Factbites
 Where results make sense
About us   |   Why use us?   |   Reviews   |   PR   |   Contact us  

Topic: Eosinophil granulocyte


Related Topics

In the News (Wed 21 Aug 19)

  
  eosinophil granulocyte Dr.Jastrow's electron microscopic atlas
Eosinophilic granulocytes or eosonophils (Terminologia histologica: Granulocyti acidophili; Eosinophili) belong to the white blood cells (leucocytes).
Eosinophils are attracted by a factor released by basophilic granulocytes and mast cells in case of inflammatory reactions where they are supposed to reduce local histamine effects.
Eosinophils are phagocyted by macrophages and during their degradation inside large phagolysosomes the macrophages show typical Charcot-Leyden crystals consisting of lysophospholipase.
www.uni-mainz.de /FB/Medizin/Anatomie/workshop/EM/EMEoE.html   (363 words)

  
 eMedicine - Eosinophilia : Article Excerpt by: Michaelann Liss, DO
Eosinophils are derived from hematopoietic stem cells initially committed to the myeloid line and then to the basophil-eosinophil granulocyte lineage.
A secondary or reactive increase in blood eosinophils, tissue eosinophils, or both is associated with a wide variety of infections (especially helminthic parasites), allergic responses, neoplasms, connective tissue disorders, medications and endocrinopathies.
In addition to these cytokines, eosinophils are a source of several cationic proteins that also contribute to the immunologic responses against infectious disease agents and to tissue damage in allergic and autoimmune diseases.
www.emedicine.com /med/byname/eosinophilia.htm   (591 words)

  
 [No title]
It was suggested that quantitation of 'eosinophil' cationic protein in serum might be useful in the study of eosinophil granulocyte turnover and function in vivo.
Serum eosinophil cationic protein (ECP) as a mediator of inflammation in acute asthma, during resolution and during the monitoring of stable asthmatic patients treated with inhaled steroids according to a dose reduction schedule.
Eosinophil cationic protein as a serological marker of disease activity in childhood bronchial asthma.
www.ayubmed.edu.pk /JAMC/PAST/16-3/Badar.htm   (4338 words)

  
 Bioline International Official Site (site up-dated regularly)
Figure 1: a simplified view of eosinophil differentiation and maturation, in the bone marrow; rolling, adhesion and migration, in the blood vessel; and activation and degranulation, in the target organ.
Many of the cytokines that regulate eosinophil function are under the control of proteins belonging to the NFAT (nuclear factor of activated T cells) family of transcription factors.
Eosinophils, T-lymphocytes, mast cells, neutrophils and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy speciments from atopic subjects without asthma and control subjects and relationship to bronchial hyperresponsiveness.
www.bioline.org.br /request?oc97180   (5102 words)

  
 CiteULike: Identification of eosinophil lineage-committed progenitors in the murine bone marrow   (Site not responding. Last check: 2007-10-12)
Identification of eosinophil lineage-committed progenitors in the murine bone marrow
Eosinophil lineage-committed progenitors (EoPs) are phenotypically isolatable in the steady-state murine bone marrow.
@article{citeulike:460566, abstract = {Eosinophil lineage-committed progenitors (EoPs) are phenotypically isolatable in the steady-state murine bone marrow.
www.citeulike.org /article/460566   (437 words)

  
 Eosinophil Apoptosis Is Mediated by Stimulators of Cellular Oxidative Metabolisms and Inhibited by Antioxidants: ...
Eosinophil Apoptosis Is Mediated by Stimulators of Cellular Oxidative Metabolisms and Inhibited by Antioxidants: Involvement of a Thiol-Sensitive Redox Regulation in Eosinophil Cell Death -- Wedi et al.
Eosinophils were incubated for 19 hours with medium control or the indicated concentration of SA and the hypodiploid DNA peak was measured using the PI method.
of spontaneous eosinophil apoptosis by NAC and GSH.
www.bloodjournal.org /cgi/content/full/94/7/2365   (4884 words)

  
 Inst för medicinska vetenskaper   (Site not responding. Last check: 2007-10-12)
Neutrophil and eosinophil degranulation during hemodialysis are mediated by the dialysis membrane.
Eosinophils, secretory responsiveness and glucocorticoid- induced effects on the nasal mucosa during a weak pollen season.
Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease.
www.medsci.uu.se /fogrupp/inflammation/ecp.htm   (3124 words)

  
 Mayo Clinic Proceedings
Eosinophils are derived from hematopoietic stem cells that are committed initially to the myeloid and subsequently to the basophil-eosinophil granulocyte lineage.
Interleukin 5 is considered the major eosinophil growth and survival factor, whereas chemokines (eotaxin, platelet-activating factor, RANTES [regulated on activation, normal T expressed and secreted]) and endothelial adhesion molecules (integrins, vascular cell adhesion molecules) contribute to eosinophil trafficking.
Major basic protein, eosinophil cationic protein, and eosinophil-derived neurotoxin are the primary mediators of eosinophil-associated toxicity to microbes (parasites, protozoa, bacteria, viruses) and human tissue (myocarditis, pneumonitis, dermatitis, neuropathy, vasculitis).
members.tripod.com /enotes/eosinophilia-2.htm   (5890 words)

