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	U.S. Patent: 5525662 - Functionalization of polymers via enamine of acetoacetate - June 11, 1996
		The reaction to form the enamine is generally rapid with the rate of formation increasing with temperature.
		The enamine formation is a reversible reaction so the amine compound should be non-volatile if the composition is likely to be exposed to the atmosphere prior to the application use of the functional group.
		Another approach to preparation of vinyl polymers containing equivalent pendant enamine functionally is to use preformed enamine monomers derived from the appropriate amine and the acetoacetate monomer.
	www.everypatent.com /comp/pat5525662.html (4957 words)

	Pharmaceutical Technology - Enamine - Screening Compounds, Building Blocks, Custom Synthesis, Discovery Chemistry and ...
		Screening compounds are produced by Enamine within validated chemistry space that is created through the rigorous selection of reactions and the appropriate building blocks in numerous tests.
		It is not only because Enamine FTE rate is one of the most competitive in the Eastern Europe, but also because of introduction of a number of enabling technologies, first of all the state-of-the-art ChemoInformatics.
		Enamine is a leading provider of screening compounds for life science industries.
	www.pharmaceutical-technology.com /contractors/compound_man/enamine (481 words)

	Enamine - General Information (Site not responding. Last check: 2007-10-03)
		Enamine is a leading supplier of Screening Compounds and Building Blocks for pharmaceutical and agricultural industries.
		During the past 10 years Enamine carried out a number of projects that allowed to synthesize many novel organic substances.
		At present Enamine's research facility is 2500 square meters.
	users.iptelecom.net.ua /~gmtd (201 words)

	Synthesis of fused N-heterocycles utilizing the heterocyclic enamine protocol (Site not responding. Last check: 2007-10-03)
		Heterocyclic enamines 1 underwent regioselective C-benzylation and C-benzoylation with o-bromobenzyl bromide and o-halobenzoyl chloride to yield the corresponding C-benzylated and C-benzoylated heterocyclic enamines 2 and 8, respectively.
		The ring size effect of the heterocyclic enamines on the reactivity of both the enaminic carbon and the secondary amine was observed.
		The C-benzylated heterocyclic enamine structure 2 and Z-configuration of the double bond was evidenced by the observation of disappearance of the vinyl proton signal and of the downfield shift of NH proton signal, due to the strong intramolecular hydrogen bonding to the ester carbonyl, in
	www.arkat-usa.org /ark/journal/2003/I02_Huang/ZH-702D/ZH-702D.asp (3162 words)

	Brown, Sean Pomeroy (2005-02-22) Iminium and enamine activation: methods for enantioselective organocatalysis. ... (Site not responding. Last check: 2007-10-03)
		Brown, Sean Pomeroy (2005-02-22) Iminium and enamine activation: methods for enantioselective organocatalysis.
		Enamine activation of aldehydes has provided the first direct asymmetric a-oxidation of carbonyls.
		The imidazolidinone framework, developed for iminium activation, was also demonstrated to participate in enamine activation of aldehydes to perform the enantioselective a-chlorination of aldehydes.
	etd.caltech.edu /etd/available/etd-02242005-174252 (260 words)

	new page1 (Site not responding. Last check: 2007-10-03)
		The competition of the enamine with a solvent for complex- formation with the tetrazine is also confirmed by the modeling of the “tetrazine–enamine–solvent” complexes provided within the algorithm MOPS.
		-atom of the tetrazine and its nearest atom of the enamine is 4.27 Å).
		Although the competition between the solvent and enamine for the complex- formation with tetrazine leads to covering of the reaction centers on the reaction pathway to the meta- isomer.
	www.arkat-usa.org /ark/journal/2004/I11_Chupakhin/OC-1188H/OC-1188H.asp (2231 words)

	BioTech Career Center
		Summary provided by Enamine: Enamine Ltd. is a diversified provider of discovery chemistry for pharmaceutical and agrochemical industry needs.
		Besides simple production of screening compounds, Enamine has earned a reputation as a leading provider of a number of chemistry services, including synthesis of analogues, custom synthesis, lead-oriented services, etc. Enamine is well known as a supplier of high quality organic compounds libraries and Building Blocks for their synthesis.
		Enamine holds a leading position with respect to the number of compounds that can be acquired from only one supplier.
	www.biotechcareercenter.com /Enamine.html (178 words)

