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Topic: Endopeptidase

In the News (Thu 31 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

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Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Distinct Properties of Neuronal and Astrocytic Endopeptidase 3.4.24.16: A Study on Differentiation, Subcellular ...
		The membrane-associated form of endopeptidase 3.4.24.16 increased during neuronal differentiation and appears to be mainly responsible for the overall augmentation of endopeptidase 3.4.24.16 activity observed during neuronal maturation.
		on endopeptidase 3.4.24.16 immunoreactivity in neurons and astrocytes.
		In neurons, endopeptidase 3.4.24.16 was associated mainly with segments of the plasma membrane and intracellular membrane-bound organelles, in keeping with the occurrence of the membrane-associated form of the enzyme demonstrated biochemically.
	www.jneurosci.org /cgi/content/full/16/16/5049 (7390 words)

	Clearance receptors and endopeptidase: equal role in natriuretic peptide metabolism in heart failure -- Rademaker et ...
		Clearance receptors and endopeptidase 24.11: equal role in natriuretic peptide metabolism in conscious sheep.
		Influence of C-ANF receptor and neutral endopeptidase on pharmacokinetics of ANF in rats.
		Neutral endopeptidase inhibition: augmented atrial and brain natriuretic peptide, haemodynamic and natriuretic responses in ovine heart failure.
	ajpheart.physiology.org /cgi/content/full/273/5/H2372 (4458 words)

	Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A -- ...
		Distribution and abundance of neutral endopeptidase (EC 3.42411) in the alimentary tract of the rat.
		Downregulation of neutral endopeptidase (EC 3.42411) in the inflamed rat intestine.
		Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.
	ajpgi.physiology.org /cgi/content/full/281/2/G544 (4186 words)

	Streptococcus parasanguis pepO Encodes an Endopeptidase with Structure and Activity Similar to Those of Enzymes That ...
		Endopeptidase activity was assayed by a procedure modified from that of Tan et al.
		Cloning and sequencing of the gene for a lactococcal endopeptidase, an enzyme with sequence similarity to mammalian enkephalinase.
		Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology.
	iai.asm.org /cgi/content/full/67/10/5206 (4926 words)

	Hormonal, renal, hemodynamic responses to acute neutral endopeptidase inhibition in heart transplant patients -- ...
		Role of neutral endopeptidase in the metabolism of endothelin.
		Inhibition of neutral endopeptidase potentiates the effects of atrial natriuretic peptide on acute cyclosporin-induced nephrotoxicity.
		Role of the endopeptidase 24.11 in the inactivation of atrial natriuretic peptide.
	jap.physiology.org /cgi/content/full/93/2/569 (4029 words)

	Smokeless tobacco potentiates VIP-induced DNA synthesis and inactivates NEP 24.11 in oral keratinocytes -- Rubinstein ...
		Investigation of neutral endopeptidases (EC 3.4.24.11) and of neutral proteinases (EC 3.4.24.4) using a new sensitive two-stage enzymatic reaction.
		CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinoma of the lung.
		Immunoreactive neutral endopeptidase is decreased in uvula epithelium of patients with obstructive sleep apnea.
	ajpcell.physiology.org /cgi/content/full/278/2/C391 (3402 words)

	Hormonal, renal, hemodynamic responses to acute neutral endopeptidase inhibition in heart transplant patients -- ...
		Hormonal, renal, hemodynamic responses to acute neutral endopeptidase inhibition in heart transplant patients -- Piquard et al.
		Hormonal, renal, hemodynamic responses to acute neutral endopeptidase inhibition in heart transplant patients
		Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs
	jap.physiology.org /cgi/content/abstract/93/2/569 (243 words)

	Structure and Function of Disease-Causing Missense Mutations in the PHEX Gene -- Sabbagh et al. 88 (5): 2213 -- Journal ...
		B, Dependence of endopeptidase activity on fluorogenic peptide substrate concentration measured in the presence of 200 ng wild-type secPHEX protein.
		HYP Consortium 1995 A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets.
		Boileau G, Tenenhouse HS, DesGroseillers L, Crine P 2001 Characterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide 107–139 as a substrate and osteocalcin, PPi and phosphate as inhibitors.
	jcem.endojournals.org /cgi/content/full/88/5/2213 (5647 words)

	Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse ...
		Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse -- Barbara et al.
		Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse
		Neurogenic inflammation of the rat trachea: fate of neutrophils that adhere to venules.
	gut.bmjjournals.com /cgi/content/full/52/10/1457 (4297 words)

