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s000414a - Prinzmetal Angina - Ergonovine Provocation Test Ergonovine echocardiography was: performed in 52 patients with insignificant disease, and coronary vasospasm was documented in 33 (63%, 33 of 52). Ergonovine echocardiography was performed in 80 consecutive patients with chest pain syndrome after: confirmation of negative treadmill or normal stress myocardial perfusion scan results using thallium-201. The results of the ergonovine test were well correlated with: the spontaneous activity of the disease in 94%, 83%, 76%, and 71% of the patients at initial observation and at 3, 6 and 12: months, respectively. www.emory.edu /WHSCL/grady/amreport/litsrch99/s000414a.html   (4232 words)

MedlinePlus Drug Information: Ergonovine/Methylergonovine (Systemic)   (Site not responding. Last check: 2007-11-05) Ergonovine and methylergonovine belong to the group of medicines known as ergot alkaloids. Ergonovine and methylergonovine may also be used for other conditions as determined by your doctor. There is no specific information comparing use of ergonovine or methylergonovine in the elderly with use in other age groups. www.nlm.nih.gov /medlineplus/druginfo/uspdi/202613.html   (1260 words)

Ergonovine - Wikipedia, the free encyclopedia Ergonovine, also known as ergometrine, d- lysergic acid beta-propanolamide, is one of primary ergot alkaloids and an alkaloid of many species of morning glory, too. Due to its oxytocic properties, it has a medical use in obstetrics. According to TIHKAL by A. Shulgin, ergonovine has LSD -like action at levels of 2-10 milligrams. en.wikipedia.org /wiki/Ergonovine   (96 words)

CHEST: Bronchial hyperresponsiveness to acetylcholine in patients with vasospastic angina pectoris   (Site not responding. Last check: 2007-11-05) Ergonovine maleate (Ergometrine maleate, Fuji, Japan) dissolved in 5 ml of warmed 0.9 percent saline solution was then injected into the coronary artery in incremental doses of 10, 20, and 40 [micro]g to evoke the anginal attack, as judged by the leads in which ST segment elevation on the ECG occurred. The responsive threshold of ergonovine maleate (RT-Ergo) which induces spasm is used as a parameter of contractibility of coronary arteries. The coronary arterial diameters were measured before and after ergonovine at the site that showed the greatest changes after ergonovine; alterations in coronary arterial diameter after the injection of ergonovine were calculated as the percentage of change from control. www.findarticles.com /p/articles/mi_m0984/is_n2_v105/ai_14971548   (1438 words)

Stanislav Grof interviewing Dr. Albert Hofmann at the Esalen Institute in Big Sur, California, 1984 The presence of this alkaloid in ergot is the reason why it has been used in obstetrics to stop uterine bleeding and as an oxytocic to stimulate the muscular activity of the uterus. First came the modifications of ergonovine and one of these modifications, methergine, a homologue of ergonovine, is today the leading medicament in obstetrics to stop post partum bleeding. Ergonovine had been used already for many decades in obstetrics without any reports that it had been psychedelic. www.maps.org /news-letters/v11n2/grofhofmann.html   (9713 words)

Long lasting spasticity in controlled vasospastic angina -- Ueda et al. 81 (5): 528 -- Heart Angiograms were obtained after administration of 20 µg of intracoronary ergonovine (A2, B2, and C2), or after administration of 5 mg of intracoronary isosorbide dinitrate (A1, B1, C1, and D1). Angiograms were obtained after administration of 20 µg of intracoronary ergonovine (A2, C2, and D2), or after administration of 5 mg of intracoronary isosorbide dinitrate (A1, B1, C1, and D1). Ergonovine testing to detect spontaneous remissions of variant angina during long-term treatment with calcium antagonist drugs. heart.bmjjournals.com /cgi/content/full/81/5/528   (2300 words)

Chest : Ventricular fibrillation in a patient with exercise-induced anaphylaxis, normal coronary arteries, and a ...   (Site not responding. Last check: 2007-11-05) Start / C / Chest / February 01, 1994 / Ventricular fibrillation in a patient with exercise-induced anaphylaxis, normal coronary arteries, and a positive ergonovine test. Exercise-induced anaphylaxis was diagnosed in a survivor of out-of-hospital cardiac arrest due to ventricular fibrillation after ECG signs of coronary spasm. Ergonovine provocation induced coronary spasm in this patient. static.highbeam.com /c/chest/february011994/ventricularfibrillationinapatientwithexerciseinduc/index.html   (267 words)

