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	: Epigenesis :
		Epigenesis Pharmaceuticals is a privately held biopharmaceutical company developing inhaled respiratory medicines for the treatment of asthma and chronic obstructive pulmonary disease (COPD).
		Epigenesis is creating a series of medicines for the treatment of respiratory diseases through small molecule discovery methods.
		Epigenesis is continuing its product development efforts by observing a broader asthma population in a Phase II clinical study using its new proprietary inhaled dry powder formulation.
	www.epigene.com /about/overview.html (1081 words)

	Pangenesis, preformation, and epigenesis attempt to explain the development of plants and animals (Site not responding. Last check: 2007-10-21)
		Epigenesis, on the other hand, suggests that organs originate from similar, indistinguishable blobs or bubbles.
		The theory of epigenesis was initially proposed by William Harvey, but he did not have sufficient evidence to prove the theory.
		Wolff’s theory of "germ layer" epigenesis was confirmed by Karl Ernst von Baer in 1817.
	www.cise.ufl.edu /~jtwright/epigenesis.htm (277 words)

	Epigenesis/Preformation (Site not responding. Last check: 2007-10-21)
		Epigenesis means to grow upon, as is opposed to preformation.
		Adherents of the theory of epigenesis recognized that the organism was not yet formed in the fertilized egg, but that it arose as a consequence of profound changes in shape and form during the course of embryogenesis.
		Epigenesis is thus the condition of any claim to absoluteness and is the very discourse that brings the distinction between natural and artificial relations into play in the first place.
	www.christianhubert.com /hypertext/Epigenesis_Preformation.html (2171 words)

	Self-Generation: Biology, Philosophy, and Literature Around 1800 - Helmut Müller-Sievers
		The genealogy and function of epigenesis—the theory that organisms generate themselves under the guidance of a formative drive—provides a unique means of understanding the profound changes in philosophy, philosophy of language, and literature at the turn of the nineteenth century.
		The book begins by describing how and why epigenesis came to replace the reigning model of biological origination, preformation—the theory that all organisms were preformed at the creation of the world.
		Contemporary with these developments, Kant used the figures of epigenesis and self-formation to illustrate his concepts of the origin of the categories, the possible success of practical reason, and the validity of aesthetic and teleological judgments.
	www.sup.org /cgi-bin/search/book_desc.cgi?book_id=2779 (316 words)

	CHIESI FARMACEUTICI SpA
		EpiGenesis has pioneered a new form of antisense oligonucleotides known as Respirable Antisense Oligonucleotides (RASONs™), designed for direct application to the lung via aerosol inhalation.
		EpiGenesis has demonstrated the utility of EPI-2010 in attenuating the expression of the adenosine A1 receptor and the adenosine-mediated bronchoconstrictive and inflammatory responses using several animal models, including the primate.
		EpiGenesis has a strong patent position in this area with five issued or allowed U.S. patents and 8 applications in the U.S. and abroad.
	www.chiesigroup.com /news/news_detail_eng.asp?id=25 (477 words)

	About Gender - Epigenesis
		Epigenesis held that "morphological complexity develops gradually during embryology from simple beginnings in an essentially formless egg".
		Once DNA was discovered, the meanings changed slightly, for the organism could be said to be preformed by the set of instructions held within the genetic code, while, in a more secular age, epigenesis was held to be the effect of the environment in shaping the way those instructions were read.
		Examples of this are the inactivation of one X chromosome by methylation in females, and a newly discovered phenomenon by which one of a pair of otherwise identical genes may be imprinted such that it is activated or inhibited by one of the parents.
	www.gender.org.uk /about/03gene/38aepgen.htm (794 words)

	BioSpace News for
		EpiGenesis gains access to state-of-the-art antisense chemistry and a patent portfolio that will dramatically reduce the time required to further develop its proprietary RASONs (respirable antisense oligonucleotides) to treat a wide range of respiratory diseases.
		EpiGenesis Pharmaceuticals Inc., today announced a development and licensing agreement with Taisho Pharmaceuticals Co. Ltd., of Tokyo, for access to the company's respiratory discovery and development platform, including EPI-2010, for asthma.
		EpiGenesis Pharmaceuticals Inc., today announced that it has begun a randomized, double-blind, first-in-man, Phase I study to assess tolerability and pharmacokinetics of inhaled EPI-2010 for asthma.
	www.biospace.com /news_company.cfm?CompanyID=3255 (869 words)

