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Topic: Epoetin

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	Epoetin Alfa and Darbepoetin Alfa
		Epoetin alfa or darbepoetin alfa for the treatment of anemia associated with chronic renal failure in symptomatic individuals not receiving dialysis is considered medically necessary if the medical appropriateness criteria are met.
		Epoetin alfa or darbepoetin alfa for the treatment of anemia associated with non-myeloid malignancies where anemia is due to the effect of concomitantly administered chemotherapy is considered medically necessary.
		Epoetin alfa for the treatment of anemia associated with hepatitis C virus infection is considered medically appropriate if the individual is being treated with a combination of ribavirin and interferon alfa or ribavirin and peginterferon alfa.
	www.bcbst.com /MPManual/Epoetin_Alfa_and_Darbepoetin_Alfa.htm (1426 words)

	Epoetin alfa – Procrit, Epogen - Chemotherapy Drugs - Chemo
		Epoetin alfa is not indicated for patients with myeloid cancers (cancers that originate in the bone marrow such as acute myelogenous leukemia).
		Epoetin alfa is not appropriate for the treatment of anemia from other causes such as iron or folate deficiency or gastrointestinal bleeding.
		Epoetin alfa is identical to a substance your body produces naturally called erythropoietin (e-rith-ro-poy-e-tin), a protein normally produced by the kidneys which helps make red blood cells.
	www.chemocare.com /bio/epoetin_alfa.asp (908 words)

	LCD : Epoetin Alfa (Epogen, EPO, Erythropoietin) (L1938)
		Epoetin is a covered service for the treatment of anemia when other treatable causes have been identified and treated and when the continued anemia is presumed to be caused by ESRD (on dialysis) OR by CRF (pre-dialysis with a creatinine clearance of 45 ml/min or less).
		Epoetin is indicated in the treatment of anemia for patients with non-myeloid malignancies both when the anemia is due to the effect of concomitantly administered chemotherapy and when the anemia is secondary to the malignancy itself.
		Epoetin is not covered for the treatment of low laboratory values but only for significant symptomatic anemia associated with a marked reduction in activities of daily living; the presence of significant clinical symptoms is considered at least as important as those abnormal laboratory values.
	www.riverbendgba.com /vlmrp/1938.html (6017 words)

	epoetin alfa - [Medication]
		Epoetin alfa is used to treat anemia (a lack of red blood cells in the body).
		Epoetin alfa is in the FDA pregnancy category C. This means that it is not known if it will be harmful to an unborn baby.
		Epoetin alfa has been reported to cause seizures in patients on dialysis, although this is uncommon.
	www.peacehealth.org /kbase/multum/d00223a1.htm (1198 words)

	MedlinePlus Drug Information: Epoetin (Systemic) (Site not responding. Last check: 2007-10-13)
		Epoetin may also be used to prevent or treat anemia caused by other conditions, such as AIDS, cancer, or surgery, as determined by your doctor.
		Epoetin is usually given by a health care professional after a dialysis treatment.
		Epoetin is injected into a vein or under the skin.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202214.html (1814 words)

	Uses of Epoetin for Anemia in Oncology
		Epoetin replicates the biologic activity of the endogenous hormone and increases the number of red blood cells and thus the blood concentration of hemoglobin when given to persons with functioning erythropoiesis.
		There is evidence that epoetin produces hematologic responses and probably reduces transfusions in patients with nonmyeloid hematologic malignancies to a similar degree as in patients with tumors of solid organs or tissues.
		The evidence concerning the use of epoetin after high-dose chemotherapy and allogeneic stem-cell transplantation is derived from 7 controlled studies (total enrollment: 493) of patients that are representative of those undergoing bone marrow-derived allogeneic stem-cell transplantation in clinical practice.
	www.ncbi.nlm.nih.gov /books/bv.fcgi?rid=hstat1.chapter.43994 (6653 words)

	Consumer Reports Medical Guide - Epoetin Alfa Injection (Site not responding. Last check: 2007-10-13)
		Epoetin alfa is also used to treat anemia caused by certain medications, including some types of chemotherapy (medications to treat cancer) and zidovudine (Retrovir, in Trizivir, in Combivir), a medication used to treat human immunodeficiency virus (HIV).
		Epoetin alfa is also used before and after certain types of surgery to prevent and treat anemia that may develop because of blood loss during the surgery.
		When epoetin alfa is used to prevent and treat anemia due to surgery, it is sometimes injected once daily for 10 days before surgery, on the day of surgery and for 4 days after surgery, and it is sometimes injected once weekly, beginning 3 weeks before surgery.
	www.consumerreports.org /mg/drug-reports/epoetin-alfa-injection.htm (2652 words)