	Differential expression of the Kell blood group and CD10 antigens: two related membrane metallopeptidases during ...
		Endopeptidase 24.11 activity was determined in the presence of 1 mM Suc-Ala-Ala-Phe-pNA and 10 µg/ml purified aminopeptidase N by the measure of absorbance of paranitroaniline at 410 nm.
		Devaux (1987) Amino acid sequence of rabbit kidney neutral endopeptidase deduced from a complementary DNA.
		Ganju, R., Shpektor, R., Brenner, D., and Shipp, M. (1996) CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn src-related kinase.
	www.fasebj.org /cgi/content/full/12/7/531 (4939 words)

	B-Type Natriuretic Peptide Prevents Acute Hypertrophic Responses in the Diabetic Rat Heart: Importance of Cyclic GMP -- ... (Site not responding. Last check: 2007-11-04)
		endopeptidase inhibition are preserved in vivo ( 31).
		Monopoli A, Ongini E, Cigola E, Olivetti G: The neutral endopeptidase inhibitor, SCH 34826, reduces left ventricular hypertrophy in spontaneously hypertensive rats.
		Dumoulin MJ, Adam A, Rouleau JL, Lamontagne D: Comparison of a vasopeptidase inhibitor with neutral endopeptidase and angiotensin-converting enzyme inhibitors on bradykinin metabolism in the rat coronary bed.
	diabetes.diabetesjournals.org /cgi/content/full/52/9/2389 (3976 words)

	Mapping sequence differences between thimet oligopeptidase and neurolysin implicates key residues in substrate ...
		Mentlein, R. and Dahms, P. Endopeptidases 24.16 and 24.15 are responsible for the degradation of somatostatin, neurotensin, and other neuropeptides by cultivated rat cortical astrocytes.
		Molineaux, C.J., Lasdun, A., Michaud, C., and Orlowski, M. Endopeptidase 24.15 is the primary enzyme that degrades luteinizing hormone releasing hormone.
		Shrimpton, C.N., Glucksman, M.J., Lew, R.A., Tullai, J.W., Margulies, E.H., Roberts, J.L., and Smith, A.I. Thiol activation of endopeptidase EC 3.4.24.15: A novel mechanism for the regulation of catalytic activity.
	www.proteinscience.org /cgi/content/full/11/9/2237 (4446 words)

	Low Neutral Endopeptidase Levels in Bronchoalveolar Lavage Fluid of Lung Cancer Patients -- COHEN et al. 159 (3): 907 ...
		CD10 (CALLA) neutral endopeptidase 24.11 modulates inflammatory peptide-induced changes in neutrophil morphology: migration, and adhesion proteins and is itself regulated by neutrophil activation.
		Neutral endopeptidase expression is high in respiratory bronchiolitis-interstitial lung disease (abstract).
		Neutral endopeptidase and kinase II activities in the bronchial mucosa of smoking and nonsmoking subjects (abstract).
	www.ajrccm.org /cgi/content/full/159/3/907 (2665 words)

	Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA ... (Site not responding. Last check: 2007-11-04)
		Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA [published erratum appears in EMBO J 1987 Aug;6(8):2506] -- Devault et al.
		Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA [published erratum appears in EMBO J 1987 Aug;6(8):2506]
		endopeptidase with that of thermolysin, a bacterial Zn-metallopeptidase,
	embojournal.npgjournals.com /cgi/content/abstract/6/5/1317 (589 words)

	The Role of Proteolysis in the Processing and Assembly of 11S Seed Globulins -- Jung et al. 10 (3): 343 -- THE PLANT ...
		that the monomers are unstable in the presence of the endopeptidase,
		Lanes 3 and 4, cleavage of purified monomeric prolegumins with heat-inactivated and active asparaginyl endopeptidase, respectively; lanes 5 and 6, purified prolegumin B trimers treated with heat-inactivated and active asparaginyl endopeptidase, respectively.
		Purified radiolabeled trimers of the unmodified and mutant proglobulin subunits were treated with asparaginyl endopeptidase.
	www.plantcell.org /cgi/content/full/10/3/343 (7441 words)

