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Epidermal growth factor - Wikipedia, the free encyclopedia Epidermal Growth Factor or EGF is a 6045 Da protein with 53 amino acid residues and three intramolecular disulfide bonds. EGF acts by binding with high affinity to its specific receptor on the cell surface thereby stimulating the intrinsic protein-tyrosine kinase activity of the receptor. Lynch TJ et al, Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. en.wikipedia.org /wiki/Epidermal_growth_factor   (249 words)

Epidermal growth factor receptor - Wikipedia, the free encyclopedia The epidermal growth factor receptor (EGFR) is the receptor for epidermal growth factor (EC 2.7.1.112). EGFR is activated by binding of its specific ligands, including epidermal growth factor, transformation growth factor α (TGFα), or others, thereby stimulating the intrinsic protein-tyrosine kinase activity of the receptor in its "kinase domain". The various names for the epidermal growth factor receptor are in existence due to the naming of oncogenes by independent researchers. en.wikipedia.org /wiki/Epidermal_growth_factor_receptor   (422 words)

Recombinant Human Epidermal Growth Factor - CYT- 217   (Site not responding. Last check: 2007-10-09) Immunohistochemical detection of transforming growth factor-alpha, epidermal growth factor, and vascular endothelial growth factor expression in hyperstimulated rat ovary. Epidermal growth factor partially restores colonic ion transport responses in mouse models of chronic colitis. Epidermal growth factor-induced signaling in breast cancer cells results in selective target gene activation by orphan nuclear receptor estrogen-related receptor alpha. www.prospec.co.il /~prospec/cart/catalog/rHuEGF.html   (448 words)

Cancer Drugs that Inhibit Epidermal Growth Factor Receptors   (Site not responding. Last check: 2007-10-09) Epidermal growth factor receptors are found in the cell membranes. Epidermal growth factor receptors are found in the cell membrane, extending from the exterior to the interior of the cell. The antibodies compete with growth factors for binding, and block dimerization and activation of the tyrosine kinase enzyme. www.suite101.com /article.cfm/new_cancer_treatments/113854   (528 words)

Targeting Epidermal Growth Factor Receptor Pathways   (Site not responding. Last check: 2007-10-09) A substantial body of evidence has recently emerged indicating that aberrant signaling and/or unregulated activation of the epidermal growth factor receptor (EGFR) may be a possible key factor in the development and progression of many cancers. The epidermal growth factor receptor and its inhibition in cancer. Epidermal growth factor-related peptides and their receptors in human malignancies. professional.cancerconsultants.com /current_oncology_2002.aspx?id=30395   (2337 words)

Overexpression of Epidermal Growth Factor and Hepatocyte Growth Factor Receptors in a Proportion of Gastrinomas ... Overexpression of Epidermal Growth Factor and Hepatocyte Growth Factor Receptors in a Proportion of Gastrinomas Correlates with Aggressive Growth and Lower Curability -- Peghini et al. Overexpression of Epidermal Growth Factor and Hepatocyte Growth Factor Receptors in a Proportion of Gastrinomas Correlates with Aggressive Growth and Lower Curability and epidermal growth factor receptor in gastrointestinal carcinoids. clincancerres.aacrjournals.org /cgi/content/full/8/7/2273   (8814 words)

Epidermal growth factor receptor double targeting by a tyrosine kinase inhibitor (Iressa) and a monoclonal antibody ...   (Site not responding. Last check: 2007-10-09) Epidermal growth factor receptor double targeting by a tyrosine kinase inhibitor (Iressa) and a monoclonal antibody (Cetuximab). Epidermal growth factor receptor (EGFR) is a protein tyrosine kinase which plays a crucial role in signal transduction pathways that regulate key cellular functions such as survival and proliferation. Epidermal growth factor receptor cell quantification and EGFR ligand affinity are depicted in Table 2and Figure 4 for the different tested conditions. www.nature.com /bjc/journal/v92/n6/full/6602428a.html   (3696 words)

SciMedWeb® - EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) The expression of EGFR by these tumors is frequently associated with high tumour grade, elevated growth fraction, an inverse relationship with oestrogen receptor, poor response to endocrine therapy, and reduced survival. (1999) Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Kondo I. and Shimizu N. (1983) Mapping of the human gene for epidermal growth factor receptor (EGFR) on the p13-q22 region of chromosome7. www.geocities.com /m.lacroix/marqueurs/egfr.htm   (1559 words)