	PCP Synthesis via enamine precursors (Site not responding. Last check: 2007-10-03)
		This method is used less frequently in underground synthesis, but has the advantage of not involving toxic cyanide compounds.
		The first step of the reaction is the dehydration of piperidine and cyclohexanone to form an enamine.
		The intermediate cyclohexenyl-piperidine (enamine) from the previous step is best used crude, but it can be distilled with adequate vacuum.
	www.erowid.org /archive/rhodium/chemistry/pcp/enam_synth.html (593 words)

	ChIN's Summary Page: Enamine (Site not responding. Last check: 2007-10-03)
		Enamine was found in 1990, derived from the Institute of Organic Chemistry (National Academy of Sciences of Ukraine).
		In the year 2000, Enamine developed a simple production scheme allowing synthesis of up to 12 000 compounds per month.
		Enamine in-house production is based on the use of the REAL DataBase (10¡¤106 structures).
	www.chinweb.com.cn /cgi-bin/chemport/getfiler.cgi?ID=nUnyT6KPAEwjaGnAi4WopfvOkGZBSjPlpjWMwF3GpboUJxB535IijpfIfoaoXo3n&VER=E (114 words)

	TSRI - News and Publications
		We describe proline-catalyzed reactions with an enamine catalysis cycle (Fig.
		The enamine then reacts with an electrophile of the general type X=Y to give an iminium ion and, after hydrolysis, the desired product and regenerated proline.
		Guided by this transition state and our enamine catalysis cycle, we are developing new proline-catalyzed reactions to expand the scope of enamine catalysis.
	www.scripps.edu /news/sr/sr2002/mb29.html (372 words)

	Enamine (Site not responding. Last check: 2007-10-03)
		Enamine in-house production is based on the use of the REAL DataBase (6·106 structures), which represents the validated chemistry space of our company.
		Besides simple production of screening compounds, Enamine has earned a reputation as a leading provider of a number of chemistry services, including synthesis of analogues, custom synthesis, lead-oriented services, and advanced chemistry products such as focused and targeted libraries.
		The high percentage of unique compounds in our Screening Collection has been achieved with the use of a large stock of the proprietary Building Blocks (12 000 items).
	www.bioscreening.com /index/companies/Enamine (197 words)

	United States Patent Application: 0040143137
		The present invention relates to a process for producing 1,5-diaminonaphthalene without formation of 1,8-diaminonaphthalene and not through an unstable nitro imine and nitro enamine as intermediates, the process including the steps of dehydrogenating 5-substituted-1-tetralone to produce a naphthol compound and then aminating the hydroxyl group of the naphthol compound.
		However, the nitro imine and nitro enamine, which are the intermediates in such processes, are relatively unstable compounds.
		[0004] It is an object of the present invention to provide a novel process for industrially advantageously producing 1,5-diaminonaphthalene without formation of 1,8-diaminonaphthalene which is an isomeric by-product and not through a nitro imine and nitro enamine as intermediates.
	appft1.uspto.gov /netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1="20040143137".PGNR.&OS=DN/20040143137&RS=DN/20040143137 (4232 words)

	VOH // Questions and Answers for 130A (Site not responding. Last check: 2007-10-03)
		I'm asking if we perform a enamine for 2-hexanone, can we say that the major will always be the kinetic (in our case), the one with the double bond on the 1st and 2nd carbon.
		The enamine will not always be the kinetic one, especially when there is a group to which the double bond of the enamine can conjugate (like an aromatic ring, see p.
		When enamines are made from aldehydes there is no ambiguity, but with non-symmetric ketones like 2-hexanone there would be a mixture of isomers, and perhaps it is best to avoid this situation altogether...
	voh.chem.ucla.edu /vohtar/winter01/130A/qa.html (15783 words)

	Model of Enamine from Cyclopentanone and Dimethylamine
		Secondary amines react with the carbonyl group of aldehydes and ketones to form a tetrahedral complex which has no hydrogen on the nitrogen.
		When water is eliminated from this complex, a C,N pi bond cannot form, and instead a C,C pi bond is formed, giving an enamine.
		Enamines have significant importance in synthesis as the C,C pi bond is activated as a nucleophile at the carbon away from the nitrogen.
	wps.prenhall.com /wps/media/objects/725/743227/reactn6.html (99 words)

