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Topic: Engineered negligible senescence

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	Highbeam Encyclopedia - Search Results for Senescence
		phylogerontism (racial senescence) The condition of an evolutionary lineage that is on the verge of extinction, according to an outmoded view of evolution which asserted that lineages proceed through a life cycle, from youth to senility.
		A biologically based model of growth and senescence of Syrian Hamster Embryo (SHE) cells after exposure to arsenic.
		N status of the leaf is central to senescence (Thomas and Rogers, 1990).
	www.encyclopedia.com /SearchResults.aspx?Q=Senescence (1307 words)

	SENS: basis for the name "engineered negligible senescence" (Site not responding. Last check: 2007-10-12)
		People, on the other hand, do senesce, because the probability of a 70-year-old dying in the next year is higher than the probability of a 60-year-old dying in the next year.
		He introduced the term "negligible senescence" to mean "senescence too slight to be statistically distinguishable from zero with the sample sizes at our disposal".
		This of course means that they immediately understand the term "engineered negligible senescence" -- the biotechnological conversion of a population that shows senescence (humans, of course) into one that does not.
	www.gen.cam.ac.uk /sens/ENSdef.htm (1450 words)

	Engineered negligible senescence - Wikipedia, the free encyclopedia
		Engineered negligible senescence refers to an engineered prevention or reversal of cellular aging (referred to as senescence in biology).
		De Grey proposes that engineered negligible senescence therapies could extend humans' lives by many centuries or more, as early therapies give them enough time to see more effective therapies later on.
		Cellular senescence might be corrected by forcing senescent cells to destroy themselves, a process called apoptosis.
	en.wikipedia.org /wiki/Engineered_negligible_senescence (1302 words)

	Aubrey de Grey - Wikipedia, the free encyclopedia
		Aubrey de Grey (D.O.B April 20, 1963) is a biomedical gerontologist and bioinformatician at the Department of Genetics, University of Cambridge, England.
		He is working to expedite the development of a 'cure' for human aging, a medical goal he refers to as engineered negligible senescence (senescence means the biological decline of aging).
		He is also the co-founder (with David Gobel) and chief scientist of the Methuselah Mouse Prize, a prize designed to accelerate research into effective life extension interventions by awarding monetary prizes to researchers who extend the lifespan of mice to unprecedented lengths.
	en.wikipedia.org /wiki/Aubrey_de_Grey (646 words)

	The Quest for Indefinite Life I
		People, on the other hand, do senesce, because the probability of a 70-year-old dying in the next year is higher than the probability of a 60-year-old dying in the next year.
		He introduced the term "negligible senescence" to mean "senescence too slight to be statistically distinguishable from zero with the sample sizes at our disposal".
		This of course means that they immediately understand the term "engineered negligible senescence" -- the biotechnological conversion of a population that shows senescence (humans, of course) into one that does not.
	www.geocities.com /rational_argumentator/questlife1.html (2825 words)

	Engineered Negligible Senescence: Biotechnology strives for the ultimate - reverse the aging process
		Engineered negligible senescence is a term which we will be hearing more about as the 21st century matures.
		Basically, engineered negligible senescence describes n engineered approach to the prevention (or reversal) of the aging of the cells within our bodies.
		In an attempt to make Engineered Negligible Senescence accessible to the non-scientist, we are adding general anti-aging articles to this new and growing website.
	engineerednegligiblesenescence.com (357 words)

	senescence
		Senescence is a horrible killer, a disease that should be fought with every available weapon.
		SIRT1 is involved in cellular senescence, or limitation of cellsâ reproductive lifespan, a process thought to ensure that aging cells donât pass on harmful...
		Crazy-sounding (to politicians, or to their electorate) schemes to "engineer negligible senescence" are deadly to a political or bureaucrataic career.
	www.mongabay.com /igapo/biotech/senescence.html (1465 words)

	SENS
		Senescent cells, can be removed by activating the immune system against them.
		Aubrey de Gray's claim that the only significant effect of nuclear DNA (nDNA) damage is cancer is open to dispute, and this impacts both of his last two strategies (neither of which is appropriately described as "repair").
		Evidence of significantly reduced oxidative damage to mitochondrial DNA (mtDNA) and negligible oxidative damage to nDNA in calorie restricted rats [FREE RADICAL BIOLOGY AND MEDICINE; Lopez-Torres,M; 32(9):882-889 (2002)] is misleading because DNA repair capability declines with age.
	www.deardeath.com /sens.htm (818 words)

	The Multiverse According to Ben: The Seven Pillars of Senescence
		On his website, he gives a table of the seven causes of senescence, showing for each one the date that the connection between this phenomenon and senescence first become well-known to biologists – and also showing, for each one, the biological mechanism that he believes will be helpful for eliminating that particular cause.
		The term “engineering” in the SENS acronym is not a coincidence -- de Grey came to biology from computer science and he tends to take a different approach from conventional biologists, thinking more in terms of “mechanical” repair solutions.
		Ben, early in 2000 I believe, it was discovered that a cell goes into senescence because some fibres at the end of chromosomes (telomeres) responsible for sequence replication in cell division become flush with the end and therefore no more telomerase is produced and the cell dies.
	www.goertzel.org /blog/2005/04/seven-pillars-of-senescence.html (1185 words)

