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Topic: Epidermal basal cell

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	The Rockefeller University - Laboratory of Mammalian Cell Biology and Development
		Later, the cells assemble an indestructible proteinaceous envelope that serves as a scaffold on which lipids are extruded and organized to form the epidermal barrier.
		In contrast, epidermal cells that stop dividing, detach from the basement membrane, and move outward toward the skin surface, switch to the expression of a new set of keratin genes, producing keratins 1 and 10 (K1 and K10), which form large bundles of keratin filaments.
		Using transgenic technology to perturb keratin filaments in the basal layer of mouse epidermis, we discovered that similarly, the epidermal cells become fragile, degenerating upon mild rubbing and causing a blister (Vassar et al., 1991).
	www.rockefeller.edu /labheads/fuchs/researchEpidermial.php (676 words)

	List of distinct cell types in the adult human body - Wikipedia, the free encyclopedia
		Surface epithelial cell of stratified squamous epithelium of cornea, tongue, oral cavity, esophagus, anal canal, distal urethra and vagina
		basal cell (stem cell) of epithelia of cornea, tongue, oral cavity, esophagus, anal canal, distal urethra and vagina
		Basal cell of olfactory epithelium (stem cell for olfactory neurons)
	en.wikipedia.org /wiki/Human_cell (527 words)

	BASAL CELL CARCINOMA (Site not responding. Last check: 2007-11-03)
		Basal cell carcinoma is a skin tumor, already known at the end of XIX century, under the name of "superficial epithelioma" and of "ulcus rodens" (rodent ulcer) [1].
		In 1903, the distintive term "basal cell", which refers to the histological resemblance of the cells to the cells of the basal layer of the epideris, was conied by Krompecher [2].
		Basal cell carcinoma occurs, almost always (except for nevoid basal cell epithelioma syndrome) on hair-bearing skin and virtually never on mucosae; it is now considered as a tumor of the hair follicle.
	xoomer.virgilio.it /cylagu/pagina14eng.html (648 words)

	Basal Cell Epithelioma \| Home remedy and Herbal Natural Cure for Basal Cell Epithelioma
		Basal Cell Epithelioma develops from the basal cell layer of the epidermis and also from the p Plant derivatives pilo-sebaceous apparatus.
		The tumor is characterized by slow growth and the presence of a pearly nodule or ulcer with a rolled edge.
		Pathology: The typical features are downward projections of the basal cell layer; strands and islands of epidermal cells surrounded by a palisade of typical columnar basal cells containing a large nucleus; deep bluish staining and inflammatory reaction in the corium which is more marked at the periphery of the lesion.
	www.skin-disease.org /disorders/basal-cell-epithelioma.htm (649 words)

	basal cell carcinoma
		Basal cell carcinoma is a common, slow-growing tumor that rarely metastasize.
		Tumor cells are basal epidermal cells that never mature and lose their nuclei as normal basal cells do.
		Tumor cells appear to bud off from the epidermis and grow downward as islands and cords of basophilic cels with hyperchromatic nuclei.
	www.brown.edu /Courses/Digital_Path/Skin/basal_cell_carcinoma.htm (137 words)

	Basal Cell Carcinoma
		RESULTS: p63 was expressed in the nuclei of epidermal basal and suprabasal cells, in the cells of the germinative hair matrix and the external root sheath of hair follicles, in the basal cells of the sebaceous gland and in the myoepithelial/basal cells of the sweat glands.
		Another basal cell carcinoma from this patient did not show the loss of the normal copy of PTCH, instead a missense mutation in a highly conserved residue was identified in the nondeleted allele, illustrating two different mechanisms of PTCH inactivation in different tumors derived from the same NBCCS patient.
		Basal cell carcinoma arising from the nipple of the breast is an uncommon malignancy, with only a handful of cases reported in the literature.
	www.thedoctorsdoctor.com /diseases/skin_basalcell_ca.htm (13974 words)

	C.Pollitt (Site not responding. Last check: 2007-11-03)
		Adjoining the plasmalemma of the epidermal cells was a pale staining layer, the lamina lucida.
		Between the plasmalemma (P) of the basal cell and the dark staining lamina densa(LD) is the pale staining lamina lucida (LL).
		The rough areas and tags are presumably the remnants of the basal cell plasmalemma.
	www.uq.edu.au /VE411/book/article/94a/rst.htm (2581 words)