	Neutral Endopeptidase Terminates Substance P-Induced Inflammation in Allergic Contact Dermatitis -- Scholzen et al. 166 ...
		Dual inhibitors of enkephalin-degrading enzymes (neutral endopeptidase 24.11 and aminopeptidase N) as potential new medications in the management of pain and opioid addiction.
		Neutral endopeptidase and neurogenic inflammation in rats with respiratory infections.
		Effects of angiotensin-converting enzyme and neutral endopeptidase inhibitors: influence of bradykinin.
	www.jimmunol.org /cgi/content/full/166/2/1285 (4580 words)

	Active amino acids of the Kell blood group protein and model of the ectodomain based on the structure of neutral ...
		Expression of neutral endopeptidase (enkephalinase) in heterologous COS-1 cells: characterization of the recombinant enzyme and evidence for a glutamic acid residue at the active site.
		Evidence by site-directed mutagenesis that arginine 203 of thermolysin and arginine 717 of neprilysin (neutral endopeptidase) play equivalent critical roles in substrate hydrolysis and inhibitor binding.
		Bianchetti L, Oudet C, Poch O. M13 endopeptidases: new conserved motifs correlated with structure, and simultaneous phylogenetic occurrence of PHEX and the bony fish.
	www.bloodjournal.org /cgi/content/full/102/8/3028 (4838 words)

	Activation of neurokinin NK2 receptors by tachykinin peptides causes contraction of uterus in pregnant women near term ...
		in the absence and presence of the endopeptidase 24.11 inhibitor,
		Endopeptidase 24.11 (EC 24.11) is the most effective of the peptidases hydrolysing not
		(1983) Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.
	molehr.oupjournals.org /cgi/content/full/6/6/549 (3562 words)

	Suppression of Atherosclerotic Changes in Cholesterol-Fed Rabbits Treated With an Oral Inhibitor of Neutral ... (Site not responding. Last check: 2007-11-04)
		Gardiner SM, Kemp PA, Bennett T. Effects of the neutral endopeptidase inhibitor, SQ 28,603, on regional haemodynamic responses to atrial natriuretic peptide or proendothelin-1 [1-38] in conscious rats.
		The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase).
		Neutral endopeptidase in the heart: neutral endopeptidase inhibition prevents isoproterenol-induced myocardial hypoperfusion in rats by reducing bradykinin degradation.
	atvb.ahajournals.org /cgi/content/full/16/8/1080 (4906 words)

	Disease-causing missense mutations in the PHEX gene interfere with membrane targeting of the recombinant protein -- ...
		3 The HYP Consortium (1995) A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets.
		22 Boileau, G., Tenenhouse, H.S., DesGroseillers, L. and Crine, P. (2001) Characterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide 107–139 as a substrate and osteocalcin, PPi and phosphate as inhibitors.
		25 Dion, N., Le Moual, H., Crine, P. and Boileau, G. (1993) Kinetic evidence that His-711 of neutral endopeptidase 24.11 is involved in stabilization of the transition state.
	hmg.oupjournals.org /cgi/content/full/10/15/1539 (5127 words)

	Positional cloning of the PEX gene: new insights into the pathophysiology of X-linked hypophosphatemic rickets -- Econs ...
		Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions.
		Regulation of serum 1,25-dihydroxyvitamin D by calcium and phosphate in the rat.
		Positional cloning of PEX: a gene with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets.
	ajprenal.physiology.org /cgi/content/full/273/4/F489 (5710 words)

	AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction ...
		AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in rats -- WALTHER et al.
		Marie, C., Mossiat, C., Gros, C., Monteil, T., Bralet, J. (1996) Effect on prolonged inhibition of neutral endopeptidase on cardiac hypertrophy in rats with myocardial infarction.
		Yang, X. P., Liu, Y. H., Peterson, E., Carretero, O. (1997) Effect of neutral endopeptidase 24.11 inhibition on myocardial ischemia/reperfusion injury: the role of kinins.
	www.fasebj.org /cgi/content/full/16/10/1237 (2064 words)

	Neutral Endopeptidase Inhibition Augments Vascular Actions of Bradykinin in Patients Treated With ...
		Neutral Endopeptidase Inhibition Augments Vascular Actions of Bradykinin in Patients Treated With Angiotensin-Converting Enzyme Inhibition -- Cruden et al.
		Neutral Endopeptidase Inhibition Augments Vascular Actions of Bradykinin in Patients Treated With Angiotensin-Converting Enzyme Inhibition
		Angiotensin-converting enzyme and neutral endopeptidase (EC 3.4.24.11; neprilysin) are metallopeptidases present on the
	www.hypertensionaha.org /cgi/content/abstract/44/6/913 (225 words)

