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Topic: Ergosterol

  ergosterol - Search Results - MSN Encarta
Ergosterol, substance that, under the action of the sun's ultraviolet rays on the skin, gives rise to the production of vitamin D. Vitamin D helps...
Ergosterol (ergosta-5,7,22-trien-3β-ol), a sterol, is the biological precursor to Vitamin D 2.
ergosterol: 2, a white crystalline organic solid of the molecular formula C28H44O belonging to the steroid family.
encarta.msn.com /ergosterol.html   (120 words)

  Ergosterol - Wikipedia, the free encyclopedia
Ergosterol (ergosta-5,7,22-trien-3β-ol), a sterol, is the biological precursor to Vitamin D
It is turned into viosterol by ultraviolet light, and is then converted into ergocalciferol, which is a form of Vitamin D. Ergosterol is a component of fungal cell walls, serving the same function that cholesterol serves in animal cells.
The presence of ergosterol in fungal cell walls coupled with its absence in animal cell membranes makes it a useful target for antifungal drugs.
en.wikipedia.org /wiki/Ergosterol   (110 words)

 Sobre el Agaricus blazei Murill - Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of ...   (Site not responding. Last check: 2007-10-19)
Intraperitoneal administration of ergosterol at doses of 5, 10 and 20 mg/kg for 5 consecutive d inhibited the neovascularization induced by Lewis lung carcinoma cell–packed chambers, suggesting that either ergosterol or its metabolites may be involved in the inhibition of tumor-induced neovascularization.
Ergosterol was administered intraperitoneally at doses of 10, 50, 100 or 200 mg/kg or orally at doses of 100, 200, 400 or 800 mg/kg for 20 consecutive d.
Ergosterol inhibited the Matrigel-induced neovascularization at concentrations of 400 and 800 mg/L. This finding indicates that ergosterol may directly inhibit Matrigel-induced neovascularization and that the antitumor activity of ergosterol may be due to direct inhibition of angiogenesis induced by solid tumors.
abm.objectis.net /investigaciones/articulos/20010512.   (3357 words)

 Definition of ergosterol - Merriam-Webster Online Dictionary
Learn more about "ergosterol" and related topics at Britannica.com
Find more about "ergosterol" instantly with Live Search
See a map of "ergosterol" in the Visual Thesaurus
www.m-w.com /cgi-bin/dictionary?book=Dictionary&va=ergosterol   (45 words)

 [No title]   (Site not responding. Last check: 2007-10-19)
Ergosterol was so named as it was first isolated from a fungus that also produced the 'ergot' alkaloids (though there is no relationship between the alkaloids and sterol beyond the name).
Ergosterol was also isolated from baker's yeast in 1926, and the amounts recovered were found to vary in quantity depending on cultivation conditions and methods.
Ergosterol is found mainly in the cellular membranes and plays a role in permeability regulation of the membranes.
www.hull.ac.uk /php/chsanb/Fungweb/Fungweb7.htm   (421 words)

 CRDReference: Pasanen, A. L., Yli-pietila, K., Pasanen, P., Kalliokoski, P. and Tarhanen, J. 1999 , Ergosterol content ...
This paper reports the ergosterol content for microbial cultures of six filamentous fungi, three yeast species, and one actinomycete and the ergosterol levels in 40 samples of building materials (wood chip, gypsum board, and glass wool) contaminated by microorganisms.
The average ergosterol content varied widely among the fungal species over the range of 2.6 to 42 g/ml of dry mass or 0.00011 to 17 pg/spore or cell.
A good agreement between the ergosterol concentration and viable fungal concentrations was detected in the wood chip (r > 0.66, P 0.009) and gypsum board samples (r > 0.48, P 0.059), whereas no relationship between these factors was observed in the glass wool samples.
alcor.concordia.ca /~raojw/crd/reference/reference002287.html   (705 words)

 CRDReference: Bjurman, J. 1994 , Ergosterol as an indicator of mould growth on wood in relation to culture age, ...
Changes in ergosterol content in cultures of Penicillium brevicompactum and Aspergillus versicolor on wood with time, changes in humidity or addition of glucose solutions to wood were studied with HPLC.
Ergosterol concentration in hyphae produced in surface liquid cultures was shown to be higher in mycelia growing on media enriched with nitrogen or with more available nutrients.
The concentration of ergosterol in the mycelia of P. brevicompactum in surface liquid cultures varied by a factor of 5 from 2 to 10 mg g-.
alcor.concordia.ca /~raojw/crd/reference/reference002283.html   (298 words)

 Ketoconazole - Wikipedia, the free encyclopedia
Ketoconazole is structurally similar to imidazole, and interferes with the fungal synthesis of ergosterol, the main constituent of cell membranes, as well as certain enzymes.
This enzyme is in the sterol biosynthesis pathway that leads from lanosterol to ergosterol.
Fluconazole and itraconazole have been found to have a greater affinity for fungal cell membrane than ketoconazole, and thus lower doses of these azoles are required to kill fungi.
en.wikipedia.org /wiki/Ketoconazole   (528 words)

 ergosterol --  Encyclopædia Britannica   (Site not responding. Last check: 2007-10-19)
Ergosterol is converted by ultraviolet irradiation into ergocalciferol, or vitamin D
Ergosterol is converted by ultraviolet irradiation into ergocalciferol, or vitamin D2, a nutritional factor that promotes proper bone development in humans and other mammals.
A drug of this type is the antifungal agent amphotericin B, which binds to a specific molecule (ergosterol) found in fungal cells.
www.britannica.com /eb/article-9032888   (357 words)