	BioMed Central \| Full text \| Notch signalling is linked to epidermal cell differentiation level in basal cell ... (Site not responding. Last check: 2007-11-03)
		Epidermal homeostasis involves the monitoring of continuous proliferative and differentiative processes as keratinocytes migrate from the basal layer to the skin surface.
		Proliferating cells, which are thought to be derived from the basal cell layer [33], migrated from the periphery to the centre of the wound, and progressively differentiated to constitute a pluristratified epidermis (Fig.
		In the epidermal basal layer, Notch receptors are present in transit amplifying cells [6] and the cell-cell signalling system promotes both expansion and differentiation of these cells.
	www.biomedcentral.com /1471-5945/2/7 (5229 words)

	Dermatology - Basal Cell Carcinoma (Site not responding. Last check: 2007-11-03)
		Basal cell carcinoma (BCC) is a malignant neoplasm usually of basal cells of the epidermis.
		Superficial basal cell carcinomas appear as round, oval, or irregularly shaped erythematous, telangiectatic plaques that may be scaly, and have a well-defined, slightly raised, fine thread-like translucent rolled border.
		Pigmented basal cell carcinomas are variants of nodular or superficial BCC which demonstrate obvious pigmentation.
	cybermed.ucsd.edu /derm1/BCC/3dermweb1.html (638 words)

	The Basement Membrane Pathology: A Feature of Acute Equine Laminitis
		Eventually, even the primary epidermal and primary dermal lamellae separated from each other and the empty shells of isolated BM, in what was once the tip of the primary epidermal lamella, signified that a global separation of the epidermal and dermal lamellae had occurred (Grade 3 lesion).
		The cytoplasm of the SEL basal cells was light pink, cloudy and vacuolated.
		Most of the epidermal cells have coalesced into an amorphous mass and the BM of each SEL appears to have separated from the epidermal basal cells and lies free, in strands, among the connective tissue of the PDL (arrows).
	www.horseshoes.com /advice/anatomyandfunction/basementmembranepathology/basementmembranepathology.htm (5745 words)

	The Basement Membrane at the Equine Hoof Dermal Epidermal Junction
		Examination of ultrathin sections of the enzyme/detergent treated tissue with the transmission electron microscope (TEM) confirmed that the epidermal basal cells were anuclear and had lost their cytoplasm and cell membranes (Fig 6).
		The smooth indentations (arrowheads) on the surface of the BM ate where epidermal basal cells were attached.
		Therefore, where hemidesmosomes occurred there was an increased density of fine cords crossing the lamina lucida and connecting the cytoskeleton of the epidermal cell (via the tonofilaments converging on the attachment plaque of the hemidesmosome) directly to the lamina densa.
	www.horseshoes.com /advice/anatomyandfunction/basementmembrane/basementmembrane.htm (6026 words)

	CBS - Rodríguez-Puebla, Marcelo L. (Site not responding. Last check: 2007-11-03)
		In mammalian cells, proliferation is under the control of factors that regulate the transitions between different cell-cycle stages at two main checkpoints, the G1/S and the G2/M transition.
		In order to study the role of the different cell cycle regulators in vivo, we have developed several transgenic mice that expressed cyclin D2, cyclin D3 or CDK4 in the basal cell layer of squamous epithelia.
		At this moment we are studying the role of this circuit in the deregulation of cyclin D2 in chemical induced mouse tumors.
	www.cvm.ncsu.edu:8110 /cbs/rodriguez-puebla_marcelo.htm (904 words)

	eMedicine - Epidermal Inclusion Cyst : Article Excerpt by: Kenneth A Becker, MD
		Epidermal inclusion cyst refers to those cysts that are the result of the implantation of epidermal elements in the dermis.
		Pathophysiology: Epidermoid cysts result from the proliferation of epidermal cells within a circumscribed space of the dermis.
		They have been shown to not be of sebaceous origin based on the analysis of their lipid pattern, which demonstrates similarities to the epidermis.
	www.emedicine.com /derm/byname/epidermal-inclusion-cyst.htm (396 words)

