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Topic: Epigenetic inheritance


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In the News (Thu 8 Jan 09)

  
  Station Information - Epigenetic inheritance
Epigenetic inheritance is the transmission of information from a cell or multicellular organism to its descendants without that information being encoded in the nucleotide sequence of the genes.
Epigenetic inheritance occurs in the development of multicellular organisms: dividing fibroblasts for instance give rise to new fibroblasts even though their genome is identical to that of all other cells.
Epigenetic Inheritance Systems (EISs) allow cells of different phenotype but identical genotype to transmit their phenotype to their offspring, even when the phenotype-inducing stimuli are absent, as is often the case.
www.stationinformation.com /encyclopedia/e/ep/epigenetic_inheritance.html   (794 words)

  
 Encyclopedia: Epigenetic inheritance
Epigenetic inheritance occurs in the development of multicellular organisms: dividing fibroblasts for instance give rise to new fibroblasts (rather than some other cell type) even though their genome is identical to that of all other cells.
Epigenetic inheritance occurs in the development of multicellular organisms: dividing (A cell from which connective tissue develops) fibroblasts for instance give rise to new (A cell from which connective tissue develops) fibroblasts even though their genome is identical to that of all other cells.
Some forms of epigenetic inheritance may be maintained even through the production of germ cells (((genetics) cell division that produces reproductive cells in sexually reproducing organisms; the nucleus divides into four nuclei each containing half the chromosome number (leading to gametes in animals and spores in plants)) meiosis).
www.nationmaster.com /encyclopedia/Epigenetic-inheritance   (685 words)

  
 Biological inheritance - Wikipedia, the free encyclopedia
Biological inheritance is the process by which an offspring cell or organism acquires or becomes predisposed to characteristics of its parent cell or organism.
Epigenetic inheritance results from, among other things, DNA modifications such as gene silencing.
The study of biological inheritance is called genetics, which includes also epigenetics.
en.wikipedia.org /wiki/Genetic_inheritance   (130 words)

  
 Talk:Epigenetic inheritance - Wikipedia, the free encyclopedia
We need to distinguish between epigenetics inheritance through mitosis and inheritance through meiosis (to distinguish between developmental phenomena and genetic phenomena).
Lamarckian inheritance acts as if mutations are created intelligently, for a purpose, and then passed on.
Lamarckian inheritance is the inheritance of acquired characters.
www.wikipedia.org /wiki/Talk:Epigenetic_inheritance   (533 words)

  
 [No title]   (Site not responding. Last check: 2007-10-22)
Once you accept that epigenetic inheritance occurs, it's far easier to envisage how drugs, hormones and starvation could have created the bizarre transgenerational effects in rodents and perhaps even in humans, says Reik: the chemicals and the diet may have triggered the heritable methylation of certain genes.
In her book with Marion Lamb, Epigenetic Inheritance and Evolution, The Lamarckian Dimension, she points out that the idea that the effect of the environment on one generation's epigenetic instruction manual can be passed to the next is old hat to students of simpler organisms like bacteria, yeast, plants, and even fruit flies.
Although epigenetic changes may be as random as mutations in the DNA sequence, they could also be adaptive, triggered by environmental changes to enable simple organisms to respond quickly to a fluctuating environment.
www.anth.org /ifgene/vines.htm   (3078 words)

  
 Lamarck   (Site not responding. Last check: 2007-10-22)
Inheritance of acquired characteristics is optimistic, soothing and sensitive.
Epigenetic inheritance systems, in which the phenotype (observed appearance of an organism) that expresses cell information is modified by environmental stress, have been noticed as modified phenotypes appearing in subsequent generations.
Epigenetic changes, which are alterations in gene expression, can be passed from mother cells to daughter cells.
www.alternativeinsight.com /Lamarck.html   (2885 words)

  
 Non-Mendelian inheritance - Wikipedia, the free encyclopedia
In genetics, non-Mendelian inheritance is the passing on of a trait in a form other than through chromosomal inheritance.
This is especially used to talk about inheritance patterns.
Forms of non-mendelian inheritance include the inheritance of Mitochondrial diseases and mutations and chloroplast mutations.
www.wikipedia.org /wiki/Non-Mendelian_inheritance   (87 words)

  
 Epigenetic inheritance in the mouse.   (Site not responding. Last check: 2007-10-22)
Epigenetic inheritance in the mouse.This is the first demonstration of epigenetic inheritance of specific alterations of gene expression through the germline.
These observations establish a mammalian model for transgenerational effects that are important for humal health, and also raise the question of the evolutionary importance of epigenetic inheritance.
Acquired epigenetic modifications, such as DNA methylation or stable chromatin structures, are not normally thought to be inherited through the germline to future generations in mammals [1] [2].
www.pdg.cnb.uam.es /UniPub/iHOP/gp/1000751.html   (180 words)