 Dynamic ergosterol- and ceramide-rich domains in the peroxisomal membrane serve as an organizing platform for ...
The inhibition of peroxisome fusion by ergosterol ligands
Ergosterol ligands, phosphoinositide-specific antibodies, and nonhydrolyzable GTP analogues are reversible inhibitors of peroxisome fusion.
ergosterol, the subsequent release of this AAA ATPase to the
www.jcb.org /cgi/content/full/168/5/761   (6753 words)

 [No title]
Ergosterol was not found in molasses, citrus pulp, carcass meal, meat-and-bone-meal, skim milk powder, whey powder, fish meal (2 of 3 samples), mineral components, vitamin mixtures and other additives.
With four mixed feeds it was demonstrated that the ergosterol content determined chemically in the mixture is in good accordance with the value calculated from the ergosterol content of the components and their percentage in the mixture.
The inhibition of growth was correlated with the accumulation of the substrate, 24-methylene-24,25-dihydrolanosterol (eburicol), and depletion of ergosterol.
www.webshells.com /medsrch/ergost.txt   (1144 words)

The content of ergosterol in the living bodies of fungi is rather constant, near 5 µg per mg dry mass (with some exceptions), and ergosterol is nearly absent in other organisms of decomposition systems.
Ergosterol is easily measured by liquid chromatography, and detected by its uniquely strong absorbance of ultraviolet light in the vicinity of 282 nm.
The size of the ergosterol peak on the right shows the rapidity with which ascomycetes begin the pervasion and decay of cordgrass shoots in the marsh.
www.arches.uga.edu /~newell/ergoster.htm   (206 words)

 Quantifying Mold Biomass on Gypsum Board: Comparison of Ergosterol and Beta-N-Acetylhexosaminidase as Mold Biomass ...
with the fungal index molecules ergosterol and the phospholipid
Ergosterol content was determined by a slightly modified version
Determination of ergosterol on mouldy building materials using isotope dilution and gas chromatography-tandem mass spectrometry.
aem.asm.org /cgi/content/full/69/7/3996   (1695 words)

 Ergosterol Content in Various Fungal Species and Biocontaminated Building Materials -- Pasanen et al. 65 (1): 138 -- ...
Ergosterol is the primary sterol in the cell membranes of filamentous fungi and is either absent or a minor component in most
In the literature, the ergosterol content in fungal cultures is usually expressed in relation to fungal dry mass.
Quantification of ergosterol and 3-hydroxy fatty acids in settled house dust by gas chromatography-mass spectrometry: comparison with fungal culture and determination of endotoxin by a Limulus amebocyte lysate assay.
aem.asm.org /cgi/content/full/65/1/138   (3294 words)

 Isolation of an Antitumor Compound from Agaricus blazei Murill and Its Mechanism of Action -- Takaku et al. 131 (5): ...   (Site not responding. Last check: 2007-10-19)
Ergosterol was administered intraperitoneally at doses of 10,
Ergosterol (50, 200 or 800 mg/kg) was administered orally
The indicated amounts of ergosterol were administered orally for 20 consecutive d, starting 12 h after the implantation of tumor cells.
www.nutrition.org /cgi/content/full/131/5/1409   (2730 words)

 Ergosterol is required for the Sec18/ATP-dependent priming step of homotypic vacuole fusion   (Site not responding. Last check: 2007-10-19)
The ergosterol ligands filipin, nystatin and amphotericin B block the in vitro fusion of vacuoles from wild-type cells.
The requirement of ergosterol for vacuole fusion might reflect a role in general membrane integrity or bilayer function, which would then extend throughout the complex membrane fusion pathway, or be specific to a defined subreaction.
Ergosterol is thus specifically needed for this priming reaction, which triggers the vacuole fusion cascade.
www.nature.com /cgi-taf/DynaPage.taf?file=/emboj/journal/v20/n15/full/7593901a.html   (4302 words)

 Biophysical Journal: Cholesterol and Ergosterol Influence Nystatin Surface Aggregation: Relation to Pore Formation
The selective toxicity of the polyene antibiotics between pathogenic eukaryotic organisms and animal cells would then be related to their stronger affinity toward ergosterol, present in the fungal membranes, relatively to cholesterol, found in the membranes of mammalian cells (Bolard, 1986).
Although the exact architecture of the channels formed by nystatin remains to be clarified, this study strongly supports the view that at least ergosterol is directly involved in their formation.
Ergosterol (>98%) and cholesterol (>99%) were purchased from Fluka (Buchs, Switzerland) and Merck (Whitehouse Station, NJ), respectively.
www.findarticles.com /p/articles/mi_qa3938/is_200411/ai_n9463101   (1214 words)