	Engineered negligible senescence: Encyclopedia topic (Site not responding. Last check: 2007-10-12)
		Engineered negligible senescence is a term meaning an engineered (engineered: engineering is the application of science to the needs of humanity....
		The term was coined by Cambridge (Cambridge: A city in eastern England on the River Cam; site of Cambridge University) associate and biogeronotologist (biogeronotologist: gerontology is the study of the elderly, and of the aging process itself....
		De Grey defines aging as "the set of accumulated side effects from metabolism that eventually kills us,", and his proposal identifies what he believes to be the seven biological causes of senescence and outlines possible solutions, each with both a research and a clinical component.
	www.absoluteastronomy.com /reference/engineered_negligible_senescence (714 words)

	It's A Miracle - Mice Regrow Hearts
		Their discoveries raise the prospect that humans could one day be given the ability to regenerate lost or damaged organs, opening up a new era in medicine.
		Details of the research will be presented next week at a scientific conference on ageing titled Strategies for Engineered Negligible Senescence, at Cambridge University in Britain.
		The research leader, Ellen Heber-Katz, professor of immunology at the Wistar Institute, a US biomedical research centre, said the ability of the mice at her laboratory to regenerate organs appeared to be controlled by about a dozen genes.
	www.rense.com /general67/mice.htm (436 words)

	End products (Site not responding. Last check: 2007-10-12)
		This phrase makes explicit the inevitable exposure to extrinsic, age-independent causes of death (which is blurred by more populist terms such as "immortality" or "eternal youth"), while also stressing the goal-driven, clinical nature of the task (in contrast to the basic-science tenor of, for example, "interventive biogerontology").
		Another central reason why biogerontologists have doubted that negligible senescence can be engineered is because it necessarily involves reversing any age-related decline that has already occurred, not merely retarding or postponing further decline.
		Cell senescence, the finite replicative potential and associated gene-expression changes seen in cell culture, has been suggested to underlie many aspects of aging and to be treatable by telomerase activation.
	research.arc2.ucla.edu /pmts/sens/article.htm (4381 words)

	Sens - Search Results - MSN Encarta
		He was born in Paris and educated at the lycée in...
		Strategies for Engineered Negligible Senescence (SENS): A practical...
		Applying engineering principles to curing aging (reversing aging), not just slowing aging: SENS (Strategies for Engineered Negligible Senescence) A practical approach to developing real anti-aging...
	ca.encarta.msn.com /Sens.html (171 words)

	For Engineered Negligible Senescence At Cambridge University (Site not responding. Last check: 2007-10-12)
		De Grey, a Cambridge University researcher, heads the Strategies for Engineered Negligible Senescence (SENS) project, in which he has defined seven causes of aging, all of which he thinks can be...
		He is working to expedite the development of a 'cure' for human cellular aging, a medical goal he refers to as engineered negligible senescence...
		Engineered Negligible Senescence (SENS) 2nd Conference 7-11 September 2005 Queens' College, Cambridge...
	cambridgeuniversity.flabcambridge.com /forengineerednegligiblesenescenceatcambridgeuniversity (875 words)

	~ Why We May Live to Be 130
		The eminent biogerontologist Caleb Finch argued in favor of the word “senescence” because it more precisely describes the accumulation of damage than does “aging,” which literally only means a passage of time.
		Finch uses the phrase “negligible senescence” to describe a virtually zero correlation between the passage of time and death due to accumulated physical deterioration.
		That is why SENS is focused on the biomedical engineering problems of fixing the biological damage known as aging.
	www.lifeextensionvitamins.com /whywemaylito.html (2713 words)

	Lifespan Extending Drug
		An aspect of biogerontology research that has been dangerously neglected during the recent spate of interest in genome-related breakthroughs, is the active reversal of various aspects of age related degeneration.
		The term "negligible senescence," defined in 1990 by Finch, describes the life history of organisms whose risk of death does not measurably rise as they get older, but remains the same as when they reach adulthood.
		Thus, "engineered negligible senescence" means restoring and maintaining, by biotechnological intervention, the health (and consequent resistance to life-threatening diseases) that we possessed in early adulthood.
	www.theantiagingdoctor.com /lifexdr.htm (1303 words)

	engineered negligible senescence Part II
		Many biogerontologists privately agree that "engineered negligible senescence" (ENS) is possible given enough time and resources.
		We report that transgenic mice engineered to overexpress the uncoupling protein 2 in hypocretin neurons (Hcrt-UCP2) have elevated hypothalamic temperature.
		The effects of local temperature elevation on the central thermostat resulted in a 0.3 degrees to 0.5 degrees C reduction of the core body temperature.
	www.cryonet.org /cgi-bin/dsp.cgi?msg=29423 (1429 words)