  
 Renato Paro´s Lab   (Site not responding. Last check: 2007-10-22)
Cavalli, G. and Paro, R. Epigenetic inheritance of active chromatin after removal of the main transactivator.
Epigenetic regulation in Drosophila: unravelling the conspiracy of silence.
Maurange, C. and Paro, R. A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila imaginal disc development.
www.zmbh.uni-heidelberg.de /Paro/Publications.shtml   (625 words)

  
 Concepts in Developmental Evolution ECOL 596e -- Alex Badyaev's Lab
Inheritance of a pre-activated paternal X chromosome in early mouse embryos.
Bergbusch, V. Evidence for cytoplasmic inheritance of a developmental organizer affecting growth habit and leaf shape in Antirrhinum majus.
Cultural inheritance as a mechanism for population sex-ratio bias in reptiles.
www.u.arizona.edu /~abadyaev/ECOL596e-papers.html   (1603 words)

  
 PCNA connects DNA replication to epigenetic inheritance in yeast.   (Site not responding. Last check: 2007-10-22)
PCNA connects DNA replication to epigenetic inheritance in yeast.
PCNA connects DNA replication to epigenetic inheritance in yeast.Once formed, such epigenetically determined structures are inherited for many mitotic divisions.
Thus, PCNA participates in inheritance of both DNA and epigenetic chromatin structures during the S phase of the cell cycle, the latter by at least two mechanisms.
www.pdg.cnb.uam.es /UniPub/iHOP/gp/8606801.html   (184 words)

  
 IngentaConnect Epigenetic inheritance of fetal genes in allergic asthma   (Site not responding. Last check: 2007-10-22)
IngentaConnect Epigenetic inheritance of fetal genes in allergic asthma
Epigenetic inheritance of fetal genes in allergic asthma
In utero programming leads to gene expression, the persistence of which may be associated with epigenetic inheritance phenomena induced by nonspecific environmental factors.
www.ingentaconnect.com /content/mksg/all/2004/00000059/00000002/art00003   (232 words)

  
 inheritance
Inheritance is the practice of passing on property, titles, debts, and obligations upon the death of an individual.
Many also have inheritance taxes, whereby a portion of any estate goes to the government.
With partible inheritance large estates are slowly divided among many descendants and great wealth is eventualyl diluted.
www.fact-library.com /inheritance.html   (259 words)

  
 12/06/00   (Site not responding. Last check: 2007-10-22)
Our ongoing research is aimed at characterizing the role of DNA methylation in controlling chromatin structure and epigenetic gene expression in maize.
The first area is the genetic analysis of the role of chromatin genes in controlling epigenetic gene expression in maize.
Epigenetic inheritance is a mitotically or meiotically stable alteration in gene expression that does not involve alteration of the primary sequence.
www.biotech.unl.edu /oldroot/12_06_00.htm   (259 words)

  
 Lamarckism - Biocrawler   (Site not responding. Last check: 2007-10-22)
Inheritance of acquired traits – Individuals inherit the traits of their ancestors.
In essence, a change in the environment brings about change in "needs" (besoins), resulting in change in behavior, bringing change in organ usage and development, bringing change in form over time—and thus the gradual transmutation of the species.
The mechanisms of inheritance were not elucidated until later in the 19th Century, after Lamarck's death.
www.biocrawler.com /biowiki/Lamarckian   (356 words)

  
 A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc ...
inheritance of En expression in the cells of the posterior compartment
Cavalli, G. and Paro, R. The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis.
Epigenetic inheritance of active chromatin after removal of the main transactivator.
www.genesdev.org /cgi/content/full/16/20/2672   (7386 words)

  
 IngentaConnect Epigenetic Inheritance, Genetic Assimilation and Speciation   (Site not responding. Last check: 2007-10-22)
Epigenetic inheritance systems enable the environmentally induced phenotypes to be transmitted between generations.
Next we show that the divergence of heritable epigenetic marks acts to reduce or to eliminate the genetic barrier between two adaptive peaks.
Therefore, an epigenetic inheritance system can increase the probability of transition from one adaptive state to another.
www.ingentaconnect.com /content/ap/jt/1999/00000200/00000001/art00974   (314 words)

  
 Epigenetic Silencing And Epigenetic Cause Of Cancer
Epigenetic silencing, the heritable repression of transcription within chromatin domains, is a highly conserved phenomenon from yeast to human.
Inappropriate gain of heterochromatin structure such as inactivation of tumor suppressor genes by DNA hyper-methylation at their promoter regions is linked directly to carcinogenesis.
We are interested in determining how heterochromatin is formed, how it is inherited and how these processes go awry in cancer cells.
mayoresearch.mayo.edu /mayo/research/zhang_lab   (215 words)

