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Topic: Ergotamine

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	Ergotamines for cluster headaches - [Medication] - Quest Diagnostics Patient Health Library (Site not responding. Last check: 2007-10-19)
		Ergotamine narrows blood vessels in the head (vasoconstriction), which relieves pain by reducing pressure on pain-sensitive structures in the head and scalp, which may be associated with cluster headaches.
		Ergotamine may be combined with caffeine or other medications to help control nausea and vomiting, which are common side effects of the medication.
		Ergotamine may be used with other medications taken to control cluster headaches, such as methysergide, verapamil, or lithium.
	www.questdiagnostics.com /kbase/topic/detail/drug/hw185271/detail.htm (461 words)

	Ergoline - Wikipedia, the free encyclopedia
		Substances derived from ergoline are used clinically as oxytocics and in the treatment of migraine and Parkinson's disease, and are implicated in the disease ergotism and in the action of psychedelic drugs such as ololiuhqui and LSD.
		With the isolation of ergotamine in 1918 by A. Stoll came the first therapeutic use of isolated ergoline alkaloids.
		With the determination of the basic chemical structure of the ergot alkaloids in the early 1930s, an era of intensive exploration of synthetic derivatives began.
	en.wikipedia.org /wiki/Ergotamine (560 words)

	Drug Profiles: Motrin for Migraines (Site not responding. Last check: 2007-10-19)
		Ergotamine reduces extracranial blood flow, causes a decline in the amplitude of pulsation in the cranial arteries, and decreases hyperperfusion of the territory of the basilar artery.
		Ergotamine is metabolized by the liver by largely undefined pathways, and 90% of the metabolites are excreted in the bile.
		Overdosage with ergotamine causes nausea, vomiting, weakness of the legs, pain in limb muscles, numbness and tingling of the fingers and toes, precordial pain, tachycardia or bradycardia, hypertension or hypotension and localized edema and itching together with signs and symptoms of ischemia due to vasoconstriction of peripheral arteries and arterioles.
	www.migraines.org /treatment/proergtm.htm (1072 words)

	British Journal of Pharmacology - Contractile responses to sumatriptan and ergotamine in the rabbit saphenous vein: ... (Site not responding. Last check: 2007-10-19)
		Ergotamine was approximately 30 and 300 fold more potent than 5-HT and sumatriptan as a contractile agonist in the saphenous vein and produced a maximal response that was approximately 50% greater than that of sumatriptan.
		In the presence of both antagonists, the response to ergotamine was shifted monophasically, consistent with the contractile response to ergotamine resulting from activation of both alpha and 5-HT receptors in the rabbit saphenous vein (compare Figure 2, bottom panel and Figure 4).
		Although ergotamine and sumatriptan are efficacious in the treatment of migraine headache, the cardiovascular liabilities of these agents limit their more wide spread utility and acceptance (Yasue et al., 1981; Bax and Saxena, 1993; Chester et al., 1993; MacIntyre et al., 1993; Koh et al., 1994).
	www.nature.com /bjp/journal/v131/n3/full/0703587a.html (4038 words)

	ergotamine Side Effects, Interactions and Information - Drugs.com
		Ergotamine is also involved in altering blood flow patterns that are associated with vascular headaches.
		Ergotamine is used to prevent and to treat vascular headaches such as migraine and cluster headaches.
		Ergotamine is in the FDA pregnancy category X. This means that it is known to be very harmful if used during pregnancy.
	www.drugs.com /MTM/ergotamine.html (1413 words)

	Ergotamine - Caffeine (Ergotamine Tartrate and Caffeine) drug warnings and precautions - prescription drugs and ...
		(ergotamine tartrate and caffeine) is contraindicated in pregnancy due to the oxytocic effects of ergotamine.
		(ergotamine tartrate and caffeine) is contraindicated in labor and delivery due to its oxytocic effect which is maximal in the third trimester.
		Ergotamine is excreted in breast milk and may cause symptoms of vomiting, diarrhea, weak pulse and unstable blood pressure in nursing infants.
	www.rxlist.com /cgi/generic2/ergot_wcp.htm (802 words)