	Enamine - Home
		ABOUT US At Enamine, we are committed to providing Life Science industries with a full spectrum of smart chemistry solutions to support their efforts in the design of new drugs and other bioactive products.
		In 1990, in response to a rapidly increasing demand for high throughput bioscreening, Enamine began the production of applicable low molecular weight organic compounds.
		Since that time, a large proprietary screening collection has been built up.
	www.enamine.net (111 words)

	Enamine Formation
		The overall equation for enamine formation from cyclohexanone (a ketone) and pyrrolidine (a 2º-amine) is shown here.
		Writing a mechanism for this reaction provides a good test of ones' understanding of acid-catalyzed processes.
		A summary of the steps in this acid-catalyzed mechanism is shown below.
	www.cem.msu.edu /~reusch/VirtualText/Questions/MechPrb/enamine.htm (138 words)

	Transition States of Amine-Catalyzed Aldol Reactions Involving Enamine Intermediates: Theoretical Studies of Mechanism, ... (Site not responding. Last check: 2007-10-03)
		Transition States of Amine-Catalyzed Aldol Reactions Involving Enamine Intermediates: Theoretical Studies of Mechanism, Reactivity, and Stereoselectivity
		The mechanisms, transition states, relative rates, and stereochemistries of amine-catalyzed aldol reactions involving enamine intermediates have been explored with density functional theory (B3LYP/6-31G*) and CPCM solvation models.
		The stereoselectivities of reactions of ketone enamines with aldehydes, including the facial stereoselectivity involving chiral aldehydes, were modeled and compared with experimental results.
	pubs.acs.org /cgi-bin/jtext?jacsat/123/i45/abs/ja011403h (190 words)

	HIC-Up files for compound CEM cis enamine bound to ser. see remark 8 (Site not responding. Last check: 2007-10-03)
		HIC-Up files for compound CEM cis enamine bound to ser.
		Google search for cis enamine bound to ser.
		KEGG-Ligand hits for cis enamine bound to ser.
	util.ucsf.edu /local/programs/hicup/CEM (209 words)

	HIC-Up files for compound TEM trans enamine bound to ser. see remark 9
		HIC-Up files for compound TEM trans enamine bound to ser.
		KEGG-Ligand hits for trans enamine bound to ser.
		Google search for trans enamine bound to ser.
	xray.bmc.uu.se /gerard/hicup/TEM (236 words)

	Thieme-connect - Abstract (Site not responding. Last check: 2007-10-03)
		The material presented in this review is separated into cases where the enamine nitrogen serves only to activate a position in a molecule to electrophilic attack or to protect a carbonyl group during certain transformations of the molecule, and is then removed, and others, where the enamine nitrogen constitutes part of the final structure: 1.
		Reactions not involving incorporation of the enamine nitrogen into the molecular skeleton of the final product 1.1.
		The use of the enamine function as protective group 1.6.
	www.thieme-connect.com /ejournals/abstract/synthesis/doi/10.1055/s-1970-21631 (129 words)

	CHEM 286 Experiments - Stork enamine reaction (Site not responding. Last check: 2007-10-03)
		If you distilled off more than 3mL of toluene earlier, add some extra toluene to this mixture.
		Once the enamine solution has cooled to room temperature, add the acetic anhydride solution, cap the flask and store it in your locker until the next lab period.
		Add 1mL of water, attach a reflux condenser and drying tube and boil the mixture for 30 minutes in an aluminum block (hotplate temp: ~120°C).
	www.sfu.ca /chemistry/students/courses/chem286/enamine.htm (778 words)

	Thieme-connect - Abstract (Site not responding. Last check: 2007-10-03)
		Thermally induced [3,3]-sigmatropic rearrangement of 3-amino-1,5-diene substrates occurs to give the corresponding enamine products in high yield and with excellent
		The enamine produced during the amino-Cope rearrangement has been directly derivatized, representing the first report of a tandem amino-Cope rearrangement/enamine alkylation reaction.
		The potential of this novel synthetic strategy is outlined.
	www.thieme-connect.com /ejournals/abstract/synlett/doi/10.1055/s-1997-3248 (103 words)

	Chemicals Biochemicals Profile, Enamine (Site not responding. Last check: 2007-10-03)
		Home > Directory of Companies > Chemical or Biochemical Products > Profile: Enamine
		Enamine Ltd. is a diversified provider of discovery chemistry for pharmaceutical and agrochemical industry needs.
		Our in-house production is based on the use of the REAL DataBase, which represents the validated chemistry space of our company.
	www.ispex.ca /companies/chemicals/Enamine.html (337 words)

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