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Topic: Ernest McCulloch

	Ernest McCulloch - Wikipedia, the free encyclopedia
		Ernest Armstrong McCulloch is a Canadian cellular biologist, best known for demonstrating – with James Till – the existence of stem cells.
		McCulloch was born in Toronto, Canada, and was educated at Upper Canada College.
		In 1974, McCulloch became a Fellow of the Royal Society of Canada.
	en.wikipedia.org /wiki/Ernest_McCulloch (494 words)

	James Till - Wikipedia, the free encyclopedia
		Subsequently, Till chose to work with Ernest McCulloch.
		Till and McCulloch dubbed the lumps 'spleen colonies', and speculated that each lump arose from a single marrow cell: perhaps a stem cell.
		In 2005, he and Ernest A. McCulloch were awarded the Albert Lasker Award for Basic Medical Research.
	en.wikipedia.org /wiki/James_Till (549 words)

	Encyclopedia :: encyclopedia : Ernest Hemingway (Site not responding. Last check: 2007-09-08)
		Hemingway was born at 8:00 A.M. on July 21, 1899 in Oak Park, Illinois, in a six-bedroom Victorian house built by his maternal grandfather, Ernest Hall, an English immigrant and Civil War veteran who lived with the family when Ernest was born.
		Hemingway's physician father, "Doctor Ed" Clarence Hemingway, attended to the birth of Ernest and subsequently blew a horn on his front porch, announcing to the Hemingways' neighbors that his wife had borne a baby boy.
		Ernest Hemingway, New York: Holt, Rinehart, and Winston.
	www.hallencyclopedia.com /Ernest_Hemingway (4535 words)

	The Gairdner Foundation
		The recent celebration of James Till and Ernest McCulloch's groundbreaking stem cell research in the early 1960s pays homage to two Canadian scientific giants, whose work went largely unnoticed by the general public until the pair were given a long overdue 2005 Lasker Award, North America's most coveted medical prize.
		McCulloch is quoted in one story as saying that the pair did not "seek celebrity." This is reminiscent (with apologies to Shakespeare) of that wonderfully humbling line in Twelfth Night and paraphrased here — some scientists are born great, some achieve greatness, and others have greatness thrust upon them.
		McCulloch and Till seem to have situated themselves squarely in the second category and for their accomplishments we Canadians are justifiably proud.
	www.gairdner.org /03_05_10_05_1.html (753 words)

	The Lasker Foundation \| This Year's Winners, Basic Medical Research
		McCulloch, E. and Till, J.E. (1960) The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation into irradiated mice.
		Till, J.E., McCulloch, E.A., and Siminovitch, L. (1964) A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells.
		McCulloch, E.A., Siminovitch, L., Till, J.E., Russell, E.S., and Bernstein, S.E. (1965) The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl/Sl d
	www.laskerfoundation.org /awards/library/2005b_key_mccullochtill.shtml (177 words)

	CTV.ca \| Canadian duo honoured for stem cell research
		But what Dr. Ernest McCulloch and James Till share is a passionate devotion to science - and their serendipitous pairing led to a discovery that laid the foundation for what may be the most promising and ethically controversial area of international medical research today.
		That discovery was recognizing the first stem cell, an entity that had been theorized about since the early 1900s, but never found until McCulloch and Till made the intellectual leap in the early 1960s while experimenting with bone marrow in laboratory mice.
		McCulloch wanted to investigate how injected bone marrow would affect lab mice that had undergone lethal doses of radiation.
	ctv.ca /servlet/ArticleNews/story/CTVNews/1127069856194_55?hub=SciTech (1204 words)