	Health Library - (Site not responding. Last check: 2007-10-19)
		Ergotamine is also involved in altering blood flow patterns that are associated with vascular headaches.
		Ergotamine is used to prevent and to treat vascular headaches such as migraine and cluster headaches.
		Ergotamine is in the FDA pregnancy category X. This means that it is known to be very harmful if used during pregnancy.
	yalenewhavenhealth.org /library/healthguide/en-us/drugguide/topic.asp?hwid=d00222a1 (1396 words)

	National Headache Foundation: Ergotamine Rebound
		Ergotamine used to be one of the drugs most frequently used to abort migraine.
		Excessive use of migraine medications containing ergotamine tartrate may result in circulatory problems or changes in the heart rate or blood pressure.
		Ergotamine is a particular danger to migraine sufferers using the drug daily or near daily.
	www.headaches.org /consumer/topicsheets/ergotaminerebound.html (219 words)

	MedlinePlus Drug Information: Ergotamine and Caffeine
		Do not take ergotamine and caffeine if you are taking antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); clarithromycin (Biaxin); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir); or troleandomycin (TAO).
		The combination of ergotamine and caffeine is used to prevent and treat migraine headaches.
		Ergotamine is in a class of medications called ergot alkaloids.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601048.html (920 words)

	caffeine and ergotamine - [Medication]
		Caffeine and ergotamine is used to prevent and to treat vascular headaches such as migraine and migraine-like headaches.
		Symptoms of a caffeine and ergotamine overdose include nausea, vomiting, numbness in the fingers or toes, confusion, drowsiness, convulsions, and possibly death.
		Caffeine and ergotamine is available with a prescription under several brand and generic names in tablet and rectal suppository formulations.
	www.peacehealth.org /kbase/multum/d04120a1.htm (1465 words)

	ARS \| Publication request: Anti-Inflammatory Effects of Acute Ergotamine Administration to Endotoxin Challenged Steers
		Results were quite different with an anti-inflammatory response suggesting that ergotamine tartrate may not mimic the effect of grazing toxic fescue or that an acute dose may be quite different than that resulting from chronic consumption in grazing cattle.
		Technical Abstract: The objective of this study was to investigate whether the ergot alkaloid, ergotamine (ET), an alkaloid used to model fescue toxicosis in cattle, modifies the response of cattle to endotoxin (LPS) challenge.
		Ergotamine by itself increased circulating cortisol, rectal temperature, plasma urea nitrogen and glucose, whereas it decreased serum prolactin.
	www.ars.usda.gov /research/publications/publications.htm?SEQ_NO_115=119701 (440 words)

	caffeine and ergotamine medical facts from Drugs.com
		Caffeine and ergotamine is used to prevent and to treat vascular headaches such as migraine and migraine-like headaches.
		Symptoms of a caffeine and ergotamine overdose include nausea, vomiting, numbness in the fingers or toes, confusion, drowsiness, convulsions, and possibly death.
		Caffeine and ergotamine is available with a prescription under several brand and generic names in tablet and rectal suppository formulations.
	www.drugs.com /mtm/caffeine_and_ergotamine.html (1586 words)

	MedWatch - Cafergot (ergotamine tartrate and caffeine) Dear Healthcare Professional letter
		Coadministration of ergotamine with potent CYP 3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, and troleandomycin) has been associated with acute ergot toxicity (ergotism) characterized by vasospasm and ischemia of the extremities, with some cases resulting in amputation.
		There have been rare reports of cerebral ischemia in patients on protease inhibitor therapy when Cafergot (ergotamine tartrate and caffeine) was coadministered, at least one resulting in death.
		Because of the increased risk for ergotism and other serious vasospastic adverse events, ergotamine use is contraindicated with these drugs and other potent inhibitors of CYP 3A4 (e.g., ketoconazole, itraconazole).
	www.fda.gov /medwatch/SAFETY/2002/cafergot.htm (425 words)

