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Topic: Epicatechin


In the News (Thu 8 Jan 09)

  
  Epicatechin
Polyphenols were shown to be useful in the long term preservation of rat pancreatic islets in vitro under physiological conditions.
Epicatechin is reported to have insulin mimetic action with protective effects on erythrocytes in a manner similar to insulin.
Epicatechin was shown to mimic the effects of insulin in restoring the acetylcholineesterase activity to normal levels in diabetic erythrocytes.
www.diabeticbar.com /epicatechin.htm   (227 words)

  
  United States Patent Application: 0020151506   (Site not responding. Last check: 2007-10-23)
The composition of claim 9 wherein the catechin is selected from the group consisting of catechin, epicatechin, gallocatechin gallate, epigallocatechin gallate, epigallocatechin, and epicatechin gallate, and pharmaceutically acceptable salts of the foregoing catechins, and the pharmaceutically acceptable analogs and derivatives thereof.
Epicatechin (from ICN and Aldrich), catechin hydrate, and catechin all inhibited A.beta.
Epicatechin (from Fluka, ICN, Aldrich and Sigma), catechin hydrate, gallocatechin gallate, and epicatechin gallate all caused a disruption/disassembly of pre-formed A.beta.
appft1.uspto.gov /netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1="20020151506".PGNR.&OS=DN/20020151506&RS=DN/20020151506   (13635 words)

  
 Flavonoid - Wikipedia, the free encyclopedia
Their effects include increasing intracellular vitamin C levels, decreasing capillary permeability and fragility, scavenging oxidants and free radicals, and inhibiting destruction of collagen, the most abundant protein in the body.
Cocoa, particularly dark chocolate, is loaded with epicatechin and has been found to have nearly twice the antioxidant content of red wine and up to three times that of green tea.
The major polyphenols in green tea are flavonoids (catechin, epicatechin, epicatechin gallate, epigallocatechin gallate, and proanthocyanidins).
en.wikipedia.org /wiki/Flavonoid   (705 words)

  
 And the biggest medical advance of our time is ... cocoa?
The health benefits of epicatechin, a compound found in cocoa, are so striking that it may rival penicillin and anaesthesia in terms of importance to public health, reports Marina Murphy in Chemistry & Industry, the magazine of the SCI.
Flavanols like epicatechin are removed for commercial cocoas because they tend to have a bitter taste.
Epicatechin is also found in teas, wine, chocolate and some fruit and vegetables.
www.sootoday.com /content/news/full_story.asp?StoryNumber=23253   (518 words)

  
 Life Enhancement:: Tea Enhances Insulin Activity - Feb. 2003
The active components in tea that cause the reduced glucose levels in animals are not known, but epicatechin gallate was shown to have the greatest activity of the catechins in lowering glucose uptake by Caco-2 cells.
Epicatechin gallate was also reported to inhibit glucose uptake in the brush border membrane vesicles from rabbit small intestine.
The decreased insulin-enhancing effects of milk and nondairy creamers was due to the precipitation of epigallocatechin, gallocatechin gallate, and epicatechin gallate.
www.life-enhancement.com /article_template.asp?ID=800   (606 words)

  
 1960.htm   (Site not responding. Last check: 2007-10-23)
This increase is regulated by the synthesis of the flavonoid epicatechin present in the fruit peel.
Epicatechin is an inhibitor of the enzyme lipoxygenase whose activity catalyze the breakdown of the antifungal diene.
Increase in epicatechin concentration inhibits the breakdown of the antifungal compound and since the compound is continuously synthesized, both combined processes result in the increase of the antifungal level.
www.bard-isus.com /FRAbst/1960.htm   (259 words)

  
 Cocoa powder, the cheap antioxidant   (Site not responding. Last check: 2007-10-23)
The primary flavonoids in cocoa and chocolate are the fiavan-3-ols (monomers) catechin and epicatechin (monomeric units) and proanthocyanidins (also termed procyanidins), which are polymeric compounds comprising catechin and epicatechin subunits (Zhu et al 2002).
The rise in plasma epicatechin concentrations is dose-dependent and dictated by the flavonoid concentration in the chocolate eaten.
High concentrations of flavonoids are present in certain cocoas, predominately as the flavanol monomers (±)-epicatechin (epicatechin) and (+)-catechin (catechin), and as oligomers of these monomeric base units, which are known as the procyanidins (Kris-Ethertona, and Keenb, 2002).
www.health-herbal.com /html/cocoa.html   (2687 words)

