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Topic: Endometrial stromal sarcoma

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	Endometrial Stromal Sarcoma
		Uterine sarcomas represent 2-5% of all uterine malignancies.
		Endometrial stromal sarcoma typically occurs in women between the ages of 42 and 59 years.
		Overall, ESS are difficult to differentiate from leiomyomas with cystic degeneration, leiomyosarcomas, and endometrial carcinomas.
	brighamrad.harvard.edu /Cases/bwh/hcache/363/full.html (617 words)

	2005 Surgical Pathology Specialty Conference Handout - Case 1
		The combination of endometrial stromal sarcoma and high grade sarcoma (dedifferentiation) was detected in the primary uterine tumors in eight cases, and in the recurrent tumors in four cases (three in the pelvis and one in the lung).
		In summary, dedifferentiation in endometrial stromal sarcoma is an uncommon event that must be recognized due to its importance from the diagnostic standpoint and its potential therapeutic implications.
		Dedifferentiation of endolymphatic stromal myosis to poorly differentiated uterine stromal sarcoma.
	www.uscap.org /site~/94th/specsurgh1.htm (1551 words)

	STROMAL SARCOMA OF THE ENDOMETRIUM (Site not responding. Last check: 2007-11-05)
		Mesenchymal tumors of the endometrium may be composed of primitive stromal cells which are derived from the mullerian mesoderm.
		The mesenchymal tumors of the endometrium are three types: benign stromal nodule, low grade stromal sarcoma (endolymphatic stromal myosis) and endometrial stromal sarcoma.
		The stromal sarcoma consists of overtly malignant stromal cells.
	www.bioscience.org /atlases/tumpath/freprod/uterus/15/synposis.htm (124 words)

	Endometrial stromal sarcoma - WrongDiagnosis.com
		Endometrial stromal sarcoma: A rare type of cancer that develops from the endometrial layer of the uterus.
		Endometrial stromal sarcoma is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that Endometrial stromal sarcoma, or a subtype of Endometrial stromal sarcoma, affects less than 200,000 people in the US population.
	www.wrongdiagnosis.com /e/endometrial_stromal_sarcoma/intro.htm (322 words)

	Endometrial Stromal Sarcoma
		Uterine sarcomas represent 2-5% of all uterine malignancies.
		Endometrial stromal sarcoma typically occurs in women between the ages of 42 and 59 years.
		Overall, ESS are difficult to differentiate from leiomyomas with cystic degeneration, leiomyosarcomas, and endometrial carcinomas.
	www.brighamrad.harvard.edu /Cases/bwh/hcache/363/full.html (617 words)

	cancerfacts.com - About Uterine Cancer
		Endometrial hyperplasia -- an abnormal increase in the cells of the endometrium -- is common among women who are nearing menopause and who seldom ovulate.
		The vast majority (95 percent) of cancers of the uterus are endometrial cancers, 75 percent of which are identified by the pathologist as adenocarcinomas, cancer of epithelium or cells lining the uterine wall.
		Low-grade stromal sarcoma enlarges the uterus uniformly, while the high-grade stromal sarcoma protrudes into the endometrial cavity, invading the lymphatic channels and blood vessels of the myometrium and the muscular wall of the uterus.
	www.cancerfacts.com /GeneralContent/Uterine/gen_overview.asp?CB=11 (1359 words)

	Glossary of terms
		Endometrial Stromal Sarcoma (ESS) - a uterine sarcoma arising in the endometrium.
		In sarcoma this occurs most frequently in the lungs, in GIST it is usually in the liver.
		This is a gyanecological cancer with characteristics of both a sarcoma and a carcinoma.
	www.sarcoma-uk.org /glossary.htm (1213 words)

	Sydney Gynaecological Oncology Group
		Uterine sarcomas are uncommon tumours, comprising about 5% of all malignant uterine tumours and less than 1% of all female cancers.
		Features of the stromal component of the tumour including grade, mitotic index and presence and type soft heterologous elements are not related to risk or presence of metastases.
		Low grade sarcomas tend to occur in premenopausal women and tend to be localized to the uterus at presentation.
	www.cs.nsw.gov.au /cancer/sgog/Sarcoma_Guide.htm (1005 words)