Epidermal growth factor - Presentation # 107 - Effects of ulvan and oligoulvans on epidermal Epidermal Growth Factor or EGF is a 6045 Da protein with 53. Immunohistochemical evaluation of human epidermal growth factor receptor 2 and estrogen and progesterone receptors in breast carcinoma in Jordan Several growth factors are involved in the control of colon carcinoma cell proliferation. factor.allinfosites.com /q/factor-epidermal-growth-factor.htm   (646 words)

Human protein: Q6QBS2 - Epidermal growth factor (Fragment). EMBL Bioinformatic Harvester Epidermal growth factor has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. egf stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. harvester.embl.de /harvester/Q6QB/Q6QBS2.htm   (499 words)

Epidermal growth factor (from human endocrine system) --  Encyclopædia Britannica   (Site not responding. Last check: 2007-10-09) Epidermal growth factor (EGF), a peptide containing 53 amino acids, has been found to be identical to urogastrone, a peptide isolated from the urine of pregnant women, which blocks the secretion of gastric juices. More results on "Epidermal growth factor (from human endocrine system)" when you join. It stimulates growth of bone and essentially all tissues of the body by stimulating protein synthesis and breaking down fat to provide energy. www.britannica.com /eb/article-45619?tocId=45619   (723 words)

Milk-Borne Epidermal Growth Factor Modulates Intestinal Transforming Growth Factor-{alpha} Levels in Neonatal Rats -- ...   (Site not responding. Last check: 2007-10-09) factors responsible for the acceleration of growth are unknown. Weaver LT, Gonnella PA, Walker WA 1990 Uptake and transport of epidermal growth factor by the small intestine epithelium of the fetal rat. Kong W, Koldovsky O, Rao RK 1992 Appearance of exogenous epidermal growth factor in liver, bile, and intestinal lumen of suckling rats. www.pedresearch.org /cgi/content/full/47/2/194   (4552 words)

Human Epidermal Growth Factor Enhances Healing of Diabetic Foot Ulcers -- Tsang et al. 26 (6): 1856 -- Diabetes Care   (Site not responding. Last check: 2007-10-09) the presence of growth factor inhibitors, or proteases, in the Nanney LB: Epidermal and dermal effects of epidermal growth factor during wound repair. Lev-Ran A, Hwang DL: Epidermal growth factor and platelet derived growth factor in blood in diabetes mellitus. care.diabetesjournals.org /cgi/content/full/26/6/1856   (3064 words)

Increased Epidermal Growth Factor Levels in Human Milk of Mothers with Extremely Premature Infants -- DVORAK et al. 54 ...   (Site not responding. Last check: 2007-10-09) EGF concentrations in human milk from mothers of infants born EPT (23–27 wk gestational age, n = 16), PT (32–36 wk gestational age, n = 16), and FT (38–42 wk gestational age, n = 15) during the first month of lactation. Carpenter G 1980 Epidermal growth factor is a major growth-promoting agent in human milk. Helmrath MA, Shin CE, Fox JW, Erwin CR, Warner BW 1998 Epidermal growth factor in saliva and serum of infants with necrotising enterocolitis. www.pedresearch.org /cgi/content/full/54/1/15   (2854 words)

Novel therapeutic strategies targeting the epidermal growth factor receptor (EGFR) family and its downstream effectors ... Expression of epidermal growth factor receptors associated with lack of response to endocrine therapy in recurrent breast cancer. Epidermal growth factor receptor expression in breast cancer: association with response to endocrine therapy. Targeting the epidermal growth factor receptor pathway improves the anti-tumor effect of tamoxifen and delays acquired resistance in a xenograft model of breast cancer. annonc.oxfordjournals.org /cgi/content/full/14/9/1346   (9095 words)

Pharmacodynamic Studies of the Epidermal Growth Factor Receptor Inhibitor ZD1839 in Skin From Cancer Patients: ... PURPOSE: The epidermal growth factor receptor (EGFR) tyrosine Hansen LA, Woodson RL II, Holbus S, et al: The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors. Mendelsohn J: Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy. www.jco.org /cgi/content/full/20/1/110   (6570 words)