Once daily felodipine in preventing ergonovine-induced myocardial ischaemia in Prinzmetal's variant angina -- Chimienti ... The ergonovine test was performed once in basal conditions and twice 5 days after beginning the oral administration of felodipine 20 mg o.d., 4 and 24 h after the last administration. During a continuous 6-lead ECG recording, ergonovine was injected at doses of 25, 50, 100, 200, and 400 micrograms at 5 min intervals. The basal ergonovine test was positive in all 14 patients (seven with anterior and seven with inferior ST segment elevation > 0.1 mV) at a mean ergonovine dose of 162 +/- 138 micrograms. www.eurheartj.org /cgi/content/abstract/15/3/389   (247 words)

Has the Mystery of the Eleusinian Mysteries been solved? The results with the mentioned ingestion of ergonovine and methyl-ergonovine, respectively, were not exactly impressive and, in other words, not at all confirmative of the ergot of barley hypothesis considering they were purported to assess it. The researchers concluded that, although psychedelic effects of ergonovine were similar to those of a minimal dose of LSD, its somatic effects so much overshadowed the psychic ones that they had no wish to ingest it at psychedelic doses any more. As with ergonovine, a semi-narcotic state was experienced during it. www.druglibrary.org /schaffer/lsd/valencic.htm   (3872 words)

Hormones and Headaches Ergonovine: Ergonovine is generally a well tolerated ergotamine derivative. Ergonovine is occasionally effective for both cluster and migraine. The primary use for ergonovine in medicine is to increase the frequency, duration, and strength of uterine contractions, thus treating and preventing postabortal and postpartum uterine hemorrhage. www.headachedrugs.com /archives/excerpt_headache_menstral.html   (3900 words)

Ergonovine-echo test to assess the significance of chest pain at rest without ECG changes -- Morales et al. 16 (10): ... The aim of this study was to assess the feasibility and diagnostic role of ergonovine maleate infusion under continuous two-dimensional echocardiographic monitoring for the identification of vasospastic myocardial ischaemia in patients with chest pain at rest not associated with diagnostic ECG changes. In none of the patients with a negative test was documentation of myocardial ischaemia due to a primary reduction in coronary blood flow. Thus, in patients who do not show ECG changes during chest pain at rest, the ergonovine maleate-echo test is feasible and safe; it permits the recognition of ischaemic episodes on the basis of wall motion abnormalities when conventional 12-lead ECG-recorded chest pain is non-diagnostic. www.eurheartj.org /cgi/content/abstract/16/10/1361   (370 words)

Progression and Regression of Coronary Stenosis in the Long-term Follow-up of Vasospastic Angina -- Ozaki et al. 92 ...   (Site not responding. Last check: 2007-11-05) At follow-up, the vasospastic responsiveness to ergonovine was lost compared with the initial test in group 2 (response during the initial study, 1.00±0.39 mm; at follow-up, 0.32±0.38 mm, P <.001). During the initial angiogram, transient total occlusion (100% coronary spasm) was observed after administration of 0.2 mg IV ergonovine (A1) at the proximal segment of the LAD, and significant fixed stenosis was observed after administration of 5 mg IC isosorbide dinitrate (A2). At follow-up at the same site of the LAD, coronary spasm was not observed after administration of 0.4 mg ergonovine (B1), and the MLD had increased (regression) from 1.21 mm (59% stenosis) at the initial angiogram to 2.11 mm (23% stenosis) after the administration of 2.5 mg isosorbide dinitrate (B2) at follow-up. circ.ahajournals.org /cgi/content/full/92/9/2446   (6315 words)

Ergonovine Information and Resources Online at The Drug Database - Find Useful Articles and Websites on Ergonovine ... In many patients with chest pain of esophageal origin, findings are normal on routine esophageal manometry and dysmotility develops only upon provocation with ergonovine maleate.^Unfortunately, ergonovine may induce myocardial ischemia in... NO) and serotonergic receptors to the effects of ergonovine on large and small coronary arteries were investigated in... Quantitative coronary angiography and repeated ergonovine provocation tests were performed 45±16... www.thedrugdatabase.com /directory/E/Ergonovine   (379 words)