	Canada's top scientists honoured for their remarkable achievements in the field of cancer research - CIHR
		Tony Pawson, Jim Till and Tak Mak were honoured for their outstanding contribution to the field of cancer research during an honorary reception and dinner held by the Canadian Institutes of Health Research (CIHR) and the Ontario Cancer Research Network, October 17, 2005 at the Royal York Hotel.
		Jim Till, Ernest McCulloch and Tak Mak of the Ontario Cancer Institute, Princess Margaret Hospital, and Dr. Tony Pawson of the Samuel Lunenfeld Research Institute of Mount Sinai Hospital for their remarkable achievements in the field of cancer research.
		Ernest McCulloch and James Till (Ontario Cancer Institute, Princess Margaret Hospital, Toronto) are known for their pioneering work on haemapoietic cells.
	www.cihr-irsc.gc.ca /e/29393.html (650 words)

	Canadian Medical Hall of Fame: Laureates (Site not responding. Last check: 2007-09-08)
		Ernest McCulloch received his MD in 1948 from the University of Toronto.
		Together with his colleague, Dr. J.E. Till, Dr. McCulloch created the first quantitative, clonal method to identify stem cells and used this technique for pioneering studies on stem cells.
		In addition to his research career, Dr. McCulloch worked tirelessly on numerous provincial, national and international advisory committees and provided leadership for the research division at the Ontario Cancer Institute, the Institute of Medical Science at the University of Toronto and as President of the National Academy of Science of the Royal Society of Canada.
	www.cdnmedhall.org /laureates/?laur_id=61 (270 words)

	Canadian cancer researchers win prestigious award for their stem cell research
		Till and McCulloch are being honoured for their groundbreaking discovery demonstrating the existence of stem cells in the blood-forming system.
		Till and McCulloch motivated me as a young scientist - and continue to influence an entire generation of Canadian health researchers," says Dr. Bernstein, a former student of Dr. Till at the University of Toronto and the Ontario Cancer Institute.
		Till and McCulloch at a prestigious ceremony on Friday, September 23 at the Pierre Hotel in New York City, NY.
	www.eurekalert.org /pub_releases/2005-09/cioh-ccr091905.php (444 words)

	Department of Medical Biophysics - Faculty - Dr. Ernest McMculloch (Site not responding. Last check: 2007-09-08)
		Yang, G.S., Wang, C., Minkin, S., Minden, M.D., and McCulloch, E.A. Hydrocortisone in culture protects the blast cells of acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.
		Koistinen, P., Wang, C., Yang, G.S., Wang, Y.-F., Williams, D.E., Lyman, S.D., Minden, M.D., and McCulloch, E.A. OCI /AML-4, an acute myeloblastic leukemia cell line: regulation and response to cytosine arabinoside.
		Tohda, S., Minden, M.D., and McCulloch, E.A. Interactions between retinoic acid and colony-stimulating factors affecting the blast cells of acute myeloblastic leukemia.
	medbio.utoronto.ca /faculty/mcculloch.html (268 words)

	McCulloch v. Maryland on Encyclopedia.com (Site not responding. Last check: 2007-09-08)
		The McCulloch theory of the Fourteenth Amendment: City of Boerne v.
		The story of McCulloch: banking on national power.
		Maryland procurement regulations on use of affiliates to avoid taxation on income from state contracts.
	www.encyclopedia.com /html/M/McCulloM.asp (460 words)

	Pioneers in stem cell research honoured - CIHR
		The Till, McCulloch and Leblond International Symposium, held at the Sheraton Centre in Montreal on Nov. 5, will feature leading stem cell researchers from around the world, discussing the latest developments in the field.
		James Till and Ernest McCulloch were recently inducted into the Canadian Medical Hall of Fame for their groundbreaking work.
		Till and McCulloch were the first to prove the existence of stem cells more than 40 years ago while working at the Ontario Cancer Institute in Toronto.
	www.cihr-irsc.gc.ca /e/25246.html (469 words)

	University of Toronto -- News@UofT -- Read about the 2004 honorary degree recipients (Jun 2/04)
		University Professor Emeritus Ernest McCulloch is a pioneering biomedical researcher whose revolutionary hematology work with colleague James Till opened new doors for research into stem cells.
		McCulloch graduated from U of T’s medical school in 1948 before spending a year at the Lister Institute in London, England.
		During his career at U of T, McCulloch was a professor in both the Departments of Medicine and Medical Biophysics and spent three years as assistant dean for the School of Graduate Studies.
	www.news.utoronto.ca /bin6/040602-75.asp (3589 words)

