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Topic: Ertapenem

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	Health Canada Approves Invanz (Ertapenem Sodium), Once Daily Injectable Antibiotic
		Ertapenem offers the convenience of a once a day monotherapy and clinical studies have found the efficacy of ertapenem similar to multi-dose combination therapies.1,2 Potential advantages of a once daily dosing regimen using a single agent include decreased resource utilization and possible reduction of medication error rate in hospitalized patients.
		Ertapenem was studied in clinical trials with commonly prescribed treatment regimens for complicated intra-abdominal infections acquired in a community setting that require multiple daily dosing and/or a combination of anti-microbial agents.
		Ertapenem monotherapy was studied with a combination therapy of ceftriaxone plus metronidazole in a prospective, randomized, multi-centred, controlled, double-blind trial on the treatment of complicated intra-abdominal infections in adults.
	www.docguide.com /dg.nsf/PrintPrint/524BF5A2155934FC85256D960045182D (801 words)

	Invanz - Drug information from Medic8.com
		Ertapenem is marketed by Merck as a first-line treatment for community-acquired infections.
		Ertapenem is dosed as 1g given by intravenous injection over 30 minutes, or 1g diluted with 3.2ml of 1% lidocaine given intramuscularly.
		Ertapenem is excreted primarily (80%) by the kidneys.
	www.medic8.com /medicines/Invanz.html (481 words)

	the Drug Monitor - Ertapenem (Invanz) - Nasr Anaizi, PhD
		Ertapenem does not appear to undergo hepatic metabolism, and only 10% of a 1 g IV dose is recovered in the feces.
		Ertapenem is excreted in human breast milk and therefore it should be administered to nursing mothers only when the expected benefit outweighs the risk.
		Ertapenem (INVANZ) is supplied as a sterile lyophilized powder in single dose vials each containing the equivalent of 1 gram of ertapenem (for IV infusion or for IM injection)(NDC 00006-3843-71 or 00006-3843-45).
	www.thedrugmonitor.com /ertapenem.html (1407 words)

	Ertapenem Information on Healthline
		Before using ertapenem, tell your doctor if you have kidney disease, a seizure disorder such as epilepsy, or a history of head injury or brain tumor.
		Ertapenem is given as an injection into a muscle, or through a needle placed into a vein.
		Ertapenem is used to treat severe bacterial infections of the skin, lungs, stomach, pelvis, and urinary tract.
	www.healthline.com /multumcontent/ertapenem (591 words)

	Brain Attack Content: Ertapenem offers convenient alternative in CSSSI
		Ertapenem has been shown to be effective against staphylococci and streptococci, most pathogenic anaerobes, and members of the Enterobacteriaceae (including strains producing extended spectrum beta-lactamases).
		Based on its spectrum of activity and its long half-life, ertapenem is being investigated as a once-a-day parenteral beta-lactam antimicrobial with the potential of being used as monotherapy for the treatment of community-acquired, mixed infections.
		In this study, Dr. Graham noted, ertapenem was as effective as piperacillin/tazobactam for the treatment of CSSSI, with a clinical response in clinically evaluable patients of 82.4 percent in the ertapenem group and 84.4 percent in the piperacillin/tazobactam group, at test-of-cure.
	brainattack.mediwire.com /main/Content.aspx?ArticleID=9616 (584 words)

	Ertapenem (Site not responding. Last check: )
		Ertapenem is designed to be effective against Gram negative bacteria.
		Ertapenem is dosed as 1g given by intravenous injection over 30 minutes, or 1g diluted with 3.2ml of 1% lidocaine given intramuscularly.
		Ertapenem is excreted primarily (80%) by the kidneys.
	www.kiwipedia.com /ertapenem.html (369 words)

