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Topic: Endonuclease

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	New England Biolabs
		Endonuclease V, often called deoxyinosine 3´ endonuclease, recognizes DNA containing deoxyinosines (paired or not) on double-stranded DNA, single-stranded DNA with deoxyinosines and to a lesser degree, DNA containing abasic sites (ap) or urea, base mismatches, insertion/deletion mismatches, hairpin or unpaired loops, flaps and pseudo-Y structures.
		It is believed that Endonuclease V needs another protein to repair the DNA, as it does not remove the deoxyinsoine or the damaged bases (1,2,3).
		Endonuclease V cleaves the second and third phosphodiester bonds 3´ to the mismatch of deoxyinosine with a 95% efficiency for the second bond and a 5% efficiency for the third bond (2), leaving a nick with 3´-hydroxyl and 5´-phosphate (4).
	www.neb.com /nebecomm/products_intl/productM0305.asp (274 words)

	ENDOG - Endonuclease G, mitochondrial precursor
		Endonuclease G (endoG) is released from mitochondria during apoptosis and is in part responsible for internucleosomal DNA cleavage.
		Endonuclease G (Endo G) is widely distributed among animals and cleaves DNA at double-stranded (dG)n.(dC)n and at single-stranded (dC)n tracts.
		Endonuclease G (Endo G) is a nuclease of prokaryotic lineage found in the mitochondria of vertebrates that has been suggested to play a role in mitochondrial DNA (mtDNA) replication.
	www.ihop-net.org /UniPub/iHOP/gi/87983.html (477 words)

	FEN1 - Flap endonuclease-1
		The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.
		Defective flap endonuclease 1 activity in mammalian cells is associated with impaired DNA repair and prolonged S phase delay.
		FEN-1 has specific endonuclease activity for repairing nicked double-stranded DNA substrates that have the 5'-end of the nick expanded into a single-stranded tail, and it is involved in processing Okazaki fragments during DNA replication.
	www.ihop-net.org /UniPub/iHOP/gi/88183.html (3417 words)

	Homology Modeling and Mutational Analysis of Ho Endonuclease of Yeast -- Bakhrat et al. 166 (2): 721 -- Genetics
		The backbone of PI-SceI is in orange, the N-terminal domain I residues of Ho are in pink, the endonuclease residues are in blue, and the C-terminal domain I residues are in green.
		P186 and R427 are the borders of the intervening endonuclease domain.
		FG and ZFs, C-terminal truncation of intein motifs F and G and the zinc finger domain (remaining endonuclease extends from 1 to 446).
	www.genetics.org /cgi/content/full/166/2/721 (4497 words)

	[No title]
		Choi, S.H., Leach, J.E. Identification of the XorII methyltransferase gene and a vsr homolog from Xanthomonas oryzae pv.
		Makula, R.A., Meagher, R.B. A new restriction endonuclease from the anaerobic bacterium, Desulfovibrio desulfuricans, Norway.
		Matvienko, N.N., Kramarov, V.M., Zheleznaya, L.A., Matvienko, N.I. Isolation of site-specific endonuclease and methylase from Bacillus cereus 83.
	www.ibiblio.org /pub/academic/biology/molbio/data/rebase/type2ref.512 (14105 words)

	Effects of Zinc and Cadmium on Apoptotic DNA Fragmentation in Isolated Bovine Liver Nuclei
		Thus cadmium exerts a dual effect: micromolar concentrations inhibit the apoptotic endonuclease in the presence but activate the enzyme in the absence of calcium.
		The Ca -mediated DNA fragmentation in mammalian cells is due to a Ca /Mg -dependent endonuclease, which is constitutive in nuclei and not lysosomal (17).
		We propose that the balance between Ca /Zn is responsible for the regulation of the endonuclease.
	ehp.niehs.nih.gov /members/1994/Suppl-3/269-271lohmann/lohmann-full.html (2494 words)

	Endonuclease VIII, DNA Repair Proteins, New England Biolabs
		Endonuclease VIII from E. coli acts as both an N-glycosylase and an AP-lyase.
		While Endonuclease VIII is similar to Endonuclease III, Endonuclease VIII has β and δ lyase activity while Endonuclease III has β lyase activity.
		A 50 μl reaction containing 1 μg of λDNA (Hind III digest) and 50units of Endonuclease VIII incubated for 16 hours at 37ºC resulted in a DNA pattern free of detectable nuclease degradation as determined by agarose gel electrophoresis.
	www.neb.com /nebecomm/products/productM0299.asp (374 words)