	Ergotamine - Patient UK
		Ergotamine is used to treat migraine headaches and some other types of throbbing headaches.
		Ergotamine eases the pain associated with migraine by narrowing these blood vessels.
		Ergotamine is available combined with caffeine or other ingredients, in tablet and suppository form.
	www.patient.co.uk /showdoc/30002124 (854 words)

	Healthopedia.com Drugs Information - Ergotamine, Belladonna Alkaloids, and Phenobarbital : Before Using (Bellergal-S, ...
		For ergotamine —Ergotamine is not recommended for use during pregnancy since it has been shown to increase the chance of early labor, which could result in a miscarriage.
		For ergotamine —Ergotamine passes into the breast milk and may cause unwanted effects, such as vomiting, diarrhea, weak pulse, unstable blood pressure, or convulsions (seizures), in nursing babies whose mothers take large amounts of the medicine.
		Although there is no specific information about the use of ergotamine in children, it is not expected to cause different side effects or problems in children than it does in adults.
	www.healthopedia.com /drugs/detailed/ergotamine-belladonna-alkaloids-and-phenobarbital/before-using.html (1044 words)

	Buy Avamigran, Cafergot (Ergotamine and Caffeine) Online Without Prescription Needed
		The combination of ergotamine and caffeine is used to prevent and treat migraine headaches.
		Ergotamine is in a class of medications called ergot alkaloids.
		The combination of ergotamine and caffeine comes as a tablet to take by mouth and as a suppository to insert rectally.
	www.1meds.com /Avamigran.html (856 words)

	Ergotamine in the acute treatment of migraine: A review and European consensus -- Tfelt-Hansen et al. 123 (1): 9 -- ...
		Oral absorption of ergotamine is 60–70%, and the concurrent
		the ergotamine abusers have to be hospitalized in the withdrawal
		The effect of ergotamine on tissue blood flow and the arteriovenous shunting of radioactive microspheres in the head.
	brain.oxfordjournals.org /cgi/content/full/123/1/9 (4560 words)

	Ergotamines for migraine headaches
		Ergotamines may be used to stop or treat symptoms of an emerging migraine.
		Ergotamines should not be taken with triptans (serotonin receptor agonists).
		If you are taking ergotamine, it is very important to follow your doctor's recommendations on when and how often to take it.
	www.webmd.com /hw/migraines/hw116570.asp (259 words)

	ARS \| Publication request: Anti-Inflammatory Effects of Ergotamine in Steers
		When we administered the drug ergotamine to cattle prior to giving a simulated infection, the ergotamine was successful in decreasing the severity of the inflammatory response.
		This data suggests that ergot drugs like ergotamine might be useful to prevent overt disease in cattle if administered prior to the exposure of the animal to the disease.
		Ergotamine by itself, increased circulating cortisol and RT, whereas it decreased prolactin levels.
	www.ars.usda.gov /research/publications/publications.htm?SEQ_NO_115=117533&pf=1 (381 words)

	BioMed Central \| Abstract \| Ergotamine and Dihydroergotamine: A Review (Site not responding. Last check: 2007-10-19)
		In randomized clinical trials, oral ergotamine was found to be superior to placebo, but inferior to 100 mg of oral sumatriptan.
		In contrast, rectal ergotamine was found to have higher efficacy (73% headache relief) than rectal sumatriptan (63% headache relief).
		Ergotamine is still widely used in some countries for the treatment of severe migraine attacks.
	www.biomedcentral.com /1531-3433/7/55/abstract (210 words)

