ELEMENT_SET=DECL Electrosprayed droplets evaporate while in the ionization chamber thereby producing gas phase analyte ions. The ionization chamber according to the present invention has a plurality of ports at predetermined locations and orientations on the body of the ionization chamber. Finally, it should be noted that whereas the preferred embodiment ionization chamber has a multitude of ports and that the sprayers or other devices are mounted on the cover via these ports, it is possible as an alternate embodiment to have these devices integrated into the cover-i. www.wipo.int /cgi-pct/guest/getbykey5?KEY=00/52735.000908&ELEMENT_SET=DECL   (6949 words)

What is hemoglobin A1c? An analysis of glycated hemoglobins by electrospray ionization mass spectrometry -- Peterson et al. 44 (9): 1951 -- Clinical Chemistry Electrospray ionization mass spectrometry for the quantitation of albumin in human serum. Electrospray ionization mass spectrometric characterization of acrylamide adducts to hemoglobin. Subunit analysis of bovine cytochrome bc1 by reverse-phase HPLC and determination of the subunit molecular masses by electrospray ionization mass spectrometry. www.clinchem.org /cgi/content/full/44/9/1951   (2829 words)

Electrospray Electrospray ionization (ESI) is an ionization technique for small amounts of large and/or labile molecules such as peptide's, proteins, organometallics, and polymers. ESI is a soft ionization technique and is particularly useful for obtaining the molecular weight of analytes that would normally exceed the normal mass range of sector and quadrupole instruments. The most obvious feature of an ESI spectrum is that the ions carry multiple charges, which reduces their mass-to-charge ratio compared to a singly charged species. minyos.its.rmit.edu.au /~rcmfa/electro.htm   (579 words)

Electrospray ionization mass spectrometric study of the metal cation complexation capabilities of a novel, doubly cage-annulated molecular box Electrospray ionization mass spectrometry (ESI-MS) was the analytical method of choice for study of metal cation complexation properties of 2 and 4. Electrospray ionization mass spectrometric study of the metal cation complexation capabilities of a novel, doubly cage-annulated molecular box CONTACT US Electrospray ionization mass spectrometric study of the metal cation complexation capabilities of a novel, doubly cage-annulated molecular box www.arkat-usa.org /ark/journal/2005/I03_Rao/AR-957K/957K.asp   (1538 words)

Determination of 11-Nor-Æ9-Tetrahydrocannabinol-9-Carboxylic Acid in a Urine-Based Standard Reference Material by Isotope-Dilution Liquid Chromatography–Mass Spectrometry with Electrospray Ionization Electrospray ionization in the negative ion mode was used to monitor the [M–H]– ions at m/z 343 and 346 for THC-9-COOH and its labeled internal standard, respectively. This method is based on isotope-dilution liquid chromatography–mass spectrometry (LC–MS) using electrospray for ionization (ESI). -Tetrahydrocannabinol-9-Carboxylic Acid in a Urine-Based Standard Reference Material by Isotope-Dilution Liquid Chromatography–Mass Spectrometry with Electrospray Ionization www.jatox.com /abstracts/2000/september/385-tai.htm   (263 words)

A rapid screening procedure for cholesterol and dehydrocholesterol by electrospray ionization tandem mass spectrometry -- Johnson et al. 42 (10): 1699 -- Journal of Lipid Research Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis, showing the product ion spectra of the protonated molecular ions, of the mono-(dimethylaminoethyl) succinyl (MDMAES) derivatives of (A) dehydrocholesterol and (B) cholesterol. A rapid screening procedure for cholesterol and dehydrocholesterol by electrospray ionization tandem mass spectrometry-- Johnson et al. Johnson, D. Analysis of alcohols, as dimethylglycine esters, by electrospray ionization tandem mass spectrometry. www.jlr.org /cgi/content/full/42/10/1699   (2909 words)

A New High-performance Interface for Capillary Electrophoresis/Electrospray Ionization Mass Spectrometry A novel capillary electrophoresis electrospray ionization mass spectrometry (CE/ESI-MS) interface has been developed based upon an alternative means of establishing electrical contact at the CE capillary terminus. The electrical connection, to close the CE circuit and simultaneously establish the electrospray voltage, is provided outside the membrane via an electrode in a small liquid reservoir. In contrast to the sheath flow and liquid junction interfaces, the flow rate of liquid to the ESI source consists of the CE eluent and is not increased. www.emsl.pnl.gov /docs/msd/mass_spec/home/publications/218.html   (174 words)