	An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates ...
		of an epidermal bilayer with a thin and dispersed dermis.
		that epidermal stem cells of the bulge are absent in Shh
		on the epidermal proliferative compartment, we analysed the
	dev.biologists.org /cgi/content/full/131/20/5009 (5996 words)

	eMedicine - Basal Cell Carcinoma : Article by Robert S Bader, MD
		Typically, basal cell tumors enlarge slowly and relentlessly and tend to be locally destructive.
		Morpheaform BCC is an uncommon variant in which tumor cells induce a proliferation of fibroblasts within the dermis and an increased collagen deposition (sclerosis) that clinically resembles a scar.
		Nevoid BCC syndrome (basal cell nevus syndrome, Gorlin syndrome): This autosomal dominant disorder results in the early formation of multiple odontogenic keratocysts, palmoplantar pitting, intracranial calcification, and rib anomalies.
	www.emedicine.com /med/topic214.htm (3661 words)

	diagnosis of melanoma-basal cell carcinoma (Site not responding. Last check: 2007-11-03)
		Nodular Basal Cell Carcinoma This retired railroad worker of Irish descent, had a career as a railroad worker.
		Basal cell carcinoma usually presents as a translucent papule growing on previously over-sun-exposed areas of fair-skinned older adults.
		(Accepting pigment from melanocytes is a normal function of epidermal cells.) The resulting lesion may be a pigmented tumor, often one with dark or irregular pigmentation.
	matrix.ucdavis.edu /tumors/new/tutorial13.html (242 words)

	The Transcription Factors c-rel and RelA Control Epidermal Development and Homeostasis in Embryonic and Adult Skin via ...
		At higher magnification (E and F), silver grains overlay the sheath cells (arrow in panel E) and the dermal papilla (arrowhead in panel E) of hair follicles, plus basal cells (arrow in panel F) and differentiating keratinocytes in the epidermis (bracket in panel E).
		Epidermal stem cell and transit-amplifying cell numbers are normal in the absence of c-rel and RelA.
		The absence of basal keratinocyte hyperproliferation in rela
	mcb.asm.org /cgi/content/full/24/13/5733 (6299 words)

	Body Glove Cell -- Recommendations and Resources (Site not responding. Last check: 2007-11-03)
		HHS' General Counsel, Harriet Rabb, concluded that then-current law prohibiting the use of HHS appropriated funds for human embryo research would not apply to research using stem cells "because such cells are not a human embryo within the statutory definition."..
		Rabb determined that the statutory ban on human embryo research defines embryo as an "organism" that when implanted in the uterus is capable of becoming a human being.
		The opinion stated that pluripotent stem cells are not and cannot develop into an organism, as defined in the statute.
	www.becomingapediatrician.com /health/20/body-glove-cell.html (683 words)

	Keratinocyte stem cells: targets for cutaneous carcinogens -- Morris 106 (1): 3 -- Journal of Clinical Investigation
		The nuclei of underlying basal cells are stained with hematoxylin.
		immature population of epidermal basal cells, we have characterized
		Gilbert, C.W., and Lajtha, L.G. The importance of cell population kinetics in determining the response to irradiation of normal and malignant tissue.
	www.jci.org /cgi/content/full/106/1/3 (4048 words)

	Epidermal stem cells: Properties, markers, and location -- Lavker and Sun, 10.1073/pnas.250380097 -- Proceedings of the ...
		cells is enriched in the dividing TA cells (11).
		It is hypothesized here that the epidermal stem cell represents a form of bulge-derived, young transit amplifying cell (SC/TA The long, curved arrow denotes the demonstrated capability of adult epidermal cells to form a new hair follicle in response to appropriate mesenchymal stimuli (46, 47).
		cells of the interfollicular epidermis (39), and that (ii) the
	www.pnas.org /cgi/content/full/250380097v1 (3812 words)

	Blockade of Lymphotoxin Signaling Inhibits the Clinical Expression of Murine Graft-versus-Host Skin Disease -- Wu et ...
		A single-cell suspension of donor BM and spleen cells was
		Apoptotic cells were detected on these sections in situ by the fluorescence TUNEL technique, as indicated in green.
		ICAM-1 expression on epidermal keratinocytes in cutaneous graft-versus-host disease.
	www.jimmunol.org /cgi/content/full/172/3/1630 (4249 words)