  
 Epicatechin and exercise boosts memory in mice | We Need Health
The compound, epicatechin, is one of a group of chemicals known as flavonols and has been shown previously to improve cardiovascular function in people and increase blood flow in the brain.
Further analysis showed that the epicatechin and exercise combination had a beneficial effect on the expression of genes important for learning and memory, and decreased the activity of genes playing a role in inflammation and neurodegeneration.
The researchers found that sedentary mice fed epicatechin showed enhanced memory, blood vessel growth, and gene activity, but these benefits were even more evident in mice that also exercised.
weneedhealth.com /2007/epicatechin-and-exercise-boosts-memory-in-mice   (501 words)

  
 Cocoa Has Beans
The compound in question, epicatechin, a flavanol, may eventually rival penicillin and anesthesia in terms of importance to public health, according to Marina Murphy, writing in the journal Chemistry and Industry.
He claims that epicatechin is so important that it should be considered a vitamin, alongside such essential trace compounds as ascorbic acid (vitamin C), vitamin B12, and folate.
Currently, compounds such as epicatechin, which have demonstrable health benefits, are excluded from the definition of vitamin because they are not "vital" to normal functioning, metabolism, regulation, and growth of cells.
www.reactivereports.com /63/63_1.html   (536 words)

  
 Epicatechin Molecule
Phenols may also prevent fat like substances in the blood stream from oxidizing and clogging the arteries.
Cranberry juice used for treating urinary tract infections contains the trimers (three-molecule aggregates) of epicatechin in the juice.
It is may act act to inhibit the adhesion of bacteria to the cells that line the urinary tract.
www.worldofmolecules.com /antioxidants/epicatechin.htm   (525 words)

  
 Yummy Natural Compound Boosts Memory Skills on Wired Science
Epicatechin was shown to increase blood-vessel growth in the dentate gyrus -- an area of the brain that undergoes neurogenesis -- and mature neuron development.
To compensate, epicatechin upregulated genes associated with neuronal extension, synaptic plasticity, and increased neuronal spine density (which is associated with improved learning and memory).
Epicatechin appears to help you make the most of what you have while inhibiting cell growth that may clutter your brain and limit the efficiency of learning.
blog.wired.com /wiredscience/2007/05/yummy_natural_c.html   (423 words)

  
 Regulation of Natural Resistance of Avocado Fruit for the Control of Postharvest Disease
Fruit resistance might be regulated in three ways: 1) development of cultivars with a naturally high concentration of epicatechin; 2) the use of antioxidants that inhibit lipoxygenase; and 3) the induction of the antifungal diene by high concentrations of CO Colletotrichum gloeosporioides attacks avocado fruit during the growing season of the fruit.
The lipoxygenase (LOX) inhibitor, epicatechin, was extracted in 5 mM sodium phosphate buffer (pH 7.2), partially purified by flash chromatography, and quantified by HPLC as described by Prusky et al.
The flavan-3-ol epicatechin is known to be an antioxidant by its action as a free radical trap which results in its own oxidation.
www.avocadosource.com /wac2/wac2_p479.htm   (1543 words)

  
 A Dose-Response Effect from Chocolate Consumption on Plasma Epicatechin and Oxidative Damage -- Wang et al. 130 (8): ...   (Site not responding. Last check: 2007-10-23)
in epicatechin was associated with an increase in the antioxidant
increases in plasma epicatechin that are associated with increases
The influence of the bread on the bioavailability of epicatechin
www.nutrition.org /cgi/content/full/130/8/2115S   (3863 words)

  
 United States Patent Application: 0040220392
The method of claim 209, wherein epicatechin and/or catechin is administered in the form of a cocoa extract fraction.
The method of claim 215, wherein epicatechin is administered in the form of a cocoa extract or a fraction thereof.
The method of claim 215, wherein epicatechin is administered in the form of a capsule or a tablet.
appft1.uspto.gov /netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1="20040220392".PGNR.&OS=DN/20040220392&RS=DN/20040220392   (14073 words)