	Acute tubulo-interstitial nephritis and renal infarction secondary to ergotamine therapy -- Janssen van Doorn et al. 15 ...
		Acute tubulo-interstitial nephritis and renal infarction secondary to ergotamine therapy -- Janssen van Doorn et al.
		Acute tubulo-interstitial nephritis and renal infarction secondary to ergotamine therapy
		ergotamine, since no lesions were seen at coronarography [9].
	ndt.oxfordjournals.org /cgi/content/full/15/11/1877 (1081 words)

	ERGOTAMINE WITH CAFFEINE - RECTAL (Cafergot, Migergot) side effects, medical uses, and drug interactions.
		WARNING: Infrequently, a very serious, life-threatening decrease in the amount of blood supply to the hands and feet (peripheral ischemia) and rarely to the brain can occur when this medication is taken with drugs that affect liver metabolism (e.g., potent CYP 3A4 enzyme inhibitors).
		USES: Ergotamine acts to reduce pulsing of migraine headaches.
		The combination is used to treat migraine and cluster headaches.
	www.medicinenet.com /ergotamine_with_caffeine-rectal/article.htm (496 words)

	Reduced Distensibility of the Common Carotid Artery in Patients Treated With Ergotamine -- Barenbrock et al. 28 (1): ... (Site not responding. Last check: 2007-10-19)
		Distensibility coefficient (DC) of the common carotid artery in the migraine group with ergotamine intake, migraine group with no ergotamine intake, and group of healthy control subjects (one-way ANOVA with Bonferroni test as posttest).
		Intima-media thickness of the common carotid artery in the migraine group with ergotamine intake (n=8) and corresponding control subjects (n=8).
		Clinical pharmacokinetics of ergotamine in migraine and cluster headache.
	hyper.ahajournals.org /cgi/content/full/28/1/115 (3446 words)

	Anti-Inflammatory Effects of Ergotamine in Steers -- Filipov et al. 225 (2): 136 -- Experimental Biology and Medicine
		Ergotamine tartrate (RBI, Natick, MA) was dissolved in a 20%
		Effect of ergotamine and ergonovine on plasma concentrations of thyroid hormones and cortisol in cattle.
		Effect of ergotamine and ergonovine on thermal regulation and cardiovascular function in cattle.
	www.ebmonline.org /cgi/content/full/225/2/136 (3558 words)

	Ergomar - Drugs & Vitamins - Drug Library - DrugDigest
		Ergotamine helps to treat certain kinds of migraine and cluster headaches.
		It is important to tell your prescriber or health care professional as soon as possible if you get any of the following side effects: cold, numb, or painful hands or feet; leg cramps when walking; any type of pain around your chest; swelling; itching.
		Ergotamine tablets decrease the circulation of blood to your skin, fingers, and toes.
	www.drugdigest.org /DD/DVH/Uses/0,3915,8215\|Ergomar,00.html (690 words)

	New Contraindications for Medications Containing Ergotamine and Dihydroergotamine
		Novartis is cautioning physicians and patients about the risk of stroke and/or gangrene when medications containing ergotamine or dihydroergotamine are taken at the same time as certain antibiotic, antiviral and antifungal drugs.
		This can lead to high levels of ergotamine in the body, which can cause serious decreases in blood flow to the brain or to the limbs (known as vasospasm or ischemia).
		In addition, products containing ergotamine or dihydroergotamine should not be taken every day, nor taken to prevent symptoms.
	www.docguide.com /dg.nsf/PrintPrint/AC414ECA6C895AE685256CD1006077B3 (654 words)

	Bellergamin, Belladonna Alkaloids, Ergotamine tartrate, Phenobarbital
		One coated tablet contains: 0.1 mg Belladonna Alkaloids; 0.3 mg Ergotamine tartrate; 20 mg Phenobarbital.
		Ergotamine toxicity is increased at the simultaneous administration with macrolide antibiotics and non-selective beta-blockers.
		Ergotamine exerts adrenolytic effect, weakly inhibits metabolism, exerts a manifested antiserotonine action, has a manifested uterotonic and vasospastic effect.
	www.sopharma.com /bellergamin.phtml (399 words)

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