	Uterine endometrial stromal sarcoma with smooth muscle and glandular differentiation -- McCluggage et al. 54 (6): 481 ...
		Endometrial stromal sarcoma and poorly differentiated endometrial sarcoma.
		Endometrial stromal sarcoma with smooth muscle differentiation: recurrence after 17 years: a follow-up report with discussion of the nomenclature.
		Endometrial stromal sarcomas of the uterus with extensive endometrioid glandular differentiation: a report of three cases that caused problems in differential diagnosis.
	jcp.bmjjournals.com /cgi/content/full/54/6/481 (1298 words)

	World Journal of Surgical Oncology \| Full text \| Low grade Endometrial Stromal Sarcoma of uterine corpus, a ...
		Endometrial stromal sarcoma is characterized by proliferations composed of cells with Endometrial stromal cell differentiation.
		The division of endometrial stromal sarcomas into low-grade and high-grade categories has fallen out of favor, and the term endometrial stromal sarcomas now considered best restricted to neoplasms that were formally to as low-grade endometrial stromal sarcomas [6].
		ESS are divided in low and high-grade tumors according to cell morphology and mitotic count [6], Boardman CH, et al defined low-grade ESS from high-grade ESS by the cellular uniformity, less frequent mitosis (<3 per 10 high-power fields versus >10), and lack of hemorrhage and necrosis [3].
	www.wjso.com /content/4/1/50 (2644 words)

	Endometrial Cancer: Free Medical and Health Information on Endometrial Cancer Research and Treatment
		Type 2 endometrial cancers often metastasize to the lymph nodes and peritoneal cavity and patients should undergo a staging procedure similar to that performed for ovarian cancer.
		Endometrial stromal sarcoma, an uncommon uterine malignancy, has shown response to hormonal treatments, with multiple case reports of efficacy of aromatase inhibition.
		Endometrial cancer is a hormone-dependent malignancy, and the majority has a precursor phase of endometrial hyperplasia.
	www.lifestages.com /health/endocanc.html (6253 words)

	2005 Cytopathology Specialty Conference Handout - Case 7
		Endometrial sarcomas are unusual lesions most often occurring as a component of high grade endometrial carcinoma (malignant mullerian mixed tumors (MMMT) or adenosarcomas) or occasionally as a pure sarcoma.
		Endometrial stromal sarcoma is a protean tumor with numerous phenotypes and vary from low grade lesions with a low recurrence rate to poorly differentiated sarcomas with little if any differentiation and a very poor prognosis.
		The division of endometrial stroma sarcomas into low-grade and high grade has somewhat fallen out of favor and some now favor limiting the designation of endometrial stromal sarcoma to those lesions formerly referred to as "low-grade".
	www.uscap.org /site~/94th/speccytoh7.htm (1283 words)

	Endometrial Stromal Tumors (Site not responding. Last check: 2007-11-05)
		Endometrial stromal sarcoma (ESS) is an uncommon neoplasm whose occurrence outside the uterus is extremely rare in the absence of metastasis or extension of a primary uterine neoplasm.
		Endometrial stromal sarcoma usually has the gross appearance of a single nodule, multiple masses, or a poorly demarcated lesion with occasional cystic degeneration; however, a multilocular form has not been described in the literature.
		The demonstration of gonadotropin-releasing hormone receptors I and II expression in endometrial stromal sarcomas may be a rationale for a clinical study of gonadotropin-releasing hormone analogs in the treatment of women with endometrial stromal sarcomas.
	www.thedoctorsdoctor.com /diseases/endometrialstromaltumors.htm (5389 words)

	Endometrial Cancer - Overview, Types, & Incidence - oncologychannel
		Endometrial cancer, which originates in the inner lining of the uterus, accounts for about 90% of uterine cancers.
		Types of uterine sarcoma include carcinosarcoma (most common type), leiomyosarcoma (develop in the muscular tissue of the myometrium), and endometrial stromal sarcoma (develop in supporting connective tissue).
		In the United States, endometrial cancer is more common in Caucasian women and uterine sarcoma is more common in African American women.
	www.oncologychannel.com /endometrialcancer (446 words)

	What are endometrial stromal sarcomas? : Cancerbackup (Site not responding. Last check: 2007-11-05)
		Endometrial stromal sarcomas (ESS) are a rare form of cancer affecting the supporting tissue of the lining of the womb (uterus).
		Endometrial stromal nodules: these tumours are confined to the inner lining of the womb, and do not spread into the surrounding tissues.
		Endometrial stromal sarcoma: a clinicopathologic study of 11 cases with determination of estrogen and progestin receptor levels in three tumors.
	www.cancerbackup.org.uk /QAs/29679082 (358 words)