	Rejuvenation Engineering: Rejuvenation Engineering
		Engineering the reversal of human aging with Dr. Aubrey de Grey's Strategies for Engineered Negligible Senescence.
		Rejuvenation Engineering is the Second Life (SL) virtual Reality (VR) simulation of the real life (RL) problem of reversing aging, and application of engineering/science toward it's solution.
		Here I am in SL watching a 2 minute slide presentation on Dr. Aubrey de Grey of Cambridge University, the Biomedical Gerontology theorist whose Strategies for Engineered Negligible Senescence (SENS) is the detailed plan for the scientific conquest of aging and death that is the basis for Rejuvenation Engineering
	rejuv.blogspot.com /2007/04/rejuvenation-engineering.html (213 words)

	Life extension - Psychology Central (Site not responding. Last check: 2007-10-12)
		Senescent cells, can be removed by activating the immune system against them.
		Aubrey de Gray's claim that the only significant effect of nuclear DNA (nDNA) damage is cancer is open to dispute, and this impacts both of his last two strategies.
		Evidence of significantly reduced oxidative damage to mitochondrial DNA (mtDNA) and negligible oxidative damage to nDNA in calorie restricted rats [FREE RADICAL BIOLOGY AND MEDICINE; Lopez-Torres,M; 32(9):882-889 (2002)] is misleading because DNA repair capability declines with age.
	psychcentral.com /psypsych/Life_extension (4170 words)

	Annals of New York Academy of Sciences
		The arrest of biological time as a bridge to engineered negligible senescence, therefore, appears consistent with current scientific and medical knowledge.
		The fact is that at the boiling point of liquid nitrogen, changes in biological systems generally are agreed to be negligible for periods of hundreds to thousands of years.
		The fact that biological systems already perform these functions on a continuous basis implies that repairs of this nature are consistent with physical law, and detailed engineering calculations and designs for molecular recognition and manipulation systems of the kind that would be capable of effecting the required repair processes are available[7-9].
	www.alcor.org /Library/html/annals.html (1561 words)

	Methuselah Foundation SENS Challenge; July 11, 2006
		SENS (Strategies for Engineered Negligible Senescence) is a detailed plan for alleviating the debilitation caused by human aging.
		SENS is an engineering project, reflecting the fact that aging is a medical condition and that medicine is an engineering discipline.
		Aging is a set of progressive changes in body composition, at the molecular and cellular level, which are side-effects of essential metabolic processes; each of these changes has the potential to be mitigated and eventually reversed.
	www.grg.org /MFSENSChallenge.htm (566 words)

	Mighty Mice Regrow Organs
		Stephen Badylak, a surgery research professor and director of the Center for Pre-Clinical Tissue Engineering at the University of Pittsburgh's McGowan Institute for Regenerative Medicine.
		Heber-Katz presented new data showing that the strain of mice can also grow back severed digits at the Strategies for Engineered Negligible Senescence conference in Cambridge, England.
		("Engineered negligible senescence" is a fancy term for life extension.)
	www.wired.com /medtech/genetics/news/2005/09/68962 (715 words)

	Strategies for Engineered Negligible Senescence (SENS): A practical way to cure human aging
		SENS is an engineering project, in the same way that medicine is a branch of engineering.
		The key to SENS is the appreciation that aging is best viewed as a set of progressive changes in body composition at the molecular and cellular level, caused as side-effects of essential metabolic processes.
		An even more short-termist alternative is the geriatric approach, namely to try to stave off pathology in the face of accumulating damage; this is a losing battle because the continuing accumulation of damage makes pathology more and more inescapable.
	myvie.ws /item/1239/catid/83 (284 words)

	Glossary: Aging and Gerontology
		Cellular, clonal, or replicative senescence: cessation of cell division, usually determined in a cell population, that can or not be accompanied by cell death.
		Negligible senescence: organisms in which the aging process cannot be detected.
		Strategies for engineered negligible senescence (SENS): a proposal by Aubrey de Grey that details how by reversing seven cellular and molecular age-related changes will allow researchers to cure aging.
	www.senescence.info /glossary.html (1000 words)

	FuturePundit: Aging Reversal Archives
		For instance, all the work on stem cells and tissue engineering builds toward the ability to grow replacement organs and to send in stem cells to replace cells lost from the accumulation of damage that comes with aging.
		This work will lead to the development of a combination of treatments which will allow the attainment of engineered negligible senescence where the body effectively ceases to age from one year to the next.
		He was at pains to argue that what he calls "negligible senescence," and what the average person would call living forever, is inevitable.
	www.futurepundit.com /archives/cat_aging_reversal.html (17715 words)

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