The Journal of Invasive Cardiology   (Site not responding. Last check: 2007-11-05) Coronary arteriography again revealed normal coronary arteries (Figure 1) and ergonovine maleate provocation at doses of 50, 100 and 200 µg in 3-minute intervals was subsequently performed. The coronary artery in which ergonovine was administered was chosen on the basis of the leads showing ST-segment elevation on the electrocardiogram during vasospastic angina attacks. Coronary artery spasm developed at the dose of 200 µg ergonovine in the proximal part of the left anterior descending coronary artery (Figure 2), which was relieved by intracoronary nitroglycerine. www.mmhc.com /JIC/displayArticle.cfm?articleID=article997   (1120 words)

Effect of ergonovine on prolactin secretion and milk let-down -- Canales et al. 48 (2): 228 -- Obstetrics & Gynecology   (Site not responding. Last check: 2007-11-05) The effect of ergonovine maleate on prolactin secretion and lactation was determined in 10 puerperal women. The serum prolactin concentration seen in the control group of nonlactating women (562.0 +/- 36.1 and 218.0 +/- 27.3 ng/ml) was significantly greater than (P less than 0.01) that seen in the treated group. In 2 additional patients it was also demonstrated that the simultaneous administration of ergonovine by oral and intravenous routes potentiates the suppressive effect on prolactin secretion. www.greenjournal.org /cgi/content/abstract/48/2/228   (195 words)

Toxin biosynthesis genes in ergopeptine-producing fungi The concentrations of the alkaloids ergine and ergonovine (the two most likely sinks for lysergic acid in a lysergyl peptide synthetase mutant) were measured in relevant grass-endophyte symbiota. Thus, although we cannot currently distinguish between ergine, ergonovine, or a combination of the two compounds, there was no significant increase in the accumulation of these polar lysergyl derivatives, collectively, in ergovaline-deficient, knockout-containing symbiota. Since the results indicate that, in the lysergyl peptide synthetase knockout strains, lysergic acid is not being shunted into ergine and ergonovine, it is likely that there is some type of feedback inhibition mechanism operating in the pathway. www.caf.wvu.edu /wvafes/projects2001/PSS_WVA00161.htm   (489 words)

British Journal of Pharmacology - Abstract of article: Influence of the endothelium, nitric oxide and serotonergic ... The respective contributions of coronary vascular endothelium, nitric oxide (NO) and serotonergic receptors to the effects of ergonovine on large and small coronary arteries were investigated in conscious dogs. Ketanserin decreased and methiothepin abolished the reduction in coronary resistance induced by ergonovine. Thus, the complex interactions between vascular endothelium and serotonergic receptors to ergonovine-induced constriction of large coronary arteries might explain the induction of coronary spasms in patients with endothelial dysfunction. www.nature.com /bjp/journal/v127/n4/abs/0702635a.html   (361 words)

Differential inhibition by ergonovine of norepinephrine release in the coronary artery and saphenous vein of the dog -- ... Differential inhibition by ergonovine of norepinephrine release in the coronary artery and saphenous vein of the dog -- O'Rourke and Vanhoutte 249 (1): 52 -- Journal of Pharmacology And Experimental Therapeutics Articles by O'Rourke, S. Articles by Vanhoutte, P. Differential inhibition by ergonovine of norepinephrine release in the coronary artery and saphenous vein of the dog Ergonovine (10(- 6) M) decreased the overflow of [3H] norepinephrine to a modest degree in the jpet.aspetjournals.org /cgi/content/abstract/249/1/52   (194 words)

[No title] Thus, complete remission of angina documented by both Holter recording and ergonovine testing occurred in 5 of 24 patients (21%) at 3 months, in 7 of 21 (33%) at 6 months and in 12 of 21 (57%) at 12 months. The object of this study was to try to evaluate the prognosis of coronary spasm on the results of provocative, ergometrine testing. The ischemia-provoking stresses were isometric handgrip (25% of maximum for 4 to 5 minutes) or ergonovine maleate (0.2 mg intravenously). www.webshells.com /medsrch/calcicor.txt   (1217 words)

JAMA -- Abstract: Predictability of the response to the ergonovine test. Value in the diagnosis of coronary spasm, ... Predictability of the response to the ergonovine test. Thirty-five patients with atypical chest pain were given ergonovine maleate ergonovine test was positive in 11 of 13 patients in group 1. jama.ama-assn.org /cgi/content/abstract/242/26/2858   (143 words)