	Acute and Chronic Neutral Endopeptidase Inhibition in Rats With Aortocaval Shunt -- Willenbrock et al. 27 (6): 1259 -- ... (Site not responding. Last check: 2007-11-04)
		Acute and Chronic Neutral Endopeptidase Inhibition in Rats With Aortocaval Shunt -- Willenbrock et al.
		Acute and Chronic Neutral Endopeptidase Inhibition in Rats With Aortocaval Shunt
		natriuretic peptide is degraded in part by a neutral endopeptidase.
	hyper.ahajournals.org /cgi/content/abstract/27/6/1259 (461 words)

	Low Neutral Endopeptidase Levels in Bronchoalveolar Lavage Fluid of Lung Cancer Patients -- COHEN et al. 159 (3): 907 ...
		Low Neutral Endopeptidase Levels in Bronchoalveolar Lavage Fluid of Lung Cancer Patients -- COHEN et al.
		Low Neutral Endopeptidase Levels in Bronchoalveolar Lavage Fluid of Lung Cancer Patients
		Neutral endopeptidase (NEP) is a cell surface enzyme found in normal human lung and which hydrolyzes small bioactive peptides,
	www.ajrccm.org /cgi/content/abstract/159/3/907 (280 words)

	Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling -- Sumitomo ...
		Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression.
		Expression of neutral endopeptidase (enkephalinase) in heterologous COS-1 cells.
		Androgen-induced growth inhibition of androgen receptor expressing androgen-independent prostate cancer cells is mediated by increased levels of neutral endopeptidase.
	www.jci.org /cgi/content/full/106/11/1399 (6047 words)

	Early Prepubertal Ontogeny of Pulsatile Gonadotropin-Releasing Hormone (GnRH) Secretion: I. Inhibitory Autofeedback ...
		Lew RA, Tetaz TJ, Glucksman MJ, Roberts JL, Smith AI 1994 Evidence for a two-step mechanism of Gonadotropin-releasing hormone metabolism by prolyl endopeptidase and metalloendopeptidase EC 3.4.24.15 in ovine hypothalamic extracts.
		Lasdun A, Orlowski M 1990 Inhibition of endopeptidase 24.15 greatly increases the release of luteinizing hormone and follicle stimulating hormone in response to luteinizing hormone/releasing hormone.
		Wu TJ, Pierotti AR, Jakubowski M, Sheward WJ, Glucksman MJ, Smith AI, King JC, Fink G, Roberts JL 1997 Endopeptidase EC 3.4.24.15 presence in the rat median eminence and hypophysial portal blood and its modulation of the luteinizing hormone surge.
	endo.endojournals.org /cgi/content/full/140/10/4609 (4436 words)

	Acute and Chronic Neutral Endopeptidase Inhibition in Rats With Aortocaval Shunt -- Willenbrock et al. 27 (6): 1259 -- ...
		Renal effects of neutral endopeptidase inhibition in euvolemic and hypervolemic rats.
		Neutral endopeptidase 24.11 in rat peripheral tissues: comparative localization by ex vivo and in vitro autoradiography.
		Effect of endopeptidase-24.11 inhibition and of atrial natriuretic peptide clearance receptor ligand on the response to rat brain natriuretic peptide in the conscious rat.
	hyper.ahajournals.org /cgi/content/full/27/6/1259 (4729 words)

	Soluble Metalloendopeptidases and Neuroendocrine Signaling -- Shrimpton et al. 23 (5): 647 -- Endocrine Reviews
		Horsthemke B, Bauer K 1980 Characterization of a nonchymotrypsin-like endopeptidase from anterior pituitary that hydrolyzes luteinizing hormone-releasing hormone at the tyrosyl-glycine and histidyl-tryptophan bonds.
		Horsthemke B, Bauer K 1982 Substrate specificity of an adenohypophyseal endopeptidase capable of hydrolyzing luteinizing hormone-releasing hormone: preferential cleavage of peptide bonds involving the carboxyl terminus of hydrophobic and basic amino acids.
		Torres MP, Prange C, Lennon G 1998 Human endopeptidase 24.15 (THOP1) is localized on chromosome 19p13.3 and is excluded from the linkage region for late-onset Alzheimer disease.
	edrv.endojournals.org /cgi/content/full/23/5/647 (8776 words)

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