	Feline Basal Cell Carcinoma (Site not responding. Last check: 2007-11-03)
		A low-grade malignant proliferation of epidermal cells that recapitulates the basal cell layer of the normal epidermis or the adnexa.
		These neoplasms show no differentiation to any of the adnexal structures and may have epidermal contiguity which may be multifocal.
		There are histologic variants of basal cell carcinoma.
	cal.vet.upenn.edu /derm2/epi/fbcc.html (141 words)

	MEDICAL BIOLOGY: UPDATE ON BASAL CELL CARCINOMA
		Primary skin cancers are of two types: a) epidermal cancers, which originate in keratinocytes, melanocytes, or skin appendages such as sweat glands; b) dermal cancers, which originate in neural, vascular, and other tissues of the skin.
		In animals, epithelial cells compose the cell layers that form the interface between a tissue and the external environment, for example, the cells of the skin, the lining of the intestinal tract, and the lung airway passages.
		This cancer arises from the undifferentiated basal keratinocytes of the epidermis.
	scienceweek.com /2005/sw051216-5.htm (1712 words)

	Altered phenotype of cultured urothelial and other stratified epithelial cells: implications for wound healing -- Sun ...
		Keratins of a wide range of epidermal diseases including psoriasis, basal cell and squamous cell carcinoma, and other epidermal diseases (B), and cultured epidermal cells in conditions favoring keratinization (vitamin A deficiency, air-liquid interface, etc; C) form a continuous spectrum in between the normal epidermis (A) and cultured epidermal cells (D).
		Once leaving the basal compartment, the cell adopts 1 of the 2 alternative pathways of differentiation, labeled "Street of Keratinization" and marked by K1/K10 expression, or "Street of Hyperproliferation" and marked by K6/K16 expression, depending on the environmental factors/instructions ("!" from the loudspeakers).
		Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogensis.
	ajprenal.physiology.org /cgi/content/full/291/1/F9 (6650 words)

	AppendixC
		Urinary epithelium cell (lining bladder and urinary ducts)
		Epithelial Absorptive Cells (Gut, Exocrine Glands and Urogenital Tract)
		Neuron cell (large variety of types, still poorly classified)
	www.nanomedicine.com /NMI/AppendixC.htm (460 words)

	Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem ...
		populations are a heterogeneous mixture of SC and TA cells of
		Cells with low Lrig1 and high Myc (arrows) or high Lrig1 and low Myc (arrowheads) are indicated.
		Lrig1 is observed in psoriatic lesions and in squamous cell
	www.pnas.org /cgi/content/full/103/32/11958 (4670 words)

	Vitamin D3 receptor ablation sensitizes skin to chemically induced tumorigenesis -- Zinser et al. 23 (12): 2103 -- ...
		The number of BrdU positive cells per 100 total cells was quantitated in interfollicular epidermal basal cells of dorsal skin.
		The number of BrdU positive cells per 100 total cells was quantified in interfollicular epidermal basal cells of dorsal skin.
		A minimum of 200 cells from two to six independent photographs were counted for each mouse, with 12–16 treated animals and three age-matched controls sampled per group.
	carcin.oxfordjournals.org /cgi/content/full/23/12/2103 (4207 words)

	Deficiency of Either Cyclooxygenase (COX)-1 or COX-2 Alters Epidermal Differentiation and Reduces Mouse Skin ...
		Epidermal Hyperplasia, Keratinocyte Proliferation, Death, and Transit in Wild-type and COX-deficient Mice.
		(e and f) mice is initially confined to the basal cells at 1 h after injection (a, c, and e).
		The expression of COX-1 in basal cells of the
	cancerres.aacrjournals.org /cgi/content/full/62/12/3395 (5944 words)

	Cell Death and Differentiation - Abstract of article: Differential roles of p63 isoforms in epidermal development: ...
		Cell Death and Differentiation - Abstract of article: Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice
		Epidermal development requires the transcription factor p63, as p63-/- mice are born dead, without skin.
		Np63), although their relative contribution to epidermal development is unknown.
	www.nature.com /doifinder/10.1038/sj.cdd.4401926 (362 words)

	Divergent Responses in Epidermal Basal Cells Exposed to the Tumor Promoter 12-O-Tetradecanoylphorbol-13-acetate -- ...
		Studies on the induction of the enzyme epidermal transglutaminase
		differentiation in approximately 50% of the basal cell population,
		the epidermal cell population and that exposure to phorbol esters
	cancerres.aacrjournals.org /cgi/content/abstract/42/6/2344 (908 words)

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