Chest: Reversible cardiac arrest related to late-onset coronary spasm after a positive ergonovine test.@ HighBeam ...   (Site not responding. Last check: 2007-11-05) Chest: Reversible cardiac arrest related to late-onset coronary spasm after a positive ergonovine test.@ HighBeam Research Reversible cardiac arrest related to late-onset coronary spasm after a positive ergonovine test. The ergonovine provocative test is a useful tool in the evaluation of patients with chest pain and normal coronary arteries, due to its high sensitivity and specificity in the diagnosis of vasospastic angina. www.highbeam.com /library/doc0.asp?DOCID=1G1:13373828&refid=ip_encyclopedia_hf   (172 words)

Stanislav Grof interviews Dr. Albert Hofmann At that time, in the 1930s, a new ergot alkaloid had been discovered which is named ergometrine, or ergonovine. First came the modifications of ergonovine and one of these modifications, methergine, a homologue of ergonovine, is today the leading medicament in obstetrics to stop postpartum bleeding. Its main components were lysergic acid amide, lysergic acid hydroxyethylamide, and also lysergic acid propanolamide (ergonovine). www.maps.org /news-letters/v11n2/11222gro.html   (8574 words)

[No title]   (Site not responding. Last check: 2007-11-05) Ergonovine also produces a entheogenic effect (Bigwood et al., 1979). Even ergot alkaloids such as chanoclavine and ergonovine which do not produce psychoactive effects when administered in low doses (Hoffman, 1963) cannot be ruled out as not being psychoactive in humans in high doses, which is what happens with ergonovine at high doses (Bigwood et al., 1979). An ergot species, Claviceps strain 178 growing on Cynodon dactylon was found to contain ergonovine and penniclavine (Porter et al., 1974). www.tacethno.com /info/claviceps/ergotalkfungi.txt   (2428 words)

Ergonovine Side Effects - Ergonovine Maleate This registry is a place to share positive or negative side effects of using Ergonovine. If you directly experienced a side effect while using Ergonovine, then we encourage you to enter it here. Please note that entries here are the experiences of individual users, and in no way means that you or anyone else will experience the same side effect, since the same medication affects people in different ways. www.medications.co.uk /go/se/Ergonovine   (142 words)

Toxic principle, Ergot -- Vet Med Library, UIUC   (Site not responding. Last check: 2007-11-05) The toxic action of ergot is due to the numerous alkaloids (ergotamine, ergocristine, ergonovine, etc.) present in the sclerotia and other components--choline, ACH, histamine, sterols. The important naturally occurring alkaloids are ergotamine and ergonovine. LSD is also derived from ergot, and the smooth muscle contracting activity, although sometimes present, is not always seen. www.library.uiuc.edu /vex/toxic/ergot/ergot4.htm   (88 words)

Detection of Coronary Atherosclerosis in the Living Rabbit by the Ergonovine Stress Test -- Rinzler et al. 184 (3): 605 ... Detection of Coronary Atherosclerosis in the Living Rabbit by the Ergonovine Stress Test -- Rinzler et al. of the ergonovine stress test was indicated by a drug-induced ergonovine stress tests were uniformly negative and coronary ajplegacy.physiology.org /cgi/content/abstract/184/3/605   (243 words)

Experience with ergonovine provocative testing for coronary arterial spasm -- Magder et al. 79 (6): 638 -- Chest Experience with ergonovine provocative testing for coronary arterial spasm -- Magder et al. The effect of ergonovine on coronary arterial caliber was determined by administration of ergonovine with that from the control. www.chestjournal.org /cgi/content/abstract/79/6/638   (333 words)

Ergonovine/Methylergonovine (Systemic) This medicine passes into the breast milk and may cause unwanted effects, such as vomiting; decreased circulation in the hands, lower legs, and feet; diarrhea; weak pulse; unstable blood pressure; or convulsions (seizures) in infants of mothers taking large doses. Although there is no specific information comparing use of ergonovine or methylergonovine in children with use in other age groups, these medicines are not expected to cause different problems in children than they do in adults. The presence of other medical problems may affect the use of ergonovine or methylergonovine. allnutritionals.com /drugs/e/ergonovine-methylergonovine-systemic.shtml   (1144 words)

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