	Evolutionary Developmental Biology
		Well, it has to be preformation or epigenesis; either all those structures are there already, and unfold like the homunculus, or they gradually and progressively appear.
		The first to make a sensible comment on epigenesis was Aristotle, who observed developing chick eggs and saw he progressive appearance of new features, and how they were similar to developing fish and mammals.
		Epigenesis had the major snag of structures arising from non existing structures - a good theory, but one as yet without a mechanism behind it.
	www.leeds.ac.uk /chb/lectures/edb10.html (2744 words)

	CATHOLIC ENCYCLOPEDIA: Life
		The opposite doctrine of "epigenesis", viz., that the development of the embryo is real successive production of visible manifoldness, real construction of new parts, goes back to Aristotle.
		It was upheld by Harvey, Stahl, Buffon, and Blumenbach.
		Moreover, in addition to the difficulty of epigenesis, the inadequacy of mechanistic theories to account for the regeneration of damaged parts of the embryo is becoming more clearly recognized every day.
	www.newadvent.org /cathen/09238c.htm (5505 words)

	Wolff: bibliographical excerpts - human evolution
		He proved satisfactorily that the evolution of every organism consists of a series of new formations, and that no trace of the form of the developed organism exists either in the egg or in the semen of the male.
		In these days we can scarcely continue to call this Theory of Epigenesis a theory, for we have been thoroughly convinced of its correctness in fact, and we are able to demonstrate it in any moment under the microscope.
		He was the son of a tailor, and studied natural science and medicine at first in Berlin, at the Medico-surgical College, under the celebrated anatomist Meckel, and subsequently in Balle.
	www.serpentfd.org /b/wolff.html (518 words)

	EpiGenesis Announces Positive Data in Trial of EPI-2010 In Patients with Asthma - MedicalNewsService.com
		EpiGenesis Pharmaceuticals, Inc., today announced positive results of a clinical trial of the potential efficacy of EPI-2010 in patients with asthma, conducted at Hammersmith Medicines Research, London, UK.
		EpiGenesis plans to sublicense EPI-2010 to a multi-national pharmaceutical company for marketing, sales and distribution throughout the world, excluding Asia.
		EpiGenesis Pharmaceuticals, Inc. is a privately held drug discovery and development company advancing both RASON-based and small molecule-based medicines for asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis.
	www.medicalnewsservice.com /ARCHIVE/MNS686.cfm (545 words)

	[No title]
		EPIGENESIS: the theory of gradual development of organs in the embryo.
		Wolff, the son of a Berlin tailor, was born in 1733, and went through his scientific and medical studies, first at Berlin under the famous anatomist Meckel, and afterwards at Halle.
		It is not surprising that the whole of the physiologists of the second half of the eighteenth century submitted to the ruling of this physiological pontiff, and attacked the theory of epigenesis as a dangerous innovation.
	www.knowledgerush.com /pg/etext04/vlmn110.txt (18232 words)

	Consciousness and Evolution by J. Mark Baldwin, (Site not responding. Last check: 2007-10-21)
		The peculiarity of the Epigenesis column is that it includes certain positions regarding consciousness while the Preformist column has nothing to say about consciousness.
		And we must in any case give the child this much; for the principle of Dynamogenesis is a fundamental law in all organisms, and the tendency to take in external 'copies' by imitation, etc., is present in all social animals, as a matter of fact.
		May not the rise of the social life be justified from the point of view of a second utility in addition to that of its utility in the struggle for existence as ordinarily understood; the second utility, i.e., of giving to each generation the attainments of the past which natural inheritance is inadequate to transmit?
	members.aol.com /jorolat/baldwinref3.html (3032 words)

