| | Centre for the Study of Evolution - University of Sussex (Site not responding. Last check: 2007-10-29) |
 | | Mutualistic, maternally transmitted endosymbiotic microorganisms undergo severe population bottlenecks at each host generation, resulting in a reduction in effective population size (Ne). |
 | | Previous studies of Buchnera, the primary endosymbiont of aphids, and of several other species of endosymbiotic bacteria have shown that these species exhibit an increase in the rate of substitution of slightly deleterious mutations, among other predicted effects of increased drift due to small Ne, such as reduced codon bias. |
 | | However, these studies have been limited in taxonomic scope, and it was therefore not clear whether the increase in rate is a general feature of endosymbiont lineages. |
| www.biols.susx.ac.uk /cse/members/mwoolfit/abstracts/woolfit.MBE2003.htm (329 words) |