  
 Presentation No. 23 - Epigenetic control of gene expression   (Site not responding. Last check: 2007-10-22)
Recent evidence, from our work and that of others in mice, suggests that these epigenetic modifications, which in the past were thought to be cleared and reset on passage through the germline, may sometimes be inherited to the next generation.
This is termed epigenetic inheritance, and while this process has been well recognised in plants, the recent findings in mice force us to consider the implications of this type of inheritance in mammals.
At this stage we do not know how extensive this phenomenon is in humans but it may well turn out to be the explanation for some diseases which appear to be sporadic or show only weak genetic linkage.
hgm2002.hgu.mrc.ac.uk /Abstracts/Publish/Symposia/Symposium06/hgms0023.htm   (245 words)

  
 Characterization of novel protein complexes involved in transcriptional repression and epigenetic inheritance of ...
Critical cellular processes such as gene transcription, DNA replication, recombination and repair are regulated epigenetically at the level of chromatin via post-synthetic modifications of DNA and core histones.
The work in my laboratory is focused on understanding how epigenetic gene silencing mediated by DNA methylation and methyl-CpG binding proteins operates mechanistically and how it contributes to the establishment of a specific transcriptional programme in different types of cells.
The aims of this project are to purify biochemically and characterize functionally the full set of components of MBD1 protein complex in human cells; the student will also examine MBD1 binding specificity towards methylated and unmethylated DNA by SELEX (systematic evolution of ligands by exponential enrichment).
www.wcb.ed.ac.uk /Web%20pages%2003/PhD_Stancheva.htm   (336 words)

  
 Cutting Edge: Stable Epigenetic Inheritance of Regional IFN-{gamma} Promoter Demethylation in CD44highCD8+ T ...
Wigler, M. The inheritance of methylation patterns in vertebrates.
Epigenetic regulation of gene expression: the effect of altered chromatin structure from yeast to mammals.
subunit of chorionic gonadotropin are inherited with variable fidelity in clonal lineages of human fibroblasts.
www.jimmunol.org /cgi/content/full/162/9/5053   (2604 words)

  
 Results: Transposon inheritance   (Site not responding. Last check: 2007-10-22)
Using a genetic approach, we have investigated the role of these modifications in the epigenetic regulation and inheritance of six Arabidopsis transposons.
In crosses to wildtype plants, epigenetic inheritance of active transposons varied from mutant to mutant, indicating these genes differ in their ability to silence transposons.
According to their pattern of transposon regulation, the mutants can be divided into two groups, which suggests that there are distinct, but interacting, complexes or pathways involved in transposon silencing.
polyploid.agronomy.wisc.edu /results/res-14.html   (238 words)

  
 Histone Deacetylase Homologs Regulate Epigenetic Inheritance of Transcriptional Silencing and Chromosome Segregation in ...
Histone Deacetylase Homologs Regulate Epigenetic Inheritance of Transcriptional Silencing and Chromosome Segregation in Fission Yeast -- Grewal et al.
Histone Deacetylase Homologs Regulate Epigenetic Inheritance of Transcriptional Silencing and Chromosome Segregation in Fission Yeast
in the chromosomally inherited imprint at the mat locus (
www.genetics.org /cgi/content/full/150/2/563   (6486 words)

  
 Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator/   (Site not responding. Last check: 2007-10-22)
A Fab-7 element is switched from a silenced to a mitotically heritable active state by an embryonic pulse of transcription.
Here, histone H4 hyperacetylation was found to be associated with Fab-7 after activation, suggesting that H4 hyperacetylation may be a heritable epigenetic tag of the activated element.
This feature may allow epigenetic maintenance of active states of developmental genes after decay of their embryonic regulators.
www.euchromatin.org /Cavalli01.htm   (178 words)

  
 Epigenetic Variation and Human Disease -- Issa 132 (8): 2388 -- Journal of Nutrition   (Site not responding. Last check: 2007-10-22)
known mechanism of epigenetic inheritance in postmeiotic cells.
Epigenetic silencing is a recently uncovered process that refers
Holliday, R. (1987) The inheritance of epigenetic defects.
www.nutrition.org /cgi/content/full/132/8/2388S   (4502 words)

  
 Evolution in Four Dimensions : Genetic, Epigenetic, Behavioral, and Symbolic Variation in the History of Life (Life and ...
Subtitling their 1995 book "The Lamarckian Dimension" was about as in-your-face a flaunt on orthodoxy imaginable, and I was surprised that the book turned out to be quite a credible review of our understanding of epigenetic inheritance.
Their new book is on the same topic, but is much more considerate of the reader, mature, and self-assured than the author's previous foray.
Genetic (DNA), epigenetic (non-DNA chemical), behavioral (learning/assimilating), and symbolic (language, theory) information transmission are important in many levels of biological organization, from the structure of the cell to the social organization of masses of ants and humans.
www.cdswap.ws /Content/findonamazonus-Asin-0262101076.html   (830 words)

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