	August 2002 Anatomic Abstracts - College of American Pathologists (Site not responding. Last check: 2007-11-05)
		Gastrointestinal stromal tumors are a heterogeneous group of neoplasms that have clinical and histologic features that vary depending on their location within the gastrointestinal tract.
		Features that may be seen in endometrial stromal nodules, such as smooth muscle metaplasia, irregular interdigitation of stromal neoplasia with metaplastic smooth muscle, and broad zones of necrosis, may be confused with endometrial stromal sarcoma.
		Endometrial stromal nodules and endometrial tumors with limited infiltration: a clinicopathologic study of 50 cases.
	www.cap.org /apps/docs/cap_today/anatomic_abstracts/anatomic_0802.html (781 words)

	Sonographic, CT, and MRI Findings of Endometrial Stromal Sarcoma Located in the Myometrium and Associated with ...
		stromal sarcoma with diffuse and multinodular involvement of
		Endometrial compression (fl arrow) and right fallopian wall invasion (open arrowheads), showing continuity with broad and round ligaments, are also marked.
		specimen yielded the diagnosis of a low-grade endometrial stromal
	www.ajronline.org /cgi/content/full/182/6/1531 (1302 words)

	Uterine Sarcoma: (Site not responding. Last check: 2007-11-05)
		The presence or absence of stromal heterologous elements, the types of such elements, the grade of the stromal components, and the mitotic activity of the stromal components bear no relationship to the presence or absence of metastases at surgical exploration.
		Stage I sarcoma is confined to the corpus uteri.
		Endometrial stromal sarcoma: a clinicopathologic study of 11 cases with determination of estrogen and progestin receptor levels in three tumors.
	www.acor.org /cnet/62938.html (3065 words)

	Ewing Sarcoma - Lucile Packard Children's Hospital
		Ewing sarcoma is a cancer that occurs primarily in the bone or soft tissue.
		Ewing sarcoma can occur in any bone, but is most often found in the extremities and can involve muscle and the soft tissues around the tumor site.
		Similar to osteogenic sarcoma, trauma or injury is sometimes involved with the site at the time of diagnosis.
	www.lpch.org /DiseaseHealthInfo/HealthLibrary/oncology/ewing.html (881 words)

	Nikon MicroscopyU: Human Pathology Digital Image Gallery - Uterine Sarcoma
		Uterine sarcomas are usually considered to be comprised of three basic types based upon the specific type of connective tissue they originate in.
		Treatment for uterine sarcoma often involves the surgical removal of part or all of the uterus, but chemotherapy, radiotherapy, or hormone therapy may be employed as well.
		Uterine Sarcoma at 10x Magnification - Uterine sarcomas occur most commonly in middle-aged and elderly women, and a subclass of the tumors, leiomyosarcomas, have a higher incidence rate among the African American population.
	www.microscopyu.com /galleries/pathology/uterinesarcoma.html (562 words)

	Endometrial cancer Information on Healthline
		Endometrial cancer involves cancerous growth of the endometrium, the lining of the uterus.
		Although the exact cause of endometrial cancer is unknown, increased levels of estrogen appear to have a role.
		Women who have a history of endometrial polyps or other benign growths of the uterine lining, postmenopausal women who use estrogen-replacement therapy (specifically if not given in conjunction with periodic progestin), and those with diabetes are also at increased risk.
	www.healthline.com /adamcontent/endometrial-cancer (729 words)

	CT and MRI of Uterine Sarcomas and Their Mimickers -- Rha et al. 181 (5): 1369 -- American Journal of Roentgenology
		Because most leiomyosarcomas are located in myometrium, endometrial biopsy is not as useful as in other sarcomas, but it may establish diagnosis in as many as one third of patients in whom lesion is submucosal.
		Usual preoperative diagnosis of low-grade endometrial stromal sarcoma is leiomyoma with unusual degree of bleeding.
		However, in practice, most patients with endometrial carcinomas have tumors that are confined to endometrium or that only superficially invade myometrium, and most malignant mixed müllerian tumors or endometrial stromal sarcomas tend to be massive with deep myometrial invasion on initial presentation.
	www.ajronline.org /cgi/content/full/181/5/1369 (1843 words)