	Health Traveler Content: Invanz (Ertapenem for injection) Merck
		Ertapenem is a 1-(beta) methyl-carbapenem that is structurally related to beta-lactam antibiotics.
		Among the 1,954 patients treated with ertapenem in clinical trials, the most common drug-related adverse events were diarrhea (5.5% incidence), infused-vein complications (3.7%), and nausea (2.2%).
		Because lidocaine HCl is used as a diluent, intramuscular administration of ertapenem is contraindicated in patients with hypersensitivity to amide-type local anesthetics.
	healthcaretraveler.mediwire.com /main/Content.aspx?ArticleID=7384 (353 words)

	REPEAT/FDA Approves New Indication for INVANZ(R) (ertapenem) for the Prevention of Surgical Site Infections (SSI) ...
		The apparent volume of distribution at steady state (Vss) of ertapenem in adults is approximately 0.12 liter/kg, approximately 0.2 liter/kg in pediatric patients 3 months to 12 years of age and approximately 0.16 liter/kg in pediatric patients 13 to 17 years of age.
		However, ertapenem does not appear to undergo hepatic metabolism based on in vitro studies and approximately 10% of an administered dose is recovered in the feces.
		Ertapenem was neither mutagenic nor genotoxic in the following in vitro assays: alkaline elution/rat hepatocyte assay, chromosomal aberration assay in Chinese hamster ovary cells, and TK6 human lymphoblastoid cell mutagenesis assay; and in the in vivo mouse micronucleus assay.
	www.businesswire.com /portal/site/google/index.jsp?ndmViewId=news_view&newsId=20061221005160&newsLang=en (8928 words)

	Ertapenem facts and comparsions at Drugs.com
		Ertapenem is usually given as an injection at your doctor's office, hospital, or clinic.
		Ertapenem should not be used in CHILDREN younger than 3 months old; safety and effectiveness in these children have not been confirmed.
		Ertapenem is to be used only by the patient for whom it is prescribed.
	www.drugs.com /cdi/ertapenem.html (1047 words)

	Data Sheet
		INVANZ (Ertapenem for Injection) is a sterile, synthetic, long-acting, parenteral, 1-β methyl-carbapenem that is structurally related to beta-lactam antibiotics, such as penicillins and cephalosporins, with activity against a wide range of gram-positive and gram-negative aerobic and anaerobic bacteria.
		Ertapenem concentrations in CSF were not sufficient to cover all likely pathogens suggesting the potential for impaired efficacy in patients developing septicaemia with CSF infection.
		Ertapenem was discontinued due to adverse experiences thought to be drug-related in 1.3% of patients.
	www.medsafe.govt.nz /profs/Datasheet/I/Invanzinj.htm (4345 words)

	Ertapenem (Invanz)
		Ertapenem is a synthetic, parenteral carbapenem that is structurally related to beta-lactam antibiotics.
		At therapeutic concentrations ertapenem is 85% to 95% bound to plasma proteins.
		Ertapenem is broken down by hydrolysis to form an inactive metabolite.
	uuhsc.utah.edu /pharmacy/bulletins/ertapenem.html (463 words)

	ERTAPENEM
		Ertapenem is used for: Treating moderate to severe infections caused by certain bacteria.
		Ertapenem (er-ta-PEN-em) is used in the treatment of infections caused by bacteria.
		Ertapenem is used to treat infections in many different parts of the body.
	www.drugs.com /search.php?is_main_search=1&searchterm=ERTAPENEM (436 words)

	Ertapenem(Systemic) - [Medication] (Site not responding. Last check: )
		Ertapenem er-ta-PEN-em is used in the treatment of infections caused by bacteria.
		Ertapenem is used to treat infections in many different parts of the body.
		Ertapenem also has not been shown to cause birth defects or other problems in animal studies.
	www.luhs.org /health/kbase/htm/mdx-/drde/5003/95/mdx-drde500395.htm (1359 words)

	Multum Drug Fact Sheets
		Ertapenem is given as an injection into a muscle, or through a needle placed into a vein.
		Ertapenem is used to treat severe bacterial infections of the skin, lungs, stomach, pelvis, and urinary tract.
		Ertapenem is usually given as a daily injection for 3 to 14 days.
	www.stfranciscare.org /body.cfm?id=869&action=factsheetdetail&drugid=42473 (1407 words)