	Uses of Epoetin for Anemia in Oncology: Structured Abstract
		The evidence is not adequate to determine whether outcomes are superior when epoetin treatment is initiated at higher hemoglobin thresholds.
		To achieve the most efficient use of epoetin, more systematic evidence is needed on patient characteristics that predict responsiveness and on early indicators of response.
		Hematologic response rates appear to be lower for patients with myelodysplastic syndrome; higher doses of epoetin may be necessary to achieve response.
	www.ahrq.gov /clinic/tp/epoettp.htm (706 words)

	epoetin alfa (Epogen, Procrit) - drug class, medical uses, medication side effects, and drug interactions by ...
		Epoetin alfa belongs to a class of drugs called colony-stimulating factors because of their ability to stimulate cells in the bone marrow to multiply and form colonies of identical cells.
		Epoetin alfa may be used to replace transfusions of red blood cells in patients who are anemic and undergoing surgery.
		Among patients with cancer receiving chemotherapy, the most common side effects of epoetin alfa are fever, diarrhea, tissue swelling, shortness of breath, paresthesia (abnormal sensations like burning or prickling that may occur anywhere in the body), and upper respiratory infection.
	www.medicinenet.com /epoetin_alfa/article.htm (742 words)

	K/DOQI Update 2000
		When Epoetin is given SC to adult patients, the dose should be 80 to 120 units/kg/wk (typically 6,000 units/wk) in two to three doses per week.
		Careful monitoring of the response to Epoetin therapy and individual titration of the dose will be necessary after conversion of hemodialysis patients from IV to SC administration of Epoetin to achieve and maintain the target Hgb/Hct.
		Continuation of Epoetin at a dose at least equal to that which the patient was receiving prior to development of an acute illness or surgery may allow for more prompt resumption of erythropoiesis once the intercurrent illness has resolved.
	www.kidney.org /professionals/kdoqi/guidelines_updates/doqiupan_iv.html (2942 words)

	Epoetin (Site not responding. Last check: 2007-10-13)
		Epoetin is most often given as a shot under your skin or in your muscles.
		Epoetin is the man-made form of something that is produced naturally by your body, erythropoietin.
		Epoetin is used to bring your blood cell count up as soon as possible.
	www.webmd.com /hw/kidney_failure/tv7471.asp (265 words)

	Uses of Epoetin for Anemia in Oncology: Summary of Evidence Report/Technology Assessment, No. 30
		Epoetin (with red blood cell transfusion used as necessary) was compared to red blood cell transfusion alone.
		Epoetin increases hematologic responses or Hb levels for patients with either multiple myeloma or NHL, irrespective of history of prior transfusion.
		It is particularly noteworthy that two studies which used the same epoetin protocol for both allogeneic and autologous stem-cell transplant patients reported several outcomes significantly improved for allogeneic stem-cell transplant patients, but not for autologous stem-cell transplant patients.
	www.ahrq.gov /clinic/epcsums/epoetsum.htm (5692 words)

	Epoetin Alfa
		Epoetin alfa helps your body make red blood cells more quickly after chemotherapy and reduces the number of blood transfusions you need.
		Epoetin alfa is injected under the skin or into the veins.
		Some people may need to take iron tablets, to build up the iron in their body while they are taking epoetin alfa.
	www.hci.utah.edu /patientdocs/hci/drugs/epoetin_alfa.htm (605 words)

	The Evolving Role of Epoetin Alfa in Cancer Therapy -- Henry 9 (1): 97 -- The Oncologist
		Epoetin alfa treatment results in clinically significant improvements in quality of life in anemic cancer patients when referenced to the general population.
		Clinical evaluation of once-weekly dosing of epoetin alfa in chemotherapy patients: improvements in hemoglobin and quality of life are similar to three-times-weekly dosing.
		Epoetin alfa therapy increases hemoglobin levels and improves quality of life in patients with cancer-related anemia who are not receiving chemotherapy and patients with anemia who are receiving chemotherapy.
	theoncologist.alphamedpress.org /cgi/content/full/9/1/97 (5299 words)

	Epoetin (Systemic)
		Epoetin has not been reported to cause birth defects or other problems in humans.
		It is not known whether epoetin passes into the breast milk.
		Be sure to follow your doctor's orders carefully, because epoetin will not work properly if there is not enough iron in your body.
	allnutritionals.com /drugs/e/epoetin-systemic.shtml (1703 words)