	All Endometrial Stromal Sarcoma messages (Site not responding. Last check: 2007-11-05)
		ESS is so rare that little is known about it, and you are so newly diagnosed I’m sure you are at a very vulnerable stage.
		Because ESS always begins in the endometrium, they knew that this abdominal mass was recurrence, as I hadn’t had an endometrium for 4 years.
		The ESS online forum that I belong to (mentioned too in my earlier email) is extremely helpful and there are lots of ladies more knowledgeable than I on it.
	www.cancercompass.com /message-board/message/all,2821,0.htm (2410 words)

	eMedicine - Uterine Cancer : Article by William E Winter III, MD
		Fortunately, most cases of endometrial cancer are diagnosed prior to this clinical presentation because of the recognition of PMP bleeding as a possible early symptom of cancer.
		Endometrial biopsy is generally accepted as the first step in the diagnosis of endometrial cancer in the patient with PMP bleeding.
		Endometrial cancer treated with surgery and radiation that does recur is less often localized and, as such, is less amenable to localized therapy such as surgical excision and radiation.
	www.emedicine.com /med/topic2832.htm (7550 words)

	ACS :: How Is Uterine Sarcoma Diagnosed?
		In most cases, the possibility of uterine sarcoma is suggested by certain symptoms such as abnormal spotting, bleeding, discharge, or pelvic pain...
		The tissue can be sampled by endometrial biopsy or by dilation and curettage (D & C) with or without a hysteroscopy (a test in which a gynecologist looks at the inside of the uterus through a thin, lighted tube).
		Some endometrial stromal sarcomas that contain estrogen and progesterone receptors depend on these hormones to grow.
	www.cancer.org /docroot/cri/content/cri_2_4_3x_how_is_uterine_sarcoma_diagnosed_63.asp?sitearea=cri (1731 words)

	Cogprints - Endometrial Stromal Sarcoma Presenting As Puberty Menorrhagia (Site not responding. Last check: 2007-11-05)
		Endometrial stromal sarcomas are rare uterine tumours usually seen in perimenopausal females.
		Mesenchymal tumours of the uterus : A clinical and pathological study of 53 endometrial stromal tumours.
		Endometrial stromal sarcoma of the uterus: A clinical and histopathological study.
	cogprints.org /4477 (289 words)

	Oncology Nursing Society.
		N, a 50-year-old woman with endometrial stromal sarcoma (ESS) of the ovary complained of worsening symptoms including increased shortness of breath, increased abdominal girth, and inability to eat.
		ESS of the ovary is exceptionally rare, but uterine ESS is slightly more common and accounts for 0.2% of all uterine malignancies (Doctor's Doctor, 2004).
		Patients with high-grade ESS appear to follow a clinical pattern similar to, albeit more aggressive than, that observed in women with epithelial ovarian cancer (Burke, Eifel, and Muggia, 2001), raising the possibility that cytotoxic agents active in epithelial ovarian cancer may prove beneficial in ESS of the ovary.
	www.ons.org /publications/journals/ONF/Volume31/Issue3/3103513.asp (1873 words)

	Uterine Sarcoma - Cancer Overview
		Sarcoma of the uterus, a very rare kind of cancer in women, is a disease in which cancer (malignant) cells grow in the muscles or other supporting tissues of the uterus.
		The majority (95 percent) are endometrial cancers, which develop in the lining of the uterus.
		Endometrial stromal sarcomas are tumors in the connective tissue of the endometrium and are the rarest of the three types.
	www.umm.edu /cancer/overview/us.html (112 words)

	eMedicine - Uterine Cancer : Article Excerpt by: William E Winter III, MD
		The remaining sarcomas are made up of heterologous tumors—tumors that contain histologic components foreign to the uterus, such as rhabdomyosarcomas, osteosarcomas, and chondrosarcomas.
		Endometrial cancer is primarily a disease of postmenopausal women.
		Endometrial cancer is more common in white women when compared to fl women.
	www.emedicine.com /med/byname/uterine-cancer.htm (586 words)

	Endometrial Stromal Sarcoma - A site for survivors and loved ones - Home
		Our site, put together by Endometrial Stromal Sarcoma (ESS) survivors, is intended to help women who are dealing with this diagnosis, as well as their loved ones.
		We will help you sort through the information that is available about our rare sarcoma, offer support through our Yahoo discussion group (see link on the left), and will provide stories from survivors.
		We know that learning that you have a rare sarcoma is often terrifying.
	ess-sarcoma.com (277 words)

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