  
 Leukotriene Receptor Antagonists and Synthesis Inhibitors Reverse Survival in Eosinophils of Asthmatic Individuals -- ...   (Site not responding. Last check: 2007-10-12)
Eosinophils were incubated for 40 h with the inhibitors before assessment of apoptosis.
Eosinophils were exposed to GM-CSF for 40 h in the presence and absence of SKF 104353.
Granulocyte macrophage colony-stimulating factor is the main cytokine enhancing survival of eosinophils in asthmatic airways.
ajrccm.atsjournals.org /cgi/content/full/161/6/1881   (3363 words)

  
 The mechanism of IL-5 signal transduction -- Adachi and Alam 275 (3): C623 -- AJP - Cell Physiology
Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL.
Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome.
The signal transduction mechanism of IL-5 in eosinophils: the involvement of lyn tyrosine kinase and the ras-raf 1-MEK-MAP kinase pathway.
ajpcell.physiology.org /cgi/content/full/275/3/C623   (5493 words)

  
 Faculty
We are characterizing the regulatory regions of the genes encoding the eosinophil-specific alpha (a) subunit of the IL-5 receptor (IL-5Ra), the eosinophil granule cationic proteins [major basic protein (MBP) and eosinophil peroxidase (EPO)], and the Charcot-Leyden crystal (CLC) protein (Galectin-10).
These eosinophil promoters/enhancers are being analyzed as models for the differential regulation of myeloid specific genes in general, and eosinophil specific genes in particular, in the process of the commitment and differentiation of stem cells and multipotential bone marrow-derived progenitors to the granulocyte lineages.
Related projects characterizing eosinophil effector mechanisms in the pathophysiology of asthma and other allergic diseases include studies of the mechanisms by which eosinophils induce airways dysfunction, fibroblast and epithelial cell activation, and the production of inflammatory cytokines and other mediators of tissue remodeling and pathological tissue fibrosis in the lung, gastrointestinal tract and other tissues.
www.uic.edu /com/bcmg/ackerman.html   (808 words)

  
 Current Drug Targets – Inflammation & Allergy, Vol. 2, No. 4, 2003
Manipulation of the process of granulocyte (eosinophil and neutrophil) apoptosis, as well as engineering modified versions of hemopoietic cytokines, such as IL-5, are current approaches to developing valuable tools for intervention in the context of hemopoiesis in allergy.
Eosinophilic infiltration is a cardinal feature of allergic inflammation; based upon its biological actions, the eosinophil has assumed the role as the principal inflammatory cell in asthma.
In assessing the mechanisms by which eosinophils are recruited to sites of inflammation, a sizeable body of evidence exists supporting the proposal that expansion of hemopoietic compartments in the bone marrow stimulates an increased turnover and traffic of mature eosinophils to the site of allergic inflammation.
www.bentham.org /cdtia/contabs/cdtia2-4.htm   (1931 words)

  
 Activation of Mitogen-Activated Protein Kinase Regulates Eotaxin-Induced Eosinophil Migration -- Boehme et al. 163 (3): ...
The eosinophil is a proinflammatory granulocyte implicated in
that it is chemotactic primarily for eosinophils (6, 7).
Eosinophils were isolated from multiple donors (five donors and five rabbits; three to five venules per rabbit were examined), and the bars represent the mean ± SD.
www.jimmunol.org /cgi/content/full/163/3/1611   (6003 words)

  
 RedOrbit - Health - Blood Eosinophilia: A New Paradigm in Disease Classification, Diagnosis, and Treatment   (Site not responding. Last check: 2007-10-12)
Eosinophils are derived from hematopoietic stem cells that are committed initially to the myeloid and subsequently to the basophil- eosinophil granulocyte lineage.1 As depicted in Figure 1, the mature eosinophil, when examined by standard blood-staining techniques, displays a bilobed nucleus and an abundant cytoplasm filled with reddish-orange granules.
Major basic protein, eosinophil cationic protein, and eosinophil- derived neurotoxin are the primary mediators of eosinophil- associated toxicity to microbes (parasites, protozoa, bacteria, viruses) and human tissue (myocarditis, pneumonitis, dermatitis, neuropathy, vasculitis).6-16 The lung and gastrointestinal systems constitute the main residence for eosinophils.
Clonality of isolated eosinophils in the hypereosinophilic syndrome.
www.redorbit.com /news/display?id=116665   (4509 words)

  
 Mechanisms of Transcription in Eosinophils: GATA-1, but not GATA-2, Transactivates the Promoter of the Eosinophil ...
Eosinophil differentiation from hematopoietic stem cells and myeloid progenitors is regulated primarily by cytokines interleukin-3
the differentiation of myeloid progenitors to the eosinophil granulocyte
and differentiation of myeloid progenitors to the eosinophil lineage.
www.bloodjournal.org /cgi/content/full/91/9/3447   (5522 words)