Electrospray ionization mass spectrometry analyses of nuclear membrane phospholipid loss after reperfusion of ischemic myocardium -- Williams et al. 41 (10): 1585 -- Journal of Lipid Research Electrospray ionization mass spectrometry analyses of nuclear membrane phospholipid loss after reperfusion of ischemic myocardium -- Williams et al. Positive-ion electrospray ionization mass spectra of choline glycerophospholipids in myocardial nuclei prepared from isolated perfused adult rat heart. Electrospray ionization mass spectrometry analyses of nuclear membrane phospholipid loss after reperfusion of ischemic myocardium www.jlr.org /cgi/content/full/41/10/1585   (4990 words)

Microfabricated Isoelectric Focusing Device for Direct Electrospray Ionization Mass Spectrometry Electrical potentials used for IEF focusing and electrospray were applied through platinum electrodes placed in the buffer reservoirs, which were isolated from the separation channel by porous membranes. The results indicated that this design can produce a stable electrospray and that performance was further improved and made more flexible with the assistance of a sheath gas and sheath liquid. Direct ESI-mass spectrometry (MS) using electrosprays produced directly from a sharp emitter "tip" on the microchip was evaluated. www.emsl.pnl.gov /docs/msd/mass_spec/home/publications/180.html   (233 words)

Relative Affinity Constants by Electrospray Ionization and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Calmodulin Binding to Peptide Analogs of Myosin Light Chain Kinase -- Nousiainen et al. 85 (1): 491 -- Biophysical Journal Relative Affinity Constants by Electrospray Ionization and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Calmodulin Binding to Peptide Analogs of Myosin Light Chain Kinase -- Nousiainen et al. Relative Affinity Constants by Electrospray Ionization and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Calmodulin Binding to Peptide Analogs of Myosin Light Chain Kinase Subtle differences in molecular recognition between modified glycopeptide antibiotics and bacterial receptor peptides identified by electrospray ionization mass spectrometry. www.biophysj.org /cgi/content/full/85/1/491   (4272 words)

Publications Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Analysis of the Recombinant Human Macrophage Colony Stimulating Factor B and Derivatives Electrospray ionization-Fourier transform ion cyclotron mass spectrometry using ion pre-selection and external accumulation for ultra-high sensitivity In-trap cleanup of proteins from electrospray ionization using soft sustained off-resonance irradiation with fourier transform ion cyclotron resonance mass spectrometry www.emsl.pnl.gov /docs/msd/mass_spec/home/publications.html   (3100 words)

JCE 1996 (73) A82 [Apr] Electrospray Ionization Mass Spectroscopy: Part I. Instrumentation and Spectral Interpretation Since Fenn and coworkers first introduced electrospray ionization (ESI) coupled with mass spectrometry (MS) as a viable analytical technique, the field of (bio)analytical mass spectrometry has seen explosive growth. Citation: Hofstadler, Steven A.; Bakhtiar, Ray; and Smith, Richard D. Electrospray Ionization Mass Spectroscopy: Part I. Instrumentation and Spectral Interpretation J. Electrospray Ionization Mass Spectroscopy: Part I. Instrumentation and Spectral Interpretation jchemed.chem.wisc.edu /Journal/Issues/1996/Apr/absA82.html   (194 words)

Electrospray ionization-mass spectrometric analysis of serum transferrin isoforms in patients with carbohydrate-deficient glycoprotein syndrome -- Yamashita et al. 114 (6): 766 -- Journal of Biochemistry Electrospray ionization-mass spectrometric analysis of serum transferrin isoforms in patients with carbohydrate-deficient glycoprotein syndrome -- Yamashita et al. Electrospray ionization-mass spectrometric analysis of serum transferrin isoforms in patients with carbohydrate-deficient glycoprotein syndrome and 75,157 +/- 6 Da by electrospray ionization mass spectrometry (ESI/MS). jb.oupjournals.org /cgi/content/abstract/114/6/766   (613 words)

Washington University Center for Biomedical and Bioorganic Mass Spectrometry: A NIH-Supported Resource Center In case only an exact mass measurement is required, the sample should be accompanied by a spectrum at wide mass range at low resolving power in the same ionization method, stating the exact conditions with which it was acquired. Tandem MS of electrosprayed ions by triple quadrupole and ion-trap. For limited sample quantities, MALDI and ESI are the prefered ionization methods, please use V-shaped interior vials (0.1-mL) or eppendorf centrifuge tubes. www.chemistry.wustl.edu /~msf   (894 words)