	Purification and Characterization of Thermotoga maritima Endonuclease IV, a Thermostable Apurinic/Apyrimidinic ...
		maritima endonuclease IV for 10 min at 65°C, the reaction mixture was electrophoresed on a 20% denaturing acrylamide gel.
		Endonuclease IV of Escherichia coli is induced by paraquat.
		The Caenorhabditis elegans gene CeAPN1 encodes a homolog of Escherichia coli and yeast apurinic/apyrimidinic endonuclease.
	jb.asm.org /cgi/content/full/181/9/2834 (4169 words)

	Expression of Yeast Apurinic/Apyrimidinic Endonuclease (APN1) Protects Lung Epithelial Cells From Bleomycin Toxicity -- ...
		AP endonucleases are DNA repair enzymes that participate in the repair of AP sites and 3' blocking termini (8).
		Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals.
		The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer.
	ajrcmb.atsjournals.org /cgi/content/full/25/6/692 (4371 words)

	Target Specificity of the Endonuclease from the Xenopus laevis Non-Long Terminal Repeat Retrotransposon, Tx1L -- ...
		The double-stranded DNA oligonucleotide shown at the bottom was the substrate for cleavage by the endonuclease.
		The other site-specific ADR endonuclease that has been examined is that from the silkmoth ribosomal insertion, R1Bm (10).
		Targeting of human retrotransposon integration is directed by the specificity of the L1 endonuclease for regions of unusual DNA structure.
	mcb.asm.org /cgi/content/full/20/4/1219 (5848 words)

	Restriction Endonuclease Selector for REF (REF Select) (Site not responding. Last check: 2007-11-07)
		Restriction Endonuclease Fingerprinting (REF) has been demonstrated as a rapid method for screening long test segments of DNA for sequence variants(1-4; 13; 14) with virtually 100% sensitivity(8; 10).
		A total of ten hypothetical restriction endonucleases (A-J) are used to generate 72 fragments (36 sense and 36 antisense) ranging in size from 50 to 450 bp.
		The range of buffer activity levels allowed in the restriction endonuclease property file is 0 to 100 which is consistent with activity levels normalized to a percentage of a maximum activity level.
	www.cityofhope.org /molgen/refsel.asp (3971 words)

	ENDONUCLEASE/TOPOISOMERASE NAEI
		Abstract: DNA topoisomerases, recombinases, endonucleases and ligases are basic to the genetic machinery of the cell.
		Endonuclease NaeI appears to hold the key that relates these DNA processing enzymes to each other.
		The discovery of topoisomerase and recombinase activity within NaeI endonuclease unites what were previously believed to be independently derived DNA processing activities.
	www.med.unc.edu /wrkunits/1dean/research/Topal397.html (216 words)

	RNA and DNA Hydrolysis Are Catalyzed by the Influenza Virus Endonuclease -- Klumpp et al. 275 (9): 6181 -- Journal of ...
		RNA and DNA Hydrolysis Are Catalyzed by the Influenza Virus Endonuclease -- Klumpp et al.
		The cap-dependent endonuclease activity may be regarded as a rather unique enzyme activity of influenza viruses.
		Endonuclease reactions were performed and analyzed on acrylamide gels as described in the legend to Fig.
	www.jbc.org /cgi/content/full/275/9/6181 (5773 words)

	Investigating the endonuclease activity of four Pyrococcus abyssi inteins -- Saves et al. 30 (19): 4158 -- Nucleic ...
		Dalgaard,J.Z., Klar,A.J., Moser,M.J., Holley,W.R., Chatterjee,A. and Mian,I.S. (1997) Statistical modeling and analysis of the LAGLIDADG family of site-specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family.
		Saves,I., Ozanne,V., Dietrich,J. and Masson,J.M. (2000) Inteins of Thermococcus fumicolans DNA polymerase are endonucleases with distinct enzymatic behaviors.
		Saves,I., Eleaume,H., Dietrich,J. and Masson,J.-M. (2000) The Thy Pol-2 intein of Thermococcus hydrothermalis is an isoschizomer of PI-TliI and PI-TfuII endonucleases.
	nar.oxfordjournals.org /cgi/content/full/30/19/4158 (4362 words)

	Mutational Analysis of Adeno-Associated Virus Type 2 Rep68 Protein Endonuclease Activity on Partially Single-Stranded ...
		The site-specific and strand-specific endonuclease assay was performed as described previously (13), with the modifications
		devoid of endonuclease activity on the unfilled hairpin substrate.
		Rep68/78 amino acids 3 to 200 are sufficient for trs endonuclease activity on unfilled hairpin DNA.
	jvi.asm.org /cgi/content/full/74/6/2936 (4246 words)