	K/DOQI Update 2000
		Therefore, an inadequate response to Epoetin therapy is defined as failure to achieve target Hgb/Hct in the presence of adequate iron stores at a dose of 450 units/kg/wk IV or 300 units/kg/wk SC within 4 to 6 months, or failure to maintain target Hgb/Hct subsequently at that dose.
		When the cause of Epoetin resistance is untreatable, either progressively increase the Epoetin dose in an attempt to reach or maintain the target Hgb/Hct, transfuse with red blood cells (see Guideline 23: Red Blood Cell Transfusions in Dialysis Patients with Chronic Renal Failure) or accept an Hgb/Hct below the target level.
		Despite this potential concern, Epoetin is not contraindicated in the treatment of the anemia of patients with myeloma kidney disease.
	www.kidney.org /professionals/kdoqi/guidelines_updates/doqiupan_v.html (1869 words)

	Clinical Trial: Epoetin Dosing Regimens in Haemodialysis
		Secondary Outcomes: the percentage of patients maintaining target Hb without any increase in epoetin dose during the assessment period;; the difference between the average Hb levels during the assessment period versus the baseline phase;; the difference between the average weekly epoetin beta dose during the assessment period versus the baseline phase.
		The survival half-life of erythrocytes produced after exogenous epoetin administration is longer than that of erythrocytes produced in the absence of exogenous stimulation.
		The study is designed to detect a difference in Hb between the study groups of at least 0.5 g/dL (5 g/L), with a probability of 95% and a power of 0.9021, assuming a standard deviation of Hb in the HD population of 1.0 g/dL (10 g/L).
	clinicaltrials.gov /show/NCT00349960 (1562 words)

	epoetin alfa Consumer Drug Information
		Generic Name: epoetin alfa (ee po EE tin AL fa)
		Some women using epoetin alfa have started having menstrual periods, even after not having a period for a long time due to a medical condition.
		Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
	www.drugs.com /MTM/epoetin_alfa.html (1262 words)

	Procrit Online, Description, Chemistry, Ingredients - Epoetin Alfa - RxList Monographs (Site not responding. Last check: 2007-10-13)
		Erythropoietin is a glycoprotein which stimulates red blood cell production.It is produced in the kidney and stimulates the division and differentiation of committed erythroid progenitors in the bone marrow.PROCRIT
		It has a molecular weight of 30,400 daltons and is produced by mammalian cells into which the human erythropoietin gene has been introduced.The product contains the identical amino acid sequence of isolated natural erythropoietin.
		Each 1 mL of solution contains 10,000 Units of Epoetin alfa, 2.5 mg Albumin (Human), 1.3 mg sodium citrate, 8.2 mg sodium chloride, 0.11 mg citric acid, and 1% benzyl alcohol as preservative in Water for Injection, USP (pH 6.1
	www.rxlist.com /cgi/generic/epoetin.htm (360 words)

	MedlinePlus Drug Information: Epoetin Alfa Injection
		If you are using epoetin alfa at home, you will need to use disposable syringes to inject your medication.
		If you are injecting epoetin alfa subcutaneously, you can inject it just under the skin anywhere on your upper arms, thighs, or stomach.
		If you are being treated with hemodialysis and your doctor has told you to inject epoetin alfa into your hemodialysis tubing, follow the steps above to prepare your dose from a vial of epoetin alfa, and use the following steps to inject your dose intravenously:
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a692034.html (2524 words)

	Welcome to PROCRIT (Epoetin alfa)
		In a study where patients were treated with another Epoetin alfa product to a target Hb range of 12 to 14 g/dL, there was an increased incidence of mortality attributed to disease progression seen in the Epoetin alfa treatment group compared to placebo.
		In clinical trials, the overall incidence of thrombotic/vascular events was similar in Epoetin alfa- and placebo-treated patients with hemoglobin (Hb) >10 to ≤13 g/dL.
		In patients with a Hb of >13 g/dL treated with 300 Units/kg of Epoetin alfa, the possibility that PROCRIT treatment may be associated with an increased risk of postoperative thrombotic/vascular events cannot be excluded.
	www.procrit.com (1850 words)

	epoetin alfa Glossary of Terms with Definitions on MedicineNet.com
		epoetin alfa Glossary of Terms with Definitions on MedicineNet.com
		The following are health and medical definitions of terms that appear in the epoetin alfa, Epogen, Procrit article.
		Deviating from the usual structure, position, condition, or behavior.
	www.medicinenet.com /epoetin_alfa/glossary.htm (2604 words)

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