 A Specific Structural Requirement for Ergosterol in Long-chain Fatty Acid Synthesis Mutants Important for Maintaining ...
The yeast sterol, ergosterol, differs from the mammalian cholesterol by i) the presence of a methyl group at position 24, ii) an additional double bond at position 22, and iii) an additional double bond at position 7 of the B ring.
mutants in genes of the ergosterol biosynthetic pathway, i.e.,
that the absence of ergosterol in this strain is compensated by
www.molbiolcell.org /cgi/content/full/13/12/4414   (7310 words)

 Disruption of Ergosterol Biosynthesis Confers Resistance to Amphotericin B in Candida lusitaniae -- Young et al. 47 ...
Disruption of Ergosterol Biosynthesis Confers Resistance to Amphotericin B in Candida lusitaniae -- Young et al.
Ergosterol content was measured as previously described (3).
Ergosterol gene expression in amphotericin B-resistant clinical isolates of C.
aac.asm.org /cgi/content/full/47/9/2717   (4978 words)

 Organic Eprints - 184: Simplified methods for extraction and quantification of ergosterol from fungi in soil   (Site not responding. Last check: 2007-10-19)
Ergosterol is the principal membrane sterol of fungi, and it is used as a biomarker for fungal biomass.
TLC proved to be a versatile technique because ergosterol could be determined quantitatively by fluorodensitometry or semi-quantitatively by visual detection under UV light.
Recoveries of ergosterol on 100.8% (SD 3.7%) from spiked soil samples and 98.9% (SD 0.2%) from ergosterol standards, respectively, were obtained.
orgprints.org /184   (317 words)

 Role of Candida albicans Transcription Factor Upc2p in Drug Resistance and Sterol Metabolism -- Silver et al. 3 (6): ...
ergosterol biosynthetic pathway in response to ergosterol starvation
ergosterol in the plasma membrane, an ergosterol extraction
of the ERG2 and ERG3 genes in the ergosterol biosynthetic pathway
ec.asm.org /cgi/content/full/3/6/1391   (4483 words)

 Ergosterol by LC   (Site not responding. Last check: 2007-10-19)
This chromatogram show the analysis of a sterol called ergosterol using HPLC obtained by a graduate student at SREL who was interested in measuring ergosterol as a way of assessing fugal biomass in decomposing leaf litter.
Since the student was only interested in ergosterol the choice of HPLC with UV detector simplified her analysis.
She didn’t have to worry about separating ergosterol from other sterols because the detector would not respond to them them even if they were co-eluding.
www.uga.edu /~srel/AACES/GCtutorial/page29.html   (177 words)

 Yeast Genome-Wide Expression Analysis Identifies a Strong Ergosterol and Oxidative Stress Response during the Initial ...
Ergosterol biosynthesis induction during the initial stages of fermentation.
Ergosterol is an essential requirement for optimal metabolic activity.
Fostel (4) that perturbation of ergosterol biosynthesis heightened
aem.asm.org /cgi/content/full/69/8/4777   (4946 words)

 Photoregulation of ergosterol biosynthesis in Rhodotorula minuta   (Site not responding. Last check: 2007-10-19)
Ergosterol in plasma membrane of the yeast R.minuta is photochamically decomposed by near-UV radiation.
When the yeast cells were exposed to near-UV radiation at 0Ž, the ergosterol content of cells exponentially decreased with increasing dosage and the rate of decrease depended on the intensity of radiation.
Thus, it is predicted that the rate of reproduction of ergosterol under continuous illumination is equal to the rate of photochemical decomposition.
abstracts.aspb.org /pb1997/45/1000.shtml   (260 words)

 Current Indoor Allergen Levels of Fungi and Cats, But Not House Dust Mites, Influence Allergy and Asthma in Adults with ...
Ergosterol levels in floor dust were a risk factor both for being
The fungal membrane lipid ergosterol was used as an indicator of total fungal biomass (i.e., cumulative exposure to fungi)
An improved ergosterol assay to estimate fungal biomass in ectomycorrhizas.
ajrccm.atsjournals.org /cgi/content/full/164/1/65   (5502 words)

 Ergosterol biosynthesis in novel melanized fungi from hypersaline environments -- Méjanelle et al. 42 (3): 352 ...
Ergosterol biosynthesis in novel melanized fungi from hypersaline environments -- Méjanelle et al.
Ergosterol biosynthesis in novel melanized fungi from hypersaline environments
(lanosterol) to ergosterol in melanized fungi and in Saccharomyces
www.jlr.org /cgi/content/full/42/3/352   (2717 words)

 Genome-Wide Expression Patterns in Saccharomyces cerevisiae: Comparison of Drug Treatments and Genetic Alterations ...
Ergosterol is an essential component of yeast plasma membranes which affects membrane fluidity, permeability, and the activity
While ergosterol is found throughout the cell membranes, it is most abundant in the plasma membrane and secretory vesicles
It can be predicted that perturbations of ergosterol levels within the cell may affect the functioning of mitochondrial enzymes.
aac.asm.org /cgi/content/full/44/5/1255   (6251 words)

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