  
 MECHANISM OF ACTION
The increase in cAMP activity is attributed to epicatechin and glucose that raise intracellular Ca concentration in the islets.
Immature rats responded better to epicatechin with respect to insulin release and cAMP content of islets compared to their mature counterparts.
With maturation there is a sharp decline in the islets response to (-)-epicatechin although the size of the islets and number of b-cells increase with age.
www.silbinol.com /mechAction.htm   (375 words)

  
 India Herbal Remedy Control Diabetes,Herbal Remedy to Control Diabetes from India.
The active principle of Episulin is Epicatechin, which is extracted from the bark of P.marsupium in a highly scientific manner.
A) Epicatechin increase the cAMP content of the islet which is associated with increased insulin release.
It has been clearly established by the findings of the experiment that although Epicatechin (P.Marsupium) showed results, but the results of imperical formulation was more prominent in lowering of blood sugar level as will as in improving the quality of life by controlling other peripheral problems.
www.episulin.com /formulation.htm   (413 words)

  
 Epicatechin from green tea reduces taurine excretion
Although the predominant flavonoids in fresh leaf and green tea are known to be flavan-3-ols and flavan-3-O-gallates ("the catechins"), the biochemical effects of tea polyphenol consumption on living systems are generally poorly understood.
Metabonomic methods utilizing (1)H NMR spectroscopy of biofluids and principal component analysis (PCA) have been applied to investigate the bioavailability and metabolic responses of rats to a single dose of 22 mg of epicatechin (EC) dissolved in water.
This is the first in vivo study demonstrating the overall endogenous metabolic effects of EC consumption and shows the bioavailability of EC via metabolic effects and excretion of EC metabolites.
www.usenet.com /newsgroups/sci.life-extension/msg01646.html   (319 words)

  
 Epicatechin and a Cocoa Polyphenolic Extract Modulate Gene Expression in Human Caco-2 Cells -- Noé et al. 134 ...   (Site not responding. Last check: 2007-10-23)
Epicatechin and a Cocoa Polyphenolic Extract Modulate Gene Expression in Human Caco-2 Cells -- Noé et al.
Epicatechin and a Cocoa Polyphenolic Extract Modulate Gene Expression in Human Caco-2 Cells
epicatechin decreased the expression of 21 genes and upregulated
www.nutrition.org /cgi/content/abstract/134/10/2509   (322 words)

  
 Unbound MEDLINE | Reactivity of epicatechin in aqueous glycine and glucose maillard reaction models: quenching of C2, ...
Reactivity of epicatechin in aqueous glycine and glucose maillard reaction models: quenching of C2, C3, and C4 sugar fragments.
Totlani VM, Peterson DG Reactivity of epicatechin in aqueous glycine and glucose maillard reaction models: quenching of C2, C3, and C4 sugar fragments.
In conclusion, the quenching of sugar fragmentation products via epicatechin was correlated with the observed inhibition on volatile compound formation when epicatechin was added to a glucose/glycine aqueous reaction model system.
www.unboundmedicine.com /medline/ebm/record/15884850/abstract/Reactivity_of_epicatechin_in_aqueous_glycine_and_glucose_maillard_reaction_models:_quenching_of_C2_C3_and_C4_sugar_fragments   (214 words)

  
 Reference.com/Encyclopedia/Catechin
Catechin and epicatechin are epimers, with (-)-epicatechin and (+)-catechin being the most common optical isomers found in nature.
Epigallocatechin and gallocatechin contain an additional phenolic hydroxyl group when compared to epicatechin and catechin, respectively, similar to the difference in pyrogallol compared to pyrocatechol.
He believes that epicatechin should be considered essential to the diet and thus classed as a vitamin.
www.reference.com /browse/wiki/Catechin   (426 words)