  
 Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors -- ...   (Site not responding. Last check: 2007-10-12)
Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors -- Querfurth et al.
, and Mim-1, all markers of the eosinophil lineage.
of GATA-1 (in eosinophils) or FOG (in FOG-expressing myeloblasts),
www.genesdev.org /cgi/content/full/14/19/2515   (6591 words)

  
 Interleukin-5 Transgene Expression and Eosinophilia Are Associated with Retarded Mammary Gland Development in Mice -- ...
Eosinophils (arrowheads) are identified as endogenous peroxidase-positive cells (stained fl) in fresh-frozen uterine and ovarian tissue counterstained with hematoxylin.
Eosinophils in paraffin-embedded mammary gland tissue stained with HandE are identified as cells with characteristic eosin-positive cytoplasmic granules and distinctive, donut-shaped nuclei (arrowheads).
Eosinophils were identified in uterine (A) and mammary tissues (B) recovered from Wt and IL-5Tg mice in estrus at 7 and 10 wk of age.
www.biolreprod.org /cgi/content/full/69/1/224   (6756 words)

  
 Eosinophilic "empyema" associated with crack cocaine use -- Strong et al. 58 (9): 823 -- Thorax
Eosinophilic pleural effusions from cocaine have not been described.
Expression of vascular endothelial growth factor by human eosinophils: upregulation by granulocyte macrophage colony-stimulating factor and interleukin-5.
Eosinophil granulocyte proliferation induced by an intermediate factor generated in the pleural cavity of rats injected with platelet- activating factor.
thorax.bmj.com /cgi/content/full/58/9/823   (1162 words)

  
 Dissertations from Karolinska Institutet - Published by Karolinska Institutet Karolinska Institutet - ki.se
Since the eosinophil is recruited from the circulation to the inflammatory lesion, it would be of practical use if measurements of the early activation of the eosinophil ("priming") in the blood stream could reflect the inflammation in local tissue, e.g.
This is in contrast to the increased expression of CD9 on eosinophils in the presence of platelets, which is probably due to adherent platelets rather than only a translocation from the intracellular pool of CD9 to the cell surface.
We suggest that the use of allergen challenge in skin chambers is a useful in vivo model for further studies of eosinophil recruitment, their state of activation and the involvement of different allergic inflammatory mediators, such as chemokines and cytokines.
diss.kib.ki.se /1999/91-628-3399-5   (584 words)

  
 ETD OAI Union Catalog
The concentration of eosinophil proteins in serum is the result of their release in vivo and ex vivo during the sampling procedure.
The expression of adhesion and phagocytosis receptors on the surface of peripheral granulocytes and monocytes was increased in patients with RA.
Eosinophils are specifically recruited to sites of allergic inflammation and parasitic infection, whereas neutrophil influx predominates in bacterial infection and rheumatoid arthritis.
oai.dlib.vt.edu /~etdunion/cgi-bin/search.pl?related=oai:UUdiva:2059   (805 words)

  
 Interleukin-3, -5, and Granulocyte Macrophage Colony-Stimulating Factor-Induced Adhesion Molecule Expression on ...
intercellular adhesion molecule (ICAM)-1, and ICAM-3 on eosinophils.
and adhesion molecules (23), eosinophil degranulation, and chemotaxis
LFA-1 expression by blood eosinophils is increased in atopic asthmatic children and is involved in eosinophil locomotion.
ajrcmb.atsjournals.org /cgi/content/full/29/1/133   (4428 words)

  
 Eotaxin Is Required for Eosinophil Homing into the Stroma of the Pubertal and Cycling Uterus -- Gouon-Evans and Pollard ...
Effect of the lack of eotaxin on eosinophil populations in the uterus.
Note the absence of eosinophils in mutant mice shown by the lack of eosin staining and eosinophil specific-peroxidase activity.
Effect of the lack of uterine eosinophils on the stromal gland formation, the age of the first parturition and on uterine edema.
endo.endojournals.org /cgi/content/full/142/10/4515   (4971 words)

  
 Making Eosinophils Through Subtle Shifts in Transcription Factor Expression -- McNagny and Graf 195 (11): 43 -- The ...
Assuming that eosinophils are specified by the coexpression
Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors.
Absence of granulocyte colony-stiumulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice.
www.jem.org /cgi/content/full/195/11/f43   (2447 words)

  
 High concentrations of eosinophil cationic protein and eosinophil protein X in eosinophilic pleural effusions -- ...
High concentrations of eosinophil cationic protein and eosinophil protein X in eosinophilic pleural effusions -- Pettersson et al.
High concentrations of eosinophil cationic protein and eosinophil protein X in eosinophilic pleural effusions
To analyze the association of the eosinophil granulocyte with pleural
www.chestjournal.org /cgi/content/abstract/103/2/475   (280 words)

Try your search on: Qwika (all wikis)

Factbites
  About us   |   Why use us?   |   Reviews   |   Press   |   Contact us  
Copyright © 2005-2007 www.factbites.com Usage implies agreement with terms.