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| | RedOrbit - Health - Blood Eosinophilia: A New Paradigm in Disease Classification, Diagnosis, and Treatment (Site not responding. Last check: 2007-10-12) |
 | | Eosinophils are derived from hematopoietic stem cells that are committed initially to the myeloid and subsequently to the basophil- eosinophil granulocyte lineage.1 As depicted in Figure 1, the mature eosinophil, when examined by standard blood-staining techniques, displays a bilobed nucleus and an abundant cytoplasm filled with reddish-orange granules. |
 | | Major basic protein, eosinophil cationic protein, and eosinophil- derived neurotoxin are the primary mediators of eosinophil- associated toxicity to microbes (parasites, protozoa, bacteria, viruses) and human tissue (myocarditis, pneumonitis, dermatitis, neuropathy, vasculitis).6-16 The lung and gastrointestinal systems constitute the main residence for eosinophils. |
 | | Clonality of isolated eosinophils in the hypereosinophilic syndrome. |
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