	[Ertapenem and other antibacterials]
		Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR (0235-2990)
		Ertapenem is a carbapenem that shares the activity of imipenem and meropenem against most species, but is less active against non-fermenters.
		Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR
	www.galenicom.com /medline/article/16878390/mt:Lactams (339 words)

	Ertapenem - QuickSeek Encyclopedia (Site not responding. Last check: )
		Ertapenem is marketed by Merck as first line treatment for community acquired infections.
		Ertapenem is dosed as 1g given by intravenous injection over 30 minutes, or 1g diluted with 3.2ml of 1% lignocaine given intramuscularly.
		Unlike imipenem and meropenem, ertapenem is highly protein blound, which explains its long half life (4 hours).
	ertapenem.quickseek.com (387 words)

	All you need to know cephalexin antibiotic (Site not responding. Last check: )
		Ertapenem kills bacteria that cephalexin antibiotic This drug treats many kinds of cephalexin antibiotic those of the skin, stomach, respiratory tract, and urinary cephalexin antibiotic also treats certain infections in women (gynecological cephalexin antibiotic cephalexin antibiotic ertapenem injection is not yet available.
		Ertapenem is cephalexin antibiotic into a muscle or cephalexin antibiotic a vein.
		Ertapenem is usually given in cephalexin antibiotic or clinic for severe infections.
	cephalexin.pharmacy-buy.com /cephalexinantibiotic.html (324 words)

	Ertapenem U.S. FDA Drug Approval : News : Micromedex (Site not responding. Last check: )
		Ertapenem is highly protein-bound, with a volume of distribution of 8 liters (L); most of a dose is excreted renally (about 40% unchanged).
		No studies with ertapenem have been published, and virtually all adverse effect data are from the manufacturer; thus detailed information is unavailable.
		Intravenous or intramuscular ertapenem is effective in a variety of serious infections, including complicated intraabdominal infections, although no studies have been published and the drug has not been compared with other carbapenems.
	www.micromedex.com /pressroom/news_feeds/fdaapprovals/fda_ertapenem.html (248 words)

	Stability and compatibility of reconstituted ertapenem with commonly used i.v. infusion and coinfusion solutions -- ...
		Ertapenem concentrations were determined by a stability-indicating high-performance liquid chromatography assay.
		Ertapenem 10 mg/mL was stable for a longer time than at the 20-mg/mL concentration.
		CONCLUSION: Ertapenem sodium injection 10 and 20 mg/mL are relatively stable in sodium chloride injections and Ringer's solution when stored at 25 and 4 degrees C, but are unstable in mannitol and dextrose solutions.
	www.ajhp.org /cgi/content/abstract/61/1/38 (286 words)

	Invanz (ertapenem) medical facts from Drugs.com
		Ertapenem must be mixed with a liquid (diluent) before it is given.
		When given as an IV infusion into a vein, ertapenem must be given slowly, and can take at least 30 minutes to complete.
		Ertapenem is usually given as a daily injection for 3 to 14 days.
	www.drugs.com /mtm/invanz.html (1574 words)

	Ertapenem - Drugs & Vitamins - Drug Library - DrugDigest
		Ertapenem is for injection into a muscle or infusion into a vein.
		Ertapenem is usually given in a hospital or clinic for severe infections.
		If you are to give yourself ertapenem at home, follow the directions on the prescription label.
	www.drugdigest.org /DD/DVH/Uses/0,3915,8001\|Ertapenem,00.html (519 words)

	NEJM -- Ertapenem versus Cefotetan Prophylaxis in Elective Colorectal Surgery
		NEJM -- Ertapenem versus Cefotetan Prophylaxis in Elective Colorectal Surgery
		Ertapenem versus Cefotetan Prophylaxis in Elective Colorectal Surgery
		was surgical-site infection: 17.1% in the ertapenem group and
	content.nejm.org /cgi/content/short/355/25/2640 (443 words)