	Stem Cells - News - Stem-Cell Pioneers Awarded U.S. Prize: Might be Step Toward Nobel. Scientific Colleagues Say ... (Site not responding. Last check: 2007-09-08)
		As the two Canadians who discovered stem cells are awarded the biggest medical prize in the United States, one of them cautioned that there's no guarantee that stem cells will ever meet the enormous hopes people have pinned on them.
		Ernest McCulloch and James Till will receive the Lasker Award this week - a prize that's often a first step toward a Nobel Prize.
		The new cells they found in the early 1960s were stem cells, which are able to transform themselves into blood, bones, muscle or other materials our bodies need.
	www.stemcellnews.com /articles/stem-cells-pioneers-prize.htm (440 words)

	Research milestones from the 1960s
		Dr Jim Till and Dr Ernest McCulloch in Toronto, Ontario discovered that all blood cells come from “blood-forming stem cells” in the bone marrow.
		When they began their work more than 25 years ago, survival rates for childhood leukemia were 50%.
		Drs Till and McCulloch were inducted into the Canadian Medical Hall of Fame in 2004 and in 2005 received both the Lasker Award and the Centenary Medal from the Royal Society of Canada.
	cancer.ca /ccs/internet/standard/0,,3331_13691_15939_langId-en,00.html (269 words)

	Union County Obituaries HEARING
		McCulloch, Creswell, Ore.; 5 grandchildren and 2 great-grandchildren.
		Oswald Anderson of Seattle; two sons, Ernest (Bud) Hearing, now living at San Diego, Calif., and Elbert Hearing, who just recently enlisted in the U.S. navy and is stationed at San Diego.
		She was educated in Haines and married Ernest Hearing in Haines.
	www.usgennet.org /usa/or/county/union1/hearingobits.htm (2843 words)

	Handbook of Texas Online:
		West Sweden was eight miles northwest of Brady in west central McCulloch County.
		Ernest Severin, a Swedish minister from Austin, founded the community in 1905, bringing several Swedish families from Travis and Williamson counties.
		BIBLIOGRAPHY: Jessie Laurie Barfoot, History of McCulloch County, Texas (M.A. thesis, University of Texas, 1937).
	www.tsha.utexas.edu /handbook/online/articles/view/WW/hvw37.html (156 words)

	Canadian cancer researchers win prestigious award for their stem cell research - CIHR congratulates Drs. Till and ... (Site not responding. Last check: 2007-09-08)
		The award is considered to be 'America's Nobel Prize,' and is one of the most distinguished scientific honors given for outstanding contributions to health research and public service.
		Till and McCulloch are being honored for their groundbreaking discovery demonstrating the existence of stem cells in the blood-forming system.
		Till and McCulloch at a prestigious ceremony on
	press.arrivenet.com /health/article.php/694113.html (441 words)

	Canadian stem cell research pioneers win prestigious U.S. science award : ArriveNet Press Releases : Health (Site not responding. Last check: 2007-09-08)
		Till and McCulloch's work created the scientific basis for the development of lifesaving therapies, such as bone-marrow transplants, and inspired a generation of medical researchers.
		According to Nature Immunology, of the 15 classic papers on blood stem cells published in the 1960s, nine have the names of Till and McCulloch.
		In 2004, Till and McCulloch were inducted into the Canadian Medical Hall of Fame for their work.
	press.arrivenet.com /health/article.php/694469.html (658 words)

	Stem cell - Wikipedia, the free encyclopedia
		Yet there is general agreement that, "significant technical hurdles remain that will only be overcome through years of intensive research."
		The study of stem cells is attributed as beginning in the 1960s after research by Canadian scientists Ernest A. McCulloch and James E. Till.
		1963 - McCulloch and Till illustrate the presence of self-renewing stem cells in mouse bone marrow
	en.wikipedia.org /wiki/Stem_cell (1525 words)