  
 MEDLINE_1996-2006 - Resultado de la búsqueda <página 1>
Epicatechin in human plasma: in vivo determination and effect of chocolate consumption on plasma oxidation status.
Chocolate is a food that is known to be rich in the flavan-3-ol epicatechin and procyanidin oligomers.
This method allows for the determination of 20 pg (69 fmol) of epicatechin, which translates to plasma concentrations as low as 1 nmol/L. We next evaluated the absorption of epicatechin, from an 80-g semisweet chocolate (procyanidin-rich chocolate) bolus.
www.bireme.br /cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE_1996-2006&exprSearch=9929521&indexSearch=UI&lang=p   (241 words)

  
 The Analyst - Internet Health Report: Treatment: Catechin
There is one natural source of epicatechin that appears to have health benefits.
Scientists targeted epicatechin, a specific flavonoid that was absorbed at high levels in the blood, to be particularly beneficial in blood vessel functions.
Researchers believe elevated levels of epicatechin trigger the release of active substances that increase blood flow through arteries and improve heart health.
www.digitalnaturopath.com /treat/T128649.html   (422 words)

  
 Food That Boosts Memory - Eat epicatechin! - Softpedia
The individuals that both exercised and were fed on the epicatechin diet performed the best on the platform location exercise.
Mice fed on epicatechin but without exercising displayed boosted memory, but to a lesser level.
The mice on the epicatechin diet seemed to display greater blood vessel growth in certain brain areas, alongside more mature brain neurons.
news.softpedia.com /news/Food-That-Boosts-Memory-56215.shtml   (437 words)

  
 IngentaConnect Insulin-Like Effect Of (-)Epicatechin On Erythrocyte Membrane Ace...   (Site not responding. Last check: 2007-10-23)
Epicatechin, a member of a group of polyphenolic compounds collectively known as ‘catechins’ that are present in tea and belong to the flavonoid family, has been reported to possess insulin-like activity.
Epicatechin (1 mmol/L) also caused an elevation in AChE activity in diabetic erythrocytes, an effect that was similar to the effect of insulin.
Epicatechin has a pronounced insulin-like effect on erythrocyte membrane-bound AChE in type 2 diabetic patients; however, the mechanism of action of epicatechin remains speculative.
www.ingentaconnect.com /content/bsc/cep/2001/00000028/00000009/art03513   (272 words)

  
 Flavonoid
Their effects include increasing intracellular vitamin C levels, decreasing capillary permeability and fragility, scavenging oxidants and free radicals, and inhibiting destruction of collagen, the most abundant protein in the body.
Cocoa, the major ingredient of dark chocolate, is loaded with epicatechin and has been found to have nearly twice the antioxidant content of red wine and up to three times that of green tea.
The major polyphenols in green tea are flavonoids (catechin, epicatechin, epicatechin gallate, epigallocatechin gallate,(EGCG), and proanthocyanidins).
www.dejavu.org /cgi-bin/get.cgi?ver=93&url=http%3A%2F%2Farticles.gourt.com%2F%3Farticle%3Dflavonoid%26type%3Den   (821 words)

  
 Society of Chemical Industry:
Epicatechin, a compound found in tea, wine, chocolate and cocoa is so important to the diet, it should be considered a vitamin.
It may be that these diseases are the result of epicatechin deficiency and that we need to rethink how we define vitamins.’ For the time being, Fabricant suggests that phytonutrient may be a more appropriate term, as epicatechin promotes health but it remains to be seen whether it is strictly essential.
Ingestion of flavanols like epicatechin is thought to cause acute elevations in levels of circulating nitric oxide (NO) species, improving blood vessel function and blood flow to the brain.
www.soci.org /SCI/general/2007/html/ge609.jsp   (578 words)

  
 [No title]
Epicatechin, a compound found in unrefined cocoa, could have health benefits that rival penicillin and anesthesia in terms of importance to public health.
Hollenberg believes that epicatechin should be considered a vitamin, and other nutrition experts believe that epicatechin is so important that it could even warrant a rethinking of how vitamins are defined.
Epicatechin is removed from commercial cocoas because it tends to have a bitter taste.
www.mercola.com /2007/mar/27/eating-chocolate-may-be-more-important-to-your-health-than-penicillin.htm   (673 words)

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