Epidermal Growth Factor [EGF] , recombinant human : GF001 Epidermal Growth Factor (EGF) is a polypeptide growth factor which stimulates the proliferation of a wide range of epidermal and epithelial cells. For most in vitro applications, EGF exerts its biological activity in the concentration range of 0.5 to 25.0 ng/mL. Reconstituted EGF should be maintained at -20°C in undiluted aliquots for up to 6 months. www.chemicon.com /Product/ProductDatasheet.asp?ProductItem=GF001   (236 words)

Epidermal Growth Factor (EFG)   (Site not responding. Last check: 2007-10-09) Epidermal Growth Factor is a healing agent which is derived from recombinant DNA/RNA. EGF is most effective when used in combination with a Glycolic Acid. As the Glycolic speeds up the rate of skin cell turnover, the EGF works to ensure the new cells are healthy and younger looking. www.hsionline.com /products/jsweave/item7872.htm   (84 words)

The Mitogenic Potential of Heparin-Binding Epidermal Growth Factor in the Human Endometrium Is Mediated by the ... The Mitogenic Potential of Heparin-Binding Epidermal Growth Factor in the Human Endometrium Is Mediated by the Epidermal Growth Factor Receptor and Is Modulated by Tumor Necrosis Factor-{alpha} -- Chobotova et al. Kennedy TG, Brown KD, Vaughan TJ 1994 Expression of the genes for the epidermal growth factor receptor and its ligands in porcine oviduct and endometrium. Zhang Z, Funk C, Glasser SR, Mulholland J 1994 Progesterone regulation of heparin-binding epidermal growth factor-like growth factor gene expression during sensitization and decidualization in the rat uterus: effects of the antiprogestin, ZK 98.299. jcem.endojournals.org /cgi/content/full/87/12/5769   (5789 words)

Epidermal growth factor -- Facts, Info, and Encyclopedia article   (Site not responding. Last check: 2007-10-09) Epidermal growth factor -- Facts, Info, and Encyclopedia article It plays an important role in the regulation of (Click link for more info and facts about cell growth) cell growth and (A rapid increase in number (especially a rapid increase in the number of deadly weapons)) proliferation. The (Click link for more info and facts about tyrosine kinase) tyrosine kinase activity of the receptor in turn initiates a (Click link for more info and facts about signal transduction) signal transduction cascade which ultimately leads to (Click link for more info and facts about DNA synthesis) DNA synthesis and cell proliferation. www.absoluteastronomy.com /encyclopedia/E/Ep/Epidermal_growth_factor.htm   (223 words)

Epidermal Growth Factor   (Site not responding. Last check: 2007-10-09) Epidermal growth factor (EGF) is a small mitogenic protein that is thought to be involved in mechanisms such as normal cell growth, oncogenesis, and wound healing. EGF is a small 53 amino acid residue long protein that contains three disulfide briges. Sequence-Specific 1H NMR Assignments and Identification of Slowly Exchanging Amide Protons in Murine Epidermal Growth Factor. www-nmr.cabm.rutgers.edu /photogallery/structures/html/page3.html   (244 words)

NEJM -- Enhancement of wound healing by topical treatment with epidermal growth factor Experimental studies in animals have demonstrated that the topical application of epidermal growth factor accelerates the rate of epidermal regeneration of partial-thickness wounds and second-degree burns. The donor sites treated with silver sulfadiazine containing epidermal growth factor had an accelerated rate of epidermal regeneration in all 12 patients as compared with that in the paired donor sites treated with silver sulfadiazine alone. Treatment with epidermal growth factor significantly decreased the average length of time to 25 percent and 50 percent healing by approximately one day and that to 75 percent and 100 percent healing by approximately 1.5 days (P less than 0.02). content.nejm.org /cgi/content/short/321/2/76   (831 words)

NEJM -- Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung ... Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib Amplification and Mutation of the Epidermal Growth Factor Receptor in Metastatic Lung Cancer With Remission From Gefitinib. Epidermal growth factor receptor activating mutations in Spanish gefitinib-treated non-small-cell lung cancer patients. content.nejm.org /cgi/content/abstract/NEJMoa040938   (6486 words)

Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a ... Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent manner -- Ware et al. Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent manner Epidermal Growth Factor Receptor Activation of Calpain Is Required for Fibroblast Motility and Occurs via an ERK/MAP Kinase Signaling Pathway jcs.biologists.org /cgi/content/abstract/111/16/2423   (1073 words)

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