	Factors Affecting the Terminal Resolution Site Endonuclease, Helicase, and ATPase Activities of Adeno-Associated Virus ...
		The strand-specific and site-specific endonuclease assay was performed by the method of Im and Muzyczka (19).
		The trs endonuclease activity of in vitro-synthesized Rep78 was determined by incubating 0.5 µl of rabbit reticulocyte lysate containing Rep78 with 25,000 cpm of 5'
		We have, however, attempted to approximate the endonuclease assay conditions by replacing ATP with a nonhydrolyzable ATP analog.
	jvi.asm.org /cgi/content/full/73/10/8235 (6672 words)

	Endonuclease III
		The primary role of the iron-sulphur cluster appears to involve positioning conserved basic residues for interaction with the DNA phosphate backbone by forming the loop of the FCL motif [4].
		AP lyase; AP endonuclease class I; endodeoxyribonuclease (apurinic or apyrimidinic); deoxyribonuclease (apurinic or apyrimidinic); E.
		Kuo, C.F., Jr., McRee, D.E., Fisher, C.L., O'Handley, S.F., Cunningham, R.P. and Tainer, J.A. Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III.
	metallo.scripps.edu /PROMISE/ENDONUCLEASE3.html (334 words)

	I-ApeI: a novel intron-encoded LAGLIDADG homing endonuclease from the archaeon, Aeropyrum pernix K1 -- Nomura et al. 33 ...
		endonucleases that recognize and cleave sequences of 14–40
		Marshall, P. and Lemieux, C. (1992) The I-CeuI endonuclease recognizes a sequence of 19 base pairs and preferentially cleaves the coding strand of the Chlamydomonas moewusii chloroplast large subunit rRNA gene Nucleic Acids Res.
		Gimble, F.S. and Wang, J. (1996) Substrate recognition and induced DNA distortion by the PI-SceI endonuclease, an enzyme generated by protein splicing J.
	nar.oxfordjournals.org /cgi/content/full/33/13/e116 (4230 words)

	An unusual mechanism for the major human apurinic/apyrimidinic (AP) endonuclease involving 5' cleavage of DNA ...
		The human AP endonuclease [variously called Ape (8), HAP1 (9), or APEX (10)] is quite similar to E.
		The major AP endonuclease is a multifunctional enzyme with its primary biological role as a class II AP endonuclease (5,
		a DNA endonuclease and incises the oligonucleotide 5
	www.pnas.org /cgi/content/full/93/24/13737 (2682 words)

	An endonuclease activity similar to Xenopus PMR1 catalyzes the degradation of normal and nonsense-containing human ...
		An endonuclease activity similar to Xenopus PMR1 catalyzes the degradation of normal and nonsense-containing human {beta}-globin mRNA in erythroid cells -- BREMER et al.
		An endonuclease activity similar to Xenopus PMR1 catalyzes the degradation of normal and nonsense-containing human ß-globin mRNA in erythroid cells
		In vitro cleavage of ß-globin and albumin mRNA by PMR1 and the ß-globin mRNA endonuclease.
	www.rnajournal.org /cgi/content/full/9/9/1157 (5358 words)

	The Evolution of Homing Endonuclease Genes and Group I Introns in Nuclear rDNA -- Haugen et al. 21 (1): 129 -- ...
		Homing endonuclease gene (HEG) insertions located in the P8 structural element of S943 group I introns of different species are boxed.
		The I-EmyI Endonuclease Gene Is Interrupted by a Spliceosomal Intron-like Sequence
		A site-specific DNA endonuclease specified by one of two ORFs encoded by a group I intron in Dictyostelium discoideum mitochondrial DNA.
	mbe.oxfordjournals.org /cgi/content/full/21/1/129 (6583 words)

	Measuring motion on DNA by the type I restriction endonuclease EcoR124I using triplex displacement -- Firman and ... (Site not responding. Last check: 2007-11-07)
		Gorbalenya,A.E. and Koonin,E.V. (1991) Endonuclease (R) subunits of type I and type III restriction enzymes contain a helicase-like domain.
		Roman,L.J. and Kowalczykowski,S.C. (1989) Characterisation of the helicase activity of the Escherichia coli RecBCD enzyme using a novel helicase assay.
		Rosamund,J., Endlich,B. and Linn,S. (1979) Electron microscopic studies of the mechanism of action of the restriction endonuclease of Escherichia coli B.
	embojournal.npgjournals.com /cgi/content/full/19/9/2094 (6200 words)