Interactions of {alpha}- and {beta}-avoparcin with bacterial cell-wall receptor-mimicking peptides studied by electrospray ionization mass spectrometry -- van de Kerk-van Hoof and Heck 44 (5): 593 -- Journal of Antimicrobial Chemotherapy Lightwahl, K. J., Schwartz, B. and Smith, R. Observation of the noncovalent quaternary associations of proteins by electrospray ionization mass spectrometry. Electrospray ionization mass spectra were recorded on a Finnigan/Thermoquest - and ß-avoparcin with bacterial cell-wall receptor-mimicking peptides studied by electrospray ionization mass spectrometry jac.oupjournals.org /cgi/content/full/44/5/593   (2365 words)

Cahill Electrospray ionization–mass spectrometry was used for qualitative identification and quantitation. Fragmentation conditions in the electrospray source were controlled so that three characteristic positive ions were produced for each compound. Initial tests indicate that the 19 pharmaceuticals can be detected at individual concentrations as low as 50 to 100 nanograms per liter. water.usgs.gov /owq/AFO/proceedings/afo/html/cahill.html   (312 words)

Divalent Cation-Mediated Interaction Between Cerebroside Sulfate and Cerebrosides: An Investigation of the Effect of Structural Variations of Lipids by Electrospray Ionization Mass Spectrometry -- Koshy et al. 77 (1): 306 -- Biophysical Journal Differentiation of Ca and Mg -coordinated branched trisaccharide isomers: an electrospray ionization and tandem mass spectrometry study. The observation of non-covalent interactions in solution by electrospray ionization mass spectrometry: promise, pitfalls and prognosis. Direct determination of solution binding constants for noncovalent complexes between bacterial cell wall peptide analogues and vancomycin group antibiotics by electrospray ionization mass spectrometry. www.biophysj.org /cgi/content/full/77/1/306   (6087 words)

Accurate and rapid modeling of iron-bleomycin-induced DNA damage using tethered duplex oligonucleotides and electrospray ionization ion trap mass spectrometric analysis -- Harsch et al. 28 (9): 1978 -- Nucleic Acids Research Electrospray ionization ion trap mass spectrometry was used Accurate and rapid modeling of iron-bleomycin-induced DNA damage using tethered duplex oligonucleotides and electrospray ionization ion trap mass spectrometric analysis -- Harsch et al. Accurate and rapid modeling of iron–bleomycin-induced DNA damage using tethered duplex oligonucleotides and electrospray ionization ion trap mass spectrometric analysis nar.oupjournals.org /cgi/content/full/28/9/1978   (3937 words)

Untitled Document Zhao, X. and Yinon, J.: Characterization of ammonium nitrate by electrospray ionization tandem mass spectrometry. Zhao, X. and Yinon, J.: Identification of nitrate ester explosives by liquid chromatography-electrospray ionization and atmospheric pressure chemical ionization mass spectrometry. Gapeev, A. and Yinon, J.: Characterization of inorganic oxidizers by electrospray mass spectrometry. ncfs.ucf.edu /phys_evd.html   (2161 words)

CiteULike: Tetraalkylammonium halides as chemical standards for positive electrospray ionization with ion mobility spectrometry/mass spectrometry. Tetraalkylammonium halides as chemical standards for positive electrospray ionization with ion mobility spectrometry/mass spectrometry. Chemical standards for positive ion mode electrospray ionization ion mobility spectrometry/mass spectrometry (ESI(+)-IMS/MS) are suggested. CiteULike: Tetraalkylammonium halides as chemical standards for positive electrospray ionization with ion mobility spectrometry/mass spectrometry. www.citeulike.org /user/Terkko/article/341321   (221 words)

Electrospray Ionization Soon after the introduction of TSP, the electrospray ionization (ESI) source was presented by Yamashita and Fenn Positive or negative ions can be produced, but a stable negative ion current is more difficult to maintain due to an increased propensity toward electric discharge at the electrospray needle tip. ESI differs from TSP in the fact that it uses a high potential to impose a charge in place of the buffers used in TSP. www.noble.org /plantbio/ms/iontech.esi.html   (382 words)

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