	EpiGenesis Pharmaceuticals, Inc. - Company Profile - Pharmaceutical Business Review
		EpiGenesis creates its medicines by researching disease targets and identifying the synergistic relationships that exist between these targets.
		EpiGenesis has three such partnerships with: Taisho Pharmaceutical, a regional Japanese pharmaceutical company, Chiesi Farmaceutici, a regional European pharmaceutical firm, to develop and market the company's main compound, EPI-2010 and with Hybridon, to develop and market up to five antisense for respiratory diseases.
		EpiGenesis relies on trade secrets, patents, trademarks, service marks and copyright protection as well as licensing to develop and maintain its competitive technological position.
	www.pharmaceutical-business-review.com /companyprofile.asp?guid=07B34A64-CF2B-4CCC-9657-C7A04056249A (271 words)

	EpiGenesis Pharmaceuticals, Inc.
		EpiGenesis Pharmaceuticals, Inc. is privately held and located in Cranbury, NJ.
		EpiGenesis uniquely combines gene identification and validation technology based upon antisense oligonucleotides with advanced proprietary animal models of human disease to identify new therapeutics with the potential to revolutionize the treatment of respiratory disease.
		EpiGenesis has a library of Multi-target Respirable Antisense Oligonucleotides whose individual members are each capable to inhibiting multiple disease mediators.
	www.biospace.com /company_profile.cfm?CompanyID=3255 (348 words)

	Benjamin Dickins reviews Cycles of Contingency: Developmental Systems and Evolution. Edited by Susan Oyama, Paul E. ... (Site not responding. Last check: 2007-10-21)
		In epigenesis, the developing organism begins in an undifferentiated state and gradually changes to a more complex state through multiple interactions (after Waddington, 1940).
		For example, the imaginal disc gives rise to an insect limb or wing largely by growth and unfolding of a pre-patterned epithelial layer, but, during early development the disc is created by means of multiple, complex interactions.
		In DST, epigenesis is broadened and contrasted with the view that genes control development.
	www.human-nature.com /ep/reviews/ep01108115.html (3017 words)

	Preformation versus epigenesis (from biology) -- Encyclopædia Britannica (Site not responding. Last check: 2007-10-21)
		Preformation versus epigenesis (from biology) -- Encyclopædia Britannica
		A question posed by Aristotle was whether the embryo is preformed and therefore only enlarges during development or whether it differentiates from an amorphous beginning.
		More results on "Preformation versus epigenesis (from biology)" when you join.
	www.britannica.com /eb/article?tocId=48864 (928 words)

	NIH Guide: GENE-ENVIRONMENT EFFECTS AND EPIGENESIS IN DEPRESSION
		Novel approaches to gene discovery, the identification of epigenetic mechanisms, elucidation of environmental risk factors, characterization of the genetic aspects of response to environmental change, and the use of biomarkers and other intermediate phenotypes correlated with the clinical disorder are encouraged.
		Most of the studies on the role of epigenesis in human disease have focused on monogenic disorders, particularly those involving imprinted genes.
		A very exciting area of human molecular genetics is to extend this work and develop tools, technologies and methodologies by which epigenetic mechanisms may be identified and characterized for common human diseases caused by multiple genes in interaction with each other and the environment.
	grants.nih.gov /grants/guide/rfa-files/RFA-MH-05-006.html (4631 words)

	Publisher description for Library of Congress control number 96031973 (Site not responding. Last check: 2007-10-21)
		The genealogy and function of epigenesis - the theory that organisms generate themselves under the guidance of a formative drive - provides a unique means of understanding the profound changes in philosophy, philosophy of language, and literature at the turn of the nineteenth century.
		The book begins by describing how and why epigenesis came to replace the reigning model of biological origination, preformation - the theory that all organisms were preformed at the creation of the world.
		The development of self-generating philosophy - also known as Idealism - was accompanied by a revaluation of the origin of language, notably by Herder and by Humboldt, who attempted to formulate self-generation as the philosophical foundation for a future Science of Language.
	www.loc.gov /catdir/description/cam028/96031973.html (214 words)