	MSD - Israel
		INVANZ™ (ertapenem, MSD) is a new once-daily carbapenem highly effective against a variety of mixed infections.
		INVANZ™ (Ertapenem for Injection) is a sterile, synthetic, parenteral, 1-beta-methyl-carbapenem that is structurally related to beta-lactam antibiotics.
		Ertapenem has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria.
	www.msd.co.il /site/product11.html (221 words)

	Ertapenem: Drug Information Provided by Lexi-Comp: Merck Manual Professional
		Ertapenem is approved for use in postpartum endomyometritis, septic abortion, and postsurgical gynecologic infections.
		The low concentrations of ertapenem in milk and low oral bioavailability suggest minimal exposure risk to the infant.
		Hypersensitivity to ertapenem, other carbapenems, or any component of the formulation; anaphylactic reactions to beta-lactam antibiotics.
	www.merck.com /mmpe/lexicomp/ertapenem.html (1518 words)

	HPA \| Resistance Alert: Carbapenem-resistant Enterobacteriaceae
		Among the klebsiellas, the typical pattern is ertapenem MIC (often 8-32 mg/L) > meropenem MIC > imipenem MIC, with the latter two MICs raised but often (70-90% cases) still within the susceptible range (< 4 mg/L).
		Among Enterobacters, the ertapenem MIC is again the highest for any carbapenem (8-16 mg/L), but then with the imipenem MIC > the meropenem MIC and, again, with these latter values raised but often (60-70% cases) still within the susceptible range.
		Laboratories should be aware of the risk of this type of selection during carbapenem usage against ESBL producers, particularly with ertapenem and particularly with Klebsiella spp and Enterobacter spp.
	www.hpa.org.uk /infections/topics_az/antimicrobial_resistance/alert.htm (624 words)

	New Study Cites Benefits Of Ertapenem For Diabetic Foot Infections
		At the end of IV therapy, ertapenem had a success rate of 94.3 percent (+/- 3 percent) while piperacillin/tazobactam had a success rate of 92.3 percent (+/- 3.5 percent).
		With the exception of methicillin resistant staphylococci, ertapenem covers “most of the aerobic gram-positive cocci that are the primary pathogens in diabetic foot infections,” explains Dr. Lipsky, a Professor of Medicine at the University of Washington and the Director of the General Internal Medicine Clinic with the VA Puget Sound Health Care System in Seattle.
		Dr. Lipsky, a Fellow of the Infectious Diseases Society of America, says ertapenem is also effective against aerobic gram-negative rods and obligate anaerobes that are often part of mixed infections in chronic or previously treated infections.
	www.podiatrytoday.com /article/3464 (1372 words)

	RemedyFind: patient ratings of Antibiotic Therapy: Invanz (Ertapenem) for Diabetes Type 2
		Invanz (Ertapenem) is a methyl-carbapenem antibiotic that is structurally related to beta-lactam antibiotics.
		Invanz etc. (Ertapenem) is approved for the treatment of moderate to severe complicated foot infection due to indicated pathogens in diabetic patients without osteomyelitis.Â
		We assigned patients intravenous ertapenem (1 g daily; n=295) or piperacillin/tazobactam (3.375 g every 6 h; n=291) given for a minimum of 5 days, after which oral amoxicillin/clavulanic acid (875/125 mg every 12 h) could be given for up to 23 days.
	www.remedyfind.com /rem.asp?ID=21764 (506 words)

	European Society of Clinical Microbiology and Infectious Diseases
		Ertapenem, a Group 1 carbapenem, is a once-a-day parenteral a-lactam antibiotic which is used as initial antimicrobial monotherapy for treatment of community-acquired pneumonia (CAP).
		After 5 days therapy with ertapenem 61 patients (95,3%) had clinical and haematological improvment, concerning the reduction of fever, WBC from 14000 ± 1700–7800 ± 1200 and CRP value from 9.1 ± 1.1–2.2 ± 0.8.
		Ertapenem, given 1 gr once a day by iv infusion was generally well tolerated and had overall a very good safety and tolerability profile.
	www.blackwellpublishing.com /eccmid15/abstract.asp?id=37435 (305 words)

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