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| | THE MERCK MANUAL, Sec. 18, Ch. 241, Gynecologic Neoplasms |
 | | Endometrial cancer is more common in women with conditions that tend to result in unopposed estrogen (high circulating levels of estrogen with no or low levels of progesterone), such as unopposed estrogen replacement therapy, obesity, polycystic ovarian syndrome, nulliparity, late menopause, estrogen-producing tumors, anovulation, or oligo-ovulation. |
 | | Endometrial hyperplasia usually precedes endometrial cancer and is classified by the degree of cytologic atypia. |
 | | Endometrial cancer may spread from the surface of the uterine cavity to the cervical canal; through the myometrium to the serosa and into the peritoneal cavity; via the lumen of the fallopian tube to the ovary, broad ligament, and peritoneal surfaces; via the bloodstream, leading to distant metastases; or via the lymphatics. |
| www.merck.com /mrkshared/mmanual/section18/chapter241/241a.jsp (855 words) |
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