	Filename: RC1025.TXT Source: +quot;Max Heindel's Letters to Students+quot; [PAGE 860] LETT
		By this mental attitude of ignoring Epigenesis they are retarding their soul growth to a greater extent than they are aware of.
		In fact some- thing is happening to them similar to that which befalls the materialist during his post-mortem existence at the time when he lives on the Borderland between Purgatory and the First Heaven in a monotony most dreadful to con- template.
		The materialist is there because of his denial of post-mortem existence, which has put him out of touch with the spiritual currents that generate motion and action during that existence.
	www.skepticfiles.org /cp002/rc1025.htm (5913 words)

	Welcome to Genta Incorporated (Site not responding. Last check: 2007-10-21)
		James C. Mannion, President and Chief Operating Officer at EpiGenesis commented: "This agreement enables EpiGenesis to both accelerate and broaden our discovery and development activities focused on creating blockbuster products for common respiratory diseases.
		EpiGenesis is a drug discovery and development company focused on the rapid transformation of genomic data into novel medicines for the treatment of common but poorly addressed respiratory diseases, including asthma, chronic obstructive pulmonary disease and allergic rhinitis.
		EpiGenesis unique blend of core competencies are based on RASON technology-used in target validation as well as for RASON and small molecule therapeutics to treat respiratory disease; and improved disease models that provide a more effective method for developing and evaluating respiratory therapeutics.
	www.genta.com /Genta/InvestorRelation/2001/press_20010725.html (389 words)

	Family Process: The epigenesis of the family system as a context for individual development (Site not responding. Last check: 2007-10-21)
		Family Process: The epigenesis of the family system as a context for individual development
		The epigenesis of the family system as a context for individual development
		However, it should be clear that epigenesis is an overarching concept that can and should be used to promote the understanding of many different kinds of developmental histories.
	www.findarticles.com /p/articles/mi_m0AZV/is_3_41/ai_93444777 (1154 words)

	Pigliucci Lab-book club (Site not responding. Last check: 2007-10-21)
		But he also points out that evo-devo is in the grave danger of simply redefining epigenesis and development as a list of what genes are being turned on or off and when.
		This is surely too simplistic a view of what development is, and yet if one reads the evo-devo literature one cannot escape the feeling that Robert is correct in his assessment of the current state of the field.
		Both, says the modern consensus: the organs themselves appear during epigenesis from simpler structures; what is preformed is the genetic program that makes such epigenesis possible.
	life.bio.sunysb.edu /ee/pigliuccilab/bookclub/Robert.html (1431 words)

	CEDNC: News: EntreNews: February 18, 1998
		The goal is to provide a significant local next-generation networked infrastructure that will give area universities and their industry partners a competitive advantage in research, higher education and business development.
		EpiGenesis plans to use the financing to advance the development of its lead compound, Epi 2010, and its technology platform for the asthmatic drug.
		EpiGenesis focuses on selective manipulation of gene expression to provide novel treatments for asthma and drug-resistant cancer.
	www.cednc.org /news/regional_news/1998/2_18.html (975 words)

	From Epigenesis to Epigenetics: The Genome in Context Volume 981 Annals of the New York Academy of Sciences
		From Epigenesis to Epigenetics: The Genome in Context Volume 981 Annals of the New York Academy of Sciences
		This volume has the triple aim of (1) highlighting the current status of epigenetics in biology, (2) explicating its resonance with historical viewpoints, and (3) articulating the main epistemological and ontological differences between a (classical) genetic and an epigenetic perspective.
		Moreover, they critically reflect upon the possible relations between genetics and epigenetics, thereby analyzing old and new metaphors used in (epi)genetic discourse, putting to the test standard views and commonly used definitions, and extrapolating their arguments into the domains of evolution and development.
	www.nyas.org /annals/detail.asp?strvolume=981 (358 words)

	A brief introduction to Epigenesis.
		Coursework and Essays: Uncategorised: A brief introduction to Epigenesis
		Below is a short sample of the essay "A brief introduction to Epigenesis.".
		If you sign up you could be reading the rest of this essay in under two minutes.
	www.coursework.info /i/46150.html (339 words)

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