	Two for the price of one: a bifunctional intron-encoded DNA endonuclease-RNA maturase -- Belfort 17 (23): 2860 -- Genes ...
		The schematic depicts invasion of self-splicing intron or intein DNA by an endonuclease gene, to generate mobile intervening sequences.
		The catalytic endonuclease residues Asp 16 and Glu 148 are shown in magenta, and Arg 239, a key amino acid in maturase function, is shown in red.
		Ho, Y., Kim, S.J., and Waring, R.B. A protein encoded by a group I intron in Aspergillus nidulans directly assists RNA splicing and is a DNA endonuclease.
	www.genesdev.org /cgi/content/full/17/23/2860 (2130 words)

	Pfam 18.0 : Endonuclease_7 (Site not responding. Last check: 2007-11-07)
		This domain is found in a family of proteins which includes phage T4 endonuclease VII, Mycobacteriophage gene 59, and other as yet uncharacterised proteins.
		Phage T4 endonuclease VII (Endo VII) recognizes a broad spectrum of DNA substrates ranging from branched DNAs to single base mismatches.
		X-ray structure of T4 endonuclease VII: a DNA junction resolvase with a novel fold and unusual domain-swapped dimer architecture.
	pfam.wustl.edu /cgi-bin/getdesc?name=Endonuclease_7 (122 words)

	T7 Endonuclease I, DNA Repair Proteins, New England Biolabs
		T7 Endonuclease I recognizes and cleaves non-perfectly matched DNA, cruciform DNA structures, Holliday structures or junctions, heteroduplex DNA and more slowly, nicked double-stranded DNA.
		A fusion of maltose binding protein and truncated, inactive T7 Endonuclease I (tT7 Endo I) possessing a C-terminal thioester is purified to near homogeneity using the IMPACT-TWIN system.
		16 µg of Hae III digested ΦX174 DNA was incubated with 40 units of T7 Endonuclease I in a total reaction volume of 400 µl for 2 hours at 37°C. The DNA was ethanol precipitated and ligated with T4 DNA Ligase and then recut with Hae III.
	www.neb.com /nebecomm/products/productM0302.asp (454 words)

	E0526 Endo III
		Asahara, H., et al., Purification and characterization of Escherichia coli endonuclease III from the cloned nth gene.
		Serafini, D.M., Schellhorn, H.E., Endonuclease III and endonuclease IV protect Escherichia coli from the lethal and mutagenic effects of near
		Eide, L., et al., Overexpression of endonuclease III protects Escherichia coli mutants defective in alkylation repair against lethal effects of methylmethanesulphonate.
	www.sigmaaldrich.com /catalog/search/ProductDetail?ProdNo=E0526&Brand=SIGMA (303 words)

	The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand ...
		The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks -- Niedernhofer et al.
		The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks
		The mechanism of ICL repair in mammalian cells is poorly understood.
	mcb.asm.org /cgi/content/abstract/24/13/5776 (648 words)

	A Novel Role for Escherichia coli Endonuclease VIII in Prevention of Spontaneous Gright-arrowT Transversions -- ...
		A Novel Role for Escherichia coli Endonuclease VIII in Prevention of Spontaneous Gright-arrowT Transversions -- Blaisdell et al.
		Wiederholt, C. J., Patro, J. N., Jiang, Y. L., Haraguchi, K., Greenberg, M. Excision of formamidopyrimidine lesions by endonucleases III and VIII is not a major DNA repair pathway in Escherichia coli.
		Gifford, C. M., Wallace, S. The genes encoding endonuclease VIII and endonuclease III in Escherichia coli are transcribed as the terminal genes in operons.
	jb.asm.org /cgi/content/abstract/181/20/6396 (973 words)

	The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells -- ... (Site not responding. Last check: 2007-11-07)
		The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells -- Niedernhofer et al.
		The structure-specific endonuclease Ercc1–Xpf is required for targeted gene replacement in embryonic stem cells
		Mus81 Endonuclease Localizes to Nucleoli and to Regions of DNA Damage in Human S-phase Cells
	embojournal.npgjournals.com /cgi/content/abstract/20/22/6540 (954 words)

	RISC is a 5' phosphomonoester-producing RNA endonuclease -- Martinez and Tuschl 18 (9): 975 -- Genes and Development
		RISC is a 5' phosphomonoester-producing RNA endonuclease -- Martinez and Tuschl 18 (9): 975 -- Genes and Development
		Pingoud, A. and Jeltsch, A. Structure and function of type II restriction endonucleases.
		Schwarz, D.S., Tomari, Y., and Zamore, P.D. The RNA-induced silencing complex is a Mg -dependent endonuclease.
	www.genesdev.org /cgi/content/full/18/9/975 (4206 words)

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