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| | Titanium implants in rabbit femur |
 | | In the cortical bone, the presence of a necrotic area was observed which was later remodelled, and also an intense proliferation of endosteum and periosteum in the regions next to the implant, resulting in a thickening of the cortical bone surface close to the implant. |
 | | In several specimens, such neoformation was very advanced, with apposition of neoformed bone and a consequent increase in the thickness of the cortical bone in contact with the implant. |
 | | In this experiment, the whole necrotic area observed in the cortical bone facing the implant seems to remain initially intact, perhaps confirming the idea that this bone sequestrum works as a structure that initially maintains the implant in position and then works as a base for neoformed bone tissue (Roberts, 1988; Roberts et al., 1989). |
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