	The Lasker Foundation \| This Year's Winners, Basic Medical Research 2005
		Ernest A. McCulloch and James E. Till for ingenious experiments that first identified a stem cell - the blood-forming stem cell - which set the stage for all current research on adult and embryonic stem cells.
		Download a.pdf of Ernest A. McCulloch and James E. Till's article in
		Key publications of Ernest A. McCulloch and James E. Till »
	www.laskerfoundation.org /awards/library/2005basic.shtml (125 words)

	BREITBART.COM - Work on Stem Cells, DNA Research Honored
		The prize for basic medical research will be shared by Ernest McCulloch and James Till of the Ontario Cancer Institute and the University of Toronto for their pioneering identification of a stem cell.
		Stem cells can give rise to specialized cell types, and scientists are studying them in hopes of creating tissue to treat diseases like diabetes and Parkinson's.
		The work of McCulloch and Till set the stage for today's stem cell research, the Lasker foundation said.
	www.breitbart.com /news/2005/09/17/D8CM8UHO3.html (427 words)

	Stem Cell Network: News (Site not responding. Last check: 2007-09-08)
		The six men — luminaries of Canadian medicine and health care — foreverchanged the country’s health care landscape through their innovation and dedication to advancing the health and well-being of people everywhere.
		Inductees include James Till and Ernest McCulloch, who discovered that stem cells were multi-potent.
		They are Dr. James Edgar Till, Dr. Ernest McCulloch, Dr. Oswald Theodore Avery, Dr. John Gerald FitzGerald, Dr. Marc Lalonde, and Dr. Maurice LeClair.
	www.stemcellnetwork.ca /news/articles.php?id=475 (168 words)

	CBC News: Canadians win Lasker prize for medical research (Site not responding. Last check: 2007-09-08)
		Ernest McCulloch and James Till of the Ontario Cancer Institute and the University of Toronto shared the prize for basic medical research for their pioneering identification of a stem cell.
		By the early 1970s, McCulloch and Till showed clearly that a single type of bone marrow stem cell could create red cells, white cells and platelets.
		Their work explained the effect of bone marrow transplantation, used to treat people with leukemia or other blood cancers.
	www.cbc.ca /story/science/national/2005/09/17/Lasker_prize20050917.html (978 words)

	Networks of Centres of Excellence
		Canada has a proud history of stem cell research.
		Ernest McCulloch and James Till in Toronto in the early 1960s, and these pioneers trained generations of Canadian scientists to follow in their footsteps.
		The Stem Cell Network (SCN)'s vision is to make stem cell therapy a reality and create an internationally competitive stem cell industry in Canada.
	www.nce.gc.ca /nces-rces/stemcell_e.htm (525 words)

	Reference.com/Encyclopedia/Stem cell
		Medical researchers believe stem cells have the potential to change the face of human disease by being used to repair specific tissues or to grow organs.
		The study of stem cells began from research at the Ontario Cancer Institute during the 1960s by Canadian scientists Ernest A. McCulloch and James E. Till.
		A single totipotent stem cell can grow into an entire organism and even produce extra-embryonic tissues.
	www.reference.com /browse/wiki/Stem_cell (4765 words)

	StemCellAction.org
		Among other things, scientists are exploring the seemingly limitless potential of stem cells to repair damaged brains, spinal cords and hearts, as well as to treat a host of debilitating conditions such as diabetes, blood disorders and Alzheimer's.
		For this they can thank two Canadians, Alberta-born biophysicist James Till and Toronto physician Ernest McCulloch, who first discovered the existence of stem cells in the 1960s while doing Cold War research on radiation.
		They seem to have started a big ball rolling.
	stemcellaction.org /pages/content/view/66/2 (1910 words)

	Medical Award Honors Two Scientists Who Found Stem Cells
		Scientists are examining adult and embryonic stem cells in hopes of treating different diseases.
		The winners are Ernest McCulloch and James Till of the Ontario Cancer Institute and the University of Toronto.
		They first identified a stem cell in the blood-forming system.
	www.voanews.com /specialenglish/2005-10